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Veterinary Pathology

Reiner Ulrich
No abstract text is available yet for this article.
February 5, 2019: Veterinary Pathology
P Nick Nation, Colleen Cassady St Clair
Dismembered cats ( Felis catus) have been found in North American schoolyards, parks, walkways, or lawns and sometimes result in local media attention. When a member of the public encounters these cats, they commonly report finding either the cranial or caudal half of a cat in a prominent location. Such findings cause public consternation and pose difficulties to investigators in identifying whether animal abuse has occurred and whether to concentrate resources on the investigation. This report describes necropsy results from 53 cats involved in such instances in the cities of Edmonton and St...
February 5, 2019: Veterinary Pathology
Alicia Maclaine, María J Forzán, Narges Mashkour, Jennifer Scott, Ellen Ariel
Juvenile eastern water dragons ( Intellagama lesueurii lesueurii) are highly susceptible to infection with Bohle iridovirus (BIV), a species of ranavirus first isolated from ornate burrowing frogs in Townsville, Australia. To investigate the progression of BIV infection in eastern water dragons, 11 captive-bred juveniles were orally inoculated with a dose of 104.33 TCID50 and euthanized at 3, 6, 8, 10, 12, and 14 days postinfection (dpi). Viral DNA was detected via polymerase chain reaction (PCR) in the liver, kidney, and cloacal swabs at 3 dpi...
January 27, 2019: Veterinary Pathology
Nagwan El-Habashi, El-Shaymaa El-Nahass, Hoda Abd-Ellatieff, Asmaa Saleh, Osama Abas, Yuya Tsuchiya, Hideto Fukushi, Tokuma Yanai
Encephalitis in hamsters, which was induced by equine herpesvirus (EHV)-9, EHV-1 strain Ab4p, and zebra-borne EHV-1, was investigated and compared to assess viral kinetics and identify the progression and severity of neuropathological findings. Hamsters were inoculated with EHV-9, EHV-1 strain Ab4p, and zebra-borne EHV-1 via the nasal route and euthanized at 24, 48, 72, 96, 120, 144, and 168 hours postinoculation (HPI). The inoculated hamsters had mild to severe neurological signs at 60 to 72, 96, and 120 HPI, and the mortality rate was 75%, 0%, and 0% for animals inoculated with EHV-9, EHV-1 strain Ab4p, and zebra-borne EHV-1 viruses, respectively...
January 27, 2019: Veterinary Pathology
Federico Bonsembiante, Ugo Bonfanti, Francesco Cian, Laura Cavicchioli, Beatrice Zattoni, Maria Elena Gelain
Digital slides created by whole-slide imaging scanners can be evaluated by pathologists located in remote sites, but the process must be validated before this technology can be applied to routine cytological diagnosis. The aim of this study was to validate a whole-slide imaging scanner for cytological samples. Sixty cytological samples, whose diagnoses were confirmed by gold-standard examinations (histology or flow cytometry), were digitalized using a whole-slide imaging scanner. Digital slides and glass slides were examined by 3 observers with different levels of cytopathological expertise...
January 27, 2019: Veterinary Pathology
Stamatina Giannikaki, Kit Sturgess, Emma Scurrell, Prado Cebrian, Natalia Escanilla, Robert C Lowe
This report describes the clinical presentation, diagnosis, and histopathologic features of oculodermal melanocytosis in a young dog. A 3-year-old male neutered Labrador Retriever presented with conjunctival and scleral hyperpigmentation of the right eye, with concurrent ipsilateral cutaneous hyperpigmentation involving the right side of the face. Initial skin and conjunctival biopsies revealed an accumulation of histologically benign melanocytes within the dermis and conjunctival stroma, respectively. Enucleation was elected 19 months later by the referring veterinarian due to the progression of ocular pigmentation with concurrent marked corneal lipidosis and the suspicion of a scleral mass...
January 27, 2019: Veterinary Pathology
Todd K Shury, Margo J Pybus, Nick Nation, Normand L Cool, W James Rettie
Thirty-seven adult female moose ( Alces alces) from 2 distinct but adjacent populations in Elk Island National Park (EINP), Alberta, Canada (19 in north EINP and 18 in south EINP), were fitted with mortality-sensing VHF radio-collars, and radio signals were acquired daily to ascertain mortality status. At capture, serum, whole blood, and feces were collected; pregnancy was determined; teeth were aged by visual inspection; and a portion of liver was assessed by ultrasound examination. Postmortem examination was conducted on 20 suitable carcasses...
January 27, 2019: Veterinary Pathology
Hisashi Yoshimura, Aya Otsuka, Masaki Michishita, Masami Yamamoto, Minori Ashizawa, Manami Zushi, Maiko Moriya, Daigo Azakami, Kazuhiko Ochiai, Yoko Matsuda, Toshiyuki Ishiwata, Shinji Kamiya, Kimimasa Takahashi
S100A4 (metastasin), a member of the S100 protein family, was initially identified in metastatic cells and is well established as a marker of aggressive human cancer. However, expression and roles of S100A4 in canine mammary tumors have not been clarified. In this study, expression of S100A4 was examined immunohistochemically in normal, hyperplastic, and neoplastic mammary glands of dogs. In all normal and benign lesions, S100A4 was restricted to a few stromal fibroblasts and inflammatory cells. However, in 7 of 57 (12%) of the malignant tumors examined, cytoplasmic and nuclear expression of S100A4 was observed in epithelial tumor cells and stromal cells...
January 27, 2019: Veterinary Pathology
Joaquín Ortega, José Manuel Verdes, Eleonora L Morrell, John W Finnie, Jim Manavis, Francisco A Uzal
Enterotoxemia caused by Clostridium perfringens type D is an important disease of sheep and goats with a worldwide distribution. Cerebral microangiopathy is considered pathognomonic for ovine enterotoxemia and is seen in most cases of the disorder in sheep. However, these lesions are poorly described in goats. In this article, we describe the vasculocentric brain lesions in 44 cases of caprine spontaneous C. perfringens type D enterotoxemia. Only 1 goat had gross changes in the brain, which consisted of mild cerebellar coning...
January 20, 2019: Veterinary Pathology
Sara Belluco, Giancarlo Avallone, Stefano Di Palma, Roberta Rasotto, Anna Oevermann
In routine diagnostic activity, pathologists may be confronted with nervous system tumors. The lack of clinical information, economic restrictions for additional testing, and the lack of expertise in neuropathology may render the diagnosis challenging. The goals of this study were to assess the agreement in diagnosing nervous system tumors in domestic carnivores among 4 board-certified surgical pathologists without particular expertise in neuropathology and a neuropathologist expert, and to investigate the utility of special stains frequently used in routine diagnostic laboratories...
January 20, 2019: Veterinary Pathology
Lauren V Powers, Mark A Mitchell, Michael M Garner
Proventricular infection with the anamorphic, ascomycetous yeast Macrorhabdus ornithogaster and disease associated with infection (macrorhabdiosis) have been widely reported in budgerigars ( Melopsittacus undulatus). Proventricular adenocarcinoma has also been previously reported in this species. In a retrospective archival search of clinical cases submitted to a zoo animal and exotic pet pathology service between 1998 and 2013, a total of 28 128 avian submissions were identified, which included 1006 budgerigars kept in zoos or aviaries or as pets...
January 16, 2019: Veterinary Pathology
Michael A Richardson, Tuddow Thaiwong, Matti Kiupel
Primary colorectal follicular lymphomas are rare indolent lymphoid neoplasms in humans that have not been reported in dogs. We describe 3 cases of primary colorectal follicular lymphoma in dogs with histologic and immunohistochemical features similar to their human counterpart. Initial clinical signs in all dogs included tenesmus, hematochezia, and a palpable rectal mass. Two dogs were castrated males and 1 an intact female, between 9 months and 2 years of age, and of varied breeds. All 3 cases of colorectal follicular lymphoma were characterized by proliferation of follicular germinal centers with no polarity or mantle zone and were composed of centrocytes admixed with fewer centroblasts...
January 13, 2019: Veterinary Pathology
Ludmila Szabova, Baktiar Karim, Melanie Gordon, Lucy Lu, Nathan Pate, Zoe Weaver Ohler
Nongestational choriocarcinoma is a rare malignancy in humans with poor prognosis. Naturally occurring choriocarcinoma is also rare in laboratory mice, and no genetic mouse model accurately recapitulates the features of this cancer. Here we report development of a genetically engineered mouse (GEM) model with alterations in Brca2, Trp53, and RB that develops ovarian tumors. Most of the ovarian tumors displayed histological characteristics of nongestational choriocarcinoma of the ovary (NGCO) (47%) with abundant syncytiotrophoblasts and cytotrophoblasts, positive immunolabeling for human chorionic gonadotropin, and positive periodic acid-Schiff reaction...
January 13, 2019: Veterinary Pathology
Davide De Biase, Orlando Paciello
No abstract text is available yet for this article.
January 13, 2019: Veterinary Pathology
Leah Stein, Cynthia Bacmeister, Kris Ylaya, Patricia Fetsch, Zengfeng Wang, Stephen M Hewitt, Matti Kiupel
Marginal zone lymphoma (MZL) and mantle cell lymphoma (MCL) belong to a subgroup of indolent B-cell lymphomas most commonly reported in the canine spleen. The goal of this study was to characterize the immunophenotype of splenic MZL and MCL in comparison to their human counterparts. Ten MCLs and 28 MZLs were selected based on morphology. A tissue microarray was generated, and expression of CD3, CD5, CD10, CD45, CD20, CD79a, Pax-5, Bcl-2, Bcl-6, cyclin D1, cyclin D3, MCL-1, MUM-1, and Sox-11 was evaluated. Neoplastic cells in all MCLs and MZLs were positive for CD5, CD20, CD45, CD79a, and BCL2 and negative for CD3, CD10, Bcl-6, cyclin D1, and cyclin D3...
January 13, 2019: Veterinary Pathology
Masaya Tsuboi, Kosei Sakai, Shingo Maeda, James K Chambers, Tomohiro Yonezawa, Naoaki Matsuki, Kazuyuki Uchida, Hiroyuki Nakayama
Canine urothelial carcinoma (UC) has a poor prognosis and high metastatic rate. Human epidermal growth factor receptor 2 (HER2), a receptor tyrosine kinase involved in cell proliferation and differentiation regulation, has been attracting interest as a therapeutic target molecule for human breast cancer. In this study, HER2 expression in canine UC and its association with clinical factors were investigated. Since it has been controversial whether commercial anti-human HER2 antibody (Dako A0485) correctly recognizes canine HER2, an application of the antibody using a canine UC cell line was validated first...
January 6, 2019: Veterinary Pathology
Eric Zini, Silvia Nolli, Filippo Ferri, Federico Massari, Gabriele Gerardi, Stefano Nicoli, Giorgio Romanelli, Vincenzo Montinaro, Davide Trez, Laura Cavicchioli, Silvia Ferro
Pheochromocytoma is frequent in dogs and carries a guarded prognosis. Current histological criteria may not predict malignant behavior in dogs, similar to humans. In humans, characterization of tumors has been refined using the pheochromocytoma of the adrenal gland scaled score (PASS) and by immunohistochemistry. The study aim was to investigate PASS and immunohistochemical markers used in humans in 24 dogs with pheochromocytoma that underwent adrenalectomy. Dogs with pheochromocytomas were reviewed and tumors collected...
December 30, 2018: Veterinary Pathology
Karin A Allenspach, Jonathan P Mochel, Yingzhou Du, Simon L Priestnall, Frances Moore, Michael Slayter, Aline Rodrigues, Mark Ackermann, Mark Krockenberger, Joanne Mansell, Nicole Luckschander, Chong Wang, Jan Suchodolski, Nora Berghoff, Albert E Jergens
Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would improve the consistency of interpretation among pathologists when describing histologic lesions of gastrointestinal inflammation. Our aim was to evaluate the correlation of histopathologic changes to clinical activity in dogs with IBD using this new system. Forty-two dogs with IBD and 19 healthy control dogs were enrolled in this retrospective study...
December 18, 2018: Veterinary Pathology
Rebecca J Egan
No abstract text is available yet for this article.
December 17, 2018: Veterinary Pathology
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