Rashmi Savant, Raj Kumar Pradhan, Savita Bhagat, Rajeswara Babu Mythri, Anu Mary Varghese, Seena Vengalil, Atchayaram Nalini, Talakad N Sathyaprabha, Trichur R Raju, K Vijayalakshmi
Amyotrophic Lateral Sclerosis (ALS) is a multifactorial neurodegenerative disorder with a significant contribution of non-cell autonomous mechanisms to motor neuronal degeneration. Amongst a plethora of molecules, Fractalkine (C-X3-C motif chemokine ligand 1), and Heat Shock Protein 60 (HSP60), are key modulators of microglial activation. The contribution of these molecules in Sporadic ALS (SALS) remains unexplored. To investigate this, fractalkine levels were estimated in Cerebrospinal fluid (CSF) of SALS patients (ALS-CSF; n = 44) by Enzyme-linked Immunosorbent Assay (ELISA) and correlated with clinical parameters including disease severity and duration...
April 16, 2024: International Journal of Neuroscience