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International Journal of Neuroscience

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https://read.qxmd.com/read/30995880/small-interfering-lncrna-tug1-situg1-decreases-ketamine-induced-neurotoxicity-in-rat-hippocampal-neurons
#1
Chunni Cao, Yanxian Zhang, Zuofu Zhang, Qi Chen
BACKGROUND: Ketamine (KET) is known to be used in pediatric anaesthetic, whereas many evidences revealed that KET generated neurotoxicity. In our study, we found KET decreased the level of LncRNA taurine-upregulated gene 1 (TUG1). Hence, the aim of our study is to investigate whether small interfering TUG1 (siTUG1) has effect on KET-induced rat hippocampal neurons. MATERIAL AND METHODS: siTUG1 and KET alone or in combination was used to treat with neurons for 12 h...
April 17, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30957600/the-positive-allosteric-modulation-of-gaba-a-receptors-mrna-in-immature-hippocampal-rat-neurons-by-midazolam-affects-receptor-expression-and-induces-apoptosis
#2
Barbara Sinner, Julia Steiner, Manuela Malsy, Bernhard M Graf, Anika Bundscherer
BACKGROUND: Numerous experimental studies show that anesthetics are potentially toxic to the immature brain. Even though benzodiazepines are widely used in pediatric anesthesia and intensive care medicine, only a few studies examine the effects of these drugs on immature neurons. METHODS: Hippocampal neuronal cell cultures of embryonic Wistar rats (15 days in culture) were incubated with midazolam 100 or 300 nM for either 30 min or 4h. The time course of the mRNA expression of the glutamate receptors subunits NR1, NR2A and NR2B of the NMDA receptor, the GluA-1 and A-2 subunits of the AMPA receptor as well as the alpha 1 subunit of the GABAA receptor were examined by PCR...
April 7, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30895838/association-of-mir-122-mir-124-mir-126-and-mir-143-gene-polymorphisms-with-ischemic-stroke-in-the-northern-chinese-han-population
#3
Ruixia Zhu, Xu Liu, Zhiyi He
Objectives Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes can have diverse functional consequence by affecting the processing and target selection of miRNA. Recent evidence indicates that miRNA play important roles in the pathogenesis of atherosclerosis, which is a major cause of ischemic stroke (IS). The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility...
March 21, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30892110/a-novel-in-frame-mutation-in-cln3-leads-to-juvenile-neuronal-ceroid-lipofuscinosis-in-a-large-pakistani-family
#4
Muhammad Sher, Muhammad Farooq, Uzma Abdullah, Zafar Ali, Sanam Faryal, Mohammad Zakaria, Farid Ullah, Hassan Bukhari, Rikke S Møller, Niels Tommerup, Shahid Mahmood Baig
AIM: Neuronal ceroid lipofuscinosis (NCLs) are the most common neurodegenerative disorders, with global incidence of 1 in 100,000 live births. NCLs affect central nervous system, primarily cerebellar and cerebral cortices. Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is the most common form of NCLs. JNCL is primarily caused by pathogenic mutations in CLN3 gene, which encodes a transporter transmembrane protein of uncertain function. The 1.02 kb deletion is the most common mutation in CLN3 that results in frame shift and a premature termination leading to nonfunctional protein...
March 20, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30889366/bioinformatic-analysis-to-explore-key-genes-associated-with-brain-ischemia-reperfusion-injury-in-rats
#5
Hong Ke, Xiaoli Zhang, Lin Cheng, Yanxia Fan, Shuping Xiao, Yingwen Ma, Guangkun Feng
OBJECTIVES: Ischemia-reperfusion (I/R) injury can aggravate the dysfunction and structural damage of tissues and organs. This study aimed at investigating the pathogenesis of I/R injury. METHODS: GSE82146 was extracted from Gene Expression Omnibus database, which included 12 nonischemic control (NIC) hippocampal tissues and 15 complete global brain ischemia (CGBI)-reperfusion hippocampal tissues. After processing the original data using the affy package, the differentially expressed genes (DEGs) between CGBI and NIC samples were analyzed by the limma package...
March 19, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30889365/electroacupuncture-induced-cannabinoid-receptor-expression-in-repair-of-abducens-nerve
#6
Lei Wang, Yi Zhang, Xudong Wang, Zi Ye
OBJECTIVE: Through the development of beagle abducens nerve injury model, taking electroacupuncture as the core and microglia as the starting point, the author investigated whether electroacupuncture can promote the repair of injured abducens nerve by cannabinoid receptor-mediated regulation of microglia activation. METHODS: Healthy beagle dogs were randomly divided into five groups: sham operation group (A), injury group (B), electroacupuncture pretreatment group (C), antagonist group (D), and solvent group (E)...
March 19, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30889362/the-expression-of-voltage-gated-sodium-channels-in-trigeminal-nerve-following-chronic-constriction-injury-in-rats
#7
MingXing Liu, Jun Zhong, Lei Xia, NingNing Dou, ShiTing Li
Despite the etiology of trigeminal neuralgia has been verified by microvascular decompression as vascular compression of the trigeminal root, very few researches concerning its underlying pathogenesis has been reported in the literature. The present study focused on those voltage-gated sodium channels, which are the structural basis for generation of ectopic action potentials. The trigeminal neuralgia modeling was obtained with infraorbital nerve chronic constriction injury (ION-CCI) in rats. Two weeks postoperatively, the infraorbital nerve (TN), the trigeminal ganglion (TG) and the brain stem (BS) were removed and analyzed with a series of molecular biological techniques...
March 19, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30885023/boron-s-neurophysiological-effects-and-tumoricidal-activity-on-glioblastoma-cells-with-implications-for-clinical-treatment
#8
Meric A Altinoz, Gulacti Topcu, İlhan Elmaci
Discovery of novel boron compounds in treatment of glioblastoma is being actively investigated, but the majority of such studies is focused on the synthesis of boron compounds as sensitizers to Boron Neutron Capture Therapy (BNCT). Nonetheless, the translational functionality of boron compounds is not limited to BNCT as many boron compounds possess direct tumoricidal activity and there is substantial evidence that certain boron compounds can cross the blood-brain barrier. Moreover, boron-containing compounds interfere with several tumorigenic pathways including intratumoral IGF-I levels, molybdenum Fe-S containing flavin hydroxylases, glycolysis, Transient Receptor Potential (TRP) and Store Operated Calcium Entry (SOCE) channels...
March 18, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30885017/effects-of-major-adipokines-and-the-420-c-g-resistin-gene-polymorphism-on-the-long-term-outcome-of-patients-with-acute-ischemic-stroke
#9
Stella Bouziana, Konstantinos Tziomalos, Antonis Goulas, Timoleon-Achilleas Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Ι Ηatzitolios
AIM: The association between adiponectin, leptin and resistin and the long-term outcome of ischemic stroke are controversial. We aimed to evaluate this relationship. METHODS: We prospectively studied 83 patients consecutively hospitalized for acute ischemic stroke (38.6% males, age 79.7 ± 6.3 years). Serum adiponectin, leptin and resistin levels and the -420C > G polymorphism of the resistin gene were determined at admission. Stroke severity at admission was evaluated with the National Institutes of Health Stroke Scale (NIHSS)...
March 18, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30821549/clustering-analysis-to-identify-key-genes-associated-with-motor-neuron-excitability-following-spinal-cord-injury
#10
Yong Ni, Kefeng Zhang
PURPOSE: As a neurodegenerative disease, spinal cord injury can lead to the loss of autonomic function, muscle function, or sensation. This study is designed to identify the key genes implicated in the excitability of motor neurons following spinal cord injury. MATERIALS AND METHODS: The GSE19701 dataset was obtained from Gene Expression Omnibus. It includes a total of 31 motor neurons after spinal cord injury (samples at day 0, 2, 7, 21 and 60 following injury)...
March 1, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30806135/thalidomide-alleviates-bone-cancer-pain-by-down-regulating-expressions-of-nf-%C3%AE%C2%BAb-and-gfap-in-spinal-astrocytes-in-a-mouse-model
#11
Jun Tian, Tieying Song, Hong Wang, Wenli Wang, Zaiwang Zhang, Ruyu Yan
AIM: Thalidomide is one of the first line therapies in cancer pain management. Previous study has shown that thalidomide decreases the expression of tumor necrosis factor alpha in the mouse spinal cord. However, the exact cellular and molecular mechanism underlying the effect of thalidomide remains unclear. Here we investigated the effect of thalidomide on the expression level of NF-κB as well as glial fibrillary acidic protein (GFAP) in the spinal cord astrocyte in a mice model. MATERIALS AND METHODS: MC57G fibrosarcoma cells were intramedullary injected into the right femurs of C57/BL mice to induce behaviors related to bone cancer pain...
February 26, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30795710/functional-brain-segregation-changes-during-demanding-mathematical-task
#12
Amir Hossein Ghaderi, Mohammad Ali Nazari, Amir Hossein Darooneh
The neural basis of demanding mathematical problem solving is currently indeterminate and unclear. Mathematical problem solving engages higher order cognition and a complex associative activity of functional neural networks occurs during demanding problem solving. Twenty right handed subjects (mean age: 24.6 years; SD =3.97 years; 50% female) participated in this study. An arithmetic logic puzzle was used as a demanding mathematical task. EEGs were recorded in the eye open rest and eye open task conditions...
February 22, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30795708/bilateral-subthalmic-nucleus-deep-brain-stimulation-with-microelectrode-recordings-in-the-setting-of-mild-inherited-hemophilia-b-a-case-report
#13
Abdulraheem Yacoub, Ghulam Rehman Mohyuddin, Jules M Nazzaro
Hemophilia B is an X linked recessive deficiency of factor IX that presents with a range of clinical severity that co-relates with factor levels. Although guidelines exist to guide perioperative hemostasis in such patients, there is scarce data on elective high-risk neurosurgeries, resulting in a reluctance to offer these patients elective neurosurgeries. These patients thus rarely if ever undergo such procedures. We report a unique case of undiagnosed mild hemophilia B in a gentleman that was found incidentally at age 64 during pre-operative workup...
February 22, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30775947/gene-and-protein-expression-profiles-of-jak-stat-signalling-pathway-in-the-developing-brain-of-the-ts1cje-down-syndrome-mouse-model
#14
Han-Chung Lee, Hadri Hadi Md Yusof, Melody Pui-Yee Leong, Shahidee Zainal Abidin, Eryse Amira Seth, Chelsee A Hewitt, Sharmili Vidyadaran, Norshariza Nordin, Hamish S Scott, Pike-See Cheah, King-Hwa Ling
AIMS: The JAK-STAT signalling pathway is one of the key regulators of pro-gliogenesis process during brain development. Down syndrome (DS) individuals, as well as DS mouse models, exhibit an increased number of astrocytes, suggesting an imbalance of neurogenic-to-gliogenic shift attributed to dysregulated JAK-STAT signalling pathway. The gene and protein expression profiles of JAK-STAT pathway members have not been characterised in the DS models. Therefore, we aimed to profile the expression of Jak1, Jak2, Stat1, Stat3, and Stat6 at different stages of brain development in the Ts1Cje mouse model of DS...
February 18, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30744538/characterization-of-functional-brain-connectivity-towards-optimization-of-music-selection-for-therapy-a-fmri-study
#15
Katherine Wu, Jeff Anderson, Jennifer Townsend, Todd Frazier, Anthony Brandt, Christof Karmonik
BACKGROUND: Music therapy, a non-traditional approach to patient care, has long been used to achieve a wide variety of positive results. A better understanding of the connection and therapeutic potential of music, music therapy, and music medicine (music administered without an interactive therapeutic relationship) to individuals by exploring music's effect on the brain remains a topic of active research. OBJECTIVE: This study is aimed at investigating the effect of different music genres and individualized music selection on brain functional connectivity (FC) measured by functional magnetic resonance imaging (fMRI)...
February 11, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30724645/high-signal-intensity-abnormalities-in-susceptibility-weighted-imaging-for-primary-intracerebral-hemorrhage
#16
Jing-Jing Liang, Lu Lei, Yanping Zeng, Zhe-Man Xiao
PURPOSE: To identify the regularity of signal evolution of intracerebral hemorrhage on susceptibility-weighted imaging (SWI) at different stages compared with T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI). METHODS: We retrospectively evaluated a series of 365 patients who underwent T1WI, T2WI, and SWI examination simultaneously or sequentially in our hospital from January 2015 to May 2017. Two neuroradiologists assessed the images and discrepancies between their interpretations were resolved by consensus...
February 6, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30722721/aquaporin-4-antibody-positive-neuromyelitis-optica-spectrum-disorder-subsequent-to-rhabdomyolysis-a-case-report-and-literature-review
#17
Ke Shang, Chuan Qin, Bi-Tao Bu, Dai-Shi Tian
Rhabdomyolysis could be caused by various mechanisms including autoimmune reaction. Here we reported a case of 76-year-woman diagnosed with aquaporin-4 (AQP4) IgG positive neuromyelitis optica spectrum disorder (NMOSD) following rhabdomyolysis. After a review of literature, we propose that physical injury of skeletal muscle cells may lead to the production of AQP4 IgG and this AQP4 IgG might further decrease the stability of skeletal muscle cells creating a positive feedback loop. HyperCKemia might be an inducement of NMOSD...
February 5, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30696321/eyes-are-mirror-of-the-brain-comparison-of-multiple-sclerosis-patients-and-healthy-controls-using-oct
#18
Ümit Doğan, Fatih Ulaş, Şule Aydın Türkoğlu, Muhammed Nur Ögün, Sümeyra Ağca
OBJECTIVE: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in Multiple Sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: In this cross-sectional study, both eyes of 52 MS patients [n = 104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n = 36 eyes) were evaluated...
January 29, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30696318/hif-1-plays-a-role-in-hypoxia-induced-gustatory-plasticity-of-caenorhabditis-elegans
#19
Nabila Sorathia, Neha Chawda, Konstantina Saraki, Medha S Rajadhyaksha, Momna Hejmadi
Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis. Caenorhabditis elegans is a soil nematode that has evolved specialized chemosensory neurons that detect changes in oxygen levels and guide its behaviour and responses to food. The role of the hif-1 gene in modifying chemosensory behaviour in response to chemical hypoxia however remains unclear...
January 29, 2019: International Journal of Neuroscience
https://read.qxmd.com/read/30929591/therapeutic-effects-of-aerobic-exercise-on-eeg-parameters-and-higher-cognitive-functions-in-mild-cognitive-impairment-patients
#20
Imran Amjad, Hamza Toor, Imran Khan Niazi, Hina Afzal, Mads Jochumsen, Muhammad Shafique, Kathryn Allen, Heidi Haavik, Touqeer Ahmed
BACKGROUND: Mild cognitive impairment (MCI) is becoming an emerging problem for developing countries where there is an increase in expected age. There is no specific curative therapeutic treatment available for these patients. OBJECTIVE: The objective of this study was to evaluate short and long-term changes in the electroencephalogram (EEG) parameters and cognition of MCI patients with aerobic exercises. METHODS: A randomized controlled trial was conducted on 40 patients which were randomly divided into two groups, 'aerobic exercise treatment group (n = 21)' and 'no-aerobic control group (n = 19)'...
June 2019: International Journal of Neuroscience
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