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Ophthalmic Research

Chiara Del Noce, Aldo Vagge, Carlo Enrico Traverso
PURPOSE: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. METHODS: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision as a treatment for failed trabeculectomy. All subjects underwent surgery with a fornix-based approach to incision. Full baseline data for each patient included a comprehensive ocular and medical history, the patient's Snellen visual acuity test results, and Goldmann applanation tonometry test results...
May 9, 2019: Ophthalmic Research
Jiying Hu, Ruiting Chen, Ying Lu, Xiaoyan Dou, Baikang Ye, Zhiming Cai, Zuhui Pu, Lisha Mou
PURPOSE: Single-field non-mydriatic fundus photography (NMFP) has been used to detect diabetic retinopathy (DR) in many studies; however, its value in a general clinical setting has not been established. Here we performed a meta-analysis to evaluate its diagnostic effectiveness. METHOD: We systematically searched PubMed, EMBASE, and Cochrane databases for candidate studies published through May 19, 2018. A random-effect model was used to calculate the diagnostic indicators including the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and 95% confidence intervals...
May 8, 2019: Ophthalmic Research
Dinah Zur, Matias Iglicki, Anat Loewenstein
Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line treatment, there is an important role for steroids in the treatment algorithm for DME. A slow-release bioerodible dexamethasone implant and an extended-release nonbioerodible fluocinolone acetonide insert are both approved for the treatment of DME and provide the advantage of sustained drug delivery and reduced treatment burden...
May 2, 2019: Ophthalmic Research
Xun-Wen Lei, Qiang Li, Jin-Zhi Zhang, Yue-Mei Zhang, Yang Liu, Ke-Hu Yang
This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. The retinal thickness was measured using optical coherence tomography (OCT) at 4 weeks after treatments. The retinal expression and serum levels of vascular formation, inflammation, and oxidative stress-associated molecules were examined...
April 24, 2019: Ophthalmic Research
Ana Rita Santos, Torcato Santos, Dalila Alves, Inês P Marques, Conceição Lobo, José Cunha-Vaz
PURPOSE: This study is aimed at characterizing the type of retinal edema in the initial stages of retinopathy in type 2 diabetes. METHODS: In this retrospective cross-sectional study, spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage, an algorithm to detect sites of low optical reflectivity, were used to examine eyes with minimal, mild, and moderate diabetic retinopathy (DR). RESULTS: A total of 142 eyes from 142 patients (28% women) aged 52-88 years were imaged...
April 23, 2019: Ophthalmic Research
Christina D Poulsen, Anders Green, Jakob Grauslund, Tunde Peto
PURPOSE: To determine the long-term outcome of patients operated with pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) and to identify potential predictors for poor visual outcome. METHODS: Prospective, observational 30-month study of patients operated for primary RRD with PPV. Examinations were performed preoperatively and after months 2, 6, and 30. RESULTS: Eighty-four patients (84 eyes) were included and 73 (86...
April 23, 2019: Ophthalmic Research
Christina Garnavou-Xirou, Tina Xirou, Ilias Gkizis, Stamatina A Kabanarou, Eleni Dimitriou, Panagiotis Theodossiadis, Irini Chatziralli
PURPOSE: The purpose of this retrospective study was to evaluate the disorganization of the retinal inner layers (DRIL) as a potential predictive factor of postoperative visual outcome in patients with idiopathic epiretinal membrane (iERM), treated with pars plana vitrectomy (PPV). METHODS: Participants in the study were 46 consecutive patients diagnosed with iERM, who underwent PPV. Best corrected visual acuity (BCVA) measurement and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline (preoperatively), and at months 3 and 6 postoperatively...
April 23, 2019: Ophthalmic Research
Anna Matysik-Woźniak, Waldemar A Turski, Monika Turska, Roman Paduch, Mirosław Łańcut, Paweł Piwowarczyk, Mirosław Czuczwar, Anselm Jünemann, Robert Rejdak
Kynurenine (KYN) is a metabolite of tryptophan, proposed for the treatment of corneal diseases. Our goal was to evaluate the effects of KYN on normal human corneal and conjunctival epithelial cells in vitro and the re-epithelization of corneal erosion in rabbits. In our study, we used corneal (10.014 pRSV-T) and conjunctival (HC0597) epithelium cell cultures. KYN was applied at a concentration range of 1-100 µM for 24 and 48 h. We examined the effects on cellular metabolism, viability, interleukin-1β (IL-1β), IL-6, IL-10 secretion, cytoskeleton organization and transwell migration ability...
April 10, 2019: Ophthalmic Research
Pascale Massin, Catherine Creuzot-Garcher, Laurent Kodjikian, Jean-François Girmens, Cecile Delcourt, Frank Fajnkuchen, Agnès Glacet-Bernard, Pierre-Jean Guillausseau, Anne Ponthieux, Patrick Blin, Angela Grelaud
PURPOSE: To report the real-world effectiveness and safety of ranibizumab 0.5 mg in patients with visual impairment due to diabetic macular edema (DME). METHODS: This is a French, 36-month, multicenter, observational cohort study. Between December 2013 and April 2015, ophthalmologists enrolled diabetic patients aged ≥18 years with DME-related visual impairment and for whom ranibizumab 0.5 mg was initiated. Here, we present the 12-month results from this cohort...
March 29, 2019: Ophthalmic Research
Ralph Michael, Luis Pareja-Aricò, Franziska G Rauscher, Rafael I Barraquer
PURPOSE: To evaluate the relationship between the presence of cortical cataract and accommodation effort, using refractive error as a proxy. METHODS: Patients between 50 and 90 years, scheduled for cataract surgery, were selected with the help of a photographic database. Nuclear and cortical cataract were graded and patients grouped having no cataract, pure cortical, mixed or pure nuclear cataract. Refraction data at the time of the photograph was converted to estimated spherical equivalent refractive error each patient would have had at the age of 45 years...
March 28, 2019: Ophthalmic Research
Akeno Tamaoki, Takashi Kojima, Asato Hasegawa, Mana Yamamoto, Tatsushi Kaga, Kiyoshi Tanaka, Kazuo Ichikawa
BACKGROUNDS: Although the OCT biometer using individual refractive index is available, comparisons of measurement value and intraocular lens (IOL) power calculation error with other SS-OCT biometers are not known. OBJECTIVES: To compare the new SS-OCT biometer ARGOS (OCTB1), which uses individual refractive indices to measure axial length, with the IOLMaster 700 (OCTB2) and OA-2000 (OLCR), which use equivalent refractive index. METHOD: Six hundred and twenty-two eyes of 622 patients who had been diagnosed with cataract were enrolled in the study...
March 19, 2019: Ophthalmic Research
Rehana Khan, Sumeer Singh, Janani Surya, Tarun Sharma, Vaitheeswaran Kulothunga, Rajiv Raman
AIM: To compare the age of onset of diabetes with the prevalence and risk factors of diabetic retinopathy (DR) in a rural population of India. METHODS: This is a population-based study for which 1,190 people with diabetes were recruited from rural areas of the districts of Kanchipuram and Thiruvallur, Tamil Nadu, India. The fundi of all patients were photographed using a 45°, four-field stereoscopic digital fundus camera. The diagnosis of DR was based on the Klein classification of the Early Treatment Diabetic Retinopathy Study scale...
March 14, 2019: Ophthalmic Research
Cláudia Virgínia Louro Farinha, Maria Luz Cachulo, Dalila Alves, Isabel Pires, João Pedro Marques, Patrícia Barreto, Sandrina Nunes, José Costa, Amélia Martins, Isa Sobral, Inês Laíns, João Figueira, Luísa Ribeiro, José Cunha-Vaz, Rufino Silva
PURPOSE: To describe the 6.5-year incidence and progression of age-related macular degeneration (AMD) in a coastal town of central Portugal. METHODS: Population-based cohort study. Participants underwent standardized interviews and ophthalmological examination. Color fundus photographs were graded according to the International Classification and Grading System for AMD and ARM. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analyzed...
March 1, 2019: Ophthalmic Research
Linlin Hao, Hui Xiao, Xue Gao, Xiaoyu Xu, Xing Liu
PURPOSE: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (CPACG), and control patients using spectral-domain optical coherence tomography (SD-OCT) and examine its association with relevant ocular parameters. METHODS: In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way of enhanced depth imaging using Heidelberg SD-OCT...
February 15, 2019: Ophthalmic Research
Cecília V Martinho, Daniel Sanches Fernandes
No abstract text is available yet for this article.
January 28, 2019: Ophthalmic Research
Kiyeun Nam, Hyun Jung Kim, Aeri Yoo
PURPOSE: A meta-analysis was performed to evaluate the safety and efficacy of topical 3% diquafosol in treating patients with dry eye disease (DED). METHODS: Nine qualified randomized controlled trials incorporating 1,467 patients were included. Two of the reviewers selected the studies and independently assessed the risk of bias. The outcome measures were Schirmer score, tear film break-up time (TFBUT), rose bengal staining score, and corneal fluorescein staining score...
January 17, 2019: Ophthalmic Research
Rino Frisina, Elisabetta Pilotto, Edoardo Midena
Lamellar macular hole (LMH) is a vitreoretinal disorder characterized by an irregular foveal contour, a break in the inner fovea, dehiscence of the inner foveal retina from the outer retina, and the absence of a full-thickness foveal defect with intact foveal photoreceptors. The pathogenesis is only partially known. The advent of high-resolution optical coherence tomography has allowed distinguishing between two types of epiretinal membrane (ERM) associated with LMH: a conventional ERM (commonly found in macular pucker) and an atypical ERM (known by varied names: dense, epiretinal proliferation, or degenerative)...
January 9, 2019: Ophthalmic Research
Hendrik P N Scholl
No abstract text is available yet for this article.
2019: Ophthalmic Research
Pradeep Venkatesh, Brijesh Takkar
Retinal angiomas are rare tumors that develop within the vascular bed of the retina. Their occurrence may be sporadic or as part of the multisystem disorder called von Hippel-Lindau disease. It is well established in literature that retinal angiomas have a natural history of evolving as small aneurysmal dilatations and progressing to vision-threatening retinal detachments. Several approaches to the management of these angiomas have been reported in the literature, but it is difficult to decipher which modality is best suited for which type of angioma...
2019: Ophthalmic Research
Rossella D'Aloisio, Rosa Giglio, Marta Di Nicola, Chiara De Giacinto, Marco Rocco Pastore, Daniele Tognetto, Tunde Peto
BACKGROUND: Digital retinal imaging is the gold standard technique for diabetic retinopathy (DR) and diabetic macular oedema (DME) assessment during DR screening. OBJECTIVES: To evaluate the diagnostic accuracy of digital retinal fundus image (DRFI) analysis in detecting DME using three manual grading systems (MGS) and comparing it with optical coherence tomography (OCT) findings. METHOD: A total of 287 DRFI of 287 eyes were analysed. Non-stereoscopic 45° images were acquired using a Kowa VX-20 camera and were graded according to three MGS: Early Treatment Diabetic Retinopathy Study (ETDRS), International Clinical Diabetic Retinopathy (ICDR), and United Kingdom National Screening Committee (UKNSC)...
December 14, 2018: Ophthalmic Research
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