Abderrezak Bouchama, Mamoon Rashid, Shuja Shafi Malik, Saeed Almahri, Yara Yassin, Mashan Abdullah, Nour Abdulmalek, Fuad Maashi, Abdulaziz Mashi, Altaf Khan, Badriah Alotaibi, Cynthia Lehe, Sameer Mohammad, Haitham Alkadi, Deemah Al Waadani, Saber Yezli
An evolutionary heat shock response (HSR) protects most living species, including humans, from heat-induced macromolecular damage. However, its role in the pathogenesis of heat stroke is unknown. We examined the whole genome transcriptome in peripheral blood mononuclear cells of a cohort of subjects exposed to the same high environmental heat conditions, who developed heat stroke (n = 19) versus those who did not (n = 19). Patients with heat stroke had a mean rectal temperature at admission of 41.7±0.8°C, and eight were in deep coma (Glasgow Coma Score = 3)...
March 23, 2023: Journal of Physiology