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Laboratory Medicine

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https://read.qxmd.com/read/30753566/neutrophil-to-monocyte-plus-lymphocyte-ratio-as-a-potential-marker-for-discriminating-pulmonary-tuberculosis-from-nontuberculosis-infectious-lung-diseases
#1
You La Jeon, Woo-In Lee, So Young Kang, Myeong Hee Kim
Objective: To determine whether NMLR has more statistical strength than NLR in discriminating TB from non-TB infectious lung diseases. Methods: Among patients who underwent 3 or more TB culture tests with molecular study between January 2016 and December 2017, 110 patients with TB, and 159 patients diagnosed with non-TB infectious lung diseases were enrolled. The original complete blood count (CBC) parameters and modified CBC indices, including NLR and NMLR, were analyzed...
February 11, 2019: Laboratory Medicine
https://read.qxmd.com/read/30726943/automation-and-process-re-engineering-work-together-to-achieve-six-sigma-quality-a-27-year-history-of-continuous-improvement
#2
Bonny L Messinger, David N Rogers, Charles D Hawker
Background: In most clinical laboratories, examination quality is considered excellent, whereas pre-/postexamination quality is an area for focused improvement. In our organization, 1 pre-/postexamination quality metric, namely, lost specimens, as tracked continuously for 27 years, has demonstrated steady improvement. During this period, many of our processes transitioned to highly automated effectors. Concurrently, we implemented behavioral controls and reengineered error-prone processes...
February 6, 2019: Laboratory Medicine
https://read.qxmd.com/read/30726936/mean-platelet-volume-platelet-distribution-width-and-platelet-count-in-connection-with-immune-thrombocytopenic-purpura-and-essential-thrombocytopenia
#3
Eunyup Lee, Miyoung Kim, Kibum Jeon, Jiwon Lee, Jee-Soo Lee, Han-Sung Kim, Hee Jung Kang, Young Kyung Lee
Objective: To examine the kinetic characteristics of platelet (PLT) destruction and thrombopoiesis by using mean platelet volume (MPV) and platelet distribution width (PDW). Methods: Using the ADVIA2120i instrument, we measured PLT counts, MPV, and PDW in 153 healthy individuals, 35 patients with immune thrombocytopenic purpura (ITP), and 48 patients with essential thrombocytopenia (ET). Results: In the ITP group, the MPV and PDW were higher than those values in healthy individuals...
February 6, 2019: Laboratory Medicine
https://read.qxmd.com/read/30722042/case-report-and-literature-review-of-nodular-hiradenoma-a-rare-adnexal-tumor-that-mimics-breast-carcinoma-in-a-20-year-old-woman
#4
Vanya Jaitly, Richard Jahan-Tigh, Tatiana Belousova, Hui Zhu, Robert Brown, Karan Saluja
Nodular hidradenoma is an uncommon cutaneous adnexal tumor arising from sweat glands. In the skin, it usually presents as a solitary dermal nodule; excision is curative in most cases. In rare instances, it may present as a breast mass and can mimic breast carcinoma clinically and radiologically, causing diagnostic dilemmas for the treating physician and pathologist. Herein, we discuss a case of nodular hidradenoma in a 20-year-old Hispanic woman as a rapidly growing mass in the breast that mimicked breast carcinoma...
February 5, 2019: Laboratory Medicine
https://read.qxmd.com/read/30690523/the-inhibitory-effect-of-essential-oils-on-rhizopus-stolonifer-trichophyton-mentagrophytes-and-microsporum-gypseum
#5
Lisa R Maness, Tanya Zubov
Background: Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth. Methods: We investigated the effects of 0.5% and 1% concentrations of Rosmarinus officinalis, Cinnamomum verum, Citrus paradisi, and Capsicum annuum extracts on the growth of R...
January 28, 2019: Laboratory Medicine
https://read.qxmd.com/read/30657960/cryoglobulinemia-as-a-possible-primer-for-trali-report-of-a-case
#6
Cameron Beech, Deepika Kumar, Jeanne Hendrickson, Sudhir Perincheri, Christopher Tormey, Burak Bahar
Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Therapeutic plasma exchange (TPE) is one of the recommended treatment modalities to manage hyperviscosity...
January 18, 2019: Laboratory Medicine
https://read.qxmd.com/read/30657950/detection-rate-of-colorectal-cancer-or-precancer-adenoma-by-colonoscopy-after-1-2-or-3-positive-results-via-fecal-immunochemical-testing
#7
Jill A Hancock, Glen A Palmer
Background: Single-vial fecal immunochemical testing (FIT) is an accepted method of colorectal cancer (CRC) screening. The available 3-vial FIT data set allows for comparison of colonoscopy results using various screening methods. Objective: To determine the optimal number of vials for a strong FIT-screening program by examining whether using only a single vial impacts the use of colonoscopy for CRC screening. Methods: Patients were given 3-vial FIT collection kits that were processed with a positive hemoglobin cut-off detection level of 100 ng per mL...
January 18, 2019: Laboratory Medicine
https://read.qxmd.com/read/30629256/the-importance-of-specimen-reception-and-the-universal-challenges-it-faces-in-laboratory-flow-a-brief-overview
#8
Kazama Tachibana
In this brief overview, I emphasize the importance of the specimen-reception department in the running and flow of a laboratory. Also, I outline the problems and the challenges it faces, which are almost universally applicable to all laboratories. To my knowledge, this topic has not been directly reported before in the literature.
January 9, 2019: Laboratory Medicine
https://read.qxmd.com/read/30615141/automated-requests-for-thyroid-stimulating-hormone-and-ferretin-tests-in-young-primary-care-patients-with-anorexia-as-an-intervention-to-improve-detection-of-underlying-conditions
#9
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
Objective: To improve clinical laboratory contribution to the treatment of primary care patients with anorexia through automated computerized strategies. Methods: We recorded the number of laboratory requests due to anorexia; the demographic data, laboratory values, and presence of pathological values for the applicable patients. In a prospective study, the laboratory information management system (LIMS) automatically added thyroid-stimulating hormone (TSH) and/or ferritin testing when it was not requested by general practitioners for all primary care patients with anorexia who were younger than 16 years...
January 7, 2019: Laboratory Medicine
https://read.qxmd.com/read/30590617/evaluation-of-sf3b1-mutation-screening-by-high-resolution-melting-analysis-and-its-clinical-utility-for-myelodysplastic-syndrome-with-ring-sideroblasts-at-the-point-of-diagnosis
#10
Shumpei Mizuta, Noriko Yamane, Takao Komai, Yusuke Koba, Naoya Ukyo, Akira Tamekane, Mitsumasa Watanabe
Background: SF3B1 (splicing factor 3B subunit-1) somatic mutation is specifically detected in myelodysplastic syndrome (MDS) with ring sideroblasts (MDS-RS). We investigated the sensitivity and utility of SF3B1 mutation analysis as a clinical laboratory test. Method: Detection limit for SF3B1 mutations by high-resolution melting (HRM) analysis was investigated by plasmid mixture. In 67 MDS patients, we examined the association between SF3B1 mutation and prognostic evaluation using the Revised International Prognostic Scoring System and revalidated MDS classifications based on the revised 4th edition of the WHO classification...
December 26, 2018: Laboratory Medicine
https://read.qxmd.com/read/30590699/comparative-evaluation-of-commercial-concentration-procedures-for-human-intestinal-parasite-detection
#11
Denis Leméteil, Gilles Gargala, Romy Razakandrainibe, Jean Jacques Ballet, Loic Favennec, Damien Costa
Background: Effective stool concentration is essential in microscopically based diagnosis of human intestinal parasite infections. Objective: To compare the performances of 4 concentration commercial kits and 1 homemade procedure in 96 clinical stool specimens that tested positive for the detection of 9 helminth and 8 protozoa parasites. Methods: The presence or absence of parasite forms was microscopically determined under conditions of standard practice...
December 22, 2018: Laboratory Medicine
https://read.qxmd.com/read/30576465/microrna-146a-polymorphisms-and-expression-in-indian-children-with-acute-lymphoblastic-leukemia
#12
Helen Jemimah Devanandan, Vettriselvi Venkatesan, Julius Xavier Scott, Latha Sneha Magatha, Solomon Franklin Durairaj Paul, Teena Koshy
Background: MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia. Objective: To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL)...
December 21, 2018: Laboratory Medicine
https://read.qxmd.com/read/30535164/advantages-of-serum-anti-m%C3%A3-llerian-hormone-as-a-marker-for-polycystic-ovarian-syndrome
#13
Xinyan Shi, Duo Peng, Yanfei Liu, Xiaofen Miao, Hui Ye, Jun Zhang
Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS). Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. We generated receiver operating characteristic (ROC) curves to assess the usefulness of AMH, AFC, the luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, and testosterone (T), to discriminate between the PCOS and control groups...
December 10, 2018: Laboratory Medicine
https://read.qxmd.com/read/30535084/a-simple-rapid-and-non-radiolabeled-immune-assay-to-detect-anti-achr-antibodies-in-myasthenia-gravis
#14
Suresh Bokoliya, Shripad Patil, Madhu Nagappa, Arun Taly
Objective: To assess the practicality of dot-blot testing for rapid and sensitive detection of the antiacetylcholine receptor (anti-AChR) antibodies in myasthenia gravis (MG). Methods: In this case-control study, we tested serum specimens of 85 patients with MG, 85 healthy control individuals, and 85 patients without MG who have other autoimmune and neurological illnesses. All the serum specimens were tested for anti-AChR antibodies using 3 assays: in-house enzyme-linked immunosorbent assay (ELISA), the dot-blot assay, and commercial ELISA...
December 7, 2018: Laboratory Medicine
https://read.qxmd.com/read/30517681/serum-cystatin-c-levels-in-twin-pregnancy-versus-singleton-pregnancy
#15
Jianming Peng, Wen Wang, Lei Zheng, Yanfei Guan, Guicheng Ye, Huichun Tong, Ying Wang, Qian Wang
Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy. Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Results: The levels of serum Cys C in all 3 trimesters for women with twin pregnancy were much higher than those in the corresponding trimesters for women with singleton pregnancy...
December 4, 2018: Laboratory Medicine
https://read.qxmd.com/read/30476147/epidem-a-model-for-quality-improvement
#16
Yaolin Zhou
Background: Existing quality improvement (QI) models have been used with varied success in health care. We developed the EPIDEM Model of Quality Improvement to apply QI principles to health care and promote a widespread culture of quality and patient safety. Methods: The EPIDEM acronym can be used to teach and remember the steps of process improvement: explore relevant issues and contextual factors, promote to the right people, implement timely solutions, document steps, evaluate with meaningful measures, and make modifications to improve interventions further...
November 21, 2018: Laboratory Medicine
https://read.qxmd.com/read/30462251/adoption-of-evidence-based-medicine-in-clinical-laboratory-science-a-survey-of-the-prevalence-of-systematic-and-narrative-reviews
#17
Lauren N Pearson, Robert L Schmidt
Background: Systematic reviews (SRs) play a critical role in evidence-based medicine. Objective: To determine the publication trends of SRs in clinical laboratory science (CLS). Methods: We searched Scopus to identify all reviews published in the top 20 CLS journals during the past 10 years (2008-2017). We determined year of publication, review type (systematic vs narrative), citations, and whether the review was accompanied by a meta-analysis (MA)...
November 20, 2018: Laboratory Medicine
https://read.qxmd.com/read/30576520/what-does-it-mean-for-a-recommendation-to-be-evidence-based
#18
Robert L Schmidt, Rachel E Factor
No abstract text is available yet for this article.
January 1, 2019: Laboratory Medicine
https://read.qxmd.com/read/30576519/corrigendum
#19
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2019: Laboratory Medicine
https://read.qxmd.com/read/30124986/molecular-diagnosis-of-solute-carrier-family-4-member-1-slc4a1-mutation-related-autosomal-recessive-distal-renal-tubular-acidosis
#20
Nipaporn Deejai, Suwannee Wisanuyotin, Choochai Nettuwakul, Sookkasem Khositseth, Nunghathai Sawasdee, Kiattichai Saetai, Pa-Thai Yenchitsomanus, Nanyawan Rungroj
Background: Two common mutations of the solute carrier family 4 member 1 (SLC4A1) gene, namely, Southeast Asian ovalocytosis (SAO) and band 3 Bangkok 1 (G701D), cause autosomal recessive distal renal tubular acidosis (AR dRTA) in ethnic Southeast Asian populations. In this study, we applied the high-resolution melting (HRM) method for screening of AR dRTA associated with SLC4A1 mutations in 10 new patients with unknown cause(s) of AR dRTA. Methods: We analyzed SAO and G701D mutations in the patients and their family members using HRM...
January 1, 2019: Laboratory Medicine
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