Journals European Journal of Clinical I...

European Journal of Clinical Investigation
Filipa I Baptista, António F Ambrósio
BACKGROUND: Pregnancy represents a window of vulnerability to fetal development. Disruptions in the prenatal environment during this crucial period can increase the risk of the offspring developing diseases over the course of their lifetime. The central nervous system (CNS) has been shown to be particularly susceptible to changes during crucial developmental windows. To date, research focused on disruptions in the development of the CNS has predominantly centred on the brain, revealing a correlation between exposure to prenatal risk factors and the onset of neuropsychiatric disorders...
June 12, 2024: European Journal of Clinical Investigation
Giorgio Busto, Andrea Morotti, Ilaria Casetta, Angelo Barra, Alessandro Fiorenza, Francesca Di Pasquale, Maria Giulia Maccaglia, Maddalena Toffali, Sara Mancini, Edoardo Carlesi, Vanessa Palumbo, Ivano Lombardo, Alessandro Padovani, Enrico Fainardi
BACKGROUND: Hypoperfusion Intensity Ratio (HIR) is associated with collaterals and outcome in acute ischemic stroke (AIS). We investigated whether a combined assessment of HIR and collaterals could provide an added value. METHODS: Retrospective single-center study, including AIS patients with large vessel occlusion and endovascular treatment 0-24 h from onset. Predictors of FIV and outcome (90 days modified Rankin Scale 0-1) were investigated with linear and logistic regression respectively...
June 10, 2024: European Journal of Clinical Investigation
Dejiang Lin, Dongxia Hu, Youlin Song, Xingxiang He, Lei Wu
BACKGROUND: Faecal microbiota transplantation holds promise in mitigating fat accumulation and improving obesity. This study aimed to evaluate the long-term efficacy of washed microbiota transplantation (WMT) among overweight patients. METHODS: The clinical data pertaining to the treatment of patients with WMT were collected retrospectively. Compared alterations in body mass index (BMI), blood glucose, blood lipids and blood pressure prior to and following WMT treatment...
June 10, 2024: European Journal of Clinical Investigation
Johann Auer, Lisa Auer
No abstract text is available yet for this article.
June 10, 2024: European Journal of Clinical Investigation
Yang Chen, Ying Gue, Maciej Banach, Dimitri Mikhailidis, Peter P Toth, Marek Gierlotka, Tadeusz Osadnik, Marcin Golawski, Tomasz Tomasik, Adam Windak, Jacek Jozwiak, Gregory Y H Lip
BACKGROUND: Comorbidities in primary care do not occur in isolation but tend to cluster together causing various clinically complex phenotypes. This study aimed to distinguish phenotype clusters and identify the risks of all-cause mortality in primary care. METHODS: The baseline cohort of the LIPIDOGEN2015 sub-study involved 1779 patients recruited by 438 primary care physicians. To identify different phenotype clusters, we used hierarchical clustering and investigated differences between clinical characteristics and mortality between clusters...
June 8, 2024: European Journal of Clinical Investigation
Kei Sato, Silver Heinsar, Jonathan Chan, Samia M Farah, Karin Wildi, Nchafatso G Obonyo, Keibun Liu, Carmen Ainola, Noriko Sato, Gabriella Abbate, Emily S Wilson, Mahé Bouquet, Kieran Hyslop, Margaret R Passmore, Shinichi Ijuin, Sun Kyun Ro, Gabriele Fior, Lucia Gandini, Brooke Lundon, David G Platts, Jacky Y Suen, Gianluigi Li Bassi, John F Fraser
BACKGROUND: Left ventricular stroke work index (LVSWI) and cardiac power index (CPI) account for the haemodynamic load of the left ventricle and are promising prognostic values in cardiogenic shock. However, accurately and non-invasively measuring these parameters during veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is challenging and potentially biased by the extracorporeal circulation. This study aimed to investigate, in an ovine model of cardiogenic shock, whether Pressure-Strain Product (PSP), a novel speckle-tracking echocardiography parameter, (1) can correlate with pressure-volume catheter-based LVSWI and CPI, and (2) can be load-independent during the flow modification of V-A ECMO...
June 7, 2024: European Journal of Clinical Investigation
Kei Sato, Louise See Hoe, Jonathan Chan, Nchafatso G Obonyo, Karin Wildi, Silver Heinsar, Sebastiano M Colombo, Carmen Ainola, Gabriella Abbate, Noriko Sato, Margaret R Passmore, Mahe Bouquet, Emily S Wilson, Kieran Hyslop, Samantha Livingstone, Andrew Haymet, Jae-Seung Jung, Kris Skeggs, Chiara Palmieri, Nicole White, David Platts, Jacky Y Suen, David C McGiffin, Gianluigi Li Bassi, John F Fraser
BACKGROUND: The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI...
June 6, 2024: European Journal of Clinical Investigation
Maria Garcia-Gil, Lia Alves-Cabratosa, Oriol Cunillera, Jordi Blanch, Ruth Martí-Lluch, Anna Ponjoan, Francesc Ribas-Aulinas, Èric Tornabell-Noguera, Lluís Zacarías-Pons, Gina Domínguez-Armengol, Elizabeth Guzmán, Rafel Ramos
BACKGROUND: The effectiveness of statin treatment to reduce coronary events and mortality has been hardly examined considering goals of LDL-C. We aimed to analyse such association in secondary cardiovascular prevention. METHODS: Retrospective cohort analysis of electronic health records from the SIDIAP database, Catalonia-Spain. Recruitment period was from 2006 to 2017 and study period finished at the end of 2018. We included 54,175 people aged ≥35 years in cardiovascular secondary prevention starting statin treatment...
June 3, 2024: European Journal of Clinical Investigation
Biagio Di Lorenzo, Stefano Zoroddu, Arduino A Mangoni, Salvatore Sotgia, Panagiotis Paliogiannis, Gian Luca Erre, Ciriaco Carru, Angelo Zinellu
BACKGROUND: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta-analysis comparing blood PTX-3 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics...
May 29, 2024: European Journal of Clinical Investigation
A Baragetti, L Da Dalt, G D Norata
BACKGROUND: Elevated levels of lipoprotein(a) [Lp(a)] represent a risk factor for cardiovascular disease including aortic valve stenosis, myocardial infarction and stroke. While the patho-physiological mechanisms linking Lp(a) with atherosclerosis are not fully understood, from genetic studies that lower Lp(a) levels protect from CVD independently of other risk factors including lipids and lipoproteins. Hereby, Lp(a) has been considered an appealing pharmacological target. RESULTS: However, approved lipid lowering therapies such as statins, ezetimibe or PCSK9 inhibitors have a neutral to modest effect on Lp(a) levels, thus prompting the development of new strategies selectively targeting Lp(a)...
May 22, 2024: European Journal of Clinical Investigation
D Moriconi, R M Bruno, E Rebelos, S Armenia, S Baldi, L Bonvicini, S Taddei, M Nannipieri
BACKGROUND: Cardiovascular trials have revealed the positive impact of GLP-1 receptor agonists (GLP-1 RAs) on cardiovascular outcomes in type 2 diabetes (T2D). However, the specific effects of endogenous GLP-1 on arterial stiffness and renal function remain understudied. This study aimed to explore the influence of endogenous GLP-1 response post-bariatric surgery on arterial stiffness and renal haemodynamic. METHODS: Thirty individuals with morbid obesity and without T2D, scheduled for Roux-en-Y Gastric Bypass (RYGB), were included...
May 22, 2024: European Journal of Clinical Investigation
Radoslaw Parma, Michael Joner, Francesco Saia, Thomas Cuisset, Victoria Delgado, Josep Rodes-Cabau, Thomas Modine, Eric Van Belle, Luca Nai Fovino, Uri Landes, Mohamed Abdel-Wahab, Jose Luis Zamorano, Matthias Eden, Filippo Cademartiri, Joanna Nawara Skipirzepa, Jana Kurucova, Daniel Greinert, Peter Bramlage, Giuseppe Tarantini
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly being used in younger patients and those with lower peri-procedural risk, meaning more patients will live long enough to experience structural valve deterioration (SVD) of the bioprosthesis, indicating repeated TAVI. Experience of repeated TAVI-transcatheter heart valve (THV) implantation into an index THV is limited. This registry aims to assess the peri-procedural and short-term safety, efficacy and durability of repeated TAVI...
May 20, 2024: European Journal of Clinical Investigation
Yvonne Koop, Laura Yousif, Rudolf A de Boer, Michiel L Bots, Wouter C Meijers, Ilonca Vaartjes
BACKGROUND: Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. Given their high prevalence, it is important to understand the disease burden of cancer mortality in CVD patients. OBJECTIVE: We aimed to evaluate whether patients with incident CVD have a higher risk of malignancy-related mortality, compared to the general population without CVD. METHODS: We performed a national population-based cohort study selecting patients with incident CVD in the Netherlands between 01 April 2000 and 31 December 2005...
May 17, 2024: European Journal of Clinical Investigation
Wenjie Chen, Zhiyong Du, Yanwen Qin, Ze Zheng, Jinghua Liu, Yuchen Shi
BACKGROUND: The effectiveness of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is still uncertain, especially for patients with ischemic left ventricular dysfunction. This study aimed to assess hibernating myocardium (HM), as determined by single-photon emission computed tomography (SPECT) and 18 F-FDG positron emission tomography (PET), and to compare the benefits of PCI and optimal medical therapy (OMT). METHODS: A retrospective study collected data from 332 patients with CTO and ischemic left ventricular dysfunction...
May 17, 2024: European Journal of Clinical Investigation
Alicia Saz-Lara, Iván Cavero-Redondo, Andrea Del Saz-Lara, Eva Rodríguez-Gutiérrez, Bruno Bizzozero-Peroni, Carlos Pascual-Morena
BACKGROUND: In recent years, it has been demonstrated that when the endothelial glycocalyx, composed of proteoglycans, glycosaminoglycans and glycoproteins, is altered or modified, this property is lost, playing a fundamental role in cardiovascular pathologies. Cardiovascular risk factors can destroy the endothelial glycocalyx layer. Exercise has a positive effect on cardiovascular risk factors, but little is known about its direct effect on the integrity of the endothelial layer. METHODS: The Cochrane Library, PubMed, Web of Science and Scopus databases were searched from their inception to June 30, 2022...
May 15, 2024: European Journal of Clinical Investigation
Claudia Torino, Federico Carbone, Patrizia Pizzini, Sabrina Mezzatesta, Graziella D'Arrigo, Mercedes Gori, Luca Liberale, Margherita Moriero, Cristina Michelauz, Federica Frè, Simone Isoppo, Aurora Gavoci, Federica La Rosa, Alessandro Scuricini, Amedeo Tirandi, Davide Ramoni, Francesca Mallamaci, Giovanni Tripepi, Fabrizio Montecucco, Carmine Zoccali
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9), a factor accelerating the degradation of LDL receptors, was associated with a gender-dependent risk for cardiovascular (CV) events in the general population and with all-cause and CV mortality in two relatively small studies in black Africans and South Korean haemodialysis patients. The effect modification by gender was untested in these studies. METHODS: The study enrolled 1188 dialysis patients from the Prospective Registry of The Working Group of Epidemiology of Dialysis Region Calabria (PROGREDIRE) cohort...
May 11, 2024: European Journal of Clinical Investigation
Yi Lin Zhang, Lei Xie, Fen Lan Wu, Xiaomei Ding, Benjamin Hernández-Wolters, Mihnea-Alexandru Găman, Hamed Kord-Varkaneh
BACKGROUND: Menopause is associated with elevated cardiovascular risk due to the loss of the cardioprotective effect of oestrogens. Postmenopausal women are often prescribed hormone replacement therapy (HRT) in order to control menopause symptoms and correct hormone imbalances; however, HRT can impact serum lipids' concentrations. At present, data on the effect of the administration of medroxyprogesterone acetate plus conjugated equine oestrogens (MPACEE) on the lipid profile in females are uncertain, as the investigations conducted so far have produced conflicting results...
May 10, 2024: European Journal of Clinical Investigation
Ghazaleh Nameni, Shima Jazayeri, Somaye Fatahi, Sanaz Jamshidi, Marsa Zaroudi
BACKGROUND & OBJECTIVES: Currently, there is a significant focus on the decrease of soluble receptor of advanced glycation end products (sRAGE) in neurocognitive and neuropsychiatric disorders. sRAGE plays a decoy role against the inflammatory response of advanced glycation end products (AGE), which has led to increased interest in its role in these disorders. This meta-analysis aimed to investigate the significant differences in sRAGE levels between neurocognitive and neuropsychiatric disorders compared to control groups...
May 3, 2024: European Journal of Clinical Investigation
Francesco Galli, Desirée Bartolini, Claudio Ronco
Oxidative stress (OS) develops in critically ill patients as a metabolic consequence of the immunoinflammatory and degenerative processes of the tissues. These induce increased and/or dysregulated fluxes of reactive species enhancing their pro-oxidant activity and toxicity. At the same time, OS sustains its own inflammatory and immunometabolic pathogenesis, leading to a pervasive and vitious cycle of events that contribute to defective immunity, organ dysfunction and poor prognosis. Protein damage is a key player of these OS effects; it generates increased levels of protein oxidation products and misfolded proteins in both the cellular and extracellular environment, and contributes to forms DAMPs and other proteinaceous material to be removed by endocytosis and proteostasis processes of different cell types, as endothelial cells, tissue resident monocytes-macrophages and peripheral immune cells...
April 27, 2024: European Journal of Clinical Investigation
Guoying Kao, Gang Xu, Ying Zhang, Chuanwei Li, Jun Xiao
BACKGROUND: Studies on the predictive ability of disease-specific health quality of life (QoL) in patients with heart failure (HF) have produced conflicting results. To address these gaps in knowledge, we conducted a meta-analysis to evaluate the predictive value of QoL measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) in patients with HF. MATERIALS AND METHODS: We searched PubMed, and Embase databases to identify studies investigating the predictive utility of baseline QoL measured by the KCCQ in HF patients...
April 26, 2024: European Journal of Clinical Investigation
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