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European Journal of Clinical Investigation

Federico Carbone, Franco Dallegri, Fabrizio Montecucco, Alessandro Poggi, Flavio Mariano Nobili, Fabio Cacciapaglia, Antonella Afeltra, Tiziano Moccetti, Barbara Maria Colombo
BACKGROUND: Ultrasound evaluation of carotid intima media thickness (cIMT) has been extensively used for potentially improving cardiovascular (CV) risk stratification in several patients' categories. Subjects with systemic lupus erythematosus (SLE) have been investigated by both imaging and molecular biomarker approaches with contrasting results. Here, we focused on the role of osteopontin (OPN) as biomarker of subclinical atherosclerosis associated with SLE. MATERIALS AND METHODS: Eighty females (age 18-65 years) affected by SLE and eighty age-matched healthy female controls without a clinical history of CV disease underwent ultrasound evaluation of cIMT and blood sample assay of high-sensitivity C-reactive protein (hs-CRP) and osteopontin (OPN)...
February 14, 2019: European Journal of Clinical Investigation
Roberto Tamma, Tiziana Annese, Simona Ruggieri, Oronzo Brunetti, Vito Longo, Eliano Cascardi, Mauro Giuseppe Mastropasqua, Eugenio Maiorano, Nicola Silvestris, Domenico Ribatti
BACKGROUND: Cholangiocarcinoma (CCA) is the second most common subtype of primary hepatobiliary cancer and one of the most aggressive characterized by an extremely poor prognosis with limited treatment options. Inflammatory cells in tumor microenvironment support tumor growth in term of progression, angiogenesis and metastatic capacity. A link between inflammation and biliary carcinogenesis has been previously observed but the mechanisms involved remain to be determined. METHODS: We investigated the microvascular density (MVD) and inflammatory cells in tissue samples from 40 patients with CCA with locally advanced CCA and metastatic CCA by means of immunohistochemical analysis of macrophages, mast cells, B and T lymphocytes and we correlated inflammatory infiltrate with MVD...
February 14, 2019: European Journal of Clinical Investigation
Francesca Saffioti, Davide Roccarina, Mette Vesterhus, Johannes Roksund Hov, William Rosenberg, Massimo Pinzani, Stephen P Pereira, Kirsten Muri Boberg, Douglas Thorburn
BACKGROUND: Cholangiocarcinoma (CCA) complicates primary sclerosing cholangitis (PSC) in 10-20% of cases, but current tools for prediction of a CCA diagnosis are inadequate. Recently we demonstrated the utility of the ELF test to stratify prognosis in PSC. We observed that patients with PSC+CCA had significantly higher ELF score than those with PSC alone. In this study, we aimed to investigate further this association in a larger cohort of PSC patients with CCA compared with patients with PSC or CCA alone...
February 14, 2019: European Journal of Clinical Investigation
J A Suárez-Cuenca, A S Ruíz-Hernández, A A Mendoza-Castañeda, G A Domínguez-Pérez, A Hernández-Patricio, E Vera-Gómez, G De la Peña-Sosa, D Z Balderas-Lares, J Montoya-Ramírez, R Blas-Azotla, M Ortíz-Fernández, M Salamanca-García, A Melchor-López, P Mondragón-Terán, A Contreras-Ramos, S L Alcaraz-Estrada
BACKGROUND: Atherosclerosis represents a cardiovascular risk. Chronic inflammation is a key factor for atherogenic progression. Neutrophil-to-Lymphocyte Ratio (NLR) has been proposed as a novel biomarker for cardiovascular risks. We aimed to explore whether NLR was related with surrogate pro-atherogenic promoters driving atherogenic progression, as measured by Carotid Intima-Media Thickness (CIMT). STUDY DESIGN: Thirty-one patients with obesity candidates for bariatric surgery were recruited from Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City...
February 11, 2019: European Journal of Clinical Investigation
Antonis Makrigiannakis, Thomas Vrekoussis, Fanourios Makrigiannakis, Halil Ruso, Sophia N Kalantaridou, Timur Gurgan
BACKGROUND: The intra-uterine administration of activated autologous peripheral blood monocytes (PBMC) prior to embryo transfer seems to improve reproductive outcomes in women with repeated implantation failure (RIF). We have previously shown that the intrauterine administration of PBMC treated with corticotropin releasing hormone (CRH) prior to blastocyst transfer (day 5), improves significantly the clinical pregnancy rate of women with RIF. In the present cross-over pilot study, we have investigated whether CRH-PBMC treatment could be of benefit in case of fresh early cleavage stage embryo transfer (day 3) in women with RIF...
February 9, 2019: European Journal of Clinical Investigation
Marianna Criscuolo, Francesco Marchesi, Anna Candoni, Chiara Cattaneo, Annamaria Nosari, Barbara Veggia, Luisa Verga, Nicola Fracchiolla, Nicola Vianelli, Maria Ilaria Del Principe, Marco Picardi, Mario Tumbarello, Franco Aversa, Alessandro Busca, Livio Pagano
BACKGROUND: Fungal infections are still a relevant challenge for clinicians involved in the cure of patients with cancer. We retrospectively reviewed charts of hospitalized patients with hematological malignancies (HMs), in which a documented fungemia was diagnosed between January 2011 and December 2015 at 28 adult and 6 pediatric Italian Hematology Departments. METHODS: During the study period we recorded 215 fungal blood stream infections (BSI). Microbiological analyses documented that BSI was due to molds in 17 patients (8%) and yeasts in 198 patients (92%), being Candida spp identified in 174 patients (81%)...
February 8, 2019: European Journal of Clinical Investigation
Zhiling Chan, Cherlyn Ding, Yu Chung Chooi, John Choo, Suresh Anand Sadananthan, S Sasikala, Amanda Chang, Navin Michael, S Sendhil Velan, Melvin K-S Leow, Faidon Magkos
BACKGROUND: The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in non-obese Asians is not known. MATERIALS AND METHODS: We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-h hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-h mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2 max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy non-obese Asian subjects (BMI=21...
February 8, 2019: European Journal of Clinical Investigation
Deborah A Cohen
I am writing to request that you revise the title and other misleading terminology in the Solmi, et al paper, "Environmental risk factors and non-pharmacological and non-pharmacological and non-surgical interventions for obesity: An umbrella review of meta-analyses of cohort studies and randomized controlled trials."1 This paper does not, in any way, shape, or form, address or review environmental risk factors. Environmental risk factors are characteristics of a person's surrounding and typically out of any individual person's control...
February 6, 2019: European Journal of Clinical Investigation
Marco Solmi, John P A Ioannidis, André F Carvalho
We thank Cohen for her letter. There is some inconsistency in the used terminology for risk factors. Investigators with different interests use "environmental" with different connotations or different specificity thresholds. Our umbrella review assessed any non-genetic risk factors, in the broadest possible fashion. This included lifestyle, biobehavioral, sociodemograhic, mental health, and many other factors and it also included all the factors that Cohen uses the term "environmental" for in a very strict sense...
February 6, 2019: European Journal of Clinical Investigation
Thorsten Gietzen, Ibrahim El-Battrawy, Siegfried Lang, Xiao-Bo Zhou, Uzair Ansari, Michael Behnes, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarization abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to traditional risk factors in ACS. This study was performed to determine the short- and long-term prognostic impact of inverted T-waves in TTS patients, as compared to ACS patients...
February 6, 2019: European Journal of Clinical Investigation
Birgitta Gatenholm, Johan Gobom, Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Mats Brittberg
BACKGROUND: The objective of this study was to develop a method for directly analyzing osteochondral samples straight out of the operating room without cell culturing, thereby enabling identification of potential peptide biomarkers to better understand the mechanisms involved in the development of osteoarthritis and pain. MATERIAL AND METHODS: Osteochondral plugs from wounded and macroscopically non-wounded zones of the femur condyle were collected from 6 patients with manifest osteoarthritis (OA) undergoing total knee arthroplasty (TKA)...
February 6, 2019: European Journal of Clinical Investigation
Milen Babic, Mirjam Schuchardt, Markus Tölle, Markus van der Giet
BACKGROUND: Smoking remains the most important avoidable cause of global mortality. Even though the number of cigarette smokers declines in first world countries, the uses of alternative nicotine delivery products increase and may even surpass the sells of cigarettes. In this light, the explicit role of nicotine in the development of cardiovascular diseases should be elucidated. OBJECTIVES: This narrative review attempts to connect current literature about possible effects of nicotine on the environement of the vasculature to the pathogenesis of vascular calcification, focusing on the tunica media of the vessel wall...
February 5, 2019: European Journal of Clinical Investigation
Sang-Cheol Bae, Young Ho Lee
OBJECTIVE: This study aimed to examine whether body mass index (BMI) is causally associated with rheumatoid arthritis (RA). METHOD: A two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods was performed. We used the publicly available summary statistics datasets of genome-wide association studies (GWAS) meta-analyses for BMI in individuals of European descent (n = 322,154) (GIANT consortium) as the exposure and a GWAS for non-cancer illness code self-reported: RA from the individuals included in the UK Biobank (total n = 337,159; case = 7,480, control = 329,679) as the outcome...
February 1, 2019: European Journal of Clinical Investigation
A G Vassiliou, G Floros, E Jahaj, G Stamogiannos, S Gennimata, D A Vassiliadi, S Tsagarakis, M Tzanela, I Ilias, S E Orfanos, A Kotanidou, I Dimopoulou
INTRODUCTION: In critically ill patients, the hypothalamic-pituitary-adrenal axis is activated, resulting in increased serum cortisol concentrations. However, in some patients, especially those with sepsis, cortisol levels are relatively low for the degree of illness severity. Therefore, in the present project we aim to characterize the time course of glucocorticoid receptor (GCR) alpha and beta expression in peripheral polymorphonuclear cells of critically ill septic or non septic patients using real-time PCR...
January 31, 2019: European Journal of Clinical Investigation
Flora Bacopoulou, Vasiliki Efthymiou, George Palaiologos, Konstantinos Tsarouhas, Georgios Landis, Ioannis Fostiropoulos, Maria Kaklea, Anastasios Rentoumis, Ioannis Papassotiriou
BACKGROUND: Using telemedicine in the school setting in Greece, we screened a representative adolescent sample for MetS (International Diabetes Federation criteria) and explored its associations with anthropometric, sociodemographic and behavioral parameters. MATERIALS AND METHODS: Cross-sectional data were obtained from 12- to 17-year-old high-school students. RESULTS: The prevalence of MetS in 1,578 adolescents (mean age±SD 14.4±1.7 years) was 2...
January 30, 2019: European Journal of Clinical Investigation
Cuifang He, Peihuan Lin, Wenbing Liu, Kuaifa Fang
BACKGROUND: The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) are conflicting. This meta-analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS. METHODS: A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI, and WanFang databases up to June 16, 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected...
January 30, 2019: European Journal of Clinical Investigation
Ioana A Cristea, Eli M Cahan, John P A Ioannidis
In 2014, one of us (JPAI) wrote a viewpoint article coining the term "stealth research" for touted biomedical innovation happening outside the peer-reviewed literature in a confusing mix of "possibly brilliant ideas, aggressive corporate announcements, and mass media hype". These reflections were prompted by Theranos, a medical diagnosis start-up company; Theranos had not published any peer-reviewed papers [1] but made claims that its technology would "disrupt medicine." However, in contrast to the tech sector, in healthcare published peer-reviewed research is essential to ensure a minimum threshold of transparency, accountability, and credibility for the underlying work in the scientific community...
January 28, 2019: European Journal of Clinical Investigation
Peizhu Chen, Xuhong Hou, Li Wei, Liang Feng, Lichang Zhong, Lei Jiao, Hongmei Wang, Yuqian Bao, Weiping Jia
BACKGROUND: The association between non-alcoholic fatty liver disease (NAFLD) and free triiodothyronine (FT3) in euthyroid subjects was in dispute. We aimed to investigate this issue in a population-based cohort study. MATERIALS AND METHODS: A total of 3,144 euthyroid subjects at baseline from the Shanghai Nicheng Atherosclerosis Study were selected for the cross-sectional analysis, and 2,089 subjects being followed up after 2.2 years were selected for the longitudinal analysis...
January 13, 2019: European Journal of Clinical Investigation
Shiang-Fen Huang, Ying-Ying Yang, Kun-Ta Chou, Chang-Phong Fung, Fu-Der Wang, Wei-Juin Su
BACKGROUND: The dysbiosis of gut microbiome and interaction with host immunity after Mycobacterium tuberculosis (MTB) infection are under-investigation. We had found fatigue symptom concurrent with dysbiosis by decreasing the ratio of Firmicutes to Bacteroidetes (F/B ratio) in active tuberculosis (TB). The study aims to assess the inflammatory biomarkers and their interaction with gut microbiome in active TB and latent TB infection before starting anti-TB regimens. MATERIALS AND METHOD: Interleukin-1 beta (IL-1B), IL-4, IL-6, IL-10, CD3+, CD4+, CD8+ T cells, and interferon-gamma (IFN-γ) releasing assay (IGRA) were measured in 25 active TB patients, 32 LTBI subjects, and 23 healthy controls (HC)...
January 8, 2019: European Journal of Clinical Investigation
Juliette Rousse, Apolline Salama, Shani Leviatan Ben-Arye, Petra Hruba, Janka Slatinska, Gwénaëlle Evanno, Odile Duvaux, Dominique Blanchard, Hai Yu, Xi Chen, Jean-Marie Bach, Vered Padler-Karavani, Ondrej Viklicky, Jean-Paul Soulillou
Antibodies of non-human mammals are glycosylated with carbohydrate antigens, such as galactose-α-1-3-galactose (α-Gal) and N-glycolylneuraminic acid (Neu5Gc). These non-human carbohydrate antigens are highly immunogenic in humans due to loss-of-function mutations of the key genes involved in their synthesis. Such immunogenic carbohydrates are expressed on therapeutic polyclonal rabbit anti-human T cell IgGs (anti-thymocyte globulin; ATG), the most popular induction treatment in allograft recipients. To decipher the quantitative and qualitative response against these antigens in immunosuppressed patients, particularly against Neu5Gc, which may induce endothelial inflammation in both the graft and the host...
January 8, 2019: European Journal of Clinical Investigation
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