Journals European Journal of Clinical I...

European Journal of Clinical Investigation
Maryam Qasemi, Vishma Pratap Sur, Ondrej Simonik, Pavla Postlerova, Pavel Skrobanek, Tomas Hradec, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Katerina Komrskova
Testicular cancer is the most common form of cancer in young men of reproductive age and its incidence is increasing globally. With the currently successful treatment and 95% survival rate, there is a need for deeper understanding of testicular cancer-related infertility. Most patients with testicular cancer experience semen abnormalities prior to cancer therapy. However, the exact mechanism of the effect of testicular cancer on sperm anomalies is not known. Mitochondria are organelles that play a crucial role in both tumorigenesis and spermatogenesis and their malfunction may be an important factor resulting in sperm abnormalities in testicular cancer patients...
December 8, 2023: European Journal of Clinical Investigation
Jennifer Gotta, Vitali Koch, Tobias Geyer, Simon S Martin, Christian Booz, Scherwin Mahmoudi, Katrin Eichler, Philipp Reschke, Tommaso D'Angelo, Konrad Klimek, Thomas J Vogl, Leon D Gruenewald
BACKGROUND: Technological progress in the acquisition of medical images and the extraction of underlying quantitative imaging data has introduced exciting prospects for the diagnostic assessment of a wide range of conditions. This study aims to investigate the diagnostic utility of a machine learning classifier based on dual-energy computed tomography (DECT) radiomics for classifying pulmonary embolism (PE) severity and assessing the risk for early death. METHODS: Patients who underwent CT pulmonary angiogram (CTPA) between January 2015 and March 2022 were considered for inclusion in this study...
December 8, 2023: European Journal of Clinical Investigation
Huan Zhang, Yanting Chang, Yujie Li, Jie Wei, Xiaoya Ma, Wenqian Zhou, Xufeng Zang, Tianbo Jin, Songdi Wu
BACKGROUND: Stroke is an important cause of death and disability worldwide, ranking second in the cause of death, and it is thought to be related to genetic factors. The purpose of our study is to investigate the association between CASZ1, WNT2B and PTPRG single nucleotide polymorphisms (SNPs) and stroke risk in the Chinese population. METHODS: We recruited 1418 volunteers, comprised of 710 stroke cases and 708 controls in this study. We used MassARRAY iPLEX GOLD method to genotype the three SNPs on CASZ1, WNT2B and PTPRG...
December 7, 2023: European Journal of Clinical Investigation
Graziella Pompei, Tim P van de Hoef, Hester M den Ruijter, Vijay Kunadian
No abstract text is available yet for this article.
December 6, 2023: European Journal of Clinical Investigation
Vittorio Picchio, Giulio Ferrero, Claudia Cozzolino, Barbara Pardini, Erica Floris, Sonia Tarallo, Xhulio Dhori, Cristina Nocella, Lorenzo Loffredo, Giuseppe Biondi-Zoccai, Roberto Carnevale, Giacomo Frati, Isotta Chimenti, Francesca Pagano
BACKGROUND: Traditional combustion cigarette (TCC) smoking is an established risk factor for several types of cancer and cardiovascular diseases. Circulating microRNAs (miRNAs) represent key molecules mediating pathogenetic mechanisms, and potential biomarkers for personalized risk assessment. TCC smoking globally changes the profile of circulating miRNAs. The use of heat-not-burn cigarettes (HNBCs) as alternative smoking devices is rising exponentially worldwide, and the circulating miRNA profile of chronic HNBC smokers is unknown...
December 5, 2023: European Journal of Clinical Investigation
Edoardo G Giannini, Tommaso Testa, Federica Grillo, Luca Mastracci, Serena Arrigo, Piero Cai, Sabrina Paolino, Martina Burlando, Livia Pisciotta, Elena Formisano, Giuseppe Cittadini, Francesco Copello, Sabrina Tuo, Giorgia Bodini
Despite the institution of an interdisciplinary Inflammatory Bowel Disease (IBD) centre is encouraged, how it may improve patient care is still unknown. In a 5-year period following organisation of an IBD centre, hospitalisations per patient/year decreased (0.41-0.17) and patients on biologics increased (7.7%-26.7%). Total number of hospitalisations (-18.4%) and length of hospitalisation (-29.4%) improved compared with a preceding 5-year period. These findings suggest that institution of an interdisciplinary IBD centre is associated with improved healthcare utilisation...
December 2, 2023: European Journal of Clinical Investigation
Weifeng Shang, Hang Qian, Sheng Zhang, Mingyang Yuan, Xiaojun Pan, Sisi Huang, Jiao Liu, Dechang Chen
BACKGROUND: Evidence supports the observational correlations between human blood metabolites and sepsis. However, whether these associations represent a causal relationship is unknown. In this study, we applied two-sample Mendelian randomization (MR) analyses to examine causality between genetically proxied 486 blood metabolites and sepsis risk. METHODS: We used summary data from genome-wide association studies (GWAS) on 486 metabolites involving 7824 individuals as exposure and a sepsis GWAS including 11,643 cases and 474,841 controls as the outcome...
December 2, 2023: European Journal of Clinical Investigation
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif
Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival. The central role of mitochondria in cellular metabolism places mitochondrial removal at the interface of key metabolic pathways affecting the biosynthesis or catabolism of acetyl-coenzyme A, nicotinamide adenine dinucleotide, polyamines, as well as fatty acids and amino acids...
December 1, 2023: European Journal of Clinical Investigation
Alena Chalupka, Lukas Richter, Ali Chakeri, Ziad El-Khatib, Verena Theiler-Schwetz, Christian Trummer, Robert Krause, Peter Willeit, Bernhard Benka, John P A Ioannidis, Stefan Pilz
INTRODUCTION: Evidence is limited on the effectiveness of a fourth vaccine dose against coronavirus disease 2019 (COVID-19) in populations with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We estimated the risk of COVID-19 deaths and SARS-CoV-2 infections according to vaccination status in previously infected individuals in Austria. METHODS: This is a nationwide retrospective observational study. We calculated age and gender adjusted Cox proportional hazard ratios (HRs) of COVID-19 deaths (primary outcome) and SARS-CoV-2 infections (secondary outcome) from 1 November to 31 December 2022, primarily comparing individuals with four versus three vaccine doses...
November 30, 2023: European Journal of Clinical Investigation
Zhihao Zhang, Julia Vlcek, Valerie Pauly, Nora Hesse, Julia Bauer, Kavi Raj Chataut, Florian Maderspacher, Lina Sophie Volz, Katharina Buchberger, Ruibing Xia, Bianca Hildebrand, Stefan Kääb, Dominik Schüttler, Philipp Tomsits, Sebastian Clauss
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and is associated with considerable morbidity and mortality. Ischaemic heart failure (IHF) remains one of the most common causes of AF in clinical practice. However, ischaemia-mediated mechanisms leading to AF are still incompletely understood, and thus, current treatment approaches are limited. To improve our understanding of the pathophysiology, we studied a porcine IHF model. METHODS: In pigs, IHF was induced by balloon occlusion of the left anterior descending artery for 90 min...
November 27, 2023: European Journal of Clinical Investigation
Juan Moreno-Vedia, Dídac Llop, Ricardo Rodríguez-Calvo, Núria Plana, Núria Amigó, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Josefa Girona
BACKGROUND AND AIM: Triglyceride-rich lipoproteins (TRLs) can have an important role in atherosclerosis development due to their size and ability to penetrate the endothelium. While high plasma triglyceride (TG) levels and chronic inflammation are relevant in metabolic diseases, it remains unclear whether TGs are atherogenic or which TRL-TG-derived metabolites are responsible for inflammation. Here, we aimed to study the lipidome modifications of TRL particles enriched in TG in patients with hyperlipidemia and their associations with a proinflammatory status both in vivo and in vitro...
November 27, 2023: European Journal of Clinical Investigation
Sidar Copur, Abdullah B Yildiz, Adrian Covic, Mehmet Kanbay
BACKGROUND: The exact pathophysiological mechanisms of SGLT-2 inhibitors in the development, progression or treatment of malignancies are not fully understood, but multiple hypotheses have been proposed. SGLT-2 inhibitors have potential anti-proliferative roles due to several underlying pathophysiological mechanisms, such as inhibition of ATP production, activation of AMPK signalling, induction of apoptosis and ferroptosis, inhibition of glutamate dehydrogenase activity and inhibition of DNA and RNA synthesis...
November 27, 2023: European Journal of Clinical Investigation
Teresa Infante, Mark E Pepin, Antonio Ruocco, Ugo Trama, Ciro Mauro, Claudio Napoli
BACKGROUND: Although mounting evidence supports that aberrant DNA methylation occurs in the hearts of patients with atrial fibrillation (AF), noninvasive epigenetic characterization of AF has not yet been defined. METHODS: We investigated DNA methylome changes in peripheral blood CD4+ T cells isolated from 10 patients with AF relative to 11 healthy subjects (HS) who were enrolled in the DIANA clinical trial (NCT04371809) via reduced-representation bisulfite sequencing (RRBS)...
November 22, 2023: European Journal of Clinical Investigation
Yufeng Xie, Yanfang Li, Jianmei Zhang, Yun Chen, Rong Ren, Lu Xiao, Min Chen
BACKGROUND: The occurrence of gout is closely related to metabolism, but there is still a lack of evidence on the causal role of metabolites in promoting or preventing gout. METHODS: We applied a two-sample Mendelian randomization (MR) analysis to assess the association between 486 serum metabolites and gout using genome-wide association study statistics. The inverse variance weighting method was used to generate the main results, while sensitivity analyses using MR-Egger, weighted median, Cochran's Q test, Egger intercept test, and leave-one-out analysis, were performed to assess the stability and reliability of the results...
November 21, 2023: European Journal of Clinical Investigation
Marie-Lise Colsoul, Laurence Galanti
No abstract text is available yet for this article.
November 20, 2023: European Journal of Clinical Investigation
Aryane Cruz Oliveira Pinho, Diana Santos, Paulo J Oliveira, Ermelindo Carreira Leal, Eugenia Carvalho
INTRODUCTION: Diabetes mellitus (DM) impairs wound healing. The aim was to determine whether DM influences mitochondrial respiration in wounded skin (WS) and non-wounded skin (NWS), in a pre-clinical wound healing model of streptozotocin (STZ)-induced diabetes. METHODS: Six weeks after diabetes induction, two wounds were created in the back of C57BL/J6 mice. Using high-resolution respirometry (HRR), oxygen flux was measured, in WS and NWS, using two substrate-uncoupler-inhibitor titration protocols, at baseline (day 0), day 3 and 10 post-wounding, in STZ-DM and non-diabetic (NDM) mice...
November 17, 2023: European Journal of Clinical Investigation
Yang Li, Xingji Gong, Mihnea-Alexandru Găman, Benjamin Hernández-Wolters, Periyannan Velu, Yushan Li
BACKGROUND: Dulaglutide, a subcutaneously administered glucagon-like peptide 1 receptor agonist, has been hypothesized to lead to weight loss in patients with Type 2 diabetes mellitus (T2DM). However, the consequences of its prescription on body weight (BW) and other anthropometric indices, for example, body mass index (BMI) or waist circumference (WC), have not been completely clarified. Therefore, we aimed to assess the effects of subcutaneous dulaglutide administration on BW, BMI and WC values in T2DM subjects by means of a systematic review and meta-analysis of RCTs...
November 11, 2023: European Journal of Clinical Investigation
Alessia Riccio, Chiara M A Cefalo, Camilla Mazzanti, Laura Vero, Teresa Vanessa Fiorentino, Mattia Massimino, Giuseppe Monea, Elena Succurro, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
INTRODUCTION: This cross-sectional study aimed to investigate the association between myocardial mechano-energetic efficiency (MEE) and whole blood viscosity (WBV) in nondiabetic adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study. METHODS: 1143 participants underwent an oral glucose tolerance test and an echocardiogram for myocardial MEE per gram of left ventricular mass (MEEi) measurement. WBV was measured as: [0.12 × h] + [0.17 × (p-2...
November 10, 2023: European Journal of Clinical Investigation
Lucia Spicuzza, Jaymin B Morjaria, Riccardo Polosa
No abstract text is available yet for this article.
November 9, 2023: European Journal of Clinical Investigation
Sanaz Barzegar, Saeed Pirouzpanah
BACKGROUND: Multidrug resistance (MDR) remains a significant challenge in cancer treatment, leading to poor clinical outcomes. Dysregulation of ATP-binding cassette (ABC) transporters has been identified as a key contributor to MDR. Zinc finger proteins (ZNPs) are key regulators of transcription and have emerged as potential contributors to cancer drug resistance. Bridging the knowledge gap between ZNPs and MDR is essential to understand a source of heterogeneity in cancer treatment. This review sought to elucidate how different ZNPs modulate the transcriptional regulation of ABC genes, contributing to resistance to cancer therapies...
November 6, 2023: European Journal of Clinical Investigation
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