journal
https://read.qxmd.com/read/38145460/correction-to-spatial-and-temporal-abnormalities-of-spontaneous-fixational-saccades-and-their-correlates-with-positive-and-cognitive-symptoms-in-schizophrenia
#21
(no author information available yet)
No abstract text is available yet for this article.
December 25, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38104255/the-psy-sim-model-using-real-world-data-to-inform-health-care-policy-for-individuals-with-chronic-psychotic-disorders
#22
JOURNAL ARTICLE
Claire de Oliveira, Joyce Mason, Linda Luu, Tomisin Iwajomo, Frances Simbulan, Paul Kurdyak, Petros Pechlivanoglou
BACKGROUND AND HYPOTHESIS: Few microsimulation models have been developed for chronic psychotic disorders, severe and disabling mental disorders associated with poor medical and psychiatric outcomes, and high costs of care. The objective of this work was to develop a microsimulation model for individuals with chronic psychotic disorders and to use the model to examine the impact of a smoking cessation initiative on patient outcomes. STUDY DESIGN: Using health records and survey data from Ontario, Canada, the PSY-SIM model was developed to simulate health and cost outcomes of individuals with chronic psychotic disorders...
December 16, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38102721/toll-like-receptor-mrna-levels-in-schizophrenia-association-with-complement-factors-and-cingulate-gyrus-cortical-thinning
#23
JOURNAL ARTICLE
Thomas W Weickert, Ellen Ji, Cherrie Galletly, Danny Boerrigter, Yosuke Morishima, Jason Bruggemann, Ryan Balzan, Maryanne O'Donnell, Dennis Liu, Rhoshel Lenroot, Cynthia Shannon Weickert, Jochen Kindler
BACKGROUND AND HYPOTHESES: Previous studies revealed innate immune system activation in people with schizophrenia (SZ), potentially mediated by endogenous pathogen recognition receptors, notably Toll-like receptors (TLR). TLRs are activated by pathogenic molecules like bacterial lipopolysaccharides (TLR1 and TLR4), viral RNA (TLR3), or both (TLR8). Furthermore, the complement system, another key component of innate immunity, has previously been linked to SZ. STUDY DESIGN: Peripheral mRNA levels of TLR1, TLR3, TLR4, and TLR8 were compared between SZ and healthy controls (HC)...
December 15, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38086528/unlocking-the-therapeutic-potential-of-exosomes-derived-from-nasal-olfactory-mucosal-mesenchymal-stem-cells-restoring-synaptic-plasticity-neurogenesis-and-neuroinflammation-in-schizophrenia
#24
JOURNAL ARTICLE
Xiao-Lin Zhong, Yan Huang, Yang Du, Li-Zheng He, Yue-Wen Chen, Yong Cheng, Hua Liu
BACKGROUND AND HYPOTHESIS: Schizophrenia (SCZ) is a multifaceted mental disorder marked by a spectrum of symptoms, including hallucinations, delusions, cognitive deficits, and negative symptoms. Its etiology involves intricate interactions between genetic and environmental factors, posing significant challenges for effective treatment. We hypothesized that intranasal administration of exosomes derived from nasal olfactory mucosal mesenchymal stem cells (OM-MSCs-exos) could alleviate SCZ-like behaviors in a murine model induced by methylazoxymethanol (MAM)...
December 12, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38085061/deep-learning-based-brain-age-prediction-in-patients-with-schizophrenia-spectrum-disorders
#25
JOURNAL ARTICLE
Woo-Sung Kim, Da-Woon Heo, Junyeong Maeng, Jie Shen, Uyanga Tsogt, Soyolsaikhan Odkhuu, Xuefeng Zhang, Sahar Cheraghi, Sung-Wan Kim, Byung-Joo Ham, Fatima Zahra Rami, Jing Sui, Chae Yeong Kang, Heung-Il Suk, Young-Chul Chung
BACKGROUND AND HYPOTHESIS: The brain-predicted age difference (brain-PAD) may serve as a biomarker for neurodegeneration. We investigated the brain-PAD in patients with schizophrenia (SCZ), first-episode schizophrenia spectrum disorders (FE-SSDs), and treatment-resistant schizophrenia (TRS) using structural magnetic resonance imaging (sMRI). STUDY DESIGN: We employed a convolutional network-based regression (SFCNR), and compared its performance with models based on three machine learning (ML) algorithms...
December 12, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38069912/self-disorder-in-schizophrenia-a-revised-view-1-comprehensive-review-dualities-of-self-and-world-experience
#26
JOURNAL ARTICLE
Jasper Feyaerts, Louis Sass
A growing body of research supports the role of self-disorders as core phenotypic features of schizophrenia-spectrum disorders. Self-disorders comprise various alterations of conscious experience whose theoretical understanding continues to present a challenge. The following 2 articles aim to provide further clarification of the nature of self-disorders in schizophrenia by offering a comprehensive review (article 1) and theoretical revision (article 2) of the currently most influential model of altered selfhood in schizophrenia: the basic-self-disturbance or ipseity-disorder model (IDM)...
December 9, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38069907/self-disorder-in-schizophrenia-a-revised-view-2-theoretical-revision-hyperreflexivity
#27
JOURNAL ARTICLE
Louis Sass, Jasper Feyaerts
A growing body of research supports the role of self-disorders as core phenotypic features of schizophrenia-spectrum conditions. Self-disorders comprise various alterations of conscious experience whose theoretical understanding continues to present a challenge. This is the second of two articles that aim to clarify the nature of self-disorders in schizophrenia by considering the currently most influential, phenomenological model of schizophrenia: the basic-self-disturbance or ipseity-disorder model (IDM). The previous paper (article 1) presented a state-of-the-art overview of this model and critically assessed its descriptive adequacy with respect to the clinical heterogeneity and variability of the alterations in self- and world-awareness characteristic of schizophrenia...
December 9, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38041862/cat-ownership-and-schizophrenia-related-disorders-and-psychotic-like-experiences-a-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
John J McGrath, Carmen C W Lim, Sukanta Saha
BACKGROUND: It has been proposed that cat ownership may be a risk-modifying factor for schizophrenia-related disorders and psychotic-like experiences (PLE). This study aimed to systematically review and meta-analyze publications that reported the relationship between cat ownership and schizophrenia-related outcomes. METHODOLOGY: We searched Medline, Embase, CINAHL, Web of Science, and gray literature for publications between January 1, 1980, and May 30, 2023, regardless of geographical location and language...
December 2, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38019938/childhood-adversity-determines-the-syndemic-effects-of-violence-substance-misuse-and-sexual-behavior-on-psychotic-spectrum-disorder-among-men
#29
JOURNAL ARTICLE
Yamin Zhang, Jeremy Coid
BACKGROUND AND HYPOTHESIS: Childhood adversity (CA) increases the risk for several adult psychiatric conditions. It is unclear why some exposed individuals experience psychotic symptoms and others do not. We investigated whether a syndemic explained a psychotic outcome determined by CA. STUDY DESIGN: We used self-reported cross-sectional data from 7461 British men surveyed in different population subgroups. Latent class analysis (LCA) identified categorical psychopathological outcomes...
November 29, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38029279/spontaneous-brain-activity-alterations-in-first-episode-psychosis-a-meta-analysis-of-functional-magnetic-resonance-imaging-studies
#30
JOURNAL ARTICLE
Giulia Cattarinussi, David Antonio Grimaldi, Fabio Sambataro
BACKGROUND AND HYPOTHESIS: Several studies have shown that spontaneous brain activity, including the total and fractional amplitude of low-frequency fluctuations (LFF) and regional homogeneity (ReHo), is altered in psychosis. Nonetheless, neuroimaging results show a high heterogeneity. For this reason, we gathered the extant literature on spontaneous brain activity in first-episode psychosis (FEP), where the effects of long-term treatment and chronic disease are minimal. STUDY DESIGN: A systematic research was conducted on PubMed, Scopus, and Web of Science to identify studies exploring spontaneous brain activity and local connectivity in FEP estimated using functional magnetic resonance imaging...
November 29, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38007605/disease-progression-patterns-of-brain-morphology-in-schizophrenia-more-progressed-stages-in-treatment-resistance
#31
JOURNAL ARTICLE
Daichi Sone, Alexandra Young, Shunichiro Shinagawa, Sakiko Tsugawa, Yusuke Iwata, Ryosuke Tarumi, Kamiyu Ogyu, Shiori Honda, Ryo Ochi, Karin Matsushita, Fumihiko Ueno, Nobuaki Hondo, Akihiro Koreki, Edgardo Torres-Carmona, Wanna Mar, Nathan Chan, Teruki Koizumi, Hideo Kato, Keisuke Kusudo, Vincenzo de Luca, Philip Gerretsen, Gary Remington, Mitsumoto Onaya, Yoshihiro Noda, Hiroyuki Uchida, Masaru Mimura, Masahiro Shigeta, Ariel Graff-Guerrero, Shinichiro Nakajima
BACKGROUND AND HYPOTHESIS: Given the heterogeneity and possible disease progression in schizophrenia, identifying the neurobiological subtypes and progression patterns in each patient may lead to novel biomarkers. Here, we adopted data-driven machine-learning techniques to identify the progression patterns of brain morphological changes in schizophrenia and investigate the association with treatment resistance. STUDY DESIGN: In this cross-sectional multicenter study, we included 177 patients with schizophrenia, characterized by treatment response or resistance, with 3D T1-weighted magnetic resonance imaging...
November 25, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/38000086/correction-to-predictors-of-mortality-following-a-schizophrenia-spectrum-diagnosis-evidence-from-the-20-year-follow-up-of-the-opus-randomized-controlled-trial
#32
(no author information available yet)
No abstract text is available yet for this article.
November 24, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37992246/the-development-of-non-affective-psychotic-syndromes-in-the-19th-century-legrand-du-saulle-and-his-1871-monograph-le-d%C3%A3-lire-de-pers%C3%A3-cutions-persecutory-delusions
#33
JOURNAL ARTICLE
Kenneth S Kendler, Virginia Justis
While the origins of two of Kraepelin's three subtypes of dementia praecox (DP), catatonic and hebephrenic, are well understood, no similar clear narrative exists for his concepts of paranoia and paranoid DP, which require a consideration of both German and French sources. An important milestone in the French literature is the massive 524 page monograph entitled "Le Délire Des Persécutions" published in 1871 by Henri Legrand du Saulle which contained extensive, clinically detailed descriptions of a wide range of cases with prominent, organized persecutory delusions...
November 22, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37992238/a-cross-sectional-conceptual-replication-and-longitudinal-evaluation-of-the-panss-autism-severity-score-measure-suggests-it-does-not-capture-autistic-traits-in-individuals-with-psychosis
#34
JOURNAL ARTICLE
Katharine Chisholm, Frederike Schirmbeck, Amy E Pinkham, Noah J Sasson, Claudia J P Simons, Lieuwe de Haan, Philip D Harvey, David L Penn, Tim Ziermans
BACKGROUND: Autism and psychosis co-occur at elevated rates, with implications for clinical outcomes, functioning, and suicidality. The PANSS-Autism-Severity-Score (PAUSS) is a measure of autism trait severity which has not yet been validated externally or longitudinally. STUDY DESIGN: Participants were derived from the GROUP and SCOPE datasets. Participants included 1448 adults with schizophrenia spectrum disorder (SSD), 800 SSD-siblings, 103 adults diagnosed with an autistic spectrum condition (ASC), and 409 typically-developing controls (TC)...
November 22, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37991994/correction-to-understanding-my-personal-schizophrenia
#35
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37991982/correction-to-genome-wide-association-analysis-of-schizophrenia-and-vitamin-d-levels-shows-shared-genetic-architecture-and-identifies-novel-risk-loci
#36
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37978044/associations-between-structural-covariance-network-and-antipsychotic-treatment-response-in-schizophrenia
#37
JOURNAL ARTICLE
Sakiko Tsugawa, Shiori Honda, Yoshihiro Noda, Cassandra Wannan, Andrew Zalesky, Ryosuke Tarumi, Yusuke Iwata, Kamiyu Ogyu, Eric Plitman, Fumihiko Ueno, Masaru Mimura, Hiroyuki Uchida, Mallar Chakravarty, Ariel Graff-Guerrero, Shinichiro Nakajima
BACKGROUND AND HYPOTHESIS: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. STUDY DESIGN: We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively...
November 18, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37962384/consent-for-research-involving-spanish-and-english-speaking-latinx-adults-with-schizophrenia
#38
JOURNAL ARTICLE
Concepción Barrio, Dahlia Fuentes, Lize Tibiriçá, Mercedes Hernandez, Paula Helu-Brown, Shahrokh Golshan, Barton W Palmer
BACKGROUND: Latinxs are vastly underrepresented in mental health research; one of many contributing factors may be complexities in the research consent process, including language preferences. We examined determinants of comprehension of research consent procedures and tested the effects of a preconsent research schema condition among 180 adults with schizophrenia (60 Latinx-English and 60 Latinx-Spanish preference, and 60 non-Latinx White). STUDY DESIGN: Participants were randomly assigned (equal allocation) to an educational session regarding clinical research concepts and processes (schema condition) or to an attention control...
November 14, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37951838/clinical-assessment-interview-for-negative-symptoms-cains-a-systematic-review-of-measurement-properties
#39
JOURNAL ARTICLE
Sophia Wehr, Lucia Weigel, John Davis, Silvana Galderisi, Armida Mucci, Stefan Leucht
BACKGROUND AND HYPOTHESIS: Negative symptoms are very important for the overall loss of functioning observed in patients with schizophrenia. There is a need for valid tools to assess these symptoms. STUDY DESIGN: We used the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) systematic review guideline to evaluate the quality of the clinical assessment interview for negative symptoms (CAINS) as a clinician-rated outcome measurement (ClinROM)...
November 10, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37951230/corollary-discharge-dysfunction-as-a-possible-substrate-of-anomalous-self-experiences-in-schizophrenia
#40
JOURNAL ARTICLE
Rosa M Beño-Ruiz-de-la-Sierra, Antonio Arjona-Valladares, Marta Hernández-García, Inés Fernández-Linsenbarth, Álvaro Díez, Sabela Fondevila Estevez, Carolina Castaño, Francisco Muñoz, Javier Sanz-Fuentenebro, Alejandro Roig-Herrero, Vicente Molina
BACKGROUND AND HYPOTHESIS: Corollary discharge mechanism suppresses the conscious auditory sensory perception of self-generated speech and attenuates electrophysiological markers such as the auditory N1 Event-Related Potential (ERP) during Electroencephalographic (EEG) recordings. This phenomenon contributes to self-identification and seems to be altered in people with schizophrenia. Therefore, its alteration could be related to the anomalous self-experiences (ASEs) frequently found in these patients...
November 10, 2023: Schizophrenia Bulletin
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