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Schizophrenia Bulletin

Camilla Jerlang Christiani, Jens R M Jepsen, Anne Thorup, Nicoline Hemager, Ditte Ellersgaard, Katrine S Spang, Birgitte K Burton, Maja Gregersen, Anne Søndergaard, Aja N Greve, Ditte L Gantriis, Gry Poulsen, Md Jamal Uddin, Larry J Seidman, Ole Mors, Kerstin J Plessen, Merete Nordentoft
OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality...
March 10, 2019: Schizophrenia Bulletin
Sandra Vieira, Qi-Yong Gong, Walter H L Pinaya, Cristina Scarpazza, Stefania Tognin, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Victor Ortiz-García, Esther Setien-Suero, Floortje E Scheepers, Neeltje E M Van Haren, Tiago R Marques, Robin M Murray, Anthony David, Paola Dazzan, Philip McGuire, Andrea Mechelli
Despite the high level of interest in the use of machine learning (ML) and neuroimaging to detect psychosis at the individual level, the reliability of the findings is unclear due to potential methodological issues that may have inflated the existing literature. This study aimed to elucidate the extent to which the application of ML to neuroanatomical data allows detection of first episode psychosis (FEP), while putting in place methodological precautions to avoid overoptimistic results. We tested both traditional ML and an emerging approach known as deep learning (DL) using 3 feature sets of interest: (1) surface-based regional volumes and cortical thickness, (2) voxel-based gray matter volume (GMV) and (3) voxel-based cortical thickness (VBCT)...
February 27, 2019: Schizophrenia Bulletin
Susan Weiner
No abstract text is available yet for this article.
February 26, 2019: Schizophrenia Bulletin
Katherine Ponte
No abstract text is available yet for this article.
February 20, 2019: Schizophrenia Bulletin
Steve Colori
No abstract text is available yet for this article.
February 19, 2019: Schizophrenia Bulletin
Jean P Lee
No abstract text is available yet for this article.
February 19, 2019: Schizophrenia Bulletin
Christian S Legind, Brian V Broberg, Rachel Brouwer, René C W Mandl, Bjørn H Ebdrup, Simon J Anhøj, Maria H Jensen, Rikke Hilker, Birgitte Fagerlund, Hilleke E Hulshoff Pol, Birte Y Glenthøj, Egill Rostrup
Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and striatal areas, and to ascertain if associations with disease were under genetic influence. Monozygotic (MZ) twin pairs concordant (n = 2) or discordant (n = 20) for schizophrenia spectrum disorders (ICD-10 F2x.x), matched on sex and age with dizygotic (DZ; n = 20) and healthy control pairs (MZ: n = 27; DZ: n = 18; total: n = 181 individuals), were recruited via the National Danish Twin Register...
February 18, 2019: Schizophrenia Bulletin
Yang Du, Yun Yu, Yang Hu, Xiao-Wan Li, Ze-Xu Wei, Rui-Yuan Pan, Xue-Song Li, Guang-En Zheng, Xiao-Yan Qin, Qing-Shan Liu, Yong Cheng
Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed the first genome-wide microRNA (miRNA) expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 controls and identified miRNAs and co-regulated modules that were perturbed in SCZ. Putative targets of these SCZ-affected miRNAs were enriched strongly for genes that have been implicated in protein glycosylation and were also related to neurotransmitter receptor and dendrite (spine) development...
February 16, 2019: Schizophrenia Bulletin
David C Cicero, Katherine G Jonas, Kaiqiao Li, Greg Perlman, Roman Kotov
The associations among normal personality and many mental disorders are well established, but it remains unclear whether and how symptoms of schizophrenia and schizotypal traits align with the personality taxonomy. This study examined the joint factor structure of normal personality, schizotypy, and schizophrenia symptoms in people with psychotic disorders (n = 288) and never-psychotic adults (n = 257) in the Suffolk County Mental Health Project. First, we evaluated the structure of schizotypal (positive schizotypy, negative schizotypy, and mistrust) and normal traits...
February 9, 2019: Schizophrenia Bulletin
Fiona Erica Nichols
No abstract text is available yet for this article.
February 8, 2019: Schizophrenia Bulletin
Dusan Hirjak, Katharina M Kubera, Georg Northoff, Stefan Fritze, Alina L Bertolino, Cristina E Topor, Mike M Schmitgen, Robert C Wolf
Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural magnetic resonance imaging data at 3 T were obtained from 56 right-handed patients with SSD. Using FreeSurfer version 6.0, we calculated cortical thickness, area, and local gyrification index (LGI)...
February 7, 2019: Schizophrenia Bulletin
Flavie Waters, Charles Fernyhough
No abstract text is available yet for this article.
February 7, 2019: Schizophrenia Bulletin
Schaub Annette, Falkai Peter
The Sixth Kraepelin Symposium was held at the Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich in October 2018, covering reports from 12 working groups (Keith H. Nuechterlein, Ph.D., University of California, Los Angeles; Kim T. Mueser, Ph.D., Center for Psychiatric Rehabilitation, Boston University, U.S.A.; Dominic Dwyer, Ph.D, Hospital LMU, Munich; David Fowler, Ph.D. University of Sussex, Brighton, U.K.; Martin Hautzinger, Ph.D., University of Tübingen; Nikolaos Koutsouleris, M...
February 5, 2019: Schizophrenia Bulletin
Alexis E Whitton, Alan I Green, Diego A Pizzagalli, Robert M Roth, Jill M Williams, Mary F Brunette
Antipsychotics that are potent dopamine (DA) D2 receptor antagonists have been linked to elevated levels of nicotine dependence in smokers with schizophrenia. Because activation of D2 receptors mediates motivation for nicotine, we examined whether potent D2 antagonists would diminish nicotine's ability to stimulate reward processing-a mechanism that may drive compensatory increases in smoking. Smokers with schizophrenia (n = 184) were recruited and stratified into medication groups based on D2 receptor antagonist potency...
January 22, 2019: Schizophrenia Bulletin
Nicola King
No abstract text is available yet for this article.
January 21, 2019: Schizophrenia Bulletin
Gregory Paul Strauss, Farnaz Zamani Esfahlani, Brian Kirkpatrick, Daniel N Allen, James M Gold, Katherine Frost Visser, Hiroki Sayama
Network analysis was used to examine how densely interconnected individual negative symptom domains are, whether some domains are more central than others, and whether sex influenced network structure. Participants included outpatients with schizophrenia (SZ; n = 201), a bipolar disorder (BD; n = 46) clinical comparison group, and healthy controls (CN; n = 27) who were rated on the Brief Negative Symptom Scale. The mutual information measure was used to construct negative symptom networks. Groups were compared on macroscopic network properties to evaluate overall network connectedness, and microscopic properties to determine which domains were most central...
January 14, 2019: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2019: Schizophrenia Bulletin
Ria M Chapman, Caroline L Tinsley, Matthew J Hill, Marc P Forrest, Katherine E Tansey, Antonio F Pardiñas, Elliott Rees, A Michelle Doyle, Lawrence S Wilkinson, Michael J Owen, Michael C O'Donovan, Derek J Blake
Genome-wide association studies have linked common variation in ZNF804A with an increased risk of schizophrenia. However, little is known about the biology of ZNF804A and its role in schizophrenia. Here, we investigate the function of ZNF804A using a variety of complementary molecular techniques. We show that ZNF804A is a nuclear protein that interacts with neuronal RNA splicing factors and RNA-binding proteins including RBFOX1, which is also associated with schizophrenia, CELF3/4, components of the ubiquitin-proteasome system and the ZNF804A paralog, GPATCH8...
December 29, 2018: Schizophrenia Bulletin
Sonja M C de Zwarte, Rachel M Brouwer, Andromachi Tsouli, Wiepke Cahn, Manon H J Hillegers, Hilleke E Hulshoff Pol, René S Kahn, Neeltje E M van Haren
Structural brain abnormalities and cognitive deficits have been reported in patients with schizophrenia and to a lesser extent in their first-degree relatives (FDRs). Here we investigated whether brain abnormalities in nonpsychotic relatives differ per type of FDR and how these abnormalities are related to intelligent quotient (IQ). Nine hundred eighty individuals from 5 schizophrenia family cohorts (330 FDRs, 432 controls, 218 patients) were included. Effect sizes were calculated to compare brain measures of FDRs and patients with controls, and between each type of FDR...
December 28, 2018: Schizophrenia Bulletin
Dinesh K Shukla, Joshua John Chiappelli, Hemalatha Sampath, Peter Kochunov, Stephanie M Hare, Krista Wisner, Laura M Rowland, L Elliot Hong
Negative symptoms represent a distinct component of psychopathology in schizophrenia (SCZ) and are a stable construct over time. Although impaired frontostriatal connectivity has been frequently described in SCZ, its link with negative symptoms has not been carefully studied. We tested the hypothesis that frontostriatal connectivity at rest may be associated with the severity of negative symptoms in SCZ. Resting state functional connectivity (rsFC) data from 95 mostly medicated patients with SCZ and 139 healthy controls (HCs) were acquired...
December 21, 2018: Schizophrenia Bulletin
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