Melissa Thalhammer, Julia Schulz, Felicitas Scheulen, Mohamed El Mehdi Oubaggi, Matthias Kirschner, Stefan Kaiser, André Schmidt, Stefan Borgwardt, Mihai Avram, Felix Brandl, Christian Sorg
BACKGROUND AND HYPOTHESIS: Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms. STUDY DESIGN: We performed a FreeSurfer-based volumetry of T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode psychosis (FEP) individuals, and 126 patients with schizophrenia to estimate thalamic nuclei volumes of six nuclei groups (anterior, lateral, ventral, intralaminar, medial, and pulvinar)...
April 5, 2024: Schizophrenia Bulletin