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Journals Stroke; a Journal of Cerebral ...

Stroke; a Journal of Cerebral Circulation

https://read.qxmd.com/read/38488382/treating-hypertension-important-for-heart-health-fundamental-for-brain-health
#1
JOURNAL ARTICLE
Sanjula D Singh, Jasper R Senff, Cornelia M van Duijn, Jonathan Rosand
The Brain Health crisis stands as one of humankind's most pressing threats, with age-related noncommunicable brain diseases, particularly stroke, and dementia, affecting hundreds of millions annually and jeopardizing the economic well-being of populations worldwide. Epidemiological studies indicate that ≈40% of dementia and 60% of stroke cases are attributable to modifiable risk factors. In this Comments and Opinions article, we underscore the pivotal role of blood pressure (BP) control in reducing suffering, enhancing economic well-being, and promoting healthy longevity for populations worldwide...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38488379/health-inequity-and-time-from-pediatric-stroke-onset-to-arrival
#2
JOURNAL ARTICLE
Akshat M Pai, Teresa To, Gabrielle A deVeber, Daniel Nichol, Andrea Kassner, Birgit Ertl-Wagner, Mubeen F Rafay, Nomazulu Dlamini
BACKGROUND: Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the association between health inequity and onset-to-arrival in a pediatric comprehensive stroke center. METHODS: A retrospective observational study was conducted on a consecutive cohort of children (>28 days-18 years) diagnosed with acute arterial ischemic stroke (AIS) between 2004 and 2019...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38488367/moving-from-ct-to-mri-paradigm-in-acute-ischemic-stroke-feasibility-effects-on-stroke-diagnosis-and-long-term-outcomes
#3
JOURNAL ARTICLE
Costanza Maria Rapillo, Vincent Dunet, Silvia Pistocchi, Alexander Salerno, Vincent Darioli, Bruno Bartolini, Steven David Hajdu, Patrik Michel, Davide Strambo
BACKGROUND: The relative value of computed tomography (CT) and magnetic resonance imaging (MRI) in acute ischemic stroke (AIS) is debated. In May 2018, our center transitioned from using CT to MRI as first-line imaging for AIS. This retrospective study aims to assess the effects of this paradigm change on diagnosis and disability outcomes. METHODS: We compared all consecutive patients with confirmed diagnosis of AIS admitted to our center during the MRI-period (May 2018-August 2022) and an identical number of patients from the preceding CT-period (December 2012-April 2018)...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38488357/ctp-defined-large-core-is-a-better-predictor-of-poor-outcome-for-endovascular-treatment-than-aspects-defined-large-core
#4
JOURNAL ARTICLE
Yi Sui, Wenhuo Chen, Chushuang Chen, Yanting Chang, Andrew Bivard, Peng Wang, Yu Geng, Mark Parsons, Longting Lin
BACKGROUND: Recent trials confirmed the effectiveness of endovascular therapy in patients with large ischemic cores. Yet the optimal neuroimaging modalities to define large core remains unclear. We tried to address this question by comparing the functional outcomes in patients receiving thrombectomy selected by either noncontrast computed tomography Alberta Stroke Program Early Computed Tomography Score (ASPECTS) or Computed Tomography perfusion (CTP). METHODS: This study retrospectively selected patients enrolled in the International Stroke Perfusion Registry between August 2011 and April 2022...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38487876/long-term-outcomes-in-patients-with-spontaneous-cerebellar-hemorrhage-an-international-cohort-study
#5
JOURNAL ARTICLE
Jasper R Senff, Sanjula D Singh, Marco Pasi, Wilmar M T Jolink, Mark A Rodrigues, Floris H B M Schreuder, Julie Staals, Tobien Schreuder, Jules P J Douwes, Jelmer Talsma, Brenna N McKaig, Christina Kourkoulis, Nirupama Yechoor, Christopher D Anderson, Laurent Puy, Charlotte Cordonnier, Marieke J H Wermer, Peter M Rothwell, Jonathan Rosand, Catharina J M Klijn, Rustam Al-Shahi Salman, Gabriël J E Rinkel, Anand Viswanathan, Joshua N Goldstein, H Bart Brouwers
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on the long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess the long-term case fatality and recurrence rate of vascular events after a first cerebellar ICH. METHODS: In this international cohort study, we included patients from 10 hospitals (the United States and Europe from 1997 to 2017) aged ≥18 years with a first spontaneous cerebellar ICH who were discharged alive...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38482715/association-of-posttraumatic-stress-disorder-and-race-on-readmissions-after-stroke
#6
JOURNAL ARTICLE
Chen Lin, Peter H King, Joshua S Richman, Lori L Davis
BACKGROUND: There is limited research on outcomes of patients with posttraumatic stress disorder (PTSD) who also develop stroke, particularly regarding racial disparities. Our goal was to determine whether PTSD is associated with the risk of hospital readmission after stroke and whether racial disparities existed. METHODS: The analytical sample consisted of all veterans receiving care in the Veterans Health Administration who were identified as having a new stroke requiring inpatient admission based on the International Classification of Diseases codes...
March 14, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38482689/plasma-metabolites-and-life-s-simple-7-in-regards
#7
JOURNAL ARTICLE
Naruchorn Kijpaisalratana, Zsuzsanna Ament, Amit Patki, Varun M Bhave, Alana C Jones, Catharine A Couch, Ana-Lucia Garcia Guarniz, Mary Cushman, D Leann Long, Suzanne E Judd, M Ryan Irvin, W Taylor Kimberly
BACKGROUND: The American Heart Association's Life's Simple 7 (LS7) is a health metric that captures important factors associated with cardiovascular and cerebrovascular health. Previous studies highlight the potential of plasma metabolites to serve as a marker for lifestyle and health behavior that could be a target for stroke prevention. The objectives of this study were to identify metabolites that were associated with LS7 and incident ischemic stroke and mediate the relationship between the two...
March 14, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38469729/heterogeneity-of-state-stroke-center-certification-and-designation-processes
#8
JOURNAL ARTICLE
Madeline Feldmeier, Anthony S Kim, Kori S Zachrison, Mark J Alberts, Yu-Chu Shen, Renee Y Hsia
BACKGROUND: Stroke centers are critical for the timely diagnosis and treatment of acute stroke and have been associated with improved treatment and outcomes; however, variability exists in the definitions and processes used to certify and designate these centers. Our study categorizes state stroke center certification and designation processes and provides examples of state processes across the United States, specifically in states with independent designation processes that do not rely on national certification...
March 12, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38469727/law-and-disorder-in-the-wild-west-of-stroke-certification-is-it-time-to-standardize-the-designation-processes
#9
EDITORIAL
Gillian L Gordon Perue, Andrew M Southerland
No abstract text is available yet for this article.
March 12, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465650/neutrophil-extracellular-traps-and-thrombolysis-resistance-new-insights-for-targeting-therapies
#10
JOURNAL ARTICLE
Luca Mengozzi, Ilaria Barison, Martin Malý, Giulia Lorenzoni, Marny Fedrigo, Chiara Castellani, Dario Gregori, Petr Malý, Radoslav Matěj, Petr Toušek, Petr Widimský, Annalisa Angelini
BACKGROUND: Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi retrieved after mechanical thrombectomy, estimate the age and organization of thrombi, and evaluate associations with the use of thrombolysis, antiplatelets, and heparin. METHODS: This retrospective observational study involved 72 samples (44 from cerebral and 28 coronary arteries), which were stained with hematoxylin and eosin, anti-NE (neutrophil elastase) antibody, and anti-histone H2B (histone H2B) antibody, representing different components in NET formation, all detectable during the later stages of NETosis, for histochemical and digital quantification of NET content...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465619/thrombolysis-is-not-indicated-for-minor-strokes-if-they-are-truly-nondisabling
#11
EDITORIAL
Sherri A Braksick, Alejandro A Rabinstein
No abstract text is available yet for this article.
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465605/cardiovascular-management-in-asymptomatic-silent-cerebral-microbleeds-and-suspected-cerebral-amyloid-angiopathy
#12
REVIEW
Andreas Charidimou, Eric E Smith
Cerebral microbleeds (CMBs) detected on blood-sensitive magnetic resonance imaging sequences are usually a sign of an underlying cerebral small vessel disease such as sporadic cerebral amyloid angiopathy or sporadic nonamyloid small vessel pathology (eg, arteriolosclerosis). Much of the enduring interest in CMBs relates to their high prevalence (partly due to the widespread use of magnetic resonance imaging) in the context of stroke, cognitive impairment and in healthy individuals, and the clinical uncertainties created about the safety of antithrombotic medications due to their association with both future hemorrhagic and ischemic stroke...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465597/relationship-of-perivascular-space-markers-with-incident-dementia-in-cerebral-small-vessel-disease
#13
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465591/intravenous-alteplase-versus-best-medical-therapy-for-patients-with-minor-stroke-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Yang Zhang, Tian Lv, Thanh N Nguyen, Simiao Wu, Zhi Li, Xue Bai, Dan Chen, Chuansheng Zhao, Wanyi Lin, Shiqin Chen, Yi Sui
BACKGROUND: The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0-5) remains inconclusive. The aim of this study is to compare the effectiveness and safety of IVT with best medical therapy (BMT) by means of a systematic review and meta-analysis of randomized controlled trials and observational studies. METHODS: We searched the PubMed, Embase, Cochrane Library, and Web of Science databases to obtain articles related to IVT in minor stroke from inception until August 10, 2023...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465587/utilization-of-optical-coherence-tomography-in-the-diagnosis-of-intraplaque-hemorrhage-causing-severe-basilar-artery-stenosis
#15
JOURNAL ARTICLE
Di Li, Tao Tang, Teng Hu, Aline M Thomas, Shen Li
No abstract text is available yet for this article.
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38456303/thrombolysis-for-wake-up-stroke-versus-non-wake-up-unwitnessed-stroke-eos-individual-patient-data-meta-analysis
#16
JOURNAL ARTICLE
Naruhiko Kamogawa, Kaori Miwa, Kazunori Toyoda, Märit Jensen, Manabu Inoue, Sohei Yoshimura, Mayumi Fukuda-Doi, Takanari Kitazono, Florent Boutitie, Henry Ma, Peter Ringleb, Ona Wu, Lee H Schwamm, Steven Warach, Werner Hacke, Stephen M Davis, Geoffrey A Donnan, Christian Gerloff, Götz Thomalla, Masatoshi Koga
BACKGROUND: Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups. METHODS: Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0...
March 8, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38456295/what-do-we-really-know-about-the-effect-of-prolonged-heart-rhythm-monitoring-after-stroke
#17
JOURNAL ARTICLE
Håkon Ihle-Hansen, Guri Hagberg, Hege Ihle-Hansen, Else Chartlotte Sandset, Jason G Andrade, John Mandrola, Søren Zöga Diederichsen
The bulk of the current knowledge on atrial fibrillation (AF)-associated stroke risk and benefit of oral anticoagulation derives from studies on patients with clinically diagnosed AF. Subclinical AF (SCAF), defined as AF discovered during the interrogation of prolonged heart monitoring, is often asymptomatic and short-lasting, is associated with increased stroke risk compared with sinus rhythm, and may progress to clinical AF. Despite the extensive screening for and treatment of SCAF, especially in secondary stroke prevention, the net benefit of this practice is not established...
March 8, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38456274/wake-up-stroke-or-non-wake-up-unwitnessed-stroke-does-the-distinction-matter-for-intravenous-thrombolysis
#18
EDITORIAL
Guillaume Turc
No abstract text is available yet for this article.
March 8, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38456262/capsaicin-for-cerebral-perfusion-augmentation-a-randomized-open-label-trial
#19
LETTER
Juan Manuel Marquez-Romero, Claudio García-Perales, Maricela García-Arellano, María Soledad Ortíz, Carlos David Pérez-Malagón, María Raquel Huerta-Franco, Francisco Miguel Vargas-Luna
No abstract text is available yet for this article.
March 8, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38445502/inhibition-of-anaplastic-lymphoma-kinase-protects-from-ischemic-stroke
#20
JOURNAL ARTICLE
Yue Hu, Luping Chang, Yuanbo Zhu, Xue Geng, Zhongwang Liu, Ranran Wang, Yiheng Wang, Bing-Qiao Zhao, Wenying Fan
BACKGROUND: Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption of the blood-brain barrier and ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found to play a role in oxidative stress and inflammation. In this study, we investigated the role of ALK inhibition in a murine model of ischemic stroke. METHODS: Focal cerebral ischemia was induced by temporary occlusion of the right middle cerebral artery in mice with a filament...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
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