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JOURNAL ARTICLE
Sanaz Sedaghat, Yuekai Ji, Jean-Philippe Empana, Timothy M Hughes, Thomas H Mosley, Rebecca F Gottesman, Michael Griswold, Clifford R Jack, Pamela L Lutsey, Thomas T van Sloten
BACKGROUND: Cardiovascular health may be used for prevention of cerebral vascular disease; however, data on the association of cardiovascular health across midlife and late-life with late-life cerebral vascular disease are lacking. Our aim was to examine whether midlife or late-life cardiovascular health as well as changes of cardiovascular health within midlife and between midlife and late-life were associated with prevalence of magnetic resonance imaging markers of cerebral vascular disease at late-life...
March 23, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Eleonora De Matteis, Federico De Santis, Raffaele Ornello, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Alessia Giossi, Pietro Di Viesti, Vincenzo Inchingolo, Giovanni Matteo Fratta, Marina Diomedi, Maria Rosaria Bagnato, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Tiziana Tassinari, Valentina Saia, Alessandro Russo, Marco Petruzzellis, Domenico Maria Mezzapesa, Martina Caccamo, Giuseppe Rinaldi, Alessandra Bavaro, Maurizio Paciaroni, Maria Giulia Mosconi, Matteo Foschi, Pietro Querzani, Francesco Muscia, Serena Gallo Cassarino, Paolo Candelaresi, Antonio De Mase, Maria Guarino, Letizia Maria Cupini, Enzo Sanzaro, Andrea Zini, Salvatore La Spada, Carmela Palmieri, Federica Nicoletta Sepe, Simone Beretta, Cristina Paci, Emanuele Alessandro Caggia, Maria Vittoria De Angelis, Laura Bonanni, Gino Volpi, Rossana Tassi, Francesca Pistoia, Umberto Scoditti, Agnese Tonon, Giovanna Viticchi, Giampietro Ruzza, Patrizia Nencini, Anna Cavallini, Danilo Toni, Stefano Ricci, Simona Sacco
BACKGROUND: Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient ischemic attack (TIA) without substantially increasing the hemorrhagic risk. We aimed at understanding whether and how real-world use of DAPT differs from RCTs. METHODS: READAPT (Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or TIA) is a prospective cohort study including >18-year-old patients treated with DAPT after a noncardioembolic minor ischemic stroke or high-risk TIA from 51 Italian centers...
March 23, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Priscilla Tjokrowijoto, Renerus J Stolwyk, David Ung, Ian Kneebone, Monique F Kilkenny, Joosup Kim, Muideen T Olaiya, Lachlan L Dalli, Dominique A Cadilhac, Mark R Nelson, Natasha A Lannin, Nadine E Andrew
BACKGROUND: Untreated poststroke mood problems may influence long-term outcomes. We aimed to investigate factors associated with receiving mental health treatment following stroke and impacts on long-term outcomes. METHODS: Observational cohort study derived from the Australian Stroke Clinical Registry (AuSCR; Queensland and Victorian registrants: 2012-2016) linked with hospital, primary care billing and pharmaceutical dispensing claims data. Data from registrants who completed the AuSCR 3 to 6 month follow-up survey containing a question on anxiety/depression were analyzed...
March 23, 2023: Stroke; a Journal of Cerebral Circulation
#4
JOURNAL ARTICLE
Eric E Adelman, Michelle H Leppert
No abstract text is available yet for this article.
March 23, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Deborah Rose, Annie Cavalier, Wayneho Kam, Sarah Cantrell, Jay Lusk, Matthew Schrag, Shadi Yaghi, Christoph Stretz, Adam de Havenon, Ian J Saldanha, Teddy Y Wu, Anna Ranta, P Alan Barber, Elizabeth Marriott, Wayne Feng, Andrzej S Kosinski, Daniel Laskowitz, Sven Poli, Brian Mac Grory
BACKGROUND: Prior systematic reviews have compared the efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke, assigning their relative complications as a secondary objective. The objective of the present study is to determine whether the risk of treatment complications differs between patients treated with either agent. METHODS: We performed a systematic review including interventional studies and prospective and retrospective, observational studies enrolling adult patients treated with intravenous tenecteplase for ischemic stroke (both comparative and noncomparative with alteplase)...
March 23, 2023: Stroke; a Journal of Cerebral Circulation
#6
REVIEW
Thomas G Brott, James F Meschia, Brajesh K Lal, Ángel Chamorro, Virginia J Howard, George Howard
The recently published SPACE-2 trial (Stent-Supported Percutaneous Angioplasty of the Carotid Artery Versus Endarterectomy-2) compared 3 treatments to prevent stroke in patients with asymptomatic carotid stenosis ≥70%: (1) carotid endarterectomy plus best medical treatment (BMT), (2) transfemoral carotid artery stenting plus BMT, or (3) BMT alone. Because of low enrollment, the findings of similar safety and efficacy for carotid endarterectomy, carotid artery stenting, or BMT alone were inconclusive...
March 21, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Yi-Chu Liao, Cheng-Yu Wei, Fu-Pang Chang, Ying-Tsen Chou, Shao-Lun Hsu, Chih-Ping Chung, Takeshi Mizuguchi, Naomichi Matsumoto, Shaw-Fang Yet, Yi-Chung Lee
BACKGROUND: Neuronal intranuclear inclusion disease (NIID), caused by GGC (guanine-guanine-cytosine) repeat expansion in NOTCH2NLC , has several clinical and radiological features akin to cerebral small vessel disease (cSVD). The present study tested the hypothesis that NOTCH2NLC GGC expansion may contribute to cSVD. METHODS: One hundred and ninety-seven unrelated patients with genetically unsolved vascular leukoencephalopathy without NOTCH3 , HTRA1 , and mitochondrial m...
March 21, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Jiangming Sun, Yan Borné, Andreas Edsfeldt, Yunpeng Wang, Mengyu Pan, Olle Melander, Gunnar Engström, Isabel Gonçalves
BACKGROUND: Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke. METHODS: We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6-23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE Consortium)...
March 21, 2023: Stroke; a Journal of Cerebral Circulation
#9
REVIEW
Adam de Havenon, Osama O Zaidat, Sepideh Amin-Hanjani, Thanh N Nguyen, Aaron Bangad, Mehdi Abbasi, Mohammad Anadani, Eyad Almallouhi, Rano Chatterjee, Mikael Mazighi, Eva A Mistry, Shadi Yaghi, Colin P Derdeyn, Keun-Sik Hong, Alexandra Kvernland, Thabele M Leslie-Mazwi, Sami Al Kasab
Large vessel occlusion stroke due to underlying intracranial atherosclerotic disease (ICAD-LVO) is prevalent in 10 to 30% of LVOs depending on patient factors such as vascular risk factors, race and ethnicity, and age. Patients with ICAD-LVO derive similar functional outcome benefit from endovascular thrombectomy as other mechanisms of LVO, but up to half of ICAD-LVO patients reocclude after revascularization. Therefore, early identification and treatment planning for ICAD-LVO are important given the unique considerations before, during, and after endovascular thrombectomy...
March 20, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Chuming Yan, Fan Yu, Yingjie Zhang, Miao Zhang, Jingkai Li, Zixin Wang, Jie Lu, Qingfeng Ma
BACKGROUND: Multidelay arterial spin labeling (ASL) is a novel perfusion method of ASL, with arterial transit time (ATT) calculated by multiple postlabeling delays to correct cerebral blood flow (CBF). We verify the accuracy of multidelay ASL in evaluating the ischemic penumbra and perfusion levels in patients with acute ischemic stroke, compared with computed tomography perfusion (CTP). METHODS: Patients with acute ischemic stroke with anterior circulation large vessel occlusion received baseline CTP, multidelay ASL, and diffusion-weighted imaging (DWI) in succession...
March 14, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Daniel P O Kaiser, Matthias Gawlitza, Jennifer Linn, Kay Engellandt
No abstract text is available yet for this article.
March 14, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Klearchos Psychogios, Odysseas Kargiotis, Apostolos Safouris, Panagiotis Repousis, Georgios Tsivgoulis
No abstract text is available yet for this article.
March 13, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Melissa D Stockbridge, Jordan Elm, Bonnie L Breining, Donna C Tippett, Rajani Sebastian, Christy Cassarly, Abeba Teklehaimanot, Leigh Ann Spell, Shannon M Sheppard, Emilia Vitti, Kristina Ruch, Emily B Goldberg, Catherine Kelly, Lynsey M Keator, Julius Fridriksson, Argye E Hillis
BACKGROUND: Transcranial direct-current stimulation (tDCS) is a promising adjunct to therapy for chronic aphasia. METHODS: This single-center, randomized, double-blind, sham-controlled efficacy trial tested the hypothesis that anodal tDCS augments language therapy in subacute aphasia. Secondarily, we compared the effect of tDCS on discourse measures and quality of life and compared the effects on naming to previous findings in chronic stroke. Right-handed English speakers with aphasia <3 months after left hemisphere ischemic stroke were included, unless they had prior neurological or psychiatric disease or injury or were taking certain medications (34 excluded; final sample, 58)...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Mikahela A López-Morales, Iris Escobar, Isabel Saul, Charles W Jackson, Fernando J Ferrier, Eric A Fagerli, Ami P Raval, Kunjan R Dave, Miguel A Perez-Pinzon
BACKGROUND: Cholinergic cells originating from the nuclei of the basal forebrain (BF) are critical for supporting various memory processes, yet BF cholinergic cell viability has not been explored in the context of focal cerebral ischemia. In the present study, we examined cell survival within several BF nuclei in rodents following transient middle cerebral artery occlusion. We tested the hypothesis that a previously established neuroprotective therapy-resveratrol preconditioning-would rescue BF cell loss, deficits in cholinergic-related memory performance, and hippocampal synaptic dysfunction after focal cerebral ischemia...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Wenting Zhang, Hongjian Pu, Xiaoming Hu, Yejie Shi, Rehana K Leak, R Anne Stetler, Qing Ye, Junxuan Lyu, Feng Zhang, Lawrence R Wechsler, Jun Chen
BACKGROUND: Stroke is the primary cause of chronic disability in the elderly, as there are no neurorestorative treatments for those who do not qualify for recanalization therapy. Experimental evidence in stroke animals suggests that transplantation of bone marrow-derived human mesenchymal stem cells (hMSCs) holds promise, but hMSC transplantation has not been systematically tested in aged animals. We tested the hypothesis that poststroke hMSC transplantation improves stroke recovery in aged mice by promoting brain repair...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
#16
JOURNAL ARTICLE
Henk van Voorst, Agnetha A E Bruggeman, Jurr Andriessen, Jan W Hoving, Praneeta R Konduri, Wenjin Yang, Manon Kappelhof, Nerea Arrarte Terreros, Yvo B W E M Roos, Wim H van Zwam, Aad van der Lugt, Anouk van der Hoorn, Jelis Boiten, Stefan Roosendaal, Sjoerd Jenniskens, Matthan W A Caan, Henk A Marquering, Bart J Emmer, Charles B L M Majoie
BACKGROUND: A larger thrombus in patients with acute ischemic stroke might result in more complex endovascular treatment procedures, resulting in poorer patient outcomes. Current evidence on thrombus volume and length related to procedural and functional outcomes remains contradicting. This study aimed to assess the prognostic value of thrombus volume and thrombus length and whether this relationship differs between first-line stent retrievers and aspiration devices for endovascular treatment...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
#17
LETTER
Marta Machado-Pereira, Alba Grayston, Miguel Garcia-Gabilondo, Vitor Francisco, Ana Cristóvão, João Marto, Helena Vieira, Miguel Viana-Baptista, Lino Ferreira, Liliana Bernardino, Anna Rosell, Raquel Ferreira
No abstract text is available yet for this article.
March 13, 2023: Stroke; a Journal of Cerebral Circulation
#18
JOURNAL ARTICLE
Xiaoxu Yang, Pengxin Yu, Haoyue Zhang, Rongguo Zhang, Yuehong Liu, Haoyuan Li, Penghui Sun, Xin Liu, Yu Wu, Xiuqin Jia, Jiangang Duan, Xunming Ji, Qi Yang
BACKGROUND: Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease. Routine brain magnetic resonance imaging is commonly used to diagnose CVT. This study aimed to develop and evaluate a novel deep learning (DL) algorithm for detecting CVT using routine brain magnetic resonance imaging. METHODS: Routine brain magnetic resonance imaging, including T1-weighted, T2-weighted, and fluid-attenuated inversion recovery images of patients suspected of CVT from April 2014 through December 2019 who were enrolled from a CVT registry, were collected...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
#19
JOURNAL ARTICLE
Hao Li, Mengfei Cai, Mina A Jacob, David G Norris, José P Marques, Maxime Chamberland, Marco Duering, Roy P C Kessels, Frank-Erik de Leeuw, Anil M Tuladhar
BACKGROUND: Structural network damage is a potentially important mechanism by which cerebral small vessel disease (SVD) can cause cognitive impairment. As a central hub of the structural network, the role of thalamus in SVD-related cognitive impairments remains unclear. We aimed to determine the associations between the structural alterations of thalamic subregions and cognitive impairments in SVD. METHODS: In this cross-sectional study, 205 SVD participants without thalamic lacunes from the third follow-up (2020) of the prospective RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort), which was initiated in 2006, Nijmegen, were included...
March 13, 2023: Stroke; a Journal of Cerebral Circulation
#20
LETTER
Adam de Havenon, Aaron Bangad, Lesli E Skolarus, Chad M Aldridge, Robynne G Braun, John W Cole, Steven C Cramer, Arne G Lindgren, N Abimbola Sunmonu, Bradford B Worrall, Keith R Lohse
No abstract text is available yet for this article.
March 10, 2023: Stroke; a Journal of Cerebral Circulation
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