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Journals Stroke; a Journal of Cerebral ...

Stroke; a Journal of Cerebral Circulation

https://read.qxmd.com/read/37732491/asl-perfusion-might-predict-treatment-outcomes-of-chronic-subdural-hematoma
#1
JOURNAL ARTICLE
Wenyan Li, Zhouyang Jiang, Yin Niu, Zhi Chen
No abstract text is available yet for this article.
September 21, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37732490/nursing-and-institutional-responsibilities-for-in-hospital-stroke
#2
REVIEW
Josh Snavely, Hilaire J Thompson
In-hospital stroke events occur less often than stroke outside of a health care facility; yet, the need for timely evaluation and treatment is the same regardless of geographic location. During hospitalization, nurses are generally the first to recognize possible symptoms of stroke and activate emergency protocols. Such actions in response to changes in patient condition are critical to optimal patient outcomes. A recent scientific statement from the American Heart Association notes that patients with in-hospital stroke are likely to experience delayed recognition of symptoms, less likely to receive intravenous thrombolysis therapy, and have worse outcomes compared with community-occurring stroke...
September 21, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37732489/effect-of-individualized-versus-standardized-blood-pressure-management-during-endovascular-stroke-treatment-on-clinical-outcome-a-randomized-clinical-trial
#3
JOURNAL ARTICLE
Min Chen, Jan Meis, Arne Potreck, Lukas D Sauer, Meinhard Kieser, Martin Bendszus, Wolfgang Wick, Peter A Ringleb, Markus A Möhlenbruch, Silvia Schönenberger
BACKGROUND: Optimal blood pressure (BP) management during endovascular stroke treatment is not well established. We studied whether an individualized approach for managing BP during endovascular stroke treatment gives a better clinical outcome than an approach with standardized systolic BP targets. METHODS: The INDIVIDUATE study (Individualized Blood Pressure Management During Endovascular Treatment of Acute Ischemic Stroke Under Procedural Sedation) is a randomized clinical trial with a prospective randomized open blinded end-point (PROBE) design...
September 21, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37712232/association-of-baseline-cerebrovascular-reactivity-and-longitudinal-development-of-enlarged-perivascular-spaces-in-the-basal-ganglia
#4
JOURNAL ARTICLE
T J Libecap, Christopher E Bauer, Valentinos Zachariou, Colleen A Pappas, Flavius D Raslau, Peiying Liu, Hanzhang Lu, Brian T Gold
BACKGROUND: Increasing evidence suggests that enlarged perivascular spaces (ePVS) are associated with cognitive dysfunction in aging. However, the pathogenesis of ePVS remains unknown. Here, we tested the possibility that baseline cerebrovascular dysfunction, as measured by a magnetic resonance imaging measure of cerebrovascular reactivity, contributes to the later development of ePVS. METHODS: Fifty cognitively unimpaired, older adults (31 women; age range, 60-84 years) underwent magnetic resonance imaging scanning at baseline and follow-up separated by ≈2...
September 15, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37706340/national-cost-estimates-of-invasive-mechanical-ventilation-and-tracheostomy-in-acute-stroke-2008-2017
#5
JOURNAL ARTICLE
George P Albert, Daryl C McHugh, David Y Hwang, Claire J Creutzfeldt, Robert G Holloway, Benjamin P George
BACKGROUND: Patients with stroke receiving invasive mechanical ventilation (IMV) and tracheostomy incur intense treatment and long hospitalizations. We aimed to evaluate US hospitalization costs for patients with stroke requiring IMV, tracheostomy, or no ventilation. METHODS: We performed a retrospective observational study of US hospitalizations for acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage receiving IMV, tracheostomy, or none using the National Inpatient Sample, 2008 to 2017...
September 14, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37706339/association-of-neighborhood-recreation-centers-and-poststroke-outcomes-in-a-population-based-cohort
#6
JOURNAL ARTICLE
Leanna M Delhey, Xu Shi, Lewis B Morgenstern, Devin L Brown, Melinda A Smith, Erin C Case, Mellanie V Springer, Lynda D Lisabeth
BACKGROUND: Higher neighborhood socioeconomic status has been favorably associated with stroke outcomes. This may be due to these areas having more beneficial resources such as recreational centers. We aimed to determine if neighborhood density of recreation centers is favorably associated with stroke outcomes. METHODS: We conducted analyses of data from the Brain Attack Surveillance in Corpus Christi project, a cohort of stroke survivors ≥45 years of age residing in Nueces County, TX (2009-2020)...
September 14, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37694403/enhancing-enrollment-in-acute-stroke-trials-current-state-and-consensus-recommendations
#7
REVIEW
Joseph P Broderick, Gisele Sampaio Silva, Magdy Selim, Scott E Kasner, Yasmin Aziz, Jocelyn Sutherland, Edward C Jauch, Opeolu M Adeoye, Michael D Hill, Eva A Mistry, Patrick D Lyden, J Mocco, Elaine M Smith, Macarena Hernandez-Jimenez, Emir Deljkich, Hooman Kamel
The Stroke Treatment Academic Industry Roundtable (STAIR) convened a session and workshop regarding enrollment in acute stroke trials during the STAIR XII meeting on March 22, 2023. This forum brought together stroke physicians and researchers, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss the current status and opportunities for improving enrollment in acute stroke trials. The workshop identified the most relevant issues impacting enrollment in acute stroke trials and addressed potential action items for each...
September 11, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37694402/ipsilesional-hippocampal-gaba-is-elevated-and-correlates-with-cognitive-impairment-and-maladaptive-neurogenesis-after-cortical-stroke-in-mice
#8
JOURNAL ARTICLE
Cristina Torres-López, Maria I Cuartero, Alicia García-Culebras, Juan de la Parra, María E Fernández-Valle, Marina Benito, Sandra Vázquez-Reyes, Tania Jareño-Flores, Francisco J de Castro-Millán, Olivia Hurtado, Marion S Buckwalter, Juan M García-Segura, Ignacio Lizasoain, María A Moro
BACKGROUND: Cognitive dysfunction is a frequent stroke sequela, but its pathogenesis and treatment remain unresolved. Involvement of aberrant hippocampal neurogenesis and maladaptive circuitry remodeling has been proposed, but their mechanisms are unknown. Our aim was to evaluate potential underlying molecular/cellular events implicated. METHODS: Stroke was induced by permanent occlusion of the middle cerebral artery occlusion in 2-month-old C57BL/6 male mice. Hippocampal metabolites/neurotransmitters were analyzed longitudinally by in vivo magnetic resonance spectroscopy...
September 11, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37675614/nimodipine-reduces-microvasospasms-after-experimental-subarachnoid-hemorrhage
#9
JOURNAL ARTICLE
Julian Schwarting, Biyan Nathanael Harapan, Xiangjiang Lin, Nikolaus Plesnila, Nicole A Terpolilli
BACKGROUND: The only established pharmacological treatment option improving outcomes for patients suffering from subarachnoid hemorrhage (SAH) is the L-type-calcium channel inhibitor nimodipine. However, the exact mechanisms of action of nimodipine conferring neuroprotection after SAH have yet to be determined. More recently, spasms of the cerebral microcirculation were suggested to play an important role in reduced cerebral perfusion after SAH and, ultimately, outcome. It is unclear whether nimodipine may influence microvasospasms and, thus, microcirculatory dysfunction...
September 7, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37675613/study-of-rivaroxaban-for-cerebral-venous-thrombosis-a-randomized-controlled-feasibility-trial-comparing-anticoagulation-with-rivaroxaban-to-standard-of-care-in-symptomatic-cerebral-venous-thrombosis
#10
JOURNAL ARTICLE
Thalia S Field, Vanessa Dizonno, Mohammed A Almekhlafi, Fouzi Bala, Ibrahim Alhabli, Hubert Wong, Monica Norena, Maria Karina Villaluna, Princess King-Azote, Namali Ratnaweera, Steven Mancini, Stephen C Van Gaal, Laura K Wilson, Brett R Graham, Luciano A Sposato, Dylan Blacquiere, Brian M Dewar, Mark I Boulos, Brian H Buck, Celine Odier, Kanjana S Perera, Aleksandra Pikula, Aleksander Tkach, George Medvedev, Carolyn Canfield, W Ben Mortenson, Janel O Nadeau, Sohaila Alshimemeri, Oscar R Benavente, Andrew M Demchuk, Dar Dowlatshahi, Sylvain Lanthier, Agnes Y Y Lee, Jennifer Mandzia, Deepa Suryanarayan, Jeffrey I Weitz, Michael D Hill
BACKGROUND: Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation for cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it is a rare disease with low rates of adverse outcomes such as major bleeding and functional dependence. To facilitate the design of future CVT trials, SECRET (Study of Rivaroxaban for Cerebral Venous Thrombosis) assessed (1) the feasibility of recruitment, (2) the safety of rivaroxaban compared with standard-of-care anticoagulation, and (3) patient-centered functional outcomes...
September 7, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37675612/neurovascular-inflammation-and-complications-of-thrombolysis-therapy-in-stroke
#11
REVIEW
Qiang Liu, Kaibin Shi, Yongjun Wang, Fu-Dong Shi
Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved pharmacological treatment for acute ischemic stroke, but its benefits are limited by hemorrhagic transformation. Emerging evidence reveals that tPA swiftly mobilizes immune cells which extravasate into the brain parenchyma via the cerebral vasculature, augmenting neurovascular inflammation, and tissue injury. In this review, we summarize the pronounced alterations of immune cells induced by tPA in patients with stroke and experimental stroke models...
September 7, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37675611/determinants-and-temporal-trends-of-dual-antiplatelet-therapy-after-mild-noncardioembolic-stroke
#12
JOURNAL ARTICLE
Victor J Del Brutto, Ruijie Yin, Hannah Gardener, Hao Ying, Carolina M Gutierrez, Angus M Jameson, David Z Rose, Ayham Alkhachroum, Dianne Foster, Chuanhui Dong, Selina Ancheta, Nicole B Sur, Gillian Gordon Perue, Tatjana Rundek, Negar Asdaghi, Ralph L Sacco, Jose G Romano
BACKGROUND: Short-term dual antiplatelet therapy (DAPT) reduces early stroke recurrence after mild noncardioembolic ischemic stroke (NCIS). We aim to evaluate temporal trends and determinants of DAPT prescription after mild NCIS in the Florida Stroke Registry, a statewide registry across Get With The Guidelines-Stroke participating hospitals. METHODS: In this cross-sectional analysis of a cohort study, we included patients with mild NCIS (National Institutes of Health Stroke Scale score ≤3) who were potentially eligible for DAPT across 168 Florida Stroke Registry participating hospitals between January 2010 and September 2022...
September 7, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37675610/developing-a-second-line-of-physician-leaders
#13
JOURNAL ARTICLE
Ivy Anne Sebastian, Dorcas B C Gandhi, Raviteja Kakarla, Atul Phillips
No abstract text is available yet for this article.
September 7, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37646161/tvns-in-stroke-a-narrative-review-on-the-current-state-and-the-future
#14
REVIEW
Sheharyar S Baig, Marharyta Kamarova, Simon M Bell, Ali N Ali, Li Su, Munya Dimairo, Jesse Dawson, Jessica N Redgrave, Arshad Majid
Ischemic stroke is a leading cause of disability and there is a paucity of therapeutic strategies that promote functional recovery after stroke. Transcutaneous vagus nerve stimulation (tVNS) has shown promising evidence as a tool to reduce infarct size in animal models of hyperacute stroke. In chronic stroke, tVNS paired with limb movements has been shown to enhance neurological recovery. In this review, we summarize the current evidence for tVNS in preclinical models and clinical trials in humans. We highlight the mechanistic pathways involved in the beneficial effects of tVNS...
August 30, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37646160/risk-and-prognosis-of-cancer-in-patients-with-cerebral-venous-thrombosis-compared-with-the-danish-general-population
#15
JOURNAL ARTICLE
Nils Skajaa, Dóra Körmendiné Farkas, Kasper Adelborg, Henrik Toft Sørensen
BACKGROUND: Whether cerebral venous thrombosis (CVT) is a marker of cancer in clinical practice remains unknown. Little is known about the prognosis of cancer detected subsequent to CVT. METHODS: We used Danish nationwide registries (1996-2019) to identify patients with a first-time primary inpatient diagnosis of CVT without a history of cancer (N=811, 65% women, median age 42 years). We assessed the risk of an incident cancer diagnosis using standardized incidence ratios (SIRs)...
August 30, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37638399/extracranial-carotid-plaque-calcification-and-cerebrovascular-ischemia-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Moayad Homssi, Atin Saha, Diana Delgado, Arindam RoyChoudhury, Charlene Thomas, Matthew Lin, Hediyeh Baradaran, Hooman Kamel, Ajay Gupta
BACKGROUND: Although coronary calcification quantification is an established approach for cardiovascular risk assessment, the value of quantifying carotid calcification is less clear. As a result, we performed a systematic review and meta-analysis to evaluate the association between extracranial carotid artery plaque calcification burden and ipsilateral cerebrovascular ischemic events. METHODS: A comprehensive literature search was performed in the following databases: Ovid MEDLINE(R) 1946 to July 6, 2022; OVID Embase 1974 to July 6, 2022; and The Cochrane Library (Wiley)...
August 28, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37638398/cerebral-microbleed-patterns-and-cortical-amyloid-%C3%AE-the-aric-pet-study
#17
JOURNAL ARTICLE
Derrick N Okine, David S Knopman, Thomas H Mosley, Dean F Wong, Michelle C Johansen, Keenan A Walker, Clifford R Jack, Kejal Kantarci, James R Pike, Jonathan Graff-Radford, Rebecca F Gottesman
BACKGROUND: Cerebral microbleeds (CMBs) are associated with cognitive decline, but their importance outside of cerebral amyloid angiopathy and the mechanisms of their impact on cognition are poorly understood. We evaluated the cross-sectional association between CMB patterns and cerebral Aβ (amyloid-β) deposition, by florbetapir positron emission tomography. METHODS: The longitudinal ARIC study (Atherosclerosis Risk in Communities) recruited individuals from 4 US communities from 1987 to 1989...
August 28, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37622385/early-recanalization-among-patients-undergoing-bridging-therapy-with-tenecteplase-or-alteplase
#18
JOURNAL ARTICLE
Thomas Checkouri, Gaspard Gerschenfeld, Pierre Seners, Marion Yger, Wagih Ben Hassen, Nicolas Chausson, Stéphane Olindo, Jildaz Caroff, Gaultier Marnat, Frédéric Clarençon, Jean-Claude Baron, Guillaume Turc, Sonia Alamowitch
BACKGROUND: Intravenous thrombolysis (IVT) with alteplase or tenecteplase before mechanical thrombectomy is the recommended treatment for large-vessel occlusion acute ischemic stroke. There are divergent data on whether these agents differ in terms of early recanalization (ER) rates before mechanical thrombectomy, and little data on their potential differences stratified by ER predictors such as IVT to ER evaluation (IVT-to-EReval ) time, occlusion site and thrombus length. METHODS: We retrospectively compared the likelihood of ER after IVT with tenecteplase or alteplase in anterior circulation large-vessel occlusion acute ischemic stroke patients from the PREDICT-RECANAL (alteplase) and Tenecteplase Treatment in Ischemic Stroke (tenecteplase) French multicenter registries...
August 25, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37622327/expression-of-concern-for-effects-of-noninvasive-facial-nerve-stimulation-in-the-dog-middle-cerebral-artery-occlusion-model-of-ischemic-stroke
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 25, 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37615093/long-term-stroke-risk-in-patients-with-new-ischemic-brain-lesions-on-mri-after-carotid-revascularization
#20
JOURNAL ARTICLE
Simone J A Donners, Marjolijn L Rots, Raechel J Toorop, Aad van der Lugt, Leo H Bonati, Gert J de Borst
BACKGROUND: Carotid artery revascularization can result in new ischemic brain lesions on diffusion-weighted magnetic resonance imaging. This study aimed to investigate the relationship between periprocedural ischemic diffusion-weighted imaging (DWI) lesions after carotid artery revascularization and recurrent long-term cerebrovascular events. METHODS: A secondary observational prospective cohort analysis of existing clinical trial data was performed on 162 patients with symptomatic carotid stenosis that were previously randomized to carotid artery stenting or carotid endarterectomy in the ICSS (International Carotid Stenting Study) and included in the magnetic resonance imaging substudy...
August 24, 2023: Stroke; a Journal of Cerebral Circulation
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