journal
https://read.qxmd.com/read/37777190/polymath-to-be-or-not-to-be
#1
JOURNAL ARTICLE
Marianna Evangelia Kapsetaki
Is it best to achieve excellence in one or multiple fields? Is it better to be a medical doctor reading only medical textbooks all your life or is it better to also tour around the world as a concert pianist and investigate the mysteries of the brain by conducting research projects? As a medical doctor, classical pianist, and neuroscientist, I discuss the advantages, disadvantages, opportunities, and challenges of pursuing multiple careers, drawing from my own experience and from polymaths of the past.
September 30, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37777188/uric-acid-and-diabetes-mellitus-an-update
#2
JOURNAL ARTICLE
Shailendra K Singh, Rina Singh, Santosh K Singh, Mir A Iquebal, Sarika Jaiswal, Pradeep K Rai
The relationship between diabetes mellitus (DM) and high serum uric acid is complex and controversial. Many epidemiological studies have reported a positive association, whereas others have reported an inverse association or none. In the pathogenesis of DM it is the intracellular urate that is more important than the extracellular and dissociation between the two is possible. Evidence suggests that high serum uric acid induces insulin resistance and beta cell failure in animal models. Reduction of intracellular uric acid can be achieved by dietary measures such as reducing fructose and salt intake, and uric acid-lowering drugs...
September 30, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37777187/lrrk2-g2019s-and-parkinson-s-disease-insight-from-neuroinflammation
#3
JOURNAL ARTICLE
Xiao-Yan Yao, Li-Na Guan, Qi Chen, Chao Ren
The multiple hypothesis holds that the pathogenesis of Parkinson's disease (PD) requires many factors such as heredity, environment and ageing. Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized the risk factors of PD, and closely related to sporadic and familial PD and can regulate a variety of cellular pathways and processes. An Increasing number of studies has shown that glial hyperactivation-mediated neuroinflammation participates in dopaminergic neuron degeneration and pathogenesis of PD...
September 30, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37773998/retraction-of-predictors-of-covid-19-vaccine-hesitancy-in-germany-a-cross-sectional-population-based-study
#4
(no author information available yet)
No abstract text is available yet for this article.
September 29, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37773985/spontaneous-coronary-artery-dissection-an-overview
#5
JOURNAL ARTICLE
Rasha Kaddoura, Fathima Aaysha Cader, Ashraf Ahmed, Mirvat Alasnag
The prevalence of spontaneous coronary artery dissection (SCAD) has increased over the last decades in young adults presenting with acute coronary syndrome. Although the diagnostic tools, including intracoronary imaging, have permitted a more accurate diagnosis of SCAD, the prognosis and overall outcomes remain dismal. Furthermore, the disproportionate sex distribution affecting more women and the underdiagnosis in many parts of the world render this pathology a persistent clinical challenge, particularly since the management remains largely supportive with a limited and controversial role for percutaneous or surgical interventions...
September 29, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37742091/circulating-sex-hormone-binding-globulin-levels-and-ischemic-stroke-risk-a-mendelian-randomization-study
#6
JOURNAL ARTICLE
Youjie Zeng, Si Cao, Heng Yang
PURPOSE: Previous studies have presented conflicting findings regarding the protective effects of circulating sex hormone-binding globulin (SHBG) on ischemic stroke (IS). This study aimed to assess the causal effect of SHBG on IS using Mendelian randomization (MR) analysis and to identify potential mediators. METHODS: First, the causal effect of SHBG on any IS (AIS), cardioembolic stroke (CES), large artery stroke (LAS), and small vessel stroke (SVS) was assessed by inverse variance weighed (IVW) method...
September 23, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37742090/differences-in-empathy-levels-among-physicians-based-on-specialty-a-nationwide-cross-sectional-study
#7
JOURNAL ARTICLE
Takashi Watari, Nathan Houchens, Tomoe Otsuka, Takeshi Endo, Seiji Odagawa, Yasuhisa Nakano, Hitomi Kataoka, Mamoru Miwa, Daisaku Yamasaki, Yasuharu Tokuda, Yoshihiko Shiraishi, Kota Sakaguchi
PURPOSE OF STUDY: A physician's ability to empathize is crucial for patient health outcomes, and this differs according to speciality, personal characteristics, and environmental factors. This study aimed to examine the empathy levels among physicians based on their specialities and to identify the influencing factors. STUDY DESIGN: A nationwide, online, cross-sectional survey was conducted using the Nikkei Business Publication online physician member homepage. Participants were 5441 physicians in Japan registered as members of Nikkei Medical Online across 20 specialities...
September 23, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37740568/the-relationship-between-low-handgrip-strength-with-or-without-asymmetry-and-fall-risk-among-middle-aged-and-older-males-in-china-evidence-from-the-china-health-and-retirement-longitudinal-study
#8
JOURNAL ARTICLE
Yilin Wang, Yalian Huang, Xiaoyan Chen
PURPOSE: This study sought to explore the potential correlation between low handgrip strength (HGS) with or without asymmetry and fall risk in middle-aged and older Chinese adults. METHODS: Baseline characteristic data from participants 45+ years of age and data regarding fall events collected from two rounds (2011-2013) of the China Health and Retirement Longitudinal Study were utilized for the present analyses. HGS and HGS asymmetry was defined according to the updated American Society of Hand Therapist...
September 22, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37738099/reflections-on-patient-resilience
#9
JOURNAL ARTICLE
Pooja Patel
No abstract text is available yet for this article.
September 19, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37738094/how-the-physician-s-financial-wellness-could-impact-patient-safety
#10
JOURNAL ARTICLE
Julianna L Richards, Karolina Brook
No abstract text is available yet for this article.
September 19, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37718247/future-of-medical-research-in-sri-lanka-amidst-economic-chaos
#11
JOURNAL ARTICLE
Nilanka Perera, Saman B Gunatilake
Sri Lanka is facing an economic crisis and medical research is significantly affected at present with researchers facing many obstacles. Urgent remedial measures are required to overcome the current situation if medical research is to continue in Sri Lanka.
September 17, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37697449/chronic-illness-a-battle-fought-on-many-fronts
#12
JOURNAL ARTICLE
Ami Schattner
No abstract text is available yet for this article.
September 11, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37689998/impact-of-immune-regulation-and-differentiation-dysfunction-of-mesenchymal-stem-cells-on-the-disease-process-in-ankylosing-spondylitis-and-prospective-analysis-of-stem-cell-transplantation-therapy
#13
JOURNAL ARTICLE
Xinzhe Feng, Junjie Qiao, Weidong Xu
Ankylosing spondylitis (AS) is a rheumatic bone and joint disease caused by inflammation, erosion, and pathological bone formation. The pathological features of chronic inflammation, bone destruction, and pathological ossification occur due to the disruption of the body's immune regulation and altered bone remodeling balance. Mesenchymal stem cells (MSCs) have multidirectional differentiation potential and immunomodulatory functions and play an important role in immune regulation and bone formation. The immune regulation and osteogenic capacity of MSCs in AS are altered by factors such as genetic background, internal environment, infection, and mechanical forces that drive disease development...
September 9, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37681245/evaluating-the-risk-of-sepsis-attributing-to-obesity-a-two-sample-mendelian-randomization-study
#14
JOURNAL ARTICLE
Jing Hu, Quan Gan, Dong Zhou, Xing Xia, Wei Xiang, Rong Xiao, Jing Tang, Jie Li
BACKGROUND: Sepsis is a reaction to infection with high morbidity and mortality. It has been noted that patients with obesity were more likely to suffer from sepsis. However, the causality remains elucidating, as reverse causality and residual confounding could not be largely mitigated in conventional observational studies. OBJECTIVE: To evaluate the risk of sepsis attributed to obesity phenotypes including body mass index (BMI), waist circumstance (WC), and WC adjusted for BMI (WCadjBMI) in a causal way...
September 7, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37668167/endoscopic-retrograde-cholangiopancreatography-as-a-single-modality-gold-standard-treatment-for-common-bile-duct-stones-in-the-elderly
#15
JOURNAL ARTICLE
David Manson, Faris Soliman, Usama Mohamed, Krishnamurthy Somasekar
BACKGROUND: There are more octogenarians presenting with gallstone disease each year. Many are not suitable for surgical intervention. An alternative treatment option for common bile duct stones in the elderly is endoscopic retrograde cholangiopancreatography (ERCP) with or without stent insertion. METHODS: We conducted a retrospective study using a prospectively collected database, analysing the outcomes of consecutive patients >80 years old who underwent an ERCP in a single centre for the treatment of common bile duct stones...
September 4, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37664899/from-adversity-to-advancement-leveraging-war-tested-approaches-for-the-post-conflict-reformation-of-the-ukrainian-healthcare-landscape
#16
JOURNAL ARTICLE
Favour Tope Adebusoye, Joecelyn Kirani Tan, Wireko Andrew Awuah, Hareesha Rishab Bharadwaj, Wara Naeem, Tomas Ferreira, Sakshi Roy, Toufik Abdul-Rahman, Volodymyr Lychko
The Russo-Ukrainian Conflict has had significant repercussions on Ukraine's healthcare system, resulting in civilian casualties and damage to healthcare institutions. The disruption of personnel, medical supplies, and patient transportation has created considerable challenges for healthcare services. However, there are successful approaches from comparable contexts that can serve as a catalyst for post-conflict healthcare reformation in Ukraine. Key strategies include improving healthcare accessibility for marginalized populations through standardized essential health and surgical care packages, rehabilitating damaged facilities, strengthening primary care provisions, and supporting war survivors with disabilities...
September 3, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37650372/glasgow-coma-scale-on-admission-as-predictor-of-neurological-sequelae-at-discharge-and-acute-respiratory-failure-in-patients-with-heatstroke
#17
JOURNAL ARTICLE
Lan Chen, Liyun Lu, Yuan Fang, Jingnan Ren, Xiaoling Yang, Zhumei Gong, Yuping Zhang, Xiuqin Feng
BACKGROUND: Transient neuronal dysfunction may occur in most brain regions with heatstroke (HS). This study aimed to explore the prognostic significance of initial Glasgow Coma Scale (GCS) scores in HS. METHODS: Retrospective data regarding HS were obtained from six hospitals. The primary outcome was neurological sequelae at discharge. Secondary outcomes included acute respiratory failure (ARF) and intensive care unit (ICU) admission. Logistic regression models and random forest imputation were used to assess the independent association between GCS score and outcomes...
August 30, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37624143/limitations-of-large-language-models-in-medical-applications
#18
JOURNAL ARTICLE
Jiawen Deng, Areeba Zubair, Ye-Jean Park
No abstract text is available yet for this article.
August 24, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37624141/rational-quality-and-cost-of-critical-care-systems-are-more-important-than-individual-considerations-a-view-from-india
#19
JOURNAL ARTICLE
Sugata Dasgupta, Atanu Chandra
Critical or Intensive Care Units (CCU/ICUs) play a crucial role in treating critically ill patients, but they contribute significantly to healthcare costs. In India and many other resource-limited countries, private ICU treatment is largely unaffordable for the poor and even a section of the middle class, who are not substantially insured. It is essential for all stakeholders involved in critical care to prioritize quality and cost-effectiveness. To ensure quality assurance, legally binding quality standards must be developed collaboratively by the government, professional bodies, hospital administrators, and domain experts...
August 24, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37624118/lipoprotein-a-and-functional-outcome-of-acute-ischemic-stroke-when-discordant-with-low-density-lipoprotein-cholesterol
#20
JOURNAL ARTICLE
Wenjing Dong, Xiaoyan Zhong, Ke Yuan, Mengyuan Miao, Yujia Zhai, Bizhong Che, Tan Xu, Xiang Xu, Chongke Zhong
BACKGROUND: Several studies have indicated that residual cardiovascular risk might be associated with elevated lipoprotein(a) [Lp(a)] even in the setting of controlled low-density lipoprotein cholesterol (LDL-C). We aimed to prospectively examine the association between Lp(a) and unfavorable functional outcome among patients with acute ischemic stroke when Lp(a) and LDL-C were discordant. METHODS: Based on samples from the Infectious Factors, Inflammatory Markers and Prognosis of Acute Ischemic Stroke study, 973 patients with baseline plasma Lp(a) levels were included...
August 24, 2023: Postgraduate Medical Journal
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