journal
https://read.qxmd.com/read/38995847/measles-outbreak-in-2019-a-warning-for-the-post-covid-19-pandemic-period
#1
JOURNAL ARTICLE
Irma Salimović-Bešić, Sanjin Musa, Šejla Kotorić-Keser, Edina Zahirović, Selma Mutevelić, Amela Dedeić-Ljubović
Introduction. At the end of 2019 and the year before, there was a significant spread of measles in the World Health Organization (WHO) European Region. Gap statement. Among the countries that reported, a measles outbreak was Bosnia and Herzegovina (BiH). Aim. To describe the measles outbreak in BiH (an entity of the Federation of BiH, FBiH) in 2019. Methodology. Confirmatory IgM serology, measles nucleic acid detection by real-time RT-PCR and virus genotyping were done in the WHO-accredited laboratory for measles and rubella at the Clinical Center of the University of Sarajevo, Unit for Clinical Microbiology...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38995835/transient-reemergence-of-bordetella-parapertussis-in-france-in-2022
#2
JOURNAL ARTICLE
Valérie Bouchez, Julie Toubiana, Sophie Guillot, Parapertussis Study Group, Fatima Aït El Belghiti, Annie Landier, Nathalie Armatys, Sabine Trombert-Paolantoni, Anaïs Soares, Carla Rodrigues, Sylvain Brisse
Between March and October 2022, a peak of detection of Bordetella parapertussis by qPCR, real-time PCR was observed in France. Hypothesis/Gap Statement. Whether this peak was due to resurgence from previous circulating lineages or reintroduction into the country was unknown. Objective. The objective of this study is to understand B. parapertussis- transient increase observed in France in 2022 whereas it had virtually stopped being reported since the start of the COVID-19 pandemic in 2020. Methods. We analysed real-time PCR (qPCR) data from the two largest French outpatient laboratories performing whooping cough diagnosis and characterized all B...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38995832/a-high-throughput-assay-identifies-molecules-with-antimicrobial-activity-against-persister-cells
#3
JOURNAL ARTICLE
Maiken Engelbrecht Petersen, Liva Kjær Hansen, Alexander Alexandrovich Mitkin, Nicholas M Kelly, Thomas Keith Wood, Nis Pedersen Jørgensen, Lars Jørgen Østergaard, Rikke Louise Meyer
Introduction. Persister cells are transiently non-growing antibiotic-tolerant bacteria that cause infection relapse, and there is no effective antibiotic therapy to tackle these infections. Gap statement. High-throughput assays in drug discovery are biased towards detecting drugs that inhibit bacterial growth rather than killing non-growing bacteria. A new and simple assay to discover such drugs is needed. Aim. This study aims to develop a simple and high-throughput assay to identify compounds with antimicrobial activity against persister cells and use it to identify molecular motifs with such activity...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38985505/cold-atmospheric-plasma-inactivates-aspergillus-flavus-and-fusarium-keratoplasticum-biofilms-and-conidia-in-vitro
#4
JOURNAL ARTICLE
Darby Roberts, Jonathan Thomas, Jacklyn Salmon, Marc A Cubeta, Katharina Stapelmann, Brian C Gilger
Introduction. Aspergillus flavus and Fusarium keratoplasticum are common causative pathogens of fungal keratitis (FK), a severe corneal disease associated with significant morbidity and vision loss. Escalating incidence of antifungal resistance to available antifungal drugs poses a major challenge to FK treatment. Cold atmospheric plasma (CAP) is a pioneering nonpharmacologic antimicrobial intervention that has demonstrated potential as a broad-spectrum antifungal treatment. Gap statement. Previous research highlights biofilm-associated resistance as a critical barrier to effective FK treatment...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38985141/enrichment-culture-evaluation-and-characterization-of-streptococcus-agalactiae-among-pregnant-women-in-japan
#5
JOURNAL ARTICLE
Satoshi Nakano, Shota Koide, Yumiko Hosaka, Yuri Hasegawa, Kasumi Ishida-Kuroki, Sayoko Kawakami, Wataru Hayashi, Liansheng Yu, Shizuo Kayama, Noriko Miyashita, Koh Nagata, Shoko Miura, Yo Sugawara, Hiroaki Miyazaki, Kiyonori Miura, Motoyuki Sugai
Introduction. Maternal screening tests and prophylactic antibiotics are important to prevent neonatal and infant group B streptococcal (GBS) infections. Hypothesis/Gap Statement. The performance of enrichment broth media for GBS screening that are available in Japan is unclear. Whole-genome data of GBS isolates from pregnant women in Japan is lacking. Aim. The aim of this study was to compare the protocol performance of six enrichment broths and two subculture agar plates, which were all available in Japan, for GBS detection...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38979984/antifungal-activity-of-propafenone-on-candida-spp-strains-interaction-with-antifungals-and-possible-mechanism-of-action
#6
JOURNAL ARTICLE
Amanda Dias Barbosa, Amanda Cavalcante Leitão, Leilson Carvalho de Oliveira, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Lara Elloyse Almeida Moreira, Maria Janielly Castelo Branco Silveira, Sarah Alves Barbosa, Beatriz Oliveira de Souza, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Bruno Coelho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva
Introduction. The development of new antifungal drugs has become a global priority, given the increasing cases of fungal diseases together with the rising resistance to available antifungal drugs. In this scenario, drug repositioning has emerged as an alternative for such development, with advantages such as reduced research time and costs. Gap statement. Propafenone is an antiarrhythmic drug whose antifungal activity is poorly described, being a good candidate for further study. Aim. This study aims to evaluate propafenone activity against different species of Candida spp...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38973691/apramycin-has-high-in-vitro-activity-against-mycobacterium-tuberculosis
#7
JOURNAL ARTICLE
Qing Sun, Jun Yan, Sibo Long, Yiheng Shi, Guanglu Jiang, Hao Li, Hairong Huang, Guirong Wang
Introduction. Aminoglycoside antibiotics such as amikacin and kanamycin are important components in the treatment of Mycobacterium tuberculosis (Mtb) infection. However, more and more clinical strains are found to be aminoglycoside antibiotic-resistant. Apramycin is another kind of aminoglycoside antibiotic that is commonly used to treat infections in animals. Hypothesis. Apramycin may have in vitro activity against Mtb. Aim. This study aims to evaluate the efficacy of apramycin against Mtb in vitro and determine its epidemiological cut-off (ECOFF) value...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38967406/transcriptome-analysis-of-candida-albicans-planktonic-cells-in-response-to-plasma-medicine
#8
JOURNAL ARTICLE
Xinhua Zhang, Kok Jun Liew, Li Cao, Jie Wang, Zhidong Chang, Melvin Chun Yun Tan, Kheng Loong Chong, Chun Shiong Chong
Introduction. Cold plasma is frequently utilized for the purpose of eliminating microbial contaminants. Under optimal conditions, it can function as plasma medicine for treating various diseases, including infections caused by Candida albicans , an opportunistic pathogen that can overgrow in individuals with weakened immune system. Gap Statement. To date, there has been less molecular study on cold plasma-treated C. albicans . Research Aim. The study aims to fill the gap in understanding the molecular response of C...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38963417/molecular-characterization-of-pseudomonas-aeruginosa-from-diabetic-foot-infections-in-tunisia
#9
JOURNAL ARTICLE
Ameni Arfaoui, Beatriz Rojo-Bezares, Meha Fethi, Maria López, Paula Toledano, Noureddine Sayem, Salma Ben Khelifa Melki, Hadda-Imene Ouzari, Naouel Klibi, Yolanda Sáenz
Background. Pseudomonas aeruginosa is an invasive organism that frequently causes severe tissue damage in diabetic foot ulcers. Gap statement. The characterisation of P. aeruginosa strains isolated from diabetic foot infections has not been carried out in Tunisia. Purpose. The aim was to determine the prevalence of P. aeruginosa isolated from patients with diabetic foot infections (DFIs) in Tunisia and to characterize their resistance, virulence and molecular typing. Methods. Patients with DFIs admitted to the diabetes department of the International Hospital Centre of Tunisia, from September 2019 to April 2021, were included in this prospective study...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38963412/dengue-virus-dv-non-cross-reactive-omicron-wave-covid-19-serums-enhanced-dv3-infectivity-in-vitro
#10
JOURNAL ARTICLE
Supratim Sarker, Chiroshri Dutta, Abinash Mallick, Sayantan Das, Chandrika Das Chowdhury, Abhishek De, Surajit Gorai, Subhajit Biswas
Introduction. In India, the SARS-CoV-2 Delta wave (2020-2021) faded away with the advent of the Omicron variants (2021-present). Dengue incidences were observed to be less in Southeast Asia during the active years of the pandemic (2020-2021). However, dengue virus type 3 (DV3) cases were increasingly reported in this region (including India) concurrent with the progression of the Omicron waves since 2022. Hypothesis. What could be the reason(s) behind this unusual DV3 surge after an overall dip in dengue incidences in many parts of Southeast Asia? Aim...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38963177/intranasal-administration-of-dsm-32444-bacillus-subtilis-spores-safety-and-tolerability
#11
JOURNAL ARTICLE
Yen-Linh Thi Ho, Daniel Hynes, Yuri Martina, Bill Love, Ed Horwell, Rong Xu, Aras Kadioglu, Linh Vo, Huynh A Hong, Linh Hanh Nguyen, Simon M Cutting
Introduction. Administered nasally, spores of the Gram-positive bacterium Bacillus subtilis have been shown to be able to induce innate immunity sufficient to confer protection to influenza and respiratory syncytial virus. Hypothesis. Although members of the aerobiome, intranasal delivery of high numbers of live spores carries potential safety issues. Aim. To address the potential safety risk of using live spores, we assessed the safety of spores that had been completely inactivated using heat sterilization...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38958241/the-role-of-n-acetylcysteine-on-adhesion-and-biofilm-formation-of-candida-parapsilosis-isolated-from-catheter-related-candidemia
#12
JOURNAL ARTICLE
Xiao-Shu Zuo, Qian-Yu Wang, Sha-Sha Wang, Guang Li, Li-Ying Zhan
Objectives. Anti-fungal agents are increasingly becoming less effective due to the development of resistance. In addition, it is difficult to treat Candida organisms that form biofilms due to a lack of ability of drugs to penetrate the biofilms. We are attempting to assess the effect of a new therapeutic agent, N -acetylcysteine (NAC), on adhesion and biofilm formation in Candida parapsilosis clinical strains. Meanwhile, to detect the transcription level changes of adhesion and biofilm formation-associated genes ( CpALS6, CpALS7, CpEFG1 and CpBCR1 ) when administrated with NAC in C...
July 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38935081/improving-the-diagnosis-of-urinary-tract-infections-by-the-use-of-enriched-media-and-a-48-hour-incubation-period
#13
JOURNAL ARTICLE
Carla Benjumea, Ferran Navarro, Carles Alonso-Tarrés
Introduction. The absence of a gold-standard methodology for the microbiological diagnosis of urinary tract infections (UTI) has led to insufficient standardization of criteria for the interpretation of results and processing methods, particularly incubation time and culture media. Hypothesis. 48-hour incubation time period and use of blood agar enhances the sensitivity of microorganisms isolated significantly. Aim. To determine the sensitivity of blood agar and Brilliance UTI chromogenic agar, incubating for different periods (24-48 hours), for the detection of positive urine cultures...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38935078/detection-of-avian-reovirus-arv-by-elisa-based-on-recombinant-%C3%AF-b-%C3%AF-c-and-%C3%AF-ns-full-length-proteins-and-protein-fragments
#14
JOURNAL ARTICLE
Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni
Introduction. Avian reovirus (ARV) is associated with arthritis/tenosynovitis and malabsorption syndrome in chickens. The σC and σB proteins, both exposed to the virus capsid, are highly immunogenic and could form the basis for diagnostic devices designed to assess the immunological status of the flock. Gap Statement. Commercial ARV ELISAs cannot distinguish between vaccinated and infected animals and might not detect circulating ARV strains. Aim. We aimed to develop a customized test to detect the circulating field ARV strains as well as distinguish between vaccinated and unvaccinated animals...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38922673/ciprofloxacin-prophylaxis-during-haematopoietic-cell-transplantation-a-role-for-use-in-patients-with-germ-cell-tumours
#15
JOURNAL ARTICLE
Konstantinos Kavallieros, Ioannis Baltas, Giannis Konstantinou, Eirini Koutoumanou, Malick M Gibani, Mark Gilchrist, Frances Davies, Jiri Pavlu
Introduction. Fluoroquinolone prophylaxis during haematopoietic cell transplantation (HCT) can lead to antimicrobial resistance (AMR). Identifying the groups of patients that have the highest likelihood of benefiting from prophylactic antimicrobials is important for antimicrobial stewardship (AMS). Hypothesis. We aimed to identify groups of HCT recipients that have the highest likelihood of benefiting from prophylactic fluroquinolones. Methods. All admissions for HCT in a tertiary centre between January 2020 and December 2022 ( N = 400) were retrospectively studied...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38916589/antimicrobial-resistance-patterns-among-critical-priority-pathogens-in-an-intensive-care-unit-at-a-tertiary-hospital-in-egypt-a-descriptive-analysis-comparing-pre-and-covid-19-eras
#16
JOURNAL ARTICLE
Mai M Zafer, Dina M Bassiouny, Soumya Ghosh, Charné Bornman, Amira F A Hussein
Background. The intensified global challenge of antimicrobial resistance, set against the backdrop of the COVID-19 pandemic, is a cause for major concern. Within healthcare settings, intensive care units are recognized as focal points for Gram-negative infections. The study pursued to assess the prevalence and antimicrobial resistance patterns of critical priority pathogens ( Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacteriaceae, comprising Klebsiella pneumoniae and Escherichia coli ) during both pre- and COVID-19 periods...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38865187/levels-of-5%C3%AE-reductase-gene-in-intestinal-lavage-fluid-decrease-with-progression-of-colorectal-cancer
#17
JOURNAL ARTICLE
Tadashi Fujii, Yoshihito Nakagawa, Kohei Funasaka, Yoshiki Hirooka, Takumi Tochio
Introduction. Colorectal cancer (CRC) is a leading cause of cancer deaths, closely linked to the intestinal microbiota and bile acid metabolism. Secondary bile acids, like deoxycholic and lithocholic acid, are associated with increased CRC risk due to their disruption of vital cellular functions. In contrast, isoallolithocholic acid (isoalloLCA) shows potential health benefits, highlighting the complex role of bile acids in CRC. A specific primer set was previously developed to amplify homologs of the 5α-reductase gene ( 5ar ), which are involved in the biosynthesis of isoalloLCA, thereby enabling the estimation of abundance of 5ar ( 5ar levels) in the intestine...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38842435/colistin-utilization-at-a-tertiary-hospital-in-south-africa-an-opportunity-for-antimicrobial-stewardship-practices
#18
JOURNAL ARTICLE
Gaalebale Prudence Matshediso, Oyewole Christopher Durojaiye, Oladele Vincent Adeniyi
Introduction. Colistin (polymyxin E) has emerged as a last-resort treatment option for multidrug-resistant infections. Hypothesis/Gap Statement. Studies on the use, safety and efficacy of colistin in South Africa are limited. Aim . This study aims to describe the use of colistin and its clinical outcomes at a tertiary public hospital in South Africa. Methodology. We conducted a retrospective review of adult and paediatric patients who received parenteral colistin between 2015 and 2019. Results. A total of 69 patients (26 adults, 13 children and 30 neonates) were reviewed...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38836745/characterization-of-aspergillus-fumigatus-secretome-during-sublethal-infection-of-galleria-mellonella-larvae
#19
JOURNAL ARTICLE
Aaron Curtis, Pavel Dobes, Jacek Marciniak, Jana Hurychova, Pavel Hyrsl, Kevin Kavanagh
Introduction. The fungal pathogen Aspergillus fumigatus can induce prolonged colonization of the lungs of susceptible patients, resulting in conditions such as allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis. Hypothesis. Analysis of the A. fumigatus secretome released during sub-lethal infection of G. mellonella larvae may give an insight into products released during prolonged human colonisation. Methodology. Galleria mellonella larvae were infected with A. fumigatus, and the metabolism of host carbohydrate and proteins and production of fungal virulence factors were analysed...
June 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38833520/the-effect-of-daily-usage-of-listerine-cool-mint-mouthwash-on-the-oropharyngeal-microbiome-a-substudy-of-the-prego-trial
#20
RANDOMIZED CONTROLLED TRIAL
J G E Laumen, C Van Dijck, S S Manoharan-Basil, T de Block, S Abdellati, B B Xavier, S Malhotra-Kumar, C Kenyon
Introduction. ListerineÒ is a bactericidal mouthwash widely used to prevent oral health problems such as dental plaque and gingivitis. However, whether it promotes or undermines a healthy oral microbiome is unclear. Hypothesis/Gap Statement. We hypothesized that the daily use of Listerine Cool Mint would have a significant impact on the oropharyngeal microbiome. Aim. We aimed to assess if daily usage of Listerine Cool Mint influenced the composition of the pharyngeal microbiome. Methodology. The current microbiome substudy is part of the Preventing Resistance in Gonorrhoea trial...
June 2024: Journal of Medical Microbiology
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