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Biological Psychiatry

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https://read.qxmd.com/read/30670304/subgenual-functional-connectivity-predicts-antidepressant-treatment-response-to-transcranial-magnetic-stimulation-independent-validation-and-evaluation-of-personalization
#1
LETTER
Robin F H Cash, Andrew Zalesky, Richard H Thomson, Ye Tian, Luca Cocchi, Paul B Fitzgerald
No abstract text is available yet for this article.
January 19, 2019: Biological Psychiatry
https://read.qxmd.com/read/30739807/accelerated-aging-of-functional-brain-networks-supporting-cognitive-function-in-psychotic-disorders
#2
Julia M Sheffield, Baxter P Rogers, Jennifer U Blackford, Stephan Heckers, Neil D Woodward
BACKGROUND: Across networks, connectivity within the frontoparietal network (FPN) and cingulo-opercular network (CON) exhibits reductions earliest during healthy aging, contributing to cognitive impairment. Individuals with psychotic disorders demonstrate evidence of accelerated aging across multiple biological systems. By leveraging a large sample of patients with psychosis from early to chronic illness stages, this study sought to determine whether the CON and FPN exhibit evidence of accelerated aging in psychotic disorders, confirm associations between network efficiency and cognition, and determine whether reduced network efficiency is observed in early-stage psychosis...
January 4, 2019: Biological Psychiatry
https://read.qxmd.com/read/30737015/model-free-and-model-based-influences-in-addiction-related-behaviors
#3
Stephanie M Groman, Bart Massi, Samuel R Mathias, Daeyeol Lee, Jane R Taylor
BACKGROUND: Disruptions in the decision-making processes that guide action selection are a core feature of many psychiatric disorders, including addiction. Decision making is influenced by the goal-directed and habitual systems that can be computationally characterized using model-based and model-free reinforcement learning algorithms, respectively. Recent evidence suggests an imbalance in the influence of these reinforcement learning systems on behavior in individuals with substance dependence, but it is unknown whether these disruptions are a manifestation of chronic drug use and/or are a preexisting risk factor for addiction...
January 4, 2019: Biological Psychiatry
https://read.qxmd.com/read/30737014/predicting-polygenic-risk-of-psychiatric-disorders
#4
REVIEW
Alicia R Martin, Mark J Daly, Elise B Robinson, Steven E Hyman, Benjamin M Neale
Genetics provides two major opportunities for understanding human disease-as a transformative line of etiological inquiry and as a biomarker for heritable diseases. In psychiatry, biomarkers are very much needed for both research and treatment, given the heterogenous populations identified by current phenomenologically based diagnostic systems. To date, however, useful and valid biomarkers have been scant owing to the inaccessibility and complexity of human brain tissue and consequent lack of insight into disease mechanisms...
December 28, 2018: Biological Psychiatry
https://read.qxmd.com/read/30732858/male-specific-camp-signaling-in-the-hippocampus-controls-spatial-memory-deficits-in-a-mouse-model-of-autism-and-intellectual-disability
#5
Marta Zamarbide, Adele Mossa, Pablo Muñoz-Llancao, Molly K Wilkinson, Heather L Pond, Adam W Oaks, M Chiara Manzini
BACKGROUND: The prevalence of neurodevelopmental disorders is biased toward male individuals, with male-to-female ratios of 2:1 in intellectual disability and 4:1 in autism spectrum disorder. However, the molecular mechanisms of such bias remain unknown. While characterizing a mouse model for loss of the signaling scaffold coiled-coil and C2 domain-containing protein 1A (CC2D1A), which is mutated in intellectual disability and autism spectrum disorder, we identified biochemical and behavioral differences between male and female mice, and explored whether CC2D1A controls male-specific intracellular signaling...
December 27, 2018: Biological Psychiatry
https://read.qxmd.com/read/30712809/neurotrophic-and-antidepressant-actions-of-brain-derived-neurotrophic-factor-require-vascular-endothelial-growth-factor
#6
Satoshi Deyama, Eunyoung Bang, Taro Kato, Xiao-Yuan Li, Ronald S Duman
BACKGROUND: Activity-dependent release of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC) is essential for the rapid and sustained antidepressant actions of ketamine, and a recent study shows a similar requirement for vascular endothelial growth factor (VEGF). Since BDNF is reported to stimulate VEGF expression and/or release in neuroblastoma cells, the present study tested the hypothesis that the actions of BDNF are mediated by VEGF. METHODS: The role of VEGF in the antidepressant behavioral actions of BDNF was tested by intra-mPFC coinfusion of a VEGF neutralizing antibody and by neuron-specific deletion of VEGF...
December 27, 2018: Biological Psychiatry
https://read.qxmd.com/read/30595232/lack-of-diagnostic-utility-of-amino-acid-dysregulation-metabotypes
#7
LETTER
Kristin L Sainani, Steven N Goodman
No abstract text is available yet for this article.
December 27, 2018: Biological Psychiatry
https://read.qxmd.com/read/30595230/reply-to-lack-of-diagnostic-utility-of-amino-acid-dysregulation-metabotypes
#8
LETTER
Alan M Smith, Elizabeth L R Donley, Robert E Burrier, Joseph J King, David G Amaral
No abstract text is available yet for this article.
December 27, 2018: Biological Psychiatry
https://read.qxmd.com/read/30711191/hyperperfusion-of-frontal-white-and-subcortical-gray-matter-in-autism-spectrum-disorder
#9
Bradley S Peterson, Ariana Zargarian, Jarod B Peterson, Suzanne Goh, Siddhant Sawardekar, Steven C R Williams, David J Lythgoe, Fernando O Zelaya, Ravi Bansal
BACKGROUND: Our aim was to assess resting cerebral blood flow (rCBF) in children and adults with autism spectrum disorder (ASD). METHODS: We acquired pulsed arterial spin labeling magnetic resonance imaging data in 44 generally high-functioning participants with ASD simplex and 66 typically developing control subjects with comparable mean full-scale IQs. We compared rCBF values voxelwise across diagnostic groups and assessed correlations with symptom scores. We also assessed the moderating influences of participant age, sex, and IQ on our findings and the correlations of rCBF with N-acetylaspartate metabolite levels...
December 21, 2018: Biological Psychiatry
https://read.qxmd.com/read/30737013/chronic-stress-causes-projection-specific-adaptation-of-amygdala-neurons-via-small-conductance-calcium-activated-potassium-channel-downregulation
#10
Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan
BACKGROUND: The role of the amygdala in mediating stress coping has been long appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized into discrete output circuits, and it remains unclear whether stress differentially impacts these circuits. METHODS: Mice were exposed to acute restraint stress or chronic restraint stress (CRS), and c-fos expression was measured as a proxy for neuronal activation in Retrobead retrogradely labeled dorsomedial prefrontal cortex-targeting PNs (BLA→dmPFC) and non-dmPFC-targeting PNs (BLA↛dmPFC)...
December 20, 2018: Biological Psychiatry
https://read.qxmd.com/read/30686506/contribution-of-rare-copy-number-variants-to-bipolar-disorder-risk-is-limited-to-schizoaffective-cases
#11
Alexander W Charney, Eli A Stahl, Elaine K Green, Chia-Yen Chen, Jennifer L Moran, Kimberly Chambert, Richard A Belliveau, Liz Forty, Katherine Gordon-Smith, Phil H Lee, Evelyn J Bromet, Peter F Buckley, Michael A Escamilla, Ayman H Fanous, Laura J Fochtmann, Douglas S Lehrer, Dolores Malaspina, Stephen R Marder, Christopher P Morley, Humberto Nicolini, Diana O Perkins, Jeffrey J Rakofsky, Mark H Rapaport, Helena Medeiros, Janet L Sobell, Lena Backlund, Sarah E Bergen, Anders Juréus, Martin Schalling, Paul Lichtenstein, James A Knowles, Katherine E Burdick, Ian Jones, Lisa A Jones, Christina M Hultman, Roy Perlis, Shaun M Purcell, Steven A McCarroll, Carlos N Pato, Michele T Pato, Ariana Di Florio, Nick Craddock, Mikael Landén, Jordan W Smoller, Douglas M Ruderfer, Pamela Sklar
BACKGROUND: Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type (SAB), bipolar I disorder (BD I), and bipolar II disorder (BD II) differ according to the prominence and timing of psychosis, mania, and depression. The genetic factors contributing to the combination of symptoms among these subtypes are poorly understood. METHODS: Rare large CNVs were analyzed in 6353 BD cases (3833 BD I [2676 with psychosis, 850 without psychosis, and 307 with unknown psychosis history], 1436 BD II, 579 SAB, and 505 BD not otherwise specified) and 8656 controls...
December 20, 2018: Biological Psychiatry
https://read.qxmd.com/read/30718039/microrna-26a-death-associated-protein-kinase-1-signaling-induces-synucleinopathy-and-dopaminergic-neuron-degeneration-in-parkinson-s-disease
#12
Ying Su, Man-Fei Deng, Wan Xiong, Ao-Ji Xie, Jifeng Guo, Zhi-Hou Liang, Bo Hu, Jian-Guo Chen, Xiongwei Zhu, Heng-Ye Man, Youming Lu, Dan Liu, Beisha Tang, Ling-Qiang Zhu
BACKGROUND: Death-associated protein kinase 1 (DAPK1) is a widely distributed serine/threonine kinase that is critical for cell death in multiple neurological disorders, including Alzheimer's disease and stroke. However, little is known about the role of DAPK1 in the pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disorder. METHODS: We used Western blot and immunohistochemistry to evaluate the alteration of DAPK1. Quantitative polymerase chain reaction and fluorescence in situ hybridization were used to analyze the expression of microRNAs in PD mice and patients with PD...
December 19, 2018: Biological Psychiatry
https://read.qxmd.com/read/30718038/pretreatment-rostral-anterior-cingulate-cortex-connectivity-with-salience-network-predicts-depression-recovery-findings-from-the-embarc-randomized-clinical-trial
#13
Alexis E Whitton, Christian A Webb, Daniel G Dillon, Jürgen Kayser, Ashleigh Rutherford, Franziska Goer, Maurizio Fava, Patrick McGrath, Myrna Weissman, Ramin Parsey, Phil Adams, Joseph M Trombello, Crystal Cooper, Patricia Deldin, Maria A Oquendo, Melvin G McInnis, Thomas Carmody, Gerard Bruder, Madhukar H Trivedi, Diego A Pizzagalli
BACKGROUND: Baseline rostral anterior cingulate cortex (rACC) activity is a well-replicated nonspecific predictor of depression improvement. The rACC is a key hub of the default mode network, which prior studies indicate is hyperactive in major depressive disorder. Because default mode network downregulation is reliant on input from the salience network and frontoparietal network, an important question is whether rACC connectivity with these systems contributes to depression improvement...
December 19, 2018: Biological Psychiatry
https://read.qxmd.com/read/30635130/central-histamine-boosts-perirhinal-cortex-activity-and-restores-forgotten-object-memories
#14
Hiroshi Nomura, Hiroto Mizuta, Hiroaki Norimoto, Fumitaka Masuda, Yuki Miura, Ayame Kubo, Hiroto Kojima, Aoi Ashizuka, Noriko Matsukawa, Zohal Baraki, Natsuko Hitora-Imamura, Daisuke Nakayama, Tomoe Ishikawa, Mami Okada, Ken Orita, Ryoki Saito, Naoki Yamauchi, Yamato Sano, Hiroyuki Kusuhara, Masabumi Minami, Hidehiko Takahashi, Yuji Ikegaya
BACKGROUND: A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H3 receptor inverse agonists upregulate histamine release, the inverse agonists may enhance learning and memory. However, whether the inverse agonists promote the retrieval of forgotten long-term memory has not yet been determined...
December 19, 2018: Biological Psychiatry
https://read.qxmd.com/read/30579532/insight-may-limit-identification-of-eating-disorders
#15
LETTER
Brooks Brodrick, Carrie McAdams
No abstract text is available yet for this article.
December 19, 2018: Biological Psychiatry
https://read.qxmd.com/read/30579531/reply-to-insight-may-limit-identification-of-eating-disorders
#16
LETTER
Tomoko Udo, Carlos M Grilo
No abstract text is available yet for this article.
December 19, 2018: Biological Psychiatry
https://read.qxmd.com/read/30563762/n-acetylcysteine-in-treatment-of-substance-use-disorders
#17
LETTER
David A Gorelick
No abstract text is available yet for this article.
December 15, 2018: Biological Psychiatry
https://read.qxmd.com/read/30563761/reply-to-n-acetylcysteine-in-treatment-of-substance-use-disorders
#18
LETTER
Peter W Kalivas, Sade Spencer
No abstract text is available yet for this article.
December 15, 2018: Biological Psychiatry
https://read.qxmd.com/read/30691673/specific-substantial-dysconnectivity-in-schizophrenia-a-transdiagnostic-multimodal-meta-analysis-of-resting-state-functional-and-structural-magnetic-resonance-imaging-studies
#19
Felix Brandl, Mihai Avram, Benedikt Weise, Jing Shang, Beatriz Simões, Teresa Bertram, Daniel Hoffmann Ayala, Nora Penzel, Deniz A Gürsel, Josef Bäuml, Afra M Wohlschläger, Zoran Vukadinovic, Nikolaos Koutsouleris, Stefan Leucht, Christian Sorg
BACKGROUND: This study investigated characteristic large-scale brain changes in schizophrenia. Numerous imaging studies have demonstrated brain changes in schizophrenia, particularly aberrant intrinsic functional connectivity (iFC) of ongoing brain activity, measured by resting-state functional magnetic resonance imaging, and aberrant gray matter volume (GMV) of distributed brain regions, measured by structural magnetic resonance imaging. It is unclear, however, which iFC changes are specific to schizophrenia compared with those of other disorders and whether such specific iFC changes converge with GMV changes...
December 11, 2018: Biological Psychiatry
https://read.qxmd.com/read/30545521/lack-of-opioid-system-in-the-antidepressant-actions-of-ketamine
#20
LETTER
Kai Zhang, Kenji Hashimoto
No abstract text is available yet for this article.
December 10, 2018: Biological Psychiatry
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