journal
https://read.qxmd.com/read/38636886/early-life-adversities-are-associated-with-lower-expected-value-signaling-in-the-adult-brain
#1
JOURNAL ARTICLE
Seda Sacu, Magda Dubois, Frank H Hezemans, Pascal-M Aggensteiner, Maximilian Monninger, Daniel Brandeis, Tobias Banaschewski, Tobias U Hauser, Nathalie E Holz
BACKGROUND: Early adverse experiences are assumed to affect fundamental processes of reward learning and decision-making. However, computational neuroimaging studies investigating these circuits in the context of adversity are sparse and limited to studies conducted in adolescent samples, leaving the long-term effects unexplored. METHODS: Using data from a longitudinal birth cohort study (n=156, 87 females), we investigated associations between adversities and computational markers of reward learning (i...
April 16, 2024: Biological Psychiatry
https://read.qxmd.com/read/38631425/longitudinal-trajectories-of-plasma-polyunsaturated-fatty-acids-and-associations-with-psychosis-spectrum-outcomes-in-early-adulthood
#2
JOURNAL ARTICLE
David Mongan, Benjamin I Perry, Colm Healy, Subash Raj Susai, Stan Zammit, Mary Cannon, David R Cotter
BACKGROUND: Evidence supports associations between polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and psychosis. However, PUFA trajectories in the general population have not been characterised and associations with psychosis-spectrum outcomes in early adulthood are unknown. background METHODS: Plasma omega-6:omega-3 ratio and DHA %total fatty acids were measured by nuclear magnetic spectroscopy at 7,15,17 and 24years in the Avon Longitudinal Study of Parents and Children...
April 15, 2024: Biological Psychiatry
https://read.qxmd.com/read/38625066/erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
April 15, 2024: Biological Psychiatry
https://read.qxmd.com/read/38604525/early-infant-prefrontal-cortical-microstructure-predicts-present-and-future-emotionality
#4
JOURNAL ARTICLE
Yicheng Zhang, Layla Banihashemi, Amelia Versace, Alyssa Samolyk, Megan Taylor, Gabrielle English, Vanessa J Schmithorst, Vincent K Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E Hipwell, Mary L Phillips
BACKGROUND: High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite Orientation Dispersion and Density Imaging (NODDI) estimates microstructural integrity and myelination via the neurite density index (NDI) and dispersion via the orientation dispersion index (ODI), with potential to more accurately evaluate microstructural alterations in the developing brain...
April 9, 2024: Biological Psychiatry
https://read.qxmd.com/read/38582277/lost-in-translation-challenges-for-translational-research-in-the-field-of-stress-and-cognition
#5
JOURNAL ARTICLE
Israel Liberzon
No abstract text is available yet for this article.
April 4, 2024: Biological Psychiatry
https://read.qxmd.com/read/38575105/sirt1-coordinates-transcriptional-regulation-of-neural-activity-and-modulates-depression-like-behaviors-in-the-nucleus-accumbens
#6
JOURNAL ARTICLE
Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G Park, Shenfeng Qiu, Deveroux Ferguson
BACKGROUND: Major depression and anxiety disorder are significant causes of disability and socio-economic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social defeat stress (CSDS) to induce depression- and anxiety-like behaviors. CSDS induces physiological and behavioral changes that recapitulate depression-like symptomatology and alters gene expression programs in the nucleus accumbens, yet cell type-specific changes in this critical structure remain largely unknown...
April 2, 2024: Biological Psychiatry
https://read.qxmd.com/read/38573298/erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Biological Psychiatry
https://read.qxmd.com/read/38552866/brain-circuit-derived-biotypes-for-treatment-selection-in-mood-disorders-a-critical-review-and-illustration-of-a-functional-neuroimaging-tool-for-clinical-translation
#8
REVIEW
Evelyn Jiayi Song, Leonardo Tozzi, Leanne M Williams
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for selecting the most effective treatments for each patient. A third to one half of patients with major depressive disorder do not respond to treatment, and we lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional neuroimaging as a modality of measurement for precision psychiatry. We begin by summarizing the current landscape of how functional neuroimaging-derived circuit predictors can forecast treatment outcomes in depression...
March 27, 2024: Biological Psychiatry
https://read.qxmd.com/read/38537670/muscarinic-receptor-activators-as-novel-treatments-for-schizophrenia
#9
REVIEW
Steven M Paul, Samantha E Yohn, Stephen K Brannan, Nichole M Neugebauer, Alan Breier
Achieving optimal treatment outcomes for individuals living with schizophrenia remains challenging, despite 70 years of drug development efforts. Many chemically distinct antipsychotics have been developed over the past seven decades with improved safety and tolerability but with only slight variation in efficacy. All currently prescribed antipsychotics act as antagonists or partial agonists at the dopamine D2 receptor. With only a few possible exceptions, antipsychotic drugs have similar and modest efficacy for treating positive symptoms and are relatively ineffective in addressing the negative and cognitive symptoms of the disease...
March 25, 2024: Biological Psychiatry
https://read.qxmd.com/read/38521159/accelerated-cortical-thinning-in-schizophrenia-is-associated-with-rare-and-common-predisposing-variation-to-schizophrenia-and-neurodevelopmental-disorders
#10
JOURNAL ARTICLE
Javier González-Peñas, Clara Alloza, Rachel Brouwer, Covadonga M Díaz-Caneja, Javier Costas, Noemí González-Lois, Ana Guil Gallego, Lucía de Hoyos, Xaquín Gurriarán, Álvaro Andreu-Bernabeu, Rafael Romero-García, Lourdes Fañanas, Julio Bobes, Ana González Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Manuel Arrojo, Elisabet Vilella, Alfonso Guitiérrez-Zotes, Marta Perez-Rando, María Dolores Moltó, Elizabeth Buimer, Neeltje van Haren, Wiepke Cahn, Michael O'Donovan, René S Kahn, Celso Arango, Hilleke Hulshoff Pol, Joost Janssen, Hugo Schnack
BACKGROUND: Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the lifespan. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. METHODS: We conducted linear mixed models to estimate the rates of accelerated cortical thinning across 68 regions from the Desikan-Killiany atlas in individuals with schizophrenia compared to healthy controls from a large longitudinal sample (NCases = 169 and NControls = 298, aged 16-70 years)...
March 21, 2024: Biological Psychiatry
https://read.qxmd.com/read/38521158/electroconvulsive-therapy-regulates-brain-connectome-dynamics-in-patients-with-major-depressive-disorder
#11
JOURNAL ARTICLE
Yuanyuan Guo, Mingrui Xia, Rong Ye, Tongjian Bai, Yue Wu, Yang Ji, Yue Yu, Gong-Jun Ji, Kai Wang, Yong He, Yanghua Tian
BACKGROUND: Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but its underlying neural mechanisms remain largely unknown. The aim of this study was to identify changes in brain connectome dynamics after ECT in MDD and to explore their associations with treatment outcome. METHODS: We collected longitudinal resting-state fMRI data from 80 MDD patients (50 with suicidal ideation and 30 without; SI and NSI, respectively) before and after ECT and 37 age- and sex-matched healthy controls...
March 21, 2024: Biological Psychiatry
https://read.qxmd.com/read/38490368/prefrontal-regulation-of-social-behavior-and-related-deficits-insights-from-rodent-studies
#12
REVIEW
Nancy R Mack, Nadia N Bouras, Wen-Jun Gao
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing social cues and influencing social behaviors. Furthermore, combining these tools with translationally-relevant behavioral paradigms has also provided novel insights into the PFC neural mechanisms that may contribute to social deficits in various psychiatric disorders...
March 13, 2024: Biological Psychiatry
https://read.qxmd.com/read/38490367/tonic-nmdar-currents-in-the-brain-regulation-and-cognitive-functions
#13
REVIEW
Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C Justin Lee
Synaptically localized N-methyl-D-aspartate receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current exists, thought to be mediated by extrasynaptic NMDARs, with a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity and their impact on cognitive functions and psychiatric disorders. We discuss the roles of three endogenous ligands (i...
March 13, 2024: Biological Psychiatry
https://read.qxmd.com/read/38490366/reduced-protein-stability-of-11-pathogenic-missense-stxbp1-munc18-1-variants-and-improved-disease-prediction
#14
JOURNAL ARTICLE
Timon André, Annemiek A van Berkel, Gurdeep Singh, Esam T Abualrous, Gaurav D Diwan, Torsten Schmenger, Lara Braun, Jörg Malsam, Ruud F Toonen, Christian Freund, Robert B Russell, Matthijs Verhage, Thomas H Söllner
BACKGROUND: Pathogenic variants in STXBP1/Munc18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed and pathogenicity prediction is limited. This study aims to define a generalized disease concept for STXBP1-related disorders and improve prediction. METHODS: A cohort of 11 disease-associated and five neutral variants (detected in healthy individuals) was tested in three cell-free assays, and in heterologous cells and primary neurons...
March 13, 2024: Biological Psychiatry
https://read.qxmd.com/read/38460582/orbitofrontal-and-prelimbic-cortices-serve-complementary-roles-in-adapting-reward-seeking-to-learned-anxiety
#15
JOURNAL ARTICLE
David S Jacobs, Alina P Bogachuk, Bita Moghaddam
BACKGROUND: Anxiety is a common symptom of several mental health disorders and adversely affects motivated behaviors. Anxiety can emerge from associating risk of future harm while engaged in goal-guided actions. Using a recently developed behavioral paradigm to model this aspect of anxiety, we investigated the role of two cortical subregions, the prelimbic medial frontal cortex (PL) and lateral orbitofrontal cortex (lOFC), which have been implicated in anxiety and outcome expectation, in flexible representation of actions associated with harm risk...
March 7, 2024: Biological Psychiatry
https://read.qxmd.com/read/38460581/multimodal-associations-of-fkbp5-methylation-with-emotion-regulatory-brain-circuits
#16
JOURNAL ARTICLE
Thomas L Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena Geiger-Primo, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I Schweiger, Fabian Streit, Stephanie H Witt, Zhenxiang Zang, Xiaolong Zhang, Markus M Noethen, Marcella Rietschel, Ulrich W Ebner-Priemer, Emanuel Schwarz, Andreas Meyer-Lindenberg, Urs Braun, Heike Tost
BACKGROUND: Understanding the biological processes underlying individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. Yet it remains unclear how FKBP5 DNA methylation (DNAm) in peripheral blood relates to individual differences in measures of neural structure and function, and their relevance to daily-life stress responsivity...
March 7, 2024: Biological Psychiatry
https://read.qxmd.com/read/38460580/generalizable-links-between-borderline-personality-traits-and-functional-connectivity
#17
JOURNAL ARTICLE
Golia Shafiei, Arielle S Keller, Maxwell Bertolero, Sheila Shanmugan, Dani S Bassett, Andrew A Chen, Sydney Covitz, Audrey Houghton, Audrey Luo, Kahini Mehta, Taylor Salo, Russell T Shinohara, Damien Fair, Michael N Hallquist, Theodore D Satterthwaite
BACKGROUND: Symptoms of borderline personality disorder (BPD) often manifest in adolescence, yet the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here we aimed to investigate how multivariate patterns of functional connectivity are associated with borderline personality traits in large samples of young adults and adolescents. METHODS: We used functional Magnetic Resonance Imaging (fMRI) data from young adults and adolescents from the Human Connectome Project: Young Adults (HCP-YA; N=870, ages 22-37 years, 457 female) and Development (HCP-D; N=223, ages 16-21 years, 121 female)...
March 7, 2024: Biological Psychiatry
https://read.qxmd.com/read/38452884/isolation-of-distinct-networks-driving-action-and-cognition-in-psychomotor-processes
#18
JOURNAL ARTICLE
Alexandra B Moussa-Tooks, Adam Beermann, Karlos Manzanarez Felix, Michael Coleman, Sylvain Bouix, Daphne Holt, Kathryn E Lewandowski, Dost Öngür, Alan Breier, Martha E Shenton, Stephan Heckers, Sebastian Walther, Roscoe O Brady, Heather Burrell Ward
BACKGROUND: Psychomotor disturbances are observed across psychiatric disorders and often present as psychomotor slowing, agitation, disorganized behavior, or catatonia. Psychomotor function includes both cognitive and motor components, but the neural circuits driving these subprocesses and how they relate to symptoms have remained elusive for centuries. METHODS: We analyzed data from the Human Connectome Project for Early Psychosis, a multi-site study of 125 people with early psychosis and 58 healthy participants with resting-state fMRI and clinical characterization...
March 5, 2024: Biological Psychiatry
https://read.qxmd.com/read/38432522/the-causal-relationship-between-gut-microbiota-brain-volume-and-intelligence-a-two-step-mendelian-randomization-analysis
#19
JOURNAL ARTICLE
Shi Yao, Ji-Zhou Han, Jing Guo, Xin Wang, Long Qian, Hao Wu, Wei Shi, Ren-Jie Zhu, Jia-Hao Wang, Shan-Shan Dong, Li-Li Cui, Yan Wang, Yan Guo, Tie-Lin Yang
BACKGROUND: Growing evidence indicates that dynamic changes in gut microbiome can affect intelligence; however, whether these relationships are causal remains elusive. We aimed to disentangle the poorly understood causal relationship between gut microbiota and intelligence. METHODS: We performed a two-sample Mendelian randomization (MR) analysis using genetic variants from the largest available genome-wide association studies of gut microbiota (n = 18,340) and intelligence (n = 269,867)...
March 1, 2024: Biological Psychiatry
https://read.qxmd.com/read/38432521/prefrontal-limbic-circuitry-is-associated-with-reward-sensitivity-in-nonhuman-primates
#20
JOURNAL ARTICLE
Kwang-Hyun Hur, Steven L Meisler, Walid Yassin, Blaise B Frederick, Stephen J Kohut
BACKGROUND: Abnormal reward sensitivity is a risk factor for psychiatric disorders, including eating disorders such as overeating and binge-eating disorder, but the brain structural mechanisms underlying it are not completely understood. Here, we sought to investigate the relationship between multi-modal whole-brain structural features and reward sensitivity in nonhuman primates. METHODS: Reward sensitivity was evaluated through behavioral economic analysis in which monkeys (adult rhesus macaques, 5 males; 7 females) responded for sweetened-condensed milk (10,30,56%), Gatorade, or water using an operant procedure in which the response requirement increased incrementally across sessions (i...
March 1, 2024: Biological Psychiatry
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