Enrica Montalban, Roman Walle, Julien Castel, Anthony Ansoult, Rim Hassouna, Ewout Foppen, Xi Fang, Zach Hutelin, Sophie Mickus, Emily Perszyk, Anna Petitbon, Jérémy Berthelet, Fernando Rodrigues-Lima, Alberto Cebrian-Serrano, Giuseppe Gangarossa, Claire Martin, Pierre Trifilieff, Clémentine Bosch-Bouju, Dana M Small, Serge Luquet
BACKGROUND: A large body of evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the TaqIA polymorphism is one of the most commonly studied in psychiatry. TaqIA is located in the gene that codes for the Ankyrin repeat and kinase domain containing 1 kinase (Ankk1) near the dopamine D2 dopamine receptor (D2R) gene. Homozygous expression of the A1 allele correlates with a 30 to 40% reduction of striatal D2R, a typical feature of addiction, over-eating and other psychiatric pathologies...
February 16, 2023: Biological Psychiatry