Debby Klooster, Helena Voetterl, Chris Baeken, Martijn Arns
Non-invasive brain stimulation (NIBS) treatments have gained considerable attention as a potential therapeutic intervention for psychiatric disorders. The identification of reliable biomarkers for predicting clinical response to NIBS has been a major focus of research in recent years. Neuroimaging techniques, such as electroencephalography (EEG) and (functional) magnetic resonance imaging (fMRI), have been used to identify potential biomarkers that could predict response to NIBS. However, identifying clinically actionable brain biomarkers requires robustness...
September 19, 2023: Biological Psychiatry
Maria E Secci, Leslie K Kelley, Elizabeth M Avegno, Eleanor B Holmgren, Lily Chen, Sydney L Rein, Sheila A Engi, Virginia Quinlan, Lisa Wilson, Nicholas W Gilpin, Tiffany A Wills
BACKGROUND: Exposure to alcohol during adolescence produces many effects that last well into adulthood. Acute alcohol is analgesic and people living with pain report drinking alcohol to reduce pain, but chronic alcohol produces increases in pain sensitivity. METHODS: Here, we tested the acute and lasting effects of chronic intermittent adolescent alcohol exposure (AIE) on pain-related behavioral and brain changes in male and female rats. We also tested the long-term effects of AIE on synaptic transmission in midbrain (vlPAG)-projecting central amygdala (CeA) neurons, using patch clamp electrophysiology...
September 15, 2023: Biological Psychiatry
Vittoria Mariano, Alexandros K Kanellopoulos, Carlotta Ricci, Daniele Di Marino, Sarah C Borrie, Sebastian Dupraz, Frank Bradke, Tilmann Achsel, Eric Legius, Sylvie Odent, Pierre Billuart, Thierry Bienvenu, Claudia Bagni
BACKGROUND: 15q11.2 Deletions and duplications have been linked to autism spectrum disorder (ASD), schizophrenia, and intellectual disability (ID). Recent evidence suggests that dysfunctional Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) contributes to the clinical phenotypes observed in individuals with 15q11.2 deletion/duplication syndrome. CYFIP1 plays crucial roles in neuronal development and brain connectivity, promoting actin polymerization and regulating local protein synthesis...
September 11, 2023: Biological Psychiatry
Valentin Ourry, Alexa Pichet Binette, Frédéric St-Onge, Cherie Strikwerda-Brown, Audrey Chagnot, Judes Poirier, John Breitner, Eider M Arenaza-Urquijo, Jennifer S Rabin, Rachel Buckley, Julie Gonneaud, Natalie L Marchant, Sylvia Villeneuve
Epidemiological studies show that modifiable risk factors account for about 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (sAD). Recent findings suggest that these factors might also modify disease trajectories of people with autosomal dominant Alzheimer's disease (ADAD). With positron emission tomography (PET) imaging it is now possible to study the disease many years before its clinical onset. Such studies can provide key knowledge regarding pathways for either the prevention of pathology or the postponement of its clinical expression...
September 7, 2023: Biological Psychiatry
Yi Zhu, Shi-Ze Xie, Ai-Bing Peng, Xiao-Dan Yu, Chun-Yue Li, Jia-Yu Fu, Chen-Jie Shen, Shu-Xia Cao, Ying Zhang, Jiadong Chen, Xiao-Ming Li
BACKGROUND: The ability to differentiate stimuli predicting fear is critical for survival, however, the underlying molecular and circuit mechanisms remain poorly understood. METHODS: We combined transgenic mice, in vivo transsynaptic circuit-dissecting anatomical approaches, optogenetics, pharmacological methods and electrophysiological recording to investigate the involvement of specific extended amygdala circuits in different fear memory. RESULTS: We identify the projections from central lateral amygdala (CeL) protein kinase C δ (PKCδ) positive neurons and somatostatin (SST) positive neurons to the ventral part of bed nucleus of stria terminalis (vBNST) GABAergic and glutamatergic neurons...
September 5, 2023: Biological Psychiatry
Keira Ja Johnston, Alanna C Cote, Emily Hicks, Jessica Johnson, Laura M Huckins
BACKGROUND: Chronic pain is a common, poorly-understood condition. Genetic studies including genome wide association studies (GWAS) identify many relevant variants, which have yet to be translated into full understanding of chronic pain. Transcriptome wide association study using transcriptomic imputation (TI) methods such as S-PrediXcan can help bridge this genotype-phenotype gap. METHODS: We carried out TI using S-PrediXcan to identify genetically regulated gene expression (GREX) associated with Multisite Chronic Pain (MCP), in thirteen brain tissues and whole blood...
September 5, 2023: Biological Psychiatry
Patrick Bach, Judith Zaiser, Sina Zimmermann, Tatjana Gessner, Sabine Hoffmann, Sarah Gerhardt, Oksana Berhe, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Heike Tost, Bernd Lenz, Sabine Vollstädt-Klein, Jan Stallkamp, Clemens Kirschbaum, Falk Kiefer
BACKGROUND: Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder (AUD). However, the neurobiological processes underlying their interaction are only little understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial stress on neural cue-reactivity and addictive behaviors. METHODS: Neural alcohol cue-reactivity was assessed in 91 individuals with AUD using a validated functional magnetic resonance imaging (fMRI) task...
September 5, 2023: Biological Psychiatry
Lvping Zhuang, Weijie Gao, Yanbing Chen, Wenting Fang, Hsuan Lo, Xiaoman Dai, Jie Zhang, Wanjing Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang
BACKGROUND: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) was recently shown to be a risk gene for major depressive disorder (MDD). LHPP has been proven to dephosphorylate the residues of histidine, serine, threonine, and tyrosine. However, much remains unknown regarding how LHPP contributes to depression. METHODS: The present study addressed this issue by integrating approaches of genetics, molecular biology, behavioral testing and electrophysiology...
September 5, 2023: Biological Psychiatry
Youngkyu Song, Jee-Hyun Cho, Hyungjun Kim, Young-Ji Eum, E-Nae Cheong, Sunyoung Choi, Jeong-Heon Park, Sungho Tak, Bumwoo Park, Jin-Hun Sohn, Gyunggoo Cho, Chaejoon Cheong
BACKGROUND: Major depressive disorder (MDD) is characterized by depressed mood or loss of interest or pleasure. Generally, women are twice as likely as men to have depression. Taurine, a type of amino acid, plays critical roles in neuronal generation, differentiation, arborization and formation of synaptic connections. Importantly, it enhances proliferation and synaptogenesis in the hippocampus. When injected into animals, taurine has an antidepressant effect. However, there is no in vivo evidence to show the association between taurine concentration in the human brain and development of MDD...
September 5, 2023: Biological Psychiatry
Tristan J Hynes, Chloe S Chernoff, Kelly M Hrelja, Maric T L Tse, Dimitrios Avramidis, Melanie R Lysenko-Martin, Lucas Calderhead, Sukhbir Kaur, Stan B Floresco, Catharine A Winstanley
BACKGROUND: Psychostimulant use and engagement with probabilistic schedules of reward both sensitize the mesocorticolimbic dopamine system. Such behaviours may act synergistically to explain the high comorbidity between stimulant use and gambling disorder. The salient audiovisual stimuli of modern electronic gambling may exacerbate the situation. METHODS: To probe these interactions, we sensitized ventral tegmental area (VTA) dopamine neurons via chronic chemogenetic stimulation while rats (n = 134) learned the rat gambling task in the presence or absence of casino-like cues...
September 4, 2023: Biological Psychiatry
Ibrahim A Akkouh, Thor Ueland, Attila Szabo, Timothy Hughes, Olav B Smeland, Ole A Andreassen, Jordi Requena Osete, Srdjan Djurovic
BACKGROUND: Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain. METHODS: We generated induced pluripotent stem cell-derived cortical spheroids (hCSs) from a large and genetically stratified sample of 14 SCZ patients and 14 age and sex-matched controls (CTRL)...
September 1, 2023: Biological Psychiatry
Rune Boen, Tobias Kaufmann, Dennis van der Meer, Oleksandr Frei, Ingrid Agartz, David Ames, Micael Andersson, Nicola J Armstrong, Eric Artiges, Joshua R Atkins, Jochen Bauer, Francesco Benedetti, Dorret I Boomsma, Henry Brodaty, Katharina Brosch, Randy L Buckner, Murray J Cairns, Vince Calhoun, Svenja Caspers, Sven Cichon, Aiden P Corvin, Benedicto Crespo Facorro, Udo Dannlowski, Friederike S David, Eco J C de Geus, Greig I de Zubicaray, Sylvane Desrivières, Joanne L Doherty, Gary Donohoe, Stefan Ehrlich, Else Eising, Thomas Espeseth, Simon E Fisher, Andreas J Forstner, Lidia Fortaner Uyà, Vincent Frouin, Masaki Fukunaga, Tian Ge, David C Glahn, Janik Goltermann, Hans J Grabe, Melissa J Green, Nynke A Groenewold, Dominik Grotegerd, Tim Hahn, Ryota Hashimoto, Jayne Y Hehir-Kwa, Frans A Henskens, Avram J Holmes, Asta K Haberg, Jan Haavik, Sebastien Jacquemont, Andreas Jansen, Christiane Jockwitz, Erik G Jonsson, Masataka Kikuchi, Tilo Kircher, Kuldeep Kumar, Stephanie Le Hellard, Costin Leu, David E Linden, Jingyu Liu, Robert Loughnan, Karen A Mather, Katie L McMahon, Allan F McRae, Sarah E Medland, Susanne Meinert, Clara A Moreau, Derek W Morris, Bryan J Mowry, Thomas W Muhleisen, Igor Nenadić, Markus M Nöthen, Lars Nyberg, Michael J Owen, Marco Paolini, Tomas Paus, Zdenka Pausova, Karin Persson, Yann Quidé, Tiago Reis Marques, Perminder S Sachdev, Sigrid B Sando, Ulrich Schall, Rodney J Scott, Geir Selbæk, Elena Shumskaya, Ana I Silva, Sanjay M Sisodiya, Frederike Stein, Dan J Stein, Benjamin Straube, Fabian Streit, Lachlan T Strike, Alexander Teumer, Lea Teutenberg, Anbupalam Thalamuthu, Paul A Tooney, Diana Tordesillas-Gutierrez, Julian N Trollor, Dennis van 't Ent, Marianne B M van den Bree, Neeltje E M van Haren, Javier Vazquez-Bourgon, Henry Volzke, Wei Wen, Katharina Wittfeld, Christopher R K Ching, Lars T Westlye, Paul M Thompson, Carrie E Bearden, Kaja K Selmer, Dag Alnæs, Ole A Andreassen, Ida E Sonderby
BACKGROUND: The 1q21.1 distal and 15q11.2 BP1-BP2 CNVs exhibit regional and global brain differences compared to non-carriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intra-individual variability measures can be used to test for regional differences beyond global differences in brain structure. METHODS: Magnetic resonance imaging data were used to obtain regional brain values for 1q21...
September 1, 2023: Biological Psychiatry
Amelia J McGuinness, Amy Loughman, Jane A Foster, Felice Jacka
Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, whilst substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology. Beyond the gut bacteriome, research into lesser explored components of the gut microbiome, including the gut virome, mycobiome, archaeome, and parasitome, is increasingly suggesting relevance in psychiatry...
September 1, 2023: Biological Psychiatry
Maya M Evans, Jaekyoon Kim, Ted Abel, Thomas Nickl-Jockschat, Hanna E Stevens
Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition that is characterized by social and communication deficits as well as patterns of restricted, repetitive behavior. Abnormal brain development has long been postulated to underlie ASD, but longitudinal studies aimed at understanding the developmental course of the disorder have been limited. More recently, abnormal development of the striatum in ASD has become an area of interest in research, partially due to overlap of striatal functions and deficit areas in ASD, as well as the critical role of striatum in early development when ASD is first detected...
August 29, 2023: Biological Psychiatry
James J Mahoney, Daisy G Y Thompson-Lake, Manish Ranjan, Jennifer L Marton, Jeffrey S Carpenter, Wanhong Zheng, James H Berry, Daniel L Farmer, Pierre D'Haese, Victor S Finomore, Padma Tirumalai, Ashley S Mears, Jacob Suffridge, Ashley Ames, Sally L Hodder, Ali R Rezai
No abstract text is available yet for this article.
August 21, 2023: Biological Psychiatry
Charles T Taylor, Murray B Stein, Alan N Simmons, Feng He, Christopher Oveis, Holly B Shakya, William J Sieber, James H Fowler, Sonia Jain
BACKGROUND: Social disconnection is common and impairing in anxiety and depressive disorders and does not respond sufficiently to available treatments. The positive valence system supports social bond formation and maintenance yet is often hyporesponsive in those with anxiety or depression. We conducted an experimental therapeutics trial testing the hypothesis that targeting positive valence processes through cognitive and behavioral strategies would enhance responsivity to social rewards, a core mechanism underlying social connectedness...
August 20, 2023: Biological Psychiatry
Adolf Pfefferbaum, Qingyu Zhao, Kilian M Pohl, Stephanie A Sassoon, Natalie M Zahr, Edith V Sullivan
BACKGROUND: Antiretroviral treatment has enabled people living with HIV infection to have a near-normal lifespan. With longevity come opportunities for engaging in risky behavior, including initiation of excessive drinking. Given that both HIV infection and alcohol use disorder (AUD) can disrupt brain white matter integrity, we questioned whether HIV infection, even if successfully treated, or AUD alone results in signs of accelerated white matter aging and whether HIV+AUD comorbidity further accelerates brain aging...
August 17, 2023: Biological Psychiatry
Junneng Shao, Jiaolong Qin, Huan Wang, Yurong Sun, Wei Zhang, Xinyi Wang, Ting Wang, Li Xue, Zhijian Yao, Qing Lu
BACKGROUND: The high heterogeneity of depression prevents us from obtaining reproducible and definite anatomical maps of brain structural changes associated with the disorder, which thereafter limits the individualized diagnosis and treatment of patients. In this study, we investigated the clinical issues related to depression according to individual deviations from normative ranges of grey matter volume (GMV). METHODS: We enrolled 1,092 participants totally, including 187 depression patients and 905 healthy controls (HCs)...
August 12, 2023: Biological Psychiatry
Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Girault
BACKGROUND: Highly palatable food triggers behavioral responses including strong motivation. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechanisms underlying the long-lasting effects of highly palatable food on feeding behavior are poorly understood. METHODS: We studied the effects of 2-week operant conditioning of mice with standard or isocaloric highly palatable food. We investigated the behavioral responses and dendritic spine modifications in the NAc...
August 12, 2023: Biological Psychiatry
Steven D Sheridan, Joy E Horng, Hana Yeh, Liam McCrea, Jennifer Wang, Ting Fu, Roy H Perlis
BACKGROUND: The CYFIP1 gene, located in the neurodevelopmental risk locus 15q11.2, is highly expressed in microglia, but its role in human microglial function as it relates to neurodevelopment is not well understood. METHODS: We generated multiple CRISPR knockouts of CYFIP1 in patient-derived models of microglia to characterize function and phenotype. Using microglia-like cells reprogrammed from peripheral blood mononuclear cells, we quantified phagocytosis of synaptosomes (isolated and purified synaptic vesicles) from human iPSC-derived neuronal cultures as an in vitro model of synaptic pruning...
August 10, 2023: Biological Psychiatry
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