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Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme

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https://read.qxmd.com/read/30695794/effect-of-il-6-receptor-blockade-on-proprotein-convertase-subtilisin-kexin-type-9-and-cholesterol-efflux-capacity-in-rheumatoid-arthritis-patients
#1
Iván Ferraz-Amaro, María Vanesa Hernández-Hernández, Beatriz Tejera-Segura, Esmeralda Delgado-Frías, María Macía-Díaz, Jose David Machado, Federico Diaz-González
The aim of the work was to examine whether abnormalities in the lipid profile that tocilizumab (TCZ), an anti-IL-6 receptor Ab, exerts in rheumatoid arthritis (RA) patients is related to changes in either proprotein convertase subtilisin/kexin-9 (PCSK9) serum concentrations or in serum cholesterol efflux capacity (CEC). TOCRIVAR is a one-year prospective clinical trial that analyzes the influence of TCZ on cardiovascular risk factors. Twenty-seven RA patients receiving TCZ (8 mg/kg IV/q4w) were assessed at baseline and weeks 12, 24, and 52...
January 29, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30690693/exenatide-delays-gastric-emptying-in-patients-with-type-2-diabetes-mellitus-but-not-in-those-with-gastroparetic-conditions
#2
Christelle Beti, Bernd Stratmann, Georgy Bokman, Jens Dreier, Michael Hauber, Young Hee Lee-Barkey, Manfred Fischer, Cornelius Knabbe, Diethelm Tschoepe
The effect of the treatment with glucagon-like peptide (GLP)-1 receptor agonists on gastric emptying in patients with diabetes with and without gastroparesis is analysed. Patients with type 2 diabetes mellitus subjected to GLP-1 receptor agonist therapy with exenatide were examined before and shortly after initiation of treatment. Gastric half-emptying time was determined by 13 C-octanoic breath test; routine laboratory parameter as well as active GLP-1, ghrelin, leptin, insulin, proinsulin and C-peptide levels were determined in fasting state as well as postprandial secretion within 1 h after a standardised meal...
January 28, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30641579/correction-optical-imaging-technology-a-useful-tool-to-identify-remission-in-cushing-disease-after-surgery
#3
Ali Afshari, Margaret Keil, Charalampos Lyssikatos, Elena Belyavskaya, Nuria Valdés, Fatima A Chowdhry, Kian Parsa, Yasaman Ardeshirpour, Randall Pursley, Siddharth Khare, Jana M Kainerstorfer, Prashant Chittiboina, Maya B Lodish, Thomas A Mazzuchi, Amir H Gandjbakhche, Constantine A Stratakis
No abstract text is available yet for this article.
January 14, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30602178/optical-imaging-technology-a-useful-tool-to-identify-remission-in-cushing-disease-after-surgery
#4
Ali Afshari, Margaret Keil, Charalampos Lyssikatos, Elena Belyavskaya, Nuria Valdés, Fatima A Chowdhry, Kian Parsa, Yasaman Ardeshirpour, Randall Pursley, Siddharth Khare, Jana M Kainerstorfer, Prashant Chittiboina, Maya B Lodish, Thomas A Mazzuchi, Amir H Gandjbakhche, Constantine A Stratakis
We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3-6 months, and 13 patients 12 months post-operatively...
January 2, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30572349/gut-hormone-responses-to-mixed-meal-test-in-new-onset-prediabetes-diabetes-after-acute-pancreatitis
#5
Sayali A Pendharkar, Ruma G Singh, Aya Cervantes, Steve V DeSouza, Sakina H Bharmal, Maxim S Petrov
The study was aimed to investigate gut hormone responses to mixed meal test in individuals with new-onset prediabetes or diabetes after acute pancreatitis (cases) compared with healthy controls, and the effect of body fat parameters. A total of 29 cases and 29 age- and sex-matched healthy controls were recruited. All participants were given standard mixed meal drink and blood samples were collected to measure dipeptidyl peptidase IV, gastric inhibitory peptide, glucagon like peptide-1, insulin, oxyntomodulin, and peptide YY...
December 20, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30572348/prediabetes-is-characterized-by-higher-fgf23-levels-and-higher-prevalence-of-vitamin-d-deficiency-compared-to-normal-glucose-tolerance-subjects
#6
Antoaneta Gateva, Yavor Assyov, Adelina Tsakova, Zdravko Kamenov
In the last years there is an increasing interest towards the bone as an endocrine organ and the role of bone and calcium-phosphate metabolism markers in a range of metabolic disturbances. The aim of the present study is to assess the changes of calcium phosphate metabolism markers in patients with prediabetes compared to normogycemic controls and their link to glucose disturbances and cardiovascular risk factors. In this study, 80 patients with mean age 50.4±10.6 years were included, divided into 2 age- and BMI-matched groups - group 1 with obesity without glycemic disturbances (n=41) and group 2 with obesity and prediabetes (n=39)...
December 20, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30522147/the-effect-of-vitamin-d-supplementation-on-prostate-cancer-a-systematic-review-and-meta-analysis-of-clinical-trials
#7
Simin Shahvazi, Sepideh Soltani, Seyed Mehdi Ahmadi, Russell J de Souza, Amin Salehi-Abargouei
Vitamin D has received attention for its potential to disrupt cancer processes. However, its effect in the treatment of prostate cancer is controversial. This study aimed to assess the effect of vitamin D supplementation on patients with prostate cancer. In the present study, PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to September 2017 for trials that evaluated the effect of vitamin D supplementation on prostate specific antigen (PSA) response, mortality, and its possible side effects in participants with prostate cancer...
December 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30522146/hypercortisolism-in-newly-diagnosed-type-2-diabetes-a-prospective-study-of-384-newly-diagnosed-patients
#8
Charlotte Steffensen, Olaf M Dekkers, Johanne Lyhne, Bodil G Pedersen, Finn Rasmussen, Jørgen Rungby, Per Løgstrup Poulsen, Jens Otto Lunde Jørgensen
Cross-sectional studies in small and selected populations report a high prevalence of hypercortisolism in patients with type 2 diabetes (T2D), which could have therapeutic implications, if confirmed. We therefore estimated the prevalence of hypercortisolism in a large and unselected cohort of recently diagnosed T2D patients. Consecutive patients with recently diagnosed T2D first underwent an overnight dexamethasone (1 mg) suppression test (OD). Patients not suppressing serum cortisol ≤50 nmol/l proceeded with a 48-h low dose dexamethasone suppression test (LDDST) and 24-h urinary free cortisol collection (UFC)...
December 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30522145/effect-of-sodium-glucose-co-transporter-2-inhibition-on-the-aldosterone-renin-ratio-in-type-2-diabetes-mellitus
#9
Tomás P Griffin, Md Nahidul Islam, Liam Blake, Marcia Bell, Matthew D Griffin, Paula M O'Shea
The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of Sodium Glucose Co-Transporter-2 Inhibition on the ARR in patients with type 2 diabetes mellitus (T2DM) who were prescribed a Sodium Glucose Co-Transporter-2 Inhibitor (SGLT-2i) as part of routine clinical care. The primary outcomes were intra-individual changes in aldosterone, renin and ARR...
December 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30497091/metabolic-syndrome-is-a-risk-factor-for-post-operative-adhesions-need-for-novel-treatment-strategies
#10
Yair Pilpel, Guy Pines, Andreas Birkenfeld, Stefan R Bornstein, Rafael Miller
Metabolic syndrome is a group of disorders which include obesity, diabetes, dyslipidemias, and hypertension. This condition is rapidly increasing in an aging population. The rates of surgery in older patients is also growing and a wide range of operations including minimally invasive procedures is now available for this segment of the population. The number of patients suffering from postoperative adhesions is therefore correspondingly increasing. In addition to preventing and treating the metabolic disease itself, improved therapeutic strategies for the prevention of surgical adhesions have to be developed...
November 29, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30497090/free-igf-1-intact-igfbp-4-and-picopapp-a-are-altered-in-acute-myocardial-infarction-compared-to-stable-coronary-artery-disease-and-healthy-controls
#11
Athanasios D Anastasilakis, Dimitrios Koulaxis, Jagriti Upadhyay, Eirini Pagkalidou, Nikoleta Kefala, Nikolaos Perakakis, Stergios A Polyzos, Fotios Economou, Christos S Mantzoros
Insulin-like growth factor-1 (IGF-1) and its binding proteins have been implicated in the pathophysiology of coronary artery disease (CAD) and myocardial infarction (MI). We investigated components of the IGF-1 system in circulation at the time of acute MI and following reperfusion in relation to levels of stable CAD patients and controls. Patients with MI (MI Group, n=31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable CAD subjected to scheduled PCI (CAD Group, n=40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n=43)...
November 29, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30759490/reduced-gene-expression-of-peroxisome-proliferator-activated-receptor-gamma-coactivator-1%C3%AE-in-whole-blood-in-euthyroid-patients-one-year-after-hemithyroidectomy-for-benign-euthyroid-goiter
#12
Tina Toft Kristensen, Palle Lyngsie Pedersen, Jacob Larsen, Anne-Dorthe Feldthusen, Søren Jelstrup, Christina Ellervik
We have previously reported decreased thyroid function within the laboratory reference range and changes in mitochondrial function after hemithyroidectomy. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and coactivator-1β (PGC-1β) are key regulators of mitochondrial biogenesis and function. The aim was to examine the influence of hemithyroidectomy on the longitudinal change in mRNA expression of these genes. In addition, we measured longitudinal changes in mRNA expressions of the mitochoncrial-related genes nuclear factor erythroid-derived 2-like 2 (NFE2L2), mitochondrial transcription factor A (TFAM), and sodium dismutase 2 (SOD2)...
February 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30759489/congenital-hypopituitarism-various-genes-various-phenotypes
#13
Maria Xatzipsalti, Antonis Voutetakis, Lela Stamoyannou, George P Chrousos, Christina Kanaka-Gantenbein
The ontogenesis and development of the pituitary gland is a highly complex process that depends on a cascade of transcription factors and signaling molecules. Spontaneous mutations and transgenic murine models have demonstrated a role for many of these factors, including HESX1 , PROP1 , PIT1 , LHX3 , LHX4 , SOX2 , SOX3, OTX2 , PAX6 , FGFR1 , SHH , GLI2 , and FGF8 in the etiology of congenital hypopituitarism. Genetic mutations in any of these factors can lead to congenital hypopituitarism, which is characterized by the deficiency in one or more pituitary hormones...
February 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30665244/hormone-and-metabolic-research-50-years-of-research
#14
Matthias Schott, Stefan R Bornstein, Constantine A Stratakis
No abstract text is available yet for this article.
January 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30650457/relationships-between-biochemical-markers-of-hyperandrogenism-and-metabolic-parameters-in-women-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#15
Mina Amiri, Fahimeh Ramezani Tehrani, Razieh Bidhendi-Yarandi, Samira Behboudi-Gandevani, Fereidoun Azizi, Enrico Carmina
While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients...
January 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30408832/serum-vitamin-d-binding-protein-level-associated-with-metabolic-cardiovascular-risk-factors-in-women-with-the-polycystic-ovary-syndrome
#16
Justyna Kuliczkowska-Plaksej, Renato Pasquali, Andrzej Milewicz, Felicja Lwow, Diana Jedrzejuk, Marek Bolanowski
The objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20-35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA...
January 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30517971/autoimmune-thyroid-diseases
#17
J Paul Banga, Matthias Schott
No abstract text is available yet for this article.
December 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30357776/reflections-on-thyroid-autoimmunity-a-personal-overview-from-the-past-into-the-future
#18
Basil Rapoport, Sandra M McLachlan
After investigating thyroid autoimmunity for more than 40 years, we present a personal perspective on the field. Despite effective therapies for Graves' hyperthyroidism and Hashimoto's thyroiditis, cures are elusive. Novel forms of therapy are being developed, such as small molecule inhibitors of the TSH receptor (TSHR), but cure will require immunotherapy. This goal requires advances in understanding the pathogenesis of thyroid autoimmunity, the 'keys' for which are the thyroid antigens themselves. Presently, however, greater investigative focus is on non-thyroid specific immune cell types and molecules...
December 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30286486/current-and-future-treatments-for-graves-disease-and-graves-ophthalmopathy
#19
Anupam Kotwal, Marius Stan
The course and pathogenesis of Graves' disease and Graves' ophthalmopathy are interdependent, influencing each other's therapeutic choices. Multiple factors including geographic location, access to medical services, patient and physician preferences influence the management of these conditions. Graves' disease is classically managed with one of three treatment options - antithyroid drugs, radioactive iodine, and thyroidectomy. In recent years, there has been a shift towards antithyroid drugs, including long term therapy with these agents, given the advantage of avoiding hypothyroidism and the apparent safety of this approach...
December 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30453336/correction-intervention-strategies-into-glycoprotein-hormone-receptors-for-modulating-mal-function-with-special-emphasis-on-the-tsh-receptor
#20
Gerd Krause, Patrick Marcinkowski
No abstract text is available yet for this article.
November 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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