journal
https://read.qxmd.com/read/38503312/preoperative-serum-thyroglobulin-levels-predict-radioiodine-therapy-outcome-in-papillary-thyroid-microcarcinoma-patients
#1
JOURNAL ARTICLE
Xian Cheng, Yijun Fan, Wanzhong Ye, Shichen Xu, Jing Wu, Wenjing Gao, Jiandong Bao, Huixin Yu, Li Zhang
Our previous study showed that elevated preoperative thyroglobulin (pre-Tg) level predicted the risk of developing radioiodine refractory in PTC patients. In the present study, we aimed to evaluate the prognostic value of pre-Tg in papillary thyroid microcarcinoma (PTMC). After a specific inclusion and exclusion criteria were applied, a total of 788 PTMCs were enrolled from Jiangyuan Hospital affiliated to Jiangsu Institute of Nuclear Medicine between Jan, 2015 and Dec, 2019. Among them, 107 PTMCs were treated with radioiodine therapy (RAIT) and the response to therapy was grouped as excellent response (ER), and non-excellent response (NER: indeterminate response, IDR and biochemical incomplete response, BIR)...
March 19, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38471571/the-pathophysiological-associations-between-obesity-nafld-and-atherosclerotic-cardiovascular-diseases
#2
JOURNAL ARTICLE
Meng Li, Man Cui, Guoxia Li, Yueqiu Liu, Yunsheng Xu, Seyed Parsa Eftekhar, Moein Ala
Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common and growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor for NAFLD, and both of them can markedly increase the odds of atherosclerotic cardiovascular diseases. On the other hand, significant weight loss achieved by lifestyle modification, bariatric surgery, or medications, such as semaglutide, can concomitantly improve NAFLD and atherosclerotic cardiovascular diseases...
March 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38471570/the-adrenal-gland-and-pancreatic-islets-a-beneficial-endocrine-alliance
#3
JOURNAL ARTICLE
Undine Schubert, Susann Lehmann, Janine Schmid, Henning Morawietz, Stefan R Bornstein, Barbara Ludwig
Intraportal islet transplantation in patients with type 1 diabetes enables restoration of glucose-regulated insulin secretion. However, several factors hamper a widespread application and long-term success: chronic hypoxia, an inappropriate microenvironment and suppression of regenerative and proliferative potential by high local levels of immunosuppressive agents. Therefore, the identification of alternative and superior transplant sites is of major scientific and clinical interest. Here, we aim to evaluate the adrenal as an alternative transplantation site...
March 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38471569/association-of-vegf-936%C3%A2-c-t-polymorphism-with-susceptibility-to-type-2-diabetic-retinopathy-a-meta-analysis
#4
JOURNAL ARTICLE
Yanhong Huo, Xin Zhang, Li Su, Yan Zhang
The objective of this study is to explore the relationship between the vascular endothelial growth factor (VEGF)+936 C/T polymorphism and the risk of type 2 diabetic retinopathy (T2DR) by a method of meta-analysis. Six online databases were queried to identify studies investigating the VEGF+936 C/T polymorphism that influenced T2DR up to August 2023. The statistical tool of the pooled data was adopted using Stata 15.0 software. The experimental group comprised patients with T2DR, while patients with type 2 diabetes mellitus without retinopathy were considered as the controls...
March 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38467155/recent-advances-in-molecular-pathways-and-therapeutic-implications-for-peptic-ulcer-management-a-comprehensive-review
#5
JOURNAL ARTICLE
Deepak Chandra Joshi, Nirmal Joshi, Ajeet Kumar, Shubhrat Maheshwari
Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5-10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and therapeutic advancements. The review deepens into H. pylori -associated and NSAID-induced ulcers, emphasizing their distinct prevalence in developing and industrialized nations, respectively...
March 11, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38447950/dysregulation-of-mir-335-5p-in-people-with-obesity-and-its-predictive-value-for-metabolic-syndrome
#6
JOURNAL ARTICLE
Lu Liting, He Yufeng
The epidemic of obesity and metabolic syndrome has become the most serious global public health problem. The part played by microRNA (miRNA) in the onset and progression of obesity and metabolic syndrome has been increasingly focused upon. The goal of this study was to explore miR-335-5p as a potential predictive biomarker or therapeutic target for obesity and metabolic syndrome. The expression level of miR-335-5p was detected by qRT-PCR. The diagnostic value of miR-335-5p was evaluated by ROC curve. The association between serum miR-335-5p levels and various clinical parameters was assessed using the chi-square test...
March 6, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38447949/relationship-between-urinary-iodine-concentration-and-the-prevalence-of-thyroid-nodules-and-subclinical-hypothyroidism
#7
JOURNAL ARTICLE
Huachao Zhu, Pu Chen, Xi Ding, Yanru Zhao
The aim of the study was to investigate the iodine intake in the resident population in Xi'an and analyze the relationship between iodine nutritional status and the prevalence of subclinical hypothyroidism and thyroid nodules (TNs). A total of 2507 people were enrolled in Xi'an. Venous serum thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), urinary iodine concentration (UIC), and thyroid ultrasonography were collected. Patients with abnormal TSH were checked for free thyroxine (FT4) and triiodothyronine (FT3)...
March 6, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38447948/salivary-cortisol-measurement-contamination-after-oral-hydrocortisone-a-randomized-crossover-trial
#8
JOURNAL ARTICLE
Melika Chihaoui, Yasmine Mouelhi, Bessem Hammami, Ibtissem Oueslati, Nadia Khessairi, Fatma Chaker, Meriem Yazidi, Moncef Feki
The study aimed to evaluate salivary cortisol (SC) contamination and determine the associated factors in secondary adrenal insufficiency (SAI) patients treated with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC was measured before the morning Hc dose, then at one, two, and four hours after. The procedure was performed twice on two days of a week: one day while taking Hc in tablet form (tablet set) and one day while taking Hc in capsule form (capsule set). Area under the curve (AUC) of SC levels over time was calculated in each participant for the two sets...
March 6, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38408595/cross-talk-between-thyroid-disorders-and-nonalcoholic-fatty-liver-disease-from-pathophysiology-to-therapeutics
#9
JOURNAL ARTICLE
Yan Yang, Jiyuan Xiao, Wen Qiu, Luxia Jiang
The medical community acknowledges the presence of thyroid disorders and nonalcoholic fatty liver disease (NAFLD). Nevertheless, the interconnection between these two circumstances is complex. Thyroid hormones (THs), including triiodothyronine (T3) and thyroxine (T4), and thyroid-stimulating hormone (TSH), are essential for maintaining metabolic balance and controlling the metabolism of lipids and carbohydrates. The therapeutic potential of THs, especially those that target the TRβ receptor isoform, is generating increasing interest...
February 26, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38387480/preservation-of-%C3%AE-cells-as-a-therapeutic-strategy-for-diabetes
#10
JOURNAL ARTICLE
Jalal Taneera, Maha M Saber-Ayad
The preservation of pancreatic islet β-cells is crucial in diabetes mellitus, encompassing both type 1 and type 2 diabetes. β-cell dysfunction, reduced mass, and apoptosis are central to insufficient insulin secretion in both types. Research is focused on understanding β-cell characteristics and the factors regulating their function to develop novel therapeutic approaches. In type 1 diabetes (T1D), β-cell destruction by the immune system calls for exploring immunosuppressive therapies, non-steroidal anti-inflammatory drugs, and leukotriene antagonists...
February 22, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38373717/energy-metabolism-in-residents-in-the-low-and-moderate-altitude-regions-of-central-asia-with-mafld-and-type-2-diabetes-mellitus
#11
JOURNAL ARTICLE
Nurgul Toktogulova, Matthias Breidert, Judith Eschbach, Indira Kudaibergenova, Uulkan Omurzakova, Feruzakhan Uvaidillaeva, Bermet Tagaeva, Roza Sultanalieva, Pierre Eftekhari
The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750-800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046-2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12)...
February 19, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38354749/elevated-levels-of-interleukin-18-are-associated-with-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#12
JOURNAL ARTICLE
Wang Chun, Meiyin Lu, Jiakang Chen, Jian Li
Interleukin-18 (IL-18) is a proinflammatory cytokine that primarily stimulates the Th1 immune response. IL-18 exhibits anticancer activity and has been evaluated in clinical trials as a potential cancer treatment. However, evidence suggests that it may also facilitate the development and progression of some cancers. So far, the impact of IL-18 on papillary thyroid cancer (PTC) has not been investigated. In this study, we found that the expression of IL-18 was significantly increased in PTC compared to normal thyroid tissue...
February 14, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38350636/targeting-abnormal-tau-phosphorylation-for-alzheimer-s-therapeutics
#13
JOURNAL ARTICLE
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Syed Misbahul Hasan, Rufaida Wasim, Shubhrat Maheshwari, Juber Akhtar, Suvaiv Sheikh, Vishal Kumar Vishwakarma
Alzheimer's disease (AD) is a widespread neurodegenerative disorder characterized by progressive memory and cognitive decline, posing a formidable public health challenge. This review explores the intricate interplay between two pivotal players in AD pathogenesis: β-amyloid (Aβ) and tau protein. While the amyloid cascade theory has long dominated AD research, recent developments have ignited debates about its centrality. Aβ plaques and tau NFTs are hallmark pathologies in AD. Aducanumab and lecanemab, monoclonal antibodies targeting Aβ, have been approved, albeit amidst controversy, raising questions about the therapeutic efficacy of Aβ-focused interventions...
February 13, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38346690/potassium-a-frontier-in-osteoporosis
#14
JOURNAL ARTICLE
Widhilika Singh, Poonam Kushwaha
Osteoporosis is a significant public health concern, particularly in aging populations, leading to fractures, decreased mobility, and reduced quality of life. While calcium and vitamin D have long been recognized as essential for bone health, emerging research suggests that potassium may play a crucial role in maintaining bone density and preventing osteoporosis. This manuscript explores the relationship between potassium and osteoporosis, delving into the mechanisms, epidemiological evidence, and potential therapeutic implications of potassium in bone health...
February 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38346689/the-evolution-of-the-bone-turnover-marker-in-patients-following-recovery-from-diabetic-ketoacidosis
#15
JOURNAL ARTICLE
Song Wen, Chenglin Xu, Yue Yuan, Yanyan Li, Dongxiang Xu, Min Gong, Mingyue Zhou, Ligang Zhou
The aim of the study was to investigate whether the biomarkers for bone turnover could rapidly recover during the period of diabetic ketoacidosis (DKA). Bone turnover biomarkers, including 25-hydroxyvitamin D3, N-terminal middle molecular fragment of osteocalcin (NMID), and β-C terminal cross-linking telopeptide of type 1 collagen were evaluated using in-patient data (n=627) from Shanghai Pudong Hospital from 2018-2022. The comparison was performed between type 2 diabetes (T2D only) (n=602) and DKA (n=25), in which we checked the bone turnover markers at pre-treatment and recovery...
February 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38335994/etv5-silencing-produces-mesenchymal-to-epithelial-transition-in-ins-1-832-13-cell-line
#16
JOURNAL ARTICLE
Yael Efrén Díaz-López, Vicenta Cázares-Domínguez, Francisco Arenas-Huertero, Ruth Gutierrez-Aguilar
ETV5 has been described to be involved in the epithelial to mesenchymal transition (EMT) mainly in cancer. It is known that EMT provokes cytoskeleton remodeling, improving cellular migratory, and invasive capabilities. Moreover, overexpression of ETV5 has been correlated to cancer development and this gene has been implicated in cell proliferation. However, little is known about the downregulation of ETV5 expression in a pancreatic cell line and the inverse mesenchymal to epithelial transition (MET). Therefore, we studied the implications of ETV5 silencing over the phenotype of the insulinoma INS-1 (832/13) cell line and described the MET by partial ETV5 silencing in the INS-1 (832/13) cell line...
February 9, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38307092/ferroptosis-a-frontier-in-osteoporosis
#17
JOURNAL ARTICLE
Shubhrat Maheshwari, Aditya Singh, Amita Verma
Reduced bone mass and degeneration of the microarchitecture of bone tissue are the hallmarks of osteoporosis, a bone metabolic disease that increases skeletal fragility and fracture susceptibility. Osteoporosis is primarily caused by unbalanced bone remodeling, in which bone synthesis is outpaced by bone resorption caused by osteoclasts. Along with the bone-building vitamins calcium and vitamin D, typical medications for treating osteoporosis include bisphosphonates and calcitonin. The present therapies effectively stop osteoclast activation that is too high, however they come with varying degrees of negative effects...
February 2, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38307091/periostin-promotes-the-proliferation-differentiation-and-mineralization-of-osteoblasts-from-ovariectomized-rats
#18
JOURNAL ARTICLE
Jun Yan, Zidong Wang, Li Xian, Dawei Wang, Yunzhen Chen, Jie Bai, Hai-Juan Liu
Perimenopausal period causes a significant amount of bone loss, which results in primary osteoporosis (OP). The Periostin (Postn) may play important roles in the pathogenesis of OP after ovariectomized (OVX) rats. To identify the roles of Postn in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in OVX rats, we investigated the expression of Wnt/β-catenin signaling pathways in BMSC-OB and the effects of Postn on bone formation by development of BMSC-OB cultures. Twenty-four female Sprague-Dawley rats at 6 months were randomized into 3 groups: sham-operated (SHAM) group, OVX group and OVX+Postn group...
February 2, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38307090/maternal-gestational-diabetes-mellitus-and-congenital-heart-disease-in-offspring-a-meta-analysis
#19
JOURNAL ARTICLE
Yun Liu, Lina Yue, Li Chang
Maternal diabetes has been related to an increased risk of congenital heart disease (CHD) in offspring. However, inconsistent results were retrieved for studies evaluating the association between gestational diabetes mellitus (GDM) and CHD in offspring. We therefore performed a systematic review and meta-analysis for comprehensive investigation. Observational studies were identified by searching PubMed, Embase, and Web of Science according to the aim of the meta-analysis. A randomized-effects model was used to pool the data by incorporating the influence of potential heterogeneity...
February 2, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38286403/hsa_circ_0092355-accelerates-papillary-thyroid-cancer-progression-by-regulating-the-mir-543-pde5a-pathway
#20
JOURNAL ARTICLE
Zhijun Sun, Min Zhang, Yangmei Ye, Leilei Yang
CircRNAs have been found to participate in the progression of various tumors. In the present study, we aimed to clarify the role of hsa_circ_0092355 in papillary thyroid cancer (PTC) cell development. RT-qPCR was used to determine the expression of hsa_circ_0092355, miR-543, and PDE5A. PTC cell proliferation was ascertained via a cell colony formation assay and the CCK-8 test. Western blotting was performed to examine the expression levels of PDE5A and apoptosis-associated proteins (Bcl-2 and Bax) in PTC cells...
January 29, 2024: Hormone and Metabolic Research
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