journal
https://read.qxmd.com/read/38580614/day-21-bone-marrow-findings-incorrectly-designate-residual-leukaemia-in-flt3-mutated-acute-myeloid-leukaemia-treated-with-intensive-induction-plus-midostaurin-a-morphology-focused-study
#21
JOURNAL ARTICLE
Aditya Tedjaseputra, Sukanya Roy, Kay Htun, Danielle Oh, Zoe McQuilten, Paul Yeh, Ashwini Bennett, Michael Sze Yuan Low, Sanjeev Chunilal, Erica M Wood, Jake Shortt
Early induction response assessment with day-21 bone marrow (D21-BM) is commonly performed in patients with FLT3-mutated acute myeloid leukaemia (AML), where detection of residual leukaemia (RL; blasts ≥5%) typically results in the administration of a second induction course. However, whether D21-BM results predict for RL at the end of first induction has not been systematically assessed. This study evaluates the predictive role of D21-BM morphology in detecting RL following first induction. Between August 2018 and March 2022, all patients with FLT3-AML receiving 7+3 plus midostaurin, with D21-BM performed, were identified...
March 13, 2024: Pathology
https://read.qxmd.com/read/38480051/prognostic-factors-in-clinicopathology-of-oesophagogastric-adenocarcinoma-a-single-centre-longitudinal-study-of-347-cases-over-a-20-year-period
#22
JOURNAL ARTICLE
Qin Huang, Edward Lew, Yuqing Cheng, Kevin Huang, Vikram Deshpande, Shweta Shinagare, Xin Yuan, Jason S Gold, Daniel Wiener, H Christian Weber
Oesophagogastric adenocarcinoma (EGA) includes oesophageal (EA), gastro-oesophageal junctional (GEJA), and gastric (GA) adenocarcinomas. The prognostic values of clinicopathological factors in these tumours remain obscure, especially for GEJA that has been inconsistently classified and staged. We studied the prognosis of EGA patients among the three geographic groups in 347 consecutive patients with a median age of 70 years (range 47-94). All patients were male, and 97.1% were white. Based on tumour epicentre location, EGAs were sub-grouped into EA (over 2 cm above the GEJ; n=3, 18...
February 27, 2024: Pathology
https://read.qxmd.com/read/38360444/bowen-disease-is-not-synonymous-with-intraepidermal-squamous-cell-carcinoma
#23
REVIEW
Benjamin A Wood, Nathan T Harvey, Nima Mesbah Ardakani, David Paton
The terms 'Bowen disease' and 'intraepidermal squamous cell carcinoma' are sometimes considered synonymous. In this paper we present historical, clinical, histological and molecular evidence that this is incorrect. The term Bowen disease should be reserved for a subset of intraepidermal squamous cell carcinoma with a distinctive and reproducible morphological pattern, described in detail by Bowen in 1912. One other common subset of intraepidermal squamous cell carcinoma represents progression of actinic keratosis...
April 2024: Pathology
https://read.qxmd.com/read/38341306/point-of-care-diagnosis-of-tissue-fibrosis-a-review-of-advances-in-vibrational-spectroscopy-with-machine-learning
#24
REVIEW
Varun J Sharma, Aashima Singh, James Llewelyn Grant, Jaishankar Raman
Histopathology is the gold standard for diagnosing fibrosis, but its routine use is constrained by the need for additional stains, time, personnel and resources. Vibrational spectroscopy is a novel technique that offers an alternative atraumatic approach, with short scan times, while providing metabolic and morphological data. This review evaluates vibrational spectroscopy for the assessment of fibrosis, with a focus on point-of-care capabilities. OVID Medline, Embase and Cochrane databases were systematically searched using PRISMA guidelines for search terms including vibrational spectroscopy, human tissue and fibrosis...
April 2024: Pathology
https://read.qxmd.com/read/38296676/tumoural-pellino-1-expression-and-pellino-1-expressive-cytotoxic-t-cells-are-associated-with-poor-prognosis-in-diffuse-large-b-cell-lymphoma
#25
JOURNAL ARTICLE
Su-Jin Shin, Jiwon Ko, Hee Sang Hwang, Jooryung Huh, Chang-Woo Lee, Jin-Kwan Lee, Heounjeong Go
Pellino-1 plays a role in regulating inflammation and immune responses, and its effects on tumours are complex, with different outcomes reported in various studies. Additionally, the role of Pellino-1 in diffuse large B-cell lymphoma (DLBCL) has not been thoroughly investigated. We aimed to examine the expression of Pellino-1 in tumour cells and tumour-infiltrating lymphocytes (TILs) separately and identify the clinicopathological significance of Pellino-1 expression in DLBCL. We evaluated Pellino-1 expression in 104 patients with DLBCL...
April 2024: Pathology
https://read.qxmd.com/read/38245478/prognostic-and-predictive-biomarkers-in-melanoma
#26
REVIEW
Nigel G Maher, Ismael A Vergara, Georgina V Long, Richard A Scolyer
Biomarkers help to inform the clinical management of patients with melanoma. For patients with clinically localised primary melanoma, biomarkers can help to predict post-surgical outcome (including via the use of risk prediction tools), better select patients for sentinel lymph node biopsy, and tailor catch-all follow-up protocols to the individual. Systemic drug treatments, including immune checkpoint inhibitor (ICI) therapies and BRAF-targeted therapies, have radically improved the prognosis of metastatic (stage III and IV) cutaneous melanoma patients, and also shown benefit in the earlier setting of stage IIB/C primary melanoma...
March 2024: Pathology
https://read.qxmd.com/read/38238239/predictive-and-prognostic-biomarkers-in-gastrointestinal-tract-tumours
#27
REVIEW
Klaudia M Nowak, Runjan Chetty
Tumours of the gastrointestinal tract represent nearly a quarter of all newly diagnosed tumours diagnosed in 2019. Various treatment modalities for gastrointestinal cancers exist, some of which may be guided by biomarkers. Biomarkers act as gauges of either normal or pathogenic processes or responses to an exposure or intervention. They come in many forms. This review explores established and potential molecular/immunohistochemical (IHC) predictive and prognostic biomarkers of the gastrointestinal tract.
March 2024: Pathology
https://read.qxmd.com/read/38199927/predictive-and-prognostic-biomarkers-in-urological-tumours
#28
REVIEW
Alessia Cimadamore, Carmine Franzese, Carla Di Loreto, Ana Blanca, Antonio Lopez-Beltran, Alessandro Crestani, Gianluca Giannarini, Puay Hoon Tan, Benedito A Carneiro, Wafik S El-Deiry, Rodolfo Montironi, Liang Cheng
Advancements in cutting-edge molecular profiling techniques, such as next-generation sequencing and bioinformatic analytic tools, have allowed researchers to examine tumour biology in detail and stratify patients based on factors linked with clinical outcome and response to therapy. This manuscript highlights the most relevant prognostic and predictive biomarkers in kidney, bladder, prostate and testicular cancers with recognised impact in clinical practice. In bladder and prostate cancer, new genetic acquisitions concerning the biology of tumours have modified the therapeutic scenario and led to the approval of target directed therapies, increasing the quality of patient care...
March 2024: Pathology
https://read.qxmd.com/read/38480050/clinical-profile-and-serological-correlation-with-haemolysis-in-dat-positive-autoimmune-haemolytic-anaemia-patients-in-bangladesh
#29
JOURNAL ARTICLE
Anika Mahmood, Ayesha Khatun, Mahamudul Hasan, Sonia Shormin Miah, Md Mazharul Hoque Tapan, Atiar Rahman
Discerning the type of autoimmune haemolytic anaemia (AIHA) is crucial for transfusion support and initiation of treatment. This study aimed to establish the clinical profile and serological character of red cell autoantibodies and to investigate the relationship with haemolysis in AIHA patients who were direct antiglobulin test (DAT)-positive. A total of 59 DAT-positive AIHA patients were included in this study. Clinical, laboratory and serological findings were evaluated to find the gradation of haemolysis and to investigate its correlation with age, sex, type of autoantibody and level of autoantibody...
February 24, 2024: Pathology
https://read.qxmd.com/read/38480049/epithelioid-cell-histiocytoma-associated-with-irf2bp2-ntrk1-fusion
#30
LETTER
Benjamin A Wood, Urszula Carr, Chris Van Vliet, Nima Mesbah Ardakani
No abstract text is available yet for this article.
February 17, 2024: Pathology
https://read.qxmd.com/read/38480048/granuloma-formation-is-insufficient-for-differentiating-hidradenitis-suppurativa-and-cutaneous-crohn-s-disease
#31
LETTER
Moeza Arona Merchant, Timothy Liu, Erin McMeniman, Duncan Lambie
No abstract text is available yet for this article.
February 17, 2024: Pathology
https://read.qxmd.com/read/38471986/cutaneous-diatoms-from-diatomaceous-earth-mimicking-myiasis-infection
#32
LETTER
Simon F Roy, Goran Micevic, Jennifer M McNiff, Sean R Christensen, Shawn E Cowper
No abstract text is available yet for this article.
February 17, 2024: Pathology
https://read.qxmd.com/read/38413253/the-frequency-and-clinical-outcome-of-mono-hit-and-multi-hit-tp53-aberrations-in-newly-diagnosed-multiple-myeloma
#33
JOURNAL ARTICLE
Sreejesh Sreedharanunni, Shelly Singla, Anand Balakrishnan, Archana Singh, Manu Jamwal, Namrata Singh, Charanpreet Singh, Aditya Jandial, Deepesh Lad, Praveen Sharma, Man Updesh Singh Sachdeva, Pankaj Malhotra, Reena Das
We investigated the frequency and outcome of mono-hit and multi-hit TP53 aberrations [biallelic or ≥1 TP53 mutations (TP53mut) or TP53mut with variant allele frequency (VAF) ≥55%] in an Indian cohort of newly diagnosed multiple myeloma (NDMM) patients. We employed fluorescence insitu hybridisation (FISH; n=457) and targeted next-generation sequencing (NGS; n=244) on plasma cell-enriched samples. We also studied the impact of TP53mut in cases with and without TP53 deletions (TP53del). In our cohort with a median age of 60 years, TP53del and TP53mut were seen in 12...
February 15, 2024: Pathology
https://read.qxmd.com/read/38413251/smarca4-deficiency-and-mutations-are-frequent-in-large-cell-lung-carcinoma-and-are-prognostically-significant
#34
JOURNAL ARTICLE
Alvin Ho-Kwan Cheung, Kit-Yee Wong, Shuk-Ling Chau, Fuda Xie, Zeta Mui, Gordon Yuan-Ho Li, Molly Siu Ching Li, Joanna Tong, Calvin Sze-Hang Ng, Tony S Mok, Wei Kang, Ka-Fai To
SMARCA4 mutation has emerged as a marker of poor prognosis in lung cancer and has potential predictive value in cancer treatment, but recommendations for which patients require its investigation are lacking. We comprehensively studied SMARCA4 alterations and the clinicopathological significance in a large cohort of immunohistochemically-subtyped non-small cell lung cancer (NSCLC). A total of 1416 patients was studied for the presence of SMARCA4 deficiency by immunohistochemistry (IHC). Thereafter, comprehensive sequencing of tumours was performed for 397 of these patients to study the mutational spectrum of SWI/SNF and SMARCA4 aberrations...
February 15, 2024: Pathology
https://read.qxmd.com/read/38413254/observations-from-a-national-sample-exchange-program-for-molecular-haematology-testing
#35
JOURNAL ARTICLE
Clare Gould, Michelle McBean, Ella Thompson, Jennifer Lickiss, Ing Soo Tiong, David Westerman, Piers Blombery
External quality assessment programs (EQAP) for molecular haematology generally only assess the analytical phase of laboratory testing or provide limited evaluation of post-analytical components. We incorporated comprehensive post-analytical evaluation into an existing national inter-laboratory sample exchange program for molecular haematology due to the increasing complexity of diagnostic molecular testing and interpretation. We report key findings from four years of longitudinal data using this approach. Eighteen participating laboratories enrolled in an annual reciprocal sample exchange program from 2019-2022, which covered conventional and next-generation sequencing (NGS) assays...
February 12, 2024: Pathology
https://read.qxmd.com/read/38413252/non-coding-rna-and-gene-expression-analyses-of-papillary-renal-neoplasm-with-reverse-polarity-prnrp-reveal-distinct-pathological-mechanisms-from-other-renal-neoplasms
#36
JOURNAL ARTICLE
Stéphane Nemours, María Armesto, María Arestín, Claudia Manini, Doriana Giustetto, Maris Sperga, Kristyna Pivovarcikova, Delia Pérez-Montiel, Ondrej Hes, Michal Michal, José I López, Charles H Lawrie
Papillary renal neoplasm with reversed polarity (PRNRP) is a recently described rare renal neoplasm. Traditionally, it was considered a variant of papillary renal cell carcinoma (PRCC). However, several studies reported significant differences between PRNRP and PRCC in terms of clinical, morphological, immunohistochemical and molecular features. Nonetheless, PRNRP remains a poorly understood entity. We used microarray analysis to elucidate the non-coding RNA (ncRNA) and gene expression profiles of 10 PRNRP cases and compared them with other renal neoplasms...
February 7, 2024: Pathology
https://read.qxmd.com/read/38403560/effects-of-blood-sample-storage-time-temperature-anti-coagulants-and-blood-stabiliser-on-lymphocyte-phenotyping
#37
JOURNAL ARTICLE
Yunyu Lao, Alex Quach, Khalida Perveen, Charles Hii, Antonio Ferrante
Medical diagnostic laboratories have come under further scrutiny to ensure quality standards of their service and external quality assurance (EQA) programs involving multiple laboratories have been used to gauge this quality based on a consensus. However, because of the geographical distances within a country or internationally, cell surface marker expressions may change due to time delays and transport temperatures. Attention was given to this issue some decades ago and hence requires a re-evaluation in consideration of updated methods, reagents and instruments for flow cytometry and phenotyping...
February 7, 2024: Pathology
https://read.qxmd.com/read/38403561/red-cell-antibodies-frequency-in-the-western-australian-antibody-register-and-australian-blood-donor-populations
#38
LETTER
Georgina Jacko, Tanya Powley, Tanya Cawthorne, Zhi Tan, James Daly
No abstract text is available yet for this article.
February 6, 2024: Pathology
https://read.qxmd.com/read/38395680/mpox-detection-in-clinical-specimens-by-three-commercial-real-time-pcr-assays-demonstrates-comparable-results
#39
LETTER
Siobhan Hurley, Ki Wook Kim, Ana Domazetovska, Cynthia Yau, Malinna Yeang, Linda Donovan, Jen Kok, William Rawlinson
No abstract text is available yet for this article.
February 1, 2024: Pathology
https://read.qxmd.com/read/38395679/clinical-significance-of-low-level-jak2-v617f-in-peripheral-blood-testing
#40
LETTER
Matthew Rubic, Linda Lee, William Stevenson
No abstract text is available yet for this article.
February 1, 2024: Pathology
journal
journal
22087
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.