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Journal of Reproductive Medicine

Miriam S Krause, Kristine Holthouser, Jeremy T Gaskins, Henry C L Bohler, Steven T Nakajima
OBJECTIVE: To determine whether the Bayes classifier can be used to distinguish between an ectopic and intrauterine pregnancy following embryo transfer based on early human chorionic gonadotropin (hCG) levels. STUDY DESIGN: Retrospective chart review of patients undergoing in vitro fertilization and diagnosed with a singleton intrauterine or with an ectopic pregnancy. Blood was drawn for hCG levels between days 12 and 20 after transvaginal oocyte aspiration. Statistical analysis was performed using a mixed effects model and the Bayes classifier...
May 2017: Journal of Reproductive Medicine
Junhao Yan, Qian Zhang, Yanqin Chen, Zi-Jiang Chen
BACKGROUND: Homologous Robertsonian translocation carriers have been considered to have no chance, theoretically, of having a normal embryo. For these carriers, traditional genetic counseling would suggest using donated sperm or oocyte rather than using their own gametes. CASE: This study reports the case of a 45,XY,t(21;21)(q10;q10) homologous Robertsonian translocation carrier who had an approximately normal offspring with a mosaic karyotype: 46,XX,[86]/46, XX,t(21;21)[14]. CONCLUSION: Carriers of homologous Robertsonian translocations might have a chance of having normal offspring...
May 2017: Journal of Reproductive Medicine
Natasha Gupta, Nirbhay Parashar, Richard Trester, Josef Blankstein
BACKGROUND: Birth-related injuries are a well-known complication of vaginal breech deliveries but are not anticipated during cesarean breech deliveries. However, long bone fractures in the neonate can result from delivery of the breech presentation by cesarean section. CASES: We report 2 cases of long bone fractures that occurred during cesarean section for breech presentation. No underlying bone pathology or systemic illness could be identified in either case. There were no other predisposing risk factors for fractures except breech presentation...
May 2017: Journal of Reproductive Medicine
Kristin Van Heertum, Stephen Somkuti, Jennifer Nichols, Jay Schinfeld, Michael Sobel, Larry Barmat
OBJECTIVE: To determine if autologous endometrial cell coculture improves embryo development and clinical outcomes. STUDY DESIGN: Patients who met the inclusion criteria were randomized to either traditional in vitro fertilization (IVF) (control, n=73) or autologous endometrial cell coculture (AECC) (n=61). All patients underwent endometrial biopsy on cycle day 5–10 post luteinizing hormone surge. A total of 129 patients underwent embryo transfer (69 control, 60 AECC). Clinical outcomes as well as embryonic quality measures were then compared between the 2 groups...
May 2017: Journal of Reproductive Medicine
Ji Yeon Lee, Jong Yun Hwang
OBJECTIVE: To evaluate the effects of 1.765 GHz microwave on fetal testicular gene expression in mice. STUDY DESIGN: We used a 1.765 GHz microwave generator with 26.7 dBm output power on average and with the estimated specific absorption rate of 0.38–1.71 W/kg. Twelve mice in the experimental group had been exposed to 1.765 GHz micro-waves for 8 hours every day. The testicular gene expression extracted from the neonates separated from all the offspring were compared with microarray and reverse transcription polymerase chain reaction (RT-PCR)...
May 2017: Journal of Reproductive Medicine
Mansour Almansour, Qais Jarrar, Abdelkader Battah, Bashir Jarrar
OBJECTIVE: To investigate the histomorphometric alterations induced in testicular tissues by variable sizes of silver nanoparticles (SNPs). STUDY DESIGN: Male mice (BALB/C) were treated with SNPs (1 mg/kg) using 5 different sizes (10, 20, 40, 60, and 100 nm) for 35 days. Testicular biopsies from all mice under study were examined histomorphologically. RESULTS: SNPs sized 10 and 20 nm had provoked morphometric changes in the testes of the subjected mice together with the following histological alterations: seminiferous tubules, degeneration, spermatocyte cytoplasmic vacuolation, spermatocyte sloughing, and spermatid giant cell formation...
May 2017: Journal of Reproductive Medicine
Teppei Takeshima, Yasushi Yumura, Shinnosuke Kuroda, Yoshitake Kato, Kazumi Noguchi, Akira Iwasaki
OBJECTIVE: To evaluate the efficacy of varicocele repair in patients with nonobstructive azoospermia. STUDY DESIGN: Ten patients with nonobstructive azoospermia and clinical varicoceles who underwent varicocele repair were retrospectively investigated. According to the postoperative appearance of motile spermatozoa in the ejaculate, the patients were divided into 2 groups: Responder and Nonresponder. The outcomes of each group were investigated. RESULTS: There were 4 (40%) patients in the Responder group. Serum follicle-stimulating hormone levels were significantly higher in the Nonresponder group than in the Responder group (19...
May 2017: Journal of Reproductive Medicine
Huiqin Xue, Lan Ma, Jinjie Xue, Xiayu Sun, Ming Li, Hongyong Lu, Yan Zhou, Yuezhen Guo, Yuping Zhang, Jigeng Bai
OBJECTIVE: To investigate the function and underlying mechanism of transforming growth factor–beta (TGF-β)/bone morphogenetic protein (BMP) signaling pathway in early unexplained miscarriage. STUDY DESIGN: Expression profiles of genes involved in TGF-β/BMP signaling pathway were compared between placental villous tissue samples from 2 women with missed abortion and those from 2 women with induced abortion by microarray assay. The protein expression level of the most downregulated gene—LEFTY1—was further measured using western blotting in another 8 women with missed abortion and 7 women with induced abortion...
May 2017: Journal of Reproductive Medicine
Aytekin Tokmak, Ali Irfan Guzel, Gürhan Güney, Umit Tasdemir, Coskun Umit, Nafiye Yilmaz
OBJECTIVE: To evaluate the effect of obesity on clinical parameters and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS), who have undergone ovulation induction. STUDY DESIGN: This retrospective study included 177 women with PCOS who presented to our gynecological endocrinology outpatient clinic for diagnosed infertility. All of the patients initially received clomiphene citrate (CC), and if CC resistance was noted, gonadotropins were used. The patients were classified into 2 groups according to BMI (<30 kg/m2=control group and ≥30 kg/m2=study group)...
May 2017: Journal of Reproductive Medicine
Jae Eun Shin, Jong Chul Shin, Sa Jin Kim, Young Lee, Soo Ah Im, In Yang Park
OBJECTIVE: To evaluate whether magnetic resonance imaging (MRI) contributes to ultrasound for the evaluation of fetal central nervous system (CNS) anomalies. The secondary objective was to investigate whether MRI adds more information regarding the evaluation of specific pathologies or conditions. STUDY DESIGN: We retrospectively compared fetal MRI findings with ultrasound findings in CNS anomalies with respect to certain pathologic groups. Additionally, we evaluated diagnostic accuracy by comparing fetal MRI and ultrasound findings with postnatal findings...
May 2017: Journal of Reproductive Medicine
Bo Xu, Haidong Cheng, Xiaotian Li, Nebhani Mouna
OBJECTIVE: To investigate the trend of cesarean section (CS) delivery rate and CS indications between January 2009 and December 2013 at Hassan II Hospital, Settat, Morocco. STUDY DESIGN: The demographic characteristics of women who gave birth at the hospital during the study period were collected. A total of 36,965 puerperal patients (aged 14–52 years at 33–42 weeks’ gestation) were enrolled. Delivery outcomes and the indication for CS delivery were studied. RESULTS: The CS rate increased from 11.48% in 2009 to 14...
May 2017: Journal of Reproductive Medicine
Sen-lin Shi, Zhao-feng Peng, Gui-dong Yao, Hai-xia Jin, Wen-yan Song, Hong-yi Yang, Ying-pu Sun
OBJECTIVE: To analyze the related causes for no embryos transferred in assisted reproductive technology (ART) in order to provide corresponding coping measures for infertile couples. STUDY DESIGN: The data of 607 couples who underwent ART and had no embryos transferred in our reproductive center between January 2010 and January 2014 were retrospectively analyzed. RESULTS: The cycles of no embryos transferred accounted for 3.99% (607/15,224) of total cycles. Of those, complete fertilization failure, oocyte retrieval failure, and complete abnormal fertilization accounted for 28...
May 2017: Journal of Reproductive Medicine
Quan Huang, Jian Liu, Tenghui Chen, Lei Li, Lu Wang, Yelin Wu
OBJECTIVE: To uncover potential genes and biological processes that contribute to breast cancer development. STUDY DESIGN: We studied gene expression profiles, which are publicly available from the Gene Expression Omnibus database, for the 2 most prevailing subtypes of breast cancer: lobular and ductal invasive breast carcinomas. RESULTS: We identified a total of 98 genes that shared regulation pattern in both subtypes of breast carcinoma. Further functional annotations indicated that 124 biological processes and 8 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were over-represented, such as cell surface receptor signaling pathway...
May 2017: Journal of Reproductive Medicine
Seung-Hyuk Shim, Sun Joo Lee, Seung Woo Yang, Ji Young Lim, Soo-Hyun Cho, Wook Youn Kim, Hee Sun Kim, Soo-Nyung Kim
OBJECTIVE: To compare the resection margin (RM) status and postoperative severe hemorrhage using different loop electrosurgical excision procedure (LEEP) techniques for cervical intraepithelial neoplasia (CIN) 2/3 treatment. STUDY DESIGN: We retrospectively reviewed 278 patients who underwent LEEPs for CIN 2/3 treatment at our institute between 2005–2014. In type A surgery (N=148), a ring-shaped loop was used. If the first pass failed to remove the entire lesion, separate loop excisions for the intracervical portion were performed...
May 2017: Journal of Reproductive Medicine
María Inés Bianconi, Silvina Otero, Claudio Storino, Gustavo Jankilevich
OBJECTIVE: To evaluate the role of capecitabine in the management of gestational trophoblastic neoplasia (GTN). STUDY DESIGN: The medical records of 155 patients with GTN were reviewed. All patients were treated and followed at our center. RESULTS: All patients were scored and stratified with the FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease. In the low-risk group (118 patients), 4 selected patients received capecitabine as second line of treatment, with a 75% response rate and long-term disease-free survival, and 1 of those patients needed EMA/CO to achieve cure...
May 2017: Journal of Reproductive Medicine
Patricia Rekawek, Frederick Friedman, Bertille Gaigbe-Togbe, Joseph Lee, Alan B Copperman
OBJECTIVE: To evaluate the correlation between em-bryo morphology and antepartum biomarker levels and obstetric outcomes following single embryo transfers (SETs). STUDY DESIGN: In vitro fertilization patients who delivered at the study site’s partnering hospital were included. Embryo morphology was compared to antepartum biomarkers and pregnancy outcomes. RESULTS: At a single academic reproductive endocrinology/infertility center, 2,882 SETs (day 3, 5, or 6) were performed from July 1, 2001, to June 30, 2013...
May 2017: Journal of Reproductive Medicine
Glauco Baiocchi, Maria Dirlei Begnami, Michael Jenwei Chen, Elza Mieko Fukazawa, Levon Badiglian-Filho, Antonio Cassio Assis Pellizzon, Fernando Augusto Soares, Ademar Lopes
Glauco Baiocchi, M.D., Ph.D., Maria Dirlei Begnami, M.D., Ph.D., Michael Jenwei Chen, M.D., Elza Mieko Fukazawa, M.D., Ph.D., Levon Badiglian-Filho, M.D., Ph.D., Antonio Cassio Assis Pellizzon, M.D., Ph.D., Fernando Augusto Soares, M.D., Ph.D., and Ademar Lopes, M.D., Ph.D. OBJECTIVE: To evaluate HER-2 expression as a predictor of the response to radiotherapy and its value as a prognostic marker. STUDY DESIGN: A retrospective analysis was performed in a series of 34 individuals with advanced stage cervical cancer who underwent radiotherapy followed by radical hysterectomy...
May 2017: Journal of Reproductive Medicine
Elie Hobeika, Shaveta Malik, Michael L Traub, Seleshi Demissie, Eric S Knochenhauer
OBJECTIVE: To investigate if administration of an additional dose of gonadotropins concomitantly to human chorionic gonadotropin (hCG) trigger increases pregnancy rates in patients undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH). STUDY DESIGN: This is a retrospective cohort study of all gonadotropin-IUI cycles performed by a single physician in a private practice between January 2012 and September 2013. Control cycles were those in which follicle-stimulating hormone (FSH) was discontinued prior to the day of hCG trigger shot, and study cycles received continuous FSH including the day of hCG trigger shot...
May 2017: Journal of Reproductive Medicine
Javine McLaughlin, Lawrence D Devoe
OBJECTIVE: To review the safety and efficacy of administering various prostaglandin formulations to achieve cervical ripening and spontaneous vaginal delivery in women near or at term. STUDY DESIGN: Peer-reviewed clinical research articles in English and searchable on A thorough literature search was conducted on using the following terms: [misoprostol], [dinoprostone], [prostaglandin E1], [prostaglandin E2], [PGE1], [PGE2], [cervical ripening], [induction of labor]. RESULTS: The review shows conflicting opinions concerning the safety and efficacy of current standard-of-care formulations for cervical ripening...
May 2017: Journal of Reproductive Medicine
Adam Ostrzenski
No abstract text is available yet for this article.
March 2017: Journal of Reproductive Medicine
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