Kanako Taba, Masako Honsho, Yukihiro Asami, Hiromu Iwasaki, Kenichi Nonaka, Yoshihiro Watanabe, Masato Iwatsuki, Hidehito Matsui, Hideaki Hanaki, Toshiaki Teruya, Takahiro Ishii
Six aromatic secondary metabolites, pestalone (1), emodin (2), phomopsilactone (3), pestalachlorides B (4), C (5), and D (6), were isolated from Pestalotiopsis sp. FKR-0115, a filamentous fungus collected from white moulds growing on dead branches in Minami Daito Island. The efficacy of these secondary metabolites against methicillin-resistant Staphylococcus aureus (MRSA) with and without meropenem (β-lactam antibiotic) was evaluated using the paper disc method and broth microdilution method. The chemical structures of the isolated compounds (1-6) were characterised using spectroscopic methods, including nuclear magnetic resonance and mass spectrometry...
June 10, 2023: Journal of General and Applied Microbiology