Li Zhui, Chen Yuling, Wang Hansheng, Li Xiangjie
Arteriovenous fistula (AVF) failure often involves venous neointimal hyperplasia (VNH) driven by elevated hypoxia-inducible factor-1 alpha (HIF-1α) in the venous wall. Omentin, known for its anti-inflammatory and anti-hyperplasia properties, has an uncertain role in early AVF failure. This study investigates omentin's impact on VNH using a chronic renal failure (CRF) rabbit model. The CRF rabbit model of AVF received omentin-expressing adenoviral vector or control β-gal vector to assess omentin's effects on VNH...
April 17, 2024: Microvascular Research
Xiaoxiang Xu, Xihui Ding, Zizhuo Wang, Shujiang Ye, Jianguang Xu, Zugang Liang, Renfei Luo, Jinyong Xu, Xiaohui Li, Zhenhua Ren
Pathological retinal angiogenesis is not only the hallmark of retinopathies, but also a major cause of blindness. Guanylate binding protein 2 (GBP2) has been reported to be associated with retinal diseases such as diabetic retinopathy and hypoxic retinopathy. However, GBP2-mediated pathological retinal angiogenesis remains largely unknown. The present study aimed to investigate the role of GBP2 in pathological retinal angiogenesis and its underlying molecular mechanism. In this study, we established oxygen-induced retinopathy (OIR) mice model for in vivo study and hypoxia-induced angiogenesis in ARPE-19 cells for in vitro study...
April 16, 2024: Microvascular Research
Mathieu Magnin, Morgane Gavet, Thien-Tam Ngo, Vanessa Louzier, Tatiana Victoni, Jean Yves Ayoub, Bernard Allaouchiche, Jeanne-Marie Bonnet-Garin, Stéphane Junot
Sepsis is associated with hypoperfusion and organ failure. The aims of the study were: 1) to assess the effect of pimobendan on macrocirculation and perfusion and 2) to describe a multimodal approach to the assessment of perfusion in sepsis and compare the evolution of the perfusion parameters. Eighteen anaesthetized female piglets were equipped for macrocirculation monitoring. Sepsis was induced by an infusion of Pseudomonas aeruginosa. After the occurrence of hypotension, animals were resuscitated. Nine pigs received pimobendan at the start of resuscitation maneuvers, the others received saline...
April 11, 2024: Microvascular Research
Kiana M Schulze, Andrew G Horn, Judy M Muller-Delp, Zachary J White, Stephanie E Hall, Steven L Medarev, Ramona E Weber, David C Poole, Timothy I Musch, Bradley J Behnke
Pulmonary hypertension (PH) is a chronic, progressive condition in which respiratory muscle dysfunction is a primary contributor to exercise intolerance and dyspnea in patients. Contractile function, blood flow distribution, and the hyperemic response are altered in the diaphragm with PH, and we sought to determine whether this may be attributed, in part, to impaired vasoreactivity of the resistance vasculature. We hypothesized that there would be blunted endothelium-dependent vasodilation and impaired myogenic responsiveness in arterioles from the diaphragm of PH rats...
April 11, 2024: Microvascular Research
Ayman A Mohammed, Siqi Li, Hengbin Zhang, Fuad A Abdu, Abdul-Quddus Mohammed, Wen Zhang, Ekhlas Mahmoud Al-Hashedi, Yawei Xu, Wenliang Che
BACKGROUND: Coronary microvascular dysfunction (CMD) is frequently observed in atrial fibrillation (AF), the most commonly sustained arrhythmia. Nevertheless, an in-depth prognostic significance of CMD in AF is lacking. We aimed to provide insight into the predictive impact of CMD assessed by a novel non-invasive coronary angiography-derived index of microcirculatory resistance (caIMR) for major adverse events (MACE) in AF patients. METHOD: This study included patients with AF who underwent invasive coronary angiography due to suspected cardiac ischemia and did not exhibit obstructive epicardial coronary artery disease (≤50 % stenosis)...
April 7, 2024: Microvascular Research
Nazir Soubine Neto, Marcela Curci Vieira de Almeida, Helton de Oliveira Couto, Carlos Henrique Miranda
BACKGROUND: Microvascular dysfunction plays a central role in organ dysfunction during septic shock. Endothelial glycocalyx (eGC) damage could contribute to impaired microcirculation. The aim was to assess whether several eGC-damaged biomarkers are associated with microvascular dysfunction in resuscitated septic shock patients. METHODS: This cross-sectional study included resuscitated septic shock patients (N = 31), and a group of healthy individuals (N = 20)...
March 22, 2024: Microvascular Research
Anamika Sharma, Dhiraj Kumar Gupta, Shivantika Bisen, Nikhlesh K Singh
Dysfunctional pericytes and disruption of adherens or tight junctions are related to many microvascular diseases, including diabetic retinopathy. In this context, visualizing retinal vascular architecture becomes essential for understanding retinal vascular disease pathophysiology. Although flat mounts provide a demonstration of the retinal blood vasculature, they often lack a clear view of microaneurysms and capillary architecture. Trypsin and elastase digestion are the two techniques for isolating retinal vasculatures in rats, mice, and other animal models...
March 21, 2024: Microvascular Research
Bowen Shen, Lili Yang, Xiaoli Jia, Deping Kong, Yongfeng Gao, Shan Gao, Ruimin Chen, Fengbao Chen, Chunyu Zhao, Yue Li, Rui Tan, Xiaomin Zhao
BACKGROUND: Arterial baroreflex dysfunction, like many other central nervous system disorders, involves disruption of the blood-brain barrier, but what causes such disruption in ABR dysfunction is unclear. Here we explored the potential role of platelets in this disruption. METHODS: ABR dysfunction was induced in rats using sinoaortic denervation, and the effects on integrity of the blood-brain barrier were explored based on leakage of Evans blue or FITC-dextran, while the effects on expression of CD40L in platelets and of key proteins in microvascular endothelial cells were explored using immunohistochemistry, western blotting and enzyme-linked immunosorbent assay...
March 15, 2024: Microvascular Research
Qianyao Ye, Hao Yin, Jianan Lin, Junzhao Liang, Mugui Xie, Cong Ye, Bin Zhou, An Huang, Zhiwei Wu, Xiaosong Li, Yanxiong Wu
Changes in the structure and function of nailfold capillaries may be indicators of numerous diseases. Noninvasive diagnostic tools are commonly used for the extraction of morphological information from segmented nailfold capillaries to study physiological and pathological changes therein. However, current segmentation methods for nailfold capillaries cannot accurately separate capillaries from the background, resulting in issues such as unclear segmentation boundaries. Therefore, improving the accuracy of nailfold capillary segmentation is necessary to facilitate more efficient clinical diagnosis and research...
March 12, 2024: Microvascular Research
Sevdalina Nikolova Lambova
No abstract text is available yet for this article.
March 11, 2024: Microvascular Research
Abhishek Banerjee, Abhishek Indoliya, Raju Poddar
In optical imaging, optical clearing agents are commonly used to enhance the structural details of a sample. The current study investigates how to use it to improve the data obtained by an optical coherence tomography angiography system. A natural edible oil with no chemical base has been used for optical clearing. In-vivo testing on mice and humans yielded excellent optical clearing. Using computational techniques, the improvement in angiography signal caused by the optical clearing agent is investigated qualitatively and quantitatively...
March 7, 2024: Microvascular Research
Min Xiang, Runlin Yang, Yaqin Zhang, Pingping Wu, Lizhen Wang, Zhenyu Gao, Jianmei Wang
No abstract text is available yet for this article.
February 21, 2024: Microvascular Research
Ehteramolsadat Hosseini, Javad Ahmadi, Faranak Kargar, Mehran Ghasemzadeh
BACKGROUND: Coronary artery bypass grafting (CABG) is considered a choice treatment for patients suffering from coronary artery disease (CAD). In the inflammatory milieu of cardiopulmonary bypass (CPB), systemic inflammatory response syndrome (SIRS) can induce a platelet pro-inflammatory state which could exacerbate post-CABG inflammatory status while affecting later hemostatic function in patients. Therefore centered on platelets, the study presented here tried to evaluate the pro-inflammatory and immunomodulatory profile of platelets as well as pro-aggregatory status during CABG...
February 13, 2024: Microvascular Research
Rohit Patel, Sanjay Kumar, Johnna F Varghese, Navneendra Singh, Rana P Singh, Umesh C S Yadav
Extracellular signal-regulated kinase (Erk)-5 is a key mediator of endothelial cell homeostasis, and its inhibition causes loss of critical endothelial markers leading to endothelial dysfunction (ED). Circulating oxidized low-density lipoprotein (oxLDL) has been identified as an underlying cause of ED and atherosclerosis in metabolic disorders. Silymarin (Sym), a flavonolignan, possesses various pharmacological activities however its preventive mechanism in ED warrants further investigation. Here, we have examined the effects of Sym in regulating the expression of Erk-5 and ameliorating ED using in vitro and in vivo models...
January 31, 2024: Microvascular Research
Aida Ajan, Karin Roberg, Ingemar Fredriksson, Jahan Abtahi
OBJECTIVES: Laser Doppler Flowmetry (LDF) is a non-invasive technique for the assessment of tissue blood flow, but increased reproducibility would facilitate longitudinal studies. The aim of the study was to assess the interday reproducibility of Laser Doppler Flowmetry (LDF) at rest, at elevated local temperatures, and with the use of the vasodilator Methyl Nicotinate (MN) in six interconnected protocols for the measurement of the blood supply to the microvascular bed of the gingiva...
January 30, 2024: Microvascular Research
Magnusson Marine, Gerk Ulrich, Schüpbach Gertraud, Rieger Juliane, Plendl Johanna, Marin Ilka, Drews Barbara, Kaessmeyer Sabine
INTRODUCTION: Contrast-associated acute kidney injury (CA-AKI) is characterized as a loss of renal function following radiological contrast media administration. While all contrast media induce variable changes in microvascular endothelial cells in vitro, only few studies report clinical significance of their findings. A comprehensive assessment of the effect of iodinated contrast media on the renal function in vitro and in vivo is essential. The aim of our study was to morphometrically quantify the effect of two different contrast media (Iobitridol and Iodixanol) on vascular endothelial capillaries in vitro and to analyze their effect on the renal function of patients who underwent cardiac catheterization including the intra-arterial administration of contrast media, by measuring serum creatinine concentration (SCr), a byproduct of muscle metabolism, primarily excreted by the kidneys...
January 27, 2024: Microvascular Research
Jie Ma, Ran Xia, Yue Lan, Anqi Wang, Yaxing Zhang, Lihong Ma
BACKGROUND: Coronary microvascular dysfunction (CMD) is an important feature of obstructive hypertrophic cardiomyopathy (oHCM). Angiographic microvascular resistance (AMR) offers a potent means for assessing CMD. This study sought to evaluate the prognostic value of CMD burden calculated by AMR among oHCM patients. METHODS: We retrospectively screened all patients diagnosed with oHCM from Fuwai Hospital between January 2017 and November 2021. Off-line AMR assessments were performed for all 3 major coronary vessels by the independent imaging core laboratory...
January 24, 2024: Microvascular Research
Ava-Gaye Simms, Rosalia Parrino, Gustavo Rosa Gameiro, Jack Cipolla, Jianhua Wang, Hong Jiang, Joseph F Signorile
PURPOSE: To determine the changes in retinal microvascular density after a 24-week high-speed circuit resistance training program (HSCT) in healthy older adults. METHODS: Thirty healthy older adults were recruited and randomly assigned to either a training group (HSCT) or a non-training (CON) group. Fifteen subjects (age 73.3 ± 7.76 yrs) in the HSCT group exercised three times per week on non-consecutive days for 24 weeks. Fifteen subjects in the CON group (age 72...
May 2024: Microvascular Research
Antonietta Gigante, Chiara Pellicano, Oriana De Marco, Eleonora Assanto, Georgia Sorato, Alberto Palladini, Edoardo Rosato, Silvia Lai, Maurizio Muscaritoli, Rosario Cianci
BACKGROUND: Renal Resistive Index (RRI) is an important and non-invasive parameter of renal damage and it is associated with abnormal microcirculation or to a parenchymal injury. The aim of our study was to compare the RRI in a cohort of patients with renal diseases categorized in three groups: nephrotic syndrome (NS), acute nephritic syndrome (ANS) and patients with urinary abnormalities (UA). METHODS: Four hundred eighty-two patients with median age of 48 years (IQR 34-62) with indications for kidney disease were included in the study...
March 2024: Microvascular Research
J Prakash, K Ramesh, D Tripathi, R Kumar
No abstract text is available yet for this article.
January 23, 2024: Microvascular Research
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