Hongliang Li, Junxia Sun, Haibo Hu, Yi Wang
INTRODUCTION: Cisplatin (DDP) is the commonest chemo drug in lung adenocarcinoma (LUAD) treatment, and DDP resistance is a significant barrier to therapeutic therapy. This study attempted to elucidate the impact of PDK1 on DDP resistance in LUAD and its mechanism. METHODS: Bioinformatics analysis was used to determine the expression and enriched pathways of PDK1 in LUAD tissue. Subsequently, E2F8, the upstream transcription factor of PDK1 was predicted, and the binding relationship between the two was analyzed using dual-luciferase and ChIP experiments...
May 29, 2024: Pharmacology
Jing Wang, Jiaojiao Sun, Huizhi Yu, Chunlan Hu, Jinbo Wu, Chunxiao Hu
INTRODUCTION: The occurrence of lung ischemia-reperfusion injury (LIRI) after lung transplantation results in primary graft dysfunction (PGD) in more than 50% of cases, which seriously affects the prognosis of recipients. Currently, donor lung protection is the focus of research on improving graft survival in lung transplant recipients. Dexmedetomidine (Dex) is a widely used general anesthesia adjuvant in clinical practice to alleviate ischemia-reperfusion injury in the lungs, liver, heart, kidneys, and brain...
May 28, 2024: Pharmacology
Yangjun Cai, Haihong Zheng, Dong Xu, Jingjing Xie, Weiwen Wang, Zhiwei Liu, Zhongqiu Zheng
INTRODUCTION: Trastuzumab is commonly used in the treatment of human epidermal growth factor receptor-2 positive (HER-2+) breast cancer patients, but its efficacy is often limited by chemotherapy resistance. Recent studies indicate that long noncoding RNAs (lncRNAs) play important roles in tumor progression and response to therapy. However, the regulatory mechanism of lncRNAs in trastuzumab resistance is still unknown to date. METHODS: qPCR was performed to detect the expression of related genes...
May 14, 2024: Pharmacology
(no author information available yet)
No abstract text is available yet for this article.
May 6, 2024: Pharmacology
(no author information available yet)
No abstract text is available yet for this article.
May 6, 2024: Pharmacology
(no author information available yet)
No abstract text is available yet for this article.
April 25, 2024: Pharmacology
Wei Jiang, Junping Wang, Jiarong Wang, Xueran Chen, Zhiyou Fang, Chengmu Hu
BACKGROUND: Acetaminophen is commonly used as an antipyretic and analgesic agent. Excessive APAP can induce liver toxicity, known as APAP induced liver injury (ALI). The metabolism and pathogenesis of APAP have been extensively studied in recent years, and many cellular processes such as autophagy, mitochondrial oxidative stress, mitochondrial dysfunction and liver regeneration have been identified to be involved in the pathogenesis of ALI. Caveolin-1 (CAV-1) as a scaffold protein has also been shown to be involved in the development of various diseases, especially liver disease and tumorigenesis...
April 24, 2024: Pharmacology
Huabin Zhang, Yue Wang, Yong Wu, Zhongxu Luo, Ming Zhong, Zongyuan Hong, Deguo Wang
INTRODUCTION: Ventricular arrhythmia is commonly provoked by acute cardiac ischemia through sympathetic exaggeration and is often resistant to antiarrhythmic therapies. Thoracic epidural anesthesia has been reported to terminate fatal ventricular arrhythmia; however, its underlying mechanism is unknown. METHODS: Rats were randomly divided into four groups: sham, sham plus bupivacaine, ischemia/reperfusion (IR), and IR plus bupivacaine groups. Bupivacaine (1 mg/mL, 0...
April 22, 2024: Pharmacology
Amanda Cristina Reis Gonzaga, Jayane Laís Dias Quintão, Giovane Galdino, Thiago Roberto Lima Romero, Grazielle Caroline da Silva, Virgínia Soares Lemos, Gabriel Henrique Campolina-Silva, Cleida Aparecida de Oliveira, Germán Arturo Bohórquez Mahecha, Igor Dimitri Gama Duarte
INTRODUCTION: Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system...
April 20, 2024: Pharmacology
Guijun Liu, Xiang Liu, Wei Zeng, Wangyan Zhou
INTRODUCTION: This work was designed to delve into the effects of SKA3 on glycolysis and cisplatin (CDDP) resistance in LUAD cells and to find new possibilities for individualized treatment of LUAD. METHODS: LUAD mRNA expression data from the TCGA database were procured to scrutinize the differential expression patterns of SKA3 in both tumor and normal tissues. GSEA and Pearson correlation analyses were employed to elucidate the impact of SKA3 on signaling pathways within the context of LUAD...
April 20, 2024: Pharmacology
Yi Wang, Ying Zheng, Lijia Chen, Lingjie Lin, Binwu Chen, Zhengfeng Lin, Shihui Bao
OBJECTIVE: To investigate the independent risk factors associated with iatrogenic withdrawal syndrome in pediatric intensive care units (PICUs) and to establish receiver operator characteristic (ROC) curve to facilitate the diagnosis of iatrogenic withdrawal syndrome in clinical settings. METHOD: Pediatric patients who received analgesic and sedative medication at a tertiary hospital in the southern Zhejiang region of China between January 2016 and December 2022 were selected for the study...
April 17, 2024: Pharmacology
Zhengjun Chen, Qi Shi, Xuxia Liu, Guodi Lu, Jie Yang, Wenrong Luo, Fude Yang
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is a non-specific chronic inflammatory lung disease with no known cure. Codonopsis Radix(CR) has been shown to exhibit anti-inflammatory and antioxidant effects. Therefore, this study aimed to investigate the potential anti-inflammatory effects of different CR variety on COPD mice. METHODS: 60 male specified pathogen free (SPF)-grade C57BL/6J mice were randomly divided into 6 groups, 10 mice in each group...
April 12, 2024: Pharmacology
Mahluga Jafarova Demirkapu, Eyyup Cavdar
INTRODUCTION: Concomitant use of drugs in the same or different indications can sometimes lead to undesirable interactions. The prevalence of drug interactions is high in cancer patients. In this study, we aimed to determine the frequency and clinical severity of drug interactions in outpatient lung cancer patients. METHODS: The drugs used, kidney and liver blood analysis results of 160 outpatient lung cancer patients over the age of 18 who received chemotherapy between October 2020 and July 2021 were evaluated...
April 6, 2024: Pharmacology
Xiufang Jiang, Yanling Lei, Yajuan Yin, Fangfang Ma, Mingqi Zheng, Gang Liu
INTRODUCTION: Fisetin has been demonstrated to inhibit the occurrence of atherosclerosis, however, the mechanism of fisetin suppressing atherosclerosis remains elusive. METHODS: The function of fisetin in the inhibition of atherosclerosis was evaluated by hematoxylin and eosin and Oil Red O staining in ApoE-/- mice. Molecular biomarkers of atherosclerosis progression were detected by Western blot and qPCR. Moreover, the inhibition of atherosclerosis on oxidative stress and ferroptosis was evaluated by immunofluorescence staining, qPCR and Western blot assays...
April 5, 2024: Pharmacology
Rahmad Abdillah, Milla Maulina, Afni Rahmatika, Netty Suharti, Armenia Armenia
INTRODUCTION: Traditionally and empirically, Hibiscus sabdariffa L. have been used in treating diabetes mellitus due to their antioxidant activity. This study aims to investigate the effect of administering the ethyl acetate fraction of hibiscus calyxes on malondialdehyde (MDA) levels, Tumor Necrosis Factor-α (TNF-α) levels, bleeding time, and platelet count in male white rats induced with streptozotocin-induced diabetes. METHOD: Thirty-six Wistar Kyoto rats were induced with intra-peritoneal streptozotocin at 55 mg/kg BW and stabilized for five days to obtain diabetic conditions...
April 5, 2024: Pharmacology
Sreoshee Rafiq, Irene Mungure, Yara Banz, Nicolas J Niklaus, Thomas Kaufmann, Stefan Müller, Arnaud Jacquel, Guillaume Robert, Patrick Auberger, Bruce E Torbett, Sylviane Muller, Mario P Tschan, Magali Humbert
INTRODUCTION: Acute myeloid leukemia (AML) is a cancer of the hematopoietic system characterized by hyperproliferation of undifferentiated cells of the myeloid lineage. While most of AML therapies are focused towards tumor debulking, all-trans retinoic acid (ATRA) induces neutrophil differentiation in the AML subtype acute promyelocytic leukemia (APL). Macroautophagy has been extensively investigated in the context of various cancers and is often dysregulated in AML where it can have context-dependent pro- or anti-leukemogenic effects...
April 3, 2024: Pharmacology
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang, Binjie Gui
INTRODUCTION: IDN5706 is a tetrahydro derivative of hyperforin. In this study, we aimed to explore the effect of IDN5706 on synovial macrophages in osteoarthritis (OA) rats, and the underlying mechanisms. METHODS: OA rats were employed for the in vivo experiments, and RAW264.7 cells were employed for the in vitro experiments. Histopathological changes in synovium were examined using hematoxylin and eosin (HE) staining; Cell apoptosis in synovium was assessed by TUNEL staining; Macrophages polarization was determined by immunohistochemical analysis and flow cytometry; The mRNA expression and protein level of genes were detected by qRT-PCR and western blot; The efferocytosis of macrophages was assessed by flow cytometry...
April 2, 2024: Pharmacology
Wenyan Zhong, Jingjing Chen, Guangfu Xu, Li Xiao
INTRODUCTION: To investigate the effect and mechanism of Kaempferol on alcoholic steatohepatitis. METHODS: C57BL/6 N mice were utilized to establish Binge-on-Chronic alcohol exposure mice model. Kaempferol was given as the interventional drug to chronic alcohol-fed mice for six weeks to assess its effects. In vitro, intestinal epithelial Caco-2 cells were stimulated by alcohol, and miRNA-155 mimics were used to further study the effect of kaempferol to miRNA-155 signaling in intestinal epithelial cells...
March 16, 2024: Pharmacology
Yaqian Luo, Fangzhou He, Yifang Zhang, Shufan Li, Ruirui Lu, Xing Wei, Ji Huang
BACKGROUND: According to the World Health Organisation's Health Report 2019, approximately 17.18 million people die from cardiovascular disease each year, accounting for more than 30% of all global deaths. Therefore, the occurrence of cardiovascular disease is still a global concern. The transcription factor 21 (TCF21) plays an important role in cardiovascular diseases. This article reviews the regulation mechanism of TCF21 expression and activity, and focuses on its important role in atherosclerosis, in order to contribute to the development of diagnosis and treatment of cardiovascular diseases...
March 16, 2024: Pharmacology
(no author information available yet)
No abstract text is available yet for this article.
March 4, 2024: Pharmacology
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