journal
https://read.qxmd.com/read/38754395/prevalence-and-risk-factors-of-constipation-symptoms-among-patients-undergoing-colonoscopy-a-single-center-cross-sectional-study
#1
JOURNAL ARTICLE
Shiori Komori, Junichi Akiyama, Naoko Tatsuno, Erika Yamada, Atsuko Izumi, Mariko Hamada, Kana Seto, Yuriko Nishiie, Keigo Suzuki, Yuya Hisada, Yuki Otake, Yuka Yanai, Hidetaka Okubo, Kazuhiro Watanabe, Naoki Akazawa, Natsuyo Yamamoto, Yasuo Tanaka, Mikio Yanase, Akiko Saito, Kazuhiko Yamada, Chizu Yokoi, Akihito Nagahara
INTRODUCTION: Constipation is one of the most common gastrointestinal symptoms. It may compromise quality of life and social functioning and result in increased healthcare use and costs. We aimed to evaluate the prevalence and risk factors of constipation symptoms, as well as those of refractory constipation symptoms among patients who underwent colonoscopy. METHODS: Over 4.5 years, patients who underwent colonoscopy and completed questionnaires were analyzed. Patients' symptoms were evaluated using the Gastrointestinal Symptoms Rating Scale...
May 16, 2024: Digestion
https://read.qxmd.com/read/38744247/efficacy-of-cricoid-pressure-application-during-esophagogastroduodenoscopy-in-patients-with-poor-gastric-wall-extension
#2
JOURNAL ARTICLE
Toshiki Horii, Hisatomo Ikehara, Suguru Arata, Takahiro Domen, Chika Kusano
INTRODUCTION: Esophagogastroduodenoscopy (EGD) requires adequate air infusion. However, cases of poor gastrointestinal wall extension due to frequent eructation have been reported. Sufficient gastrointestinal wall extension can be achieved by applying cricoid pressure during EGD. Herein, we evaluated the frequency of cases with poor gastrointestinal wall extension and the efficacy and safety of applying cricoid pressure during EGD. METHODS: This interventional study included patients who underwent EGD between January 2020 and December 2020 at the JA Akita Koseiren Yuri Kumiai General Hospital...
May 14, 2024: Digestion
https://read.qxmd.com/read/38697038/endoscopic-features-of-synchronous-multiple-early-gastric-cancers-findings-from-a-nationwide-cohort
#3
JOURNAL ARTICLE
Yoshito Hayashi, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Hiroyuki Kurakami, Mitsuhiro Fujishiro, Atsushi Masamune, Tetsuo Takehara
INTRODUCTION: We investigated the factors associated with synchronous multiple early gastric cancers and determined their localization. METHODS: We analyzed 8191 patients who underwent endoscopic submucosal dissection for early gastric cancers at 33 hospitals in Japan from November 2013 to October 2016. Background factors were compared between single-lesion (n=7221) and synchronous multi-lesion cases (n=970) using univariate and multivariate analyses. We extracted cases with two synchronous lesions (n=832) and evaluated their localization...
May 2, 2024: Digestion
https://read.qxmd.com/read/38663369/tead4-activates-pcsk9-to-promote-stomach-adenocarcinoma-cell-stemness-through-fatty-acid-metabolism
#4
JOURNAL ARTICLE
Dongsheng Xu, Gaohua Han, Xueyi Zhou, Hongmei Yong, Yuanyuan Jia, Fengjiao Zhao, Huichang Shi
INTRODUCTION: This study attempted to investigate how PCSK9 influences the stemness of stomach adenocarcinoma (STAD) cells. METHODS: CCK-8 and sphere formation assays were used to detect cell viability and stemness. qRT-PCR and western blot were used to detect PCSK9 and TEAD4 expression. The binding relationship was verified by dual luciferase and chromatin immunoprecipitation (ChIP) assays. The effect of TEAD4 activating PCSK9 on the stemness of STAD cells was detected by bioinformatics, BODIPY 493/503, Oil red O, western blot, and kits...
April 25, 2024: Digestion
https://read.qxmd.com/read/38631318/analysis-of-the-characteristics-of-coexisting-lesions-in-colorectal-cancer-patients-in-an-international-study-a-subgroup-analysis-of-the-atlas-trial
#5
JOURNAL ARTICLE
Naohisa Yoshida, Sho Suzuki, Ken Inoue, Satimai Aniwan, Han-Mo Chiu, Kannikar Laohavichitra, Sakkarin Chirapongsathorn, Takeshi Yamamura, Chen-Ya Kuo, Tiing Leong Ang, Takahito Takezawa, Rungsun Rerknimitr, Hideki Ishikawa
INTRODUCTION: We investigated coexisting lesion types in patients with invasive colorectal cancer (CRC) in a multinational study for comprehending the adenoma-carcinoma and serrated pathway about the development of CRC. METHODS: We retrospectively reviewed 3050 patients enrolled in the international randomized controlled trial (ATLAS study) to evaluate the colorectal polyp detection performance of image-enhanced endoscopy in 11 institutions in four Asian countries/regions...
April 17, 2024: Digestion
https://read.qxmd.com/read/38560978/association-between-sense-of-coherence-disease-specific-symptoms-and-health-related-quality-of-life-among-japanese-patients-with-ulcerative-colitis-a-cross-sectional-study
#6
JOURNAL ARTICLE
Chika Horanai, Hideki Hashimoto, Tadakazu Hisamatsu, Hiroki Ikeuchi, Kazuhiro Watanabe, Sohachi Nanjo, Riichiro Nezu, Michio Itabashi, Ryota Hokari, Daijiro Higashi, Minoru Matsuura, Takayuki Ogino, Kenichi Takahashi, Akira Andoh, Masaru Shinozaki, Akira Sugita
INTRODUCTION: We examined the associations among disease-related symptoms, health-related quality of life (HRQOL), and sense of coherence (SOC) in Japanese patients with ulcerative colitis (UC). METHODS: This cross-sectional survey involved patients and physicians at 23 hospitals specializing in UC treatment in Japan (December 2019-December 2020). Multiple linear regression analysis was performed using scores on the Mental Health and General Health subscales of the Medical Outcomes Study 36-Item Short-Form Health Survey as outcomes and SOC as the main independent variable...
April 1, 2024: Digestion
https://read.qxmd.com/read/38537624/the-risk-of-metastatic-recurrence-after-non-curative-endoscopic-resection-with-negative-deep-margins-for-early-colorectal-cancer-two-center-retrospective-cohort-study
#7
JOURNAL ARTICLE
Kenji Yamauchi, Tomoki Inaba, Takeshi Morimoto, Yusuke Aya, Hugh Shunsuke Colvin, Teruya Nagahara, Shigenao Ishikawa, Masaki Wato, Atsushi Imagawa
INTRODUCTION: Non-curative endoscopic resection of T1 colorectal cancers (CRC) carries a substantial risk of recurrence. However, previous studies have reported a significant proportion of cases in which the deep margin of endoscopic resection was positive for cancer due to the technical difficulties of colorectal endoscopic submucosal dissection (ESD). With the advancement of endoscopic technology and techniques resulting in the reduction of positive resection margins, it is important to reassess the long-term prognosis and major risk factors for recurrence in cases of negative deep margins...
March 27, 2024: Digestion
https://read.qxmd.com/read/38527451/analysis-of-the-medication-persistence-rate-for-and-adherence-to-oral-5-aminosalicylic-acid-preparations-in-japanese-patients-with-ulcerative-colitis-study-using-a-nationwide-claims-database
#8
JOURNAL ARTICLE
Takumi Ota, Takahiro Takebe, Yutaka Shimizu, Takashi Orido, Hiroyuki Tanaka, Shiro Nakamura
Introduction 5-aminosalicylic acid (5-ASA) is the first-line drug for the treatment of mild-to-moderate ulcerative colitis (UC). Three oral sustained-release formulations are often used. However, no unified view of their actual use in routine medical practice has been presented to date. Methods Using a health insurance claims database, we extracted patients with an initial diagnosis of mild-to-moderate UC during the period from December 1, 2017 to March 31, 2022. For the three types of oral 5-ASA formulation, we calculated and compared descriptive statistics of medication persistence rates (MPR), proportions of days covered (PDC) and adherence proportion (PDC ≥ 80%) in the extracted population...
March 25, 2024: Digestion
https://read.qxmd.com/read/38479373/closing-the-gap-a-critical-examination-of-adherence-inconsistency-and-improvements-in-colonoscopy-reporting-practices
#9
JOURNAL ARTICLE
Thomas J Lux, Katja Herold, Ioannis Kafetzis, Phillip Sodmann, Zita Sassmanshausen, Alexander Meining, Alexander Hann
INTRODUCTION: Comprehensive and standardized colonoscopy reports are crucial in colorectal cancer prevention, monitoring, and research. This study investigates adherence to national and international guidelines by analyzing reporting practices among 21 endoscopists in 7 German centers, with a focus on polyp reporting. METHODS: We identified and assessed German, European, American and World Health Organization provided statements to identify key elements in colonoscopy reporting...
March 13, 2024: Digestion
https://read.qxmd.com/read/38417416/characteristics-and-prognosis-of-sporadic-neoplasias-detected-in-patients-with-ulcerative-colitis
#10
JOURNAL ARTICLE
Noriko Yamamoto, Ken Yamashita, Yudai Takehara, Shin Morimoto, Fumiaki Tanino, Yuki Kamigaichi, Hidenori Tanaka, Koji Arihiro, Fumio Shimamoto, Shiro Oka
INTRODUCTION: Patients with ulcerative colitis (UC) develop not only UC-associated neoplasias but also sporadic neoplasias (SNs). However, few studies have described the characteristics of SNs in patients with UC. Therefore, this study aimed to evaluate the clinical features and prognosis of SNs in patients with UC. METHODS: A total of 141 SNs in 59 patients with UC, detected by surveillance colonoscopy at Hiroshima University Hospital between January 1999 and December 2021, were included...
February 28, 2024: Digestion
https://read.qxmd.com/read/38350430/evaluation-of-a-multimodal-stress-management-and-comprehensive-lifestyle-modification-program-on-quality-of-life-and-gastrointestinal-symptoms-in-patients-with-crohn-s-disease-a-randomized-controlled-pilot-trial-with-nine-month-follow-up
#11
JOURNAL ARTICLE
Nina Bauer, Claudia Löffler, Oezlem Oeznur, Christine Uecker, Christoph Schlee, Alexandra Adamczyk, Sigrid Elsenbruch S, Katrin Pfuhlmann, Ralf Reissmann, Astrid Westendorf, Thomas Keil, Jost Langhorst
BACKGROUND: Stress and lifestyle factors impact the course of Crohn's Disease (CD). Our primary objective was to assess whether patients with CD benefit from a mind-body-medicine stress management and lifestyle modification (MBM) program. METHODS: This 9-month two-arm pilot trial was conducted in Bamberg, Germany (2020-2021). Patients (18-75 years) with mild to moderate activity of CD and stable medication were enrolled and randomly assigned to either a 10-week MBM program (intervention group, IG) or a single 90-minutes education session (waiting list control group, CG)...
February 13, 2024: Digestion
https://read.qxmd.com/read/38310859/clinical-impact-of-proton-pump-inhibitor-and-potassium-competitive-acid-blocker-for-predicting-the-curability-of-endoscopic-resection-in-ulcerative-early-gastric-cancer
#12
JOURNAL ARTICLE
Konomu Uno, Takaya Shimura, Shingo Inaguma, Keita Kuroyanagi, Ruriko Nishigaki, Takuya Kanno, Makiko Sasaki, Shigeki Fukusada, Naomi Sugimura, Yusuke Mizuno, Takayuki Nukui, Yuki Kojima, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Satoru Takahashi, Hiromi Kataoka
BACKGROUND: Endoscopic diagnosis is essential for predicting the curability of early gastric cancer (EGC; R0 resection) before treatment, but the relationship between ulcerative lesions and clinical outcomes remains unclear. We aimed to investigate the effect of proton pump inhibitor (PPI) or potassium-competitive acid blocker (P-CAB) on the morphological changes of ulcerative EGCs and its relevance to the clinical outcomes. METHODS: Altogether, 143 patients with differentiated ulcerative EGC that were resected by endoscopic submucosal dissection were retrospectively identified and divided into the following two cohorts depending on their PPI/P-CAB administration status: PPI/P-CAB (n = 76) and non-PPI/P-CAB (n = 67) cohorts...
February 2, 2024: Digestion
https://read.qxmd.com/read/38290483/relationship-between-helicobacter-pylori-eradication-and-barrett-s-esophagus-elongation
#13
JOURNAL ARTICLE
Kenta Hashigami, Yugo Iwaya, Tadanobu Nagaya, Daichi Hara, Atsuhiro Hirayama, Takuma Okamura, Taiji Akamatsu, Takeji Umemura
INTRODUCTION: Helicobacter pylori eradication therapy may worsen gastroesophageal reflux disease that is a significant risk factor for Barrett's esophagus. However, the relationship between eradication therapy and Barrett's esophagus remains controversial. This study evaluated the impact of Helicobacter pylori eradication on the lengthening of Barrett's esophagus. MATERIALS AND METHODS: We conducted a retrospective analysis of consecutive patients who successfully underwent Helicobacter pylori eradication between 2004 and 2017...
January 30, 2024: Digestion
https://read.qxmd.com/read/38246134/efficacy-and-safety-of-stw-5-ii-for-functional-dyspepsia-treatment-a-patient-data-based-meta-analysis
#14
Viola Andresen, Ayesha Shah, Careen Fink, Sabine Rabini, Manfred Wargenau, Gerald Holtmann
BACKGROUND: Functional dyspepsia (FD) is a chronic relapsing gastroduodenal disorder with limited treatment options. Herbal products, like the six-herb combination STW5-II, can target multiple FD gastrointestinal symptoms. In this meta-analysis, we evaluated the efficacy and safety of STW 5-II for overall FD, and key symptoms, based on Rome IV criteria. SUMMARY: We systematically screened the literature for randomized controlled clinical studies testing STW 5-II in FD...
January 19, 2024: Digestion
https://read.qxmd.com/read/38232718/feasibility-of-colorectal-endoscopic-submucosal-dissection-in-elderly-patients-the-impact-of-sarcopenia
#15
JOURNAL ARTICLE
Hiroyuki Hisada, Yosuke Tsuji, Rina Cho, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Yu Takahashi, Yoshiki Sakaguchi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro
INTRODUCTION: Colorectal cancer (CRC) is a public health concern associated with high incidence rates. Sarcopenia is a known risk factor for postoperative complications, although an association between increased complications after colorectal endoscopic submucosal dissection (ESD) and sarcopenia remains undocumented. Herein, we aimed to explore the feasibility of colorectal ESD in patients with sarcopenia. METHODS: This retrospective study included 499 patients (69 with and 430 without sarcopenia)...
January 17, 2024: Digestion
https://read.qxmd.com/read/38198778/a-novel-dry-simulator-model-for-learning-comprehensive-endoscopic-retrograde-cholangiopancreatography-endoscopic-sphincterotomy-procedures-while-minimizing-adverse-bleeding-events-with-video
#16
JOURNAL ARTICLE
Yutaka Hatayama, Takeshi Kanno, Tetsuya Takikawa, Ryotaro Matsumoto, Yutaro Arata, Suguo Suzuki, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Shin Miura, Waku Hatta, Shin Hamada, Kaname Uno, Kiyoshi Kume, Kazuhiro Kikuta, Naoki Asano, Akira Imatani, Tomoyuki Koike, Atsushi Masamune
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST) are essential skills for endoscopic cholangio-pancreatic procedures. However, these procedures have a high incidence of adverse events, and most training is currently patient-based. Herein, we aimed to develop an ERCP/EST simulator model to address the need for safer training alternatives, especially for learners with limited ERCP experience. METHODS: The model was designed to facilitate the use of actual endoscopic devices, supporting learning objectives that align with the components of the validated Bethesda ERCP Skill Assessment Tool (BESAT)...
January 10, 2024: Digestion
https://read.qxmd.com/read/38198754/ef%C3%AF-cacy-and-safety-of-cold-snare-polypectomy-versus-cold-endoscopic-mucosal-resection-for-resecting-3-10-mm-colorectal-polyps-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Shao-Tong Wang, Qing-Zhou Kong, Yan-Qing Li, Rui Ji
Introduction The safety and efficacy of cold snare polypectomy (CSP) compared to those of cold endoscopic mucosal resection (CEMR) have been reported. This meta-analysis compared the efficacy and safety of CEMR and CSP. Methods PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched to identify randomized controlled trials comparing the efficacy and safety of CEMR and CSP in removing 3-10 mm polyps. The outcomes assessed included complete resection rate, intraoperative bleeding rate, delayed bleeding rate, perforation, and polyp removal time...
January 10, 2024: Digestion
https://read.qxmd.com/read/38190818/endoscopic-kyoto-and-kimura-takemoto-classifications-are-comparable-in-predicting-high-risk-gastric-precancerous-lesions
#18
JOURNAL ARTICLE
Doan Thi Nha Nguyen, Duc Trong Quach, Quang Dinh Le, Nhu Thi Hanh Vu, Ngoc Le Bich Dang, Huy Minh Le, Nhan Quang Le, Shiro Oka, Shinji Tanaka, Toru Hiyama
BACKGROUND/AIMS: Severe and extensive gastric atrophy, extensive or incomplete gastric intestinal metaplasia, and gastric dysplasia are considered high-risk gastric precancerous lesions (HGPLs). Endoscopic findings based on the endoscopic Kyoto classification (EKC) and the Kimura-Takemoto classification (KTC) have been reported to be significantly associated with HGPLs. This study aimed to compare these two classifications in predicting active Helicobacter pylori (H. pylori) infection and HGPLs...
January 8, 2024: Digestion
https://read.qxmd.com/read/37844547/belching-disorders-and-rumination-syndrome-a-literature-review
#19
REVIEW
Akinari Sawada, Yasuhiro Fujiwara
BACKGROUND: Belching disorders and rumination syndrome (RS) are disorders of gut-brain interaction (DGBIs) in Rome IV. Belching disorders are composed of excessive gastric belching (GB) and supragastric belching (SGB). Excessive GB is related to physiological phenomenon whereas excessive SGB and RS are behavioral disorders. SUMMARY: A recent large internet survey found that prevalence of belching disorders and RS were 1% and 2.8%, respectively. It has been recognized that not a few patients with two behavioral disorders, excessive SGB and RS, could be misdiagnosed as proton pump inhibitors (PPI)-refractory gastroesophageal reflux disease (GERD)...
2024: Digestion
https://read.qxmd.com/read/37634495/esophageal-motility-disorders-diagnosis-and-treatment-strategies
#20
REVIEW
Yoshimasa Hoshikawa, Katsuhiko Iwakiri
BACKGROUND: Esophageal motility disorders (EMDs) are caused by the impaired relaxation of the upper/lower esophageal sphincter and/or defective esophageal peristaltic contractions, resulting in dysphagia and noncardiac chest pain. High-resolution manometry (HRM) is essential for the diagnosis of primary EMD; however, the recognition of EMD and HRM by general practitioners in Japan is limited. This review summarizes the diagnosis of and treatment strategies for EMD. SUMMARY: HRM is a specific test for the diagnosis of EMD, whereas endoscopy and barium swallow as screening tests provide characteristic findings (i...
2024: Digestion
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