Takeo Yasu, Makoto Hoshino, Naoya Sakamoto, Masayuki Kobayashi
INTRODUCTION: Mucormycosis presents a diagnostic challenge characterized by high morbidity and mortality rates due to its swift and pervasive nature, which leads to extensive tissue destruction and dissemination. Immunocompromised individuals, notably those with hematological malignancies, are at a heightened risk. First-line antifungal agents include liposomal amphotericin B (L-AMB), posaconazole, and isavuconazole (IVZ), which offer advantages, such as minimal drug interactions and a favorable safety profile...
June 15, 2024: Chemotherapy
Edy Ippolito, Francesco Pantano, Sonia Silipigni, Rita Alaimo, Jessica Infante, Elena Onorati, Claudia Talocco, Carlo Greco, Michele Fiore, Marco Donato, Giuseppe Tonini, Rolando Maria D'Angelillo, Sara Ramella
INTRODUCTION: There is little evidence regarding the safety and efficacy of the combination of abemaciclib plus radiotherapy (RT). The majority of studies investigated the combination of RT with Palbociclib or Ribociclib reporting that hematological toxicity is common. Given the unique toxicity profile of Abemaciclib with greater gastrointestinal toxicity compared to hematological toxicity, we wanted to evaluate the toxicity of the combination with RT in metastatic breast cancer (BC) patients...
June 10, 2024: Chemotherapy
Xin-Jie Liu, Ping-Wei Song, Li-Gang Wang, Hai-Ning Zou, Lin-Lin Zhang
OBJECTIVE: To conduct a systematic review to explore the therapeutic effect of transcatheter arterial chemoembolisation (TACE) combined with portal vein embolisation (PVE) for patients with hepatocellular carcinoma (HCC). METHODS: Chinese and English databases (PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, and VIP Database) were searched from database inception to 15 August 2023. Studies comparing TACE combined with PVE versus TACE alone for patients with HCC were included...
May 26, 2024: Chemotherapy
Qirong Wang, Yu Duan, Zhifang Zan, Kai Yang, Jinjuan Wang, Fengfeng Jia, Yanhong Tan, Hongwei Wang, Li Li
INTRODUCTION: Abnormalities in splicing factors, such as mutations or deregulated expression, can lead to aberrant splicing of target genes, potentially contributing to the pathogenesis of acute myeloid leukemia (AML). Despite this, the precise mechanism underlying the abnormal alternative splicing induced by SRSF1, a splicing factor associated with poor AML prognosis, remains elusive. METHODS: Using strict splicing criteria, we globally screened for alternative splicing(AS) events in NPMc-positive and NPMc-negative AML samples from TCGA...
May 19, 2024: Chemotherapy
(no author information available yet)
No abstract text is available yet for this article.
May 2, 2024: Chemotherapy
Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Hilal Sipahi, Oguz Resat Sipahi
INTRODUCTION: Nosocomial meningitis may occur after procedures affecting the central nervous system or following traumatic injury. The causative infectious organism is commonly Staphylococcus aureus, a gram-positive bacterium. The aim of the present study was to compare the effectiveness of two antibacterial agents, ceftobiprole and vancomycin in an animal model of methicillin-resistant Staphylococcus aureus (MRSA) meningitis. METHOD: The strain of MRSA used was ATCC 43300...
May 2, 2024: Chemotherapy
James Alexander Korolewicz, Bernhard Scheiner, Claudia A M Fulgenzi, Antonio D'Alessio, Alessio Cortellini, Chynna Pascual, Aman Mehan, Sarah Partridge, Dorothy M Gujral, Waleed Mohammed, Oreoluwa Mohammed, Aneta Grzesiak, Lauren Booker, Susan Cleator, Tzveta Pokrovska, Waqar Saleem, James Rackie, Yasmine Needham, Jonathan Krell, Iain McNeish, Laura Tookman, Won-Ho Edward Park, Muzamil Asif, Joanne S Evans, David J Pinato
INTRODUCTION: As tumour response rates are increasingly demonstrated in early-phase cancer trials (EPCT), optimal patient selection and accurate prognostication is paramount. Hammersmith Score (HS), a simple prognostic index derived on routine biochemical measures (Albumin <35g/L, Lactate Dehydrogenase (LDH) >450 IU/L, Sodium <135mmol/L) is a validated predictor of response and survival in EPCT participants. HS has not been validated in the cancer immunotherapy era...
April 27, 2024: Chemotherapy
Tao Dong, Yuanyuan Gu
INTRODUCTION: The relationship of CYP2A6 polymorphisms with S-1 therapy outcomes in gastric cancer is unclear. This review aims to assess the association between CYP2A6 gene polymorphisms (CYP2A6*4, *7, *9, *10) and S-1 therapy outcomes in gastric cancer, aiming to identify predictive markers for S-1 efficacy and adverse reactions. METHODS: We searched seven databases, using random or fixed effect models to calculate hazard ratio (HR) and 95% confidence interval (CI) based on study heterogeneity...
April 10, 2024: Chemotherapy
Grazia Pavia, Fabio Scarpa, Alessandra Ciccozzi, Chiara Romano, Francesco Branda, Angela Quirino, Nadia Marascio, Giovanni Matera, Daria Sanna, Massimo Ciccozzi
BACKGROUND: Influenza viruses are etiological agents which cause contagious respiratory, seasonal epidemics and, for Influenza A subtypes, pandemics. The clinical picture of Influenza has undergone continuous change over the years, due to intrinsic viral evolution as well as "reassortment" of its genomic segments. The history of Influenza highlights its ability to adapt and to rapidly evolve, without specific circumstances. This reflects the complexity of this pathology and poses the fundamental question about its assumption as a "common illness" and its impact on public health...
March 20, 2024: Chemotherapy
Yue Yin, Kaini Shen, Hanyu Li, Lu Zhang
Introduction With the increasing use of Blinatumomab in relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL), including MRD-positive cases, awareness of its adverse effects has gradually improved. Pneumocystis jiroveci pneumonia (PCP) associated with Blinatumomab therapy is rare. Case Presentation We present a case of PCP in a patient undergoing Blinatumomab therapy. A 70-year-old female diagnosed with Philadelphia-like, CRLF2 overexpression B-cell precursor ALL received Blinatumomab as consolidation therapy after achieving complete remission with prior induction chemotherapy...
March 20, 2024: Chemotherapy
José Delgado-Domínguez, Lizet Mejía-Camacho, Lisset Torres-Martínez, Jaime Zamora-Chimal, Rocely Cervantes-Sarabia, Adrián Espinoza-Guillén, Lena Ruiz-Azuara, Ingeborg Becker
Introduction Casiopeina III-ia (CasIII-ia) is a mixed chelate copper (II) compound capable of interacting with free radicals generated in the respiratory chain through redox reactions, producing toxic reactive oxygen species (ROS) that compromise the viability of cancer cells, bacteria and protozoa. Due to its remarkable effect on protozoa, this study evaluated the effect of CasIII-ia on Leishmania mexicana (L. mexicana) amastigotes and its potential use as a treatment for cutaneous leishmaniasis in the murine model...
March 18, 2024: Chemotherapy
Goncagul Akdag, Sedat Yildirim, Akif Dogan, Zeynep Yuksel Yasar, Hamit Bal, Oguzcan Kinikoglu, Sila Oksuz, Ugur Ozkerim, Salih Tunbekici, Hacer Sahika Yildiz, Ezgi Turkoglu, Ozkan Alan, Sermin Coban Kokten, Deniz Isik, Ozlem Nuray Sever, Hatice Odabas, Mahmut Emre Yildirim, Nedim Turan
INTRODUCTION: Neoadjuvant chemotherapy (NAC) is extensively employed in breast cancer (BC), primarily for aggressive subtypes like triple-negative and human epidermal growth factor receptor 2 (HER2) positive BC, and in estrogen receptor-positive (ER+)/ HER2- BC with high-risk features. In ER+/HER2- breast cancer, pathological complet rates are much lower (<10%), while axillary dissection rates are higher. This study focuses on hormone receptor positive (HR+)/HER2- BC patients undergoing NAC, examining its impact on pathological complete response (pCR) rates, with specific attention to tumor Ki67 and ER status...
February 16, 2024: Chemotherapy
Ombretta Annibali, Annamaria Altomare, Valeria Tomarchio, Giulia Rocchi, Carlo Augusto Mallio, Maria Antonietta Tafuri, Bruno Beomonte Zobel, Bruno Vincenzi, Michele Pier Luca Guarino, Luigi Rigacci, Giuseppe Avvisati
Sarcopenia has been associated with chronic diseases and cancer. Aim of this study was to evaluate sarcopenia in Multiple Myeloma patients undergoing autologous stem cell trans-plantation. In 68 eligible patients' measurement of skeletal muscle area (cm2) on computed tomography scans at the level of the L3 vertebra (L3-SMI) was performed. 37(54%) patients were categorized as sarcopenic: 26 males with L3-SMI values < 52.4 cm2/m2, and 11 women with L3-SMI values < 38.9 cm2/m2. The majority of sarcopenic patients included were older than 60 years (69%, p=0...
February 8, 2024: Chemotherapy
Angelo Aita, Diana Lelli, Giovanni Gherardi, Claudio Pedone, Raffaele Antonelli Incalzi
INTRODUCTION: Kodamaea ohmeri (K. ohmeri) is an emerging fungus recognized as an important pathogen in immunocompromised hosts, responsible for life-threatening infections. CASE PRESENTATION: We describe a case of a 69-year-old immunocompetent man with a long history of leg skin ulcers infected by K. ohmeri. This is the first case of leg wounds infected by K. ohmeri in an immunocompetent patient. The infection was successfully treated with voriconazole 200 mg daily...
February 1, 2024: Chemotherapy
Tugan Bese, Elifnur Bicer, Basak Ozge Kayan, Sait Sukru Cebi, Abdullah Serdar Acikgoz, Hande Turna, Fuat Demirkiran
INTRODUCTION: The aim of this study was to compare the disease-free survival (DFS) and overall survival (OS) of patients who underwent interval cytoreductive surgery after 3-4 cycles or 6 cycles of neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer patients. METHODS: Out of 219 patients with advanced epithelial ovarian cancer,123 patients received 3-4 cycles and 96 patients received 6 cycles of platinum-based NACT. Afterwards, laparotomy was performed for interval cytoreductive surgery...
December 19, 2023: Chemotherapy
Chun-Han Chen, Chih-Jung Chen, Yi-Ching Huang, Po-Shuan Huang, Hsiang-Cheng Chi, Huei-Chieh Chuang, Meng-Hung Lin, Tzu-Hao Huang, Jun-Te Hsu, Cheng-Yi Chen
INTRODUCTION: Gastric cancer is the 5th most common cancer and 3rd leading cause of cancer-related death worldwide. There are three main ways to treat gastric cancer: surgical resection, radiation therapy, and drug therapy. Furthermore, combinations of two to three regimens can improve survival. However, the survival outcomes of chemotherapy in advanced gastric cancer patients are still unsatisfactory. Unfortunately, no widely useful biomarkers have been verified to predict the efficacy of chemotherapy for locally advanced gastric cancer...
December 10, 2023: Chemotherapy
Emanuele Cencini, Alberto Fabbri, Elisa Cinotti, Pietro Rubegni, Monica Bocchia
No abstract text is available yet for this article.
December 8, 2023: Chemotherapy
Yu-Ce Wei, Fei Qi, Bo Chen, Chang-Gong Zhang, Hui Fang, Di Zhang, Shu-Nan Qi, Yue Chai, Ye-Xiong Li, Mei Dong
INTRODUCTION: Although there is now a consensus on asparaginase-based chemotherapy regimens in treatment of advanced-stage extranodal natural killer / T cell lymphomas (ENKTCLs), patient survival in the real-world setting is still not optimistic according to previous literature reports, and the optimal chemotherapeutic regimens and integration of different therapeutic methods under the concept of combined-modality treatment still need to be further explored and verified. METHODS: Newly diagnosed stage Ⅲ / Ⅳ ENKTCL patients from Chinese National Cancer Center in the last two decades were retrospectively collected and analyzed...
November 20, 2023: Chemotherapy
Andrea Di Lorenzo, Lorenzo Vittorio Rindi, Laura Campogiani, Alessandra Imeneo, Grazia Alessio, Pier Giorgio Pace, Alessandra Lodi, Benedetta Rossi, Angela Maria Antonia Crea, Pietro Vitale, Dimitra Kontogiannis, Vincenzo Malagnino, Massimo Andreoni, Marco Iannetta, Loredana Sarmati
Introduction Acute eosinophilic pneumonia (AEP) is a rare respiratory condition caused by eosinophil accumulation in the pulmonary tissue that can be related to drug administration. Daptomycin, an antibiotic active against gram-positive bacteria, is one of the leading causes of AEP among drugs. In order to raise awareness of this rare syndrome, in our work we have described a case of an 82 years-old male with Enterococcus faecalis endocarditis treated with daptomycin, who developed a daptomycin-induced AEP...
November 14, 2023: Chemotherapy
Elena Imperia, Graziana Bonincontro, Annamaria Altomare, Giovanna Simonetti, Giovanni Gherardi, Elisa Brasili, Camilla Badiali, Manuela Bove, Gabriella Pasqua, Laura De Gara, Michele Cicala, Michele Pier Luca Guarino
BACKGROUNDS: Oral colonization and infections are frequently observed in patients during and soon after radiation therapy (RT). Infective mucositis is a common side effect associated with cancer therapy, characterized by an inflammation of the oral mucous membranes with histological mucosal and submucosal changes. Ulcerative mucositis is responsible for significant pain, impairing the patient's nutritional intake and leading to local or systemic infections promoting mycosis due to several species of the genus Candida...
November 14, 2023: Chemotherapy
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