journal
https://read.qxmd.com/read/38948381/does-platelet-rich-plasma-deserve-a-role-in-accelerating-the-recovery-of-reflex-sympathetic-dystrophy-following-distal-radius-fracture
#1
JOURNAL ARTICLE
Raghavendra S Kulkarni, SriRam R Kulkarni, Rachana A Kulkarni, Ranjani R Kulkarni
INTRODUCTION: This study was to evaluate the efficacy of multiple platelet-rich plasma injections in reflex sympathetic dystrophy following distal radius fracture after previous various treatments have failed. MATERIALS AND METHODS: This comparative prospective study was designed for 64 patients of reflex sympathetic dystrophy developed following distal radius fracture, from January 2009 to December 2020 were enrolled in this study. This cohort of patient was given either four multiple subcutaneous platelet-rich plasma injections at weekly interval ( n  = 32) or two injections in a month with 15 days interval ( n  = 32)...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948380/metabolomics-in-osteoarthritis-knee-a-systematic-review-of-literature
#2
REVIEW
Akhilesh Arjun, Girinivasan Chellamuthu, Naveen Jeyaraman, Madhan Jeyaraman, Manish Khanna
INTRODUCTION: Osteoarthritis (OA) is a common degenerative disorder of the synovial joints and is usually an age-related disease that occurs due to continuous wear and tear of the cartilage in the joints. Presently, there is no proven medical management to halt the progression of the disease in the early stages. The purpose of our systematic review is to analyze the possible metabolites and metabolic pathways that are specifically involved in OA pathogenesis and early treatment of the disease...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948379/screening-and-analysis-of-core-genes-for-osteoporosis-based-on-bioinformatics-analysis-and-machine-learning-algorithms
#3
JOURNAL ARTICLE
Yongxia Lu, Wei Wang, Baiyuan Yang, Gui Cao, Yue Du, JingYu Liu
OBJECTIVE: This study aimed to identify osteoporosis-related core genes using bioinformatics analysis and machine learning algorithms. METHODS: mRNA expression profiles of osteoporosis patients were obtained from the Gene Expression Profiles (GEO) database, with GEO35958 and GEO84500 used as training sets, and GEO35957 and GSE56116 as validation sets. Differential gene expression analysis was performed using the R software "limma" package. A weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and modular genes of osteoporosis...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948378/exosomes-in-osteoarthritis-a-review-on-their-isolation-techniques-and-therapeutic-potential
#4
REVIEW
Nazmul Huda Syed, Iffath Misbah, Maryam Azlan, Muhammad Rajaei Ahmad Mohd Zain, Asma Abdullah Nurul
BACKGROUND: Exosomes are the smallest extracellular vesicles (30-150 nm) secreted by all cell types, including synovial fluid. However, because biological fluids are complex, heterogeneous, and contain contaminants, their isolation is difficult and time-consuming. Furthermore, the pathophysiology of osteoarthritis (OA) involves exosomes carrying complex components that cause macrophages to release chemokines and proinflammatory cytokines. This narrative review aims to provide in-depth insights into exosome biology, isolation techniques, role in OA pathophysiology, and potential role in future OA therapeutics...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948377/optimizing-tourniquet-pressure-in-primary-total-knee-arthroplasty-limb-occlusion-pressure-vs-systolic-blood-pressure-method-a-randomised-controlled-study
#5
JOURNAL ARTICLE
Rajkumar Natesan, Mohammad Istiyak, P Dhanasekara Raja, Shanmuganathan Rajasekaran
BACKGROUND: This study aims to systematically compare the efficacy of two distinct approaches that is limb occlusion pressure (LOP) and systolic blood pressure (SBP) in determining the optimal tourniquet pressure for primary total knee arthroplasty. The overarching goal is to identify the method that yields superior outcomes in minimizing post-operative thigh pain while simultaneously reducing complications in our patient population. METHODS: 311 patients scheduled for primary total knee replacement (TKR) were randomized in two groups...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948376/safety-and-efficacy-of-bone-marrow-aspirate-concentrate-in-hip-osteoarthritis-a-systematic-review-of-current-clinical-evidence
#6
REVIEW
Sushma Chandrashekar, Madhan Jeyaraman, Prabu Mounissamy, Naveen Jeyaraman, Manish Khanna, Ashim Gupta
INTRODUCTION: Hip osteoarthritis (OA) is one of the leading causes of disability and morbidity worldwide. It is estimated to affect 9.2% individuals globally with age over 45 years. Conventional treatment modalities have limitations and side-effects. To overcome these limitations, over the last decade, there has been an increased interest in the use of orthobiologics derived from autologous sources including platelet-rich plasma (PRP), bone-marrow aspirate concentrate (BMAC) and adipose tissue derived formulations...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948375/growth-factor-concentrate-gfc-for-the-management-of-osteoarthritis-of-the-knee-a-systematic-review
#7
REVIEW
Ashim Gupta, Nicola Maffulli
INTRODUCTION: The knee is the most commonly affected joint in osteoarthritis (OA), affecting millions of people worldwide. Knee OA significantly impacts the activities of daily living (ADL) along with affecting overall quality of life of patients (QoL), thereby leading to substantial socio-economic burden. Conservative therapies are prioritized, resorting to surgery only when needed. However, these traditional approaches have limitations. Regenerative medicine, involving the use of orthobiologics, including autologous peripheral blood-derived orthobiologics such as growth factor concentrate (GFC), has evolved and shown potential for managing knee OA...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948374/global-stem-cell-research-in-orthopaedics-a-bibliometric-study-from-1995-to-2020
#8
JOURNAL ARTICLE
Raju Vaishya, Mallikarjun M Kappi, Brij Mohan Gupta, Ghouse Modin N Mamdapur, Abhishek Vaish
BACKGROUND: The research field of stem cell-based therapies in orthopaedics has witnessed significant growth in the recent past. We aimed to identify and analyze the bibliometric characteristics of the global highly cited papers (HCPs) in stem cell research in orthopaedics. METHODS: This study relied on secondary data extracted from Scopus, Elsevier's abstract and citation database. An advanced search string was employed, for the period from 1995 to 2020. For each paper, the extracted information included the number of citations, title, authors (name, number, authorship position, and country), year of publication, title of the journals, study design, and thematic field...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948373/efficacy-of-intraoperative-platelet-rich-plasma-after-meniscal-repair-systematic-review-and-meta-analysis
#9
REVIEW
Muhammad Thahir, Iffath Misbah, Jagadeesh Bhaskaran, Nazmul Huda Syed, Munis Ashraf, Navin Balasubramanian
BACKGROUND: Meniscal injuries frequently require surgical intervention to restore knee joint function and stability. Intraoperative platelet-rich plasma (PRP) injection has emerged as a potential adjunctive therapy to enhance tissue healing post-meniscal repair. This systematic review and meta-analysis aimed to evaluate the efficacy of PRP in terms of pain relief, functional recovery, and overall success rates in patients undergoing meniscal repair procedures . METHODS: A comprehensive search strategy was employed to identify relevant studies across Scopus, PubMed, Embase, and the Cochrane Library databases...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948372/chondroprotective-effects-of-a-single-prp-injection-in-a-spontaneous-osteoarthritis-model-of-dunkin-hartley-guinea-pig-an-immunohistochemical-analysis
#10
JOURNAL ARTICLE
Devendra Kumar Chouhan, Sandeep Patel, Tarkik Thami, Narayan Prasad Mishra, Uma Nahar, Mandeep Singh Dhillon
PURPOSE OF THE STUDY: The evaluation of anti-apoptotic and chondroprotective properties of a single injection of PRP using immunohistochemistry (IHC). METHODS: This was a placebo-controlled blinded experimental study. Ten healthy Dunkin Hartley guinea pigs were selected. One knee of each animal was injected with a single injection of PRP (Group A); the contralateral knee acted as a control and was injected with a single injection of normal saline (Group B). These groups were further divided into A3 and B3 based on the timeline of animal sacrifice (3 months) and A6 and B6 (6 months)...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948371/efficacy-and-complications-of-fixator-assisted-correction-with-internal-fixation-in-the-genu-valgum
#11
JOURNAL ARTICLE
Aashrya Malik, Parmanand Gupta, Ravi Gupta, Ravi Jethwa
BACKGROUND AND PURPOSE: Two basic methods for genu valgum correction are osteotomy and internal fixation or external fixator assited correction. External fixators have the advantage of stabilizing fragments before osteotomy allowing better control of fragments and preventing secondary displacements. The purpose of this study was to evaluate the efficacy and complications of fixator assisted correction for genu valgum and internal fixation, using the AO distal femur pediatric osteotomy plate...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948370/bone-marrow-aspirate-concentrate-for-treatment-of-primary-knee-osteoarthritis-a-prospective-single-center-non-randomized-study-with-2-year-follow-up
#12
JOURNAL ARTICLE
Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Rajni Ranjan, Saurabh Kumar Jha, Ashim Gupta
INTRODUCTION: Knee osteoarthritis (OA) is a widespread, disabling condition with no intervention to fully restore cartilage or halt progression. Bone marrow aspirate concentrate (BMAC), an autologous product from bone marrow aspiration, has shown promise as a regenerative therapy due to its cell composition and chondrogenic effects. Our study aims to assess the functional outcomes, including pain, function, satisfaction, and complications post-BMAC injection in knee OA patients. MATERIALS AND METHODS: In this prospective, single-center study, 63 patients with grade II-III knee OA (Kellgren-Lawrence (K-L) scale) unresponsive to conservative management underwent BMAC injection...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948369/a-histological-and-biomechanical-analysis-of-human-acellular-dermis-had-created-using-a-novel-processing-and-preservation-technique
#13
JOURNAL ARTICLE
Damini Shah, Madhu Rathod, Anjali Tiwari, Abhishek Kini, Prasad Bhagunde, Vaibhav Bagaria
BACKGROUND: Large and complex defects requiring reconstruction are challenging for orthopaedic surgeons. The use of human acellular dermal (HAD) matrices to augment large soft tissue defects such as those seen in massive rotator cuff tears, knee extensor mechanism failures and neglected Tendo-Achilles tears has proven to be a valuable tool in surgeons reconstructive armamentarium. Different methods for allograft decellularization and preservation alter the native properties of the scaffold...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948368/morphological-changes-and-concentricity-of-the-hip-joint-during-gradual-reduction-in-infants-with-late-detected-developmental-dysplasia-of-the-hip-a-retrospective-study
#14
JOURNAL ARTICLE
Yaichiro Okuzu, Masako Tsukanaka, Koji Goto, Yutaka Kuroda, Toshiyuki Kawai, Yugo Morita, Tohru Futami, Shuichi Matsuda
BACKGROUND: The relationship between hip morphological changes and joint concentricity in infants with late-detected developmental dysplasia of the hip (DDH) treated with gradual reduction remains unclear. Therefore, we investigated hip morphological changes and concentricity in infants with late-detected unilateral DDH using magnetic resonance imaging (MRI) during gradual reduction. METHODS: We enrolled 20 infants aged ≥ 12 months with unilateral DDH...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948367/goldic-therapy-holds-promise-as-an-orthobiologic-agent-a-systematic-review-of-the-literature
#15
REVIEW
Madhan Jeyaraman, R P Packkyarathinam, Thamizhmathi Thangaraju, Naveen Jeyaraman, Girinivasan Chellamuthu, Manish Khanna
INTRODUCTION: Orthobiologic agents play a significant role in regenerative medicine. The quest for newer and more effective Orthobiologic agents is never-ending, leading to the evolution of more reformed products. GOLDIC (GOLD Induced cytokine) is a recently evolving Orthobiologic agent developed by conditioning autologous serum with gold particles. We aim to collate the available evidence on GOLDIC and provide a systematic literature review. MATERIALS AND METHODS: Using Cochrane and PRISMA guidelines literature search was done for GOLDIC...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948366/peroneus-longus-tendon-autografts-have-better-graft-diameter-less-morbidity-and-enhanced-muscle-recuperation-than-hamstring-tendon-in-acl-reconstruction
#16
JOURNAL ARTICLE
Deepu Jacob Punnoose, Jacob Varghese, Bipin Theruvil, Appu Benny Thomas
BACKGROUND: Recently the peroneus longus tendon (PLT) gained popularity in anterior cruciate ligament (ACL) reconstruction and has been utilized with satisfactory outcomes. However, there are concerns regarding donor site morbidity. This study aims to compare the functional outcome of ACL reconstruction using hamstring (HT) and PLT autografts and evaluate the donor site morbidity. METHODS: Patients who underwent ACL reconstruction were allocated to two groups (HT and PLT)...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948365/is-there-a-need-for-an-exogenous-activator-along-with-prp-for-early-knee-osteoarthritis-a-triple-blinded-randomized-control-trial
#17
JOURNAL ARTICLE
Shivam Rai, Sandeep Patel, Devendra Kumar Chouhan, Ashish Jain, Tarkik Thami, Ankit Dadra, Mandeep Singh Dhillon
BACKGROUND: In addition to other variables associated with PRP injections for Knee Osteoarthritis (OA), some confusion exists about the role of exogenous activators. The current study looks at matched groups getting PRP injections with or without activator (Calcium gluconate) in early knee OA patients. METHODS: Patients of early OA knee meeting inclusion criteria were randomly divided into 2 groups; Group A (43 patients) received 8 ml PRP injection alone, and Group B (48 patients) received 8 ml PRP along with 2 ml Calcium gluconate as activator...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38948364/a-gelatin-based-biomimetic-scaffold-promoting-osteogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells
#18
JOURNAL ARTICLE
Anjitha S Prasad, S Banu, S Silpa Das, Lynda V Thomas
BACKGROUND: In bone tissue engineering segment, numerous approaches have been investigated to address critically sized bone defects via 3D scaffolds, as the amount of autologous bone grafts are limited, accompanied with complications on harvesting. Moreover, the use of bone-marrow-derived stem cells is also a limiting factor owing to the invasive procedures involved and the low yield of stem cells. Hence, research is ongoing on the search for an ideal bone graft system promoting bone growth and regeneration...
July 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38812877/pathological-hip-dislocation-in-a-neurofibromatosis-patient-secondary-to-capsular-hemangioma
#19
Badaruddin Sahito, Muhammad Waqas Khan, Muhammad Hamdan, Ushna Sunain Ansari, Awais Abro, Bakht Hussain, Maratib Ali
Neurofibromatosis is an autosomal-dominant multi-system disease affecting the nervous, integumentary, ocular, and musculoskeletal systems. In the small number of reported cases, the cause was either atraumatic or an intra-articular neurofibroma. Only a couple of articles in medical literature have reported synovial and capsular hemangioma originating within the hip joint. In this article, we present a rare case of pathological hip dislocation in a neurofibromatosis patient secondary to capsular hemangioma that would be reported for the first time in medical literature...
June 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38812876/long-term-surgical-and-radiological-outcome-of-discoid-lateral-meniscus-an-updated-systematic-review
#20
REVIEW
Kriti Mohan, Ajay Bharti, Manish Kumar, Nitish Kumar, Vivek Kumar, Rajnand Kumar, Sudhir Shyam Kushwaha
PURPOSE OF THE STUDY: This study aimed to reach a consensus for ideal surgical treatment of discoid lateral meniscus (DLM) and to evaluate its long term surgical and radiological outcome. METHODS: All authors independently searched for peer reviewed publications with keywords like discoid lateral meniscus, tibial menisci abnormalities, tibial menisci surgery and clinical outcome and their representative Medical Subjects Headings (MeSH) in databases of PubMed, EBSCO, Cochrane Central Register of Controlled Trials, from inception to December 2022...
June 2024: Indian Journal of Orthopaedics
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