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Advances in Experimental Medicine and Biology

Jakub Kucharz, Paulina Dumnicka, Agnieszka Giza, Urszula Demkow, Beata Kusnierz-Cabala, Tomasz Demkow, Pawel Wiechno
Renal cell carcinoma (RCC) represents 2-3% of all malignancies. Most RCC-related deaths are caused by metastases of the disease. Studies suggest that inflammation-related parameters are of prognostic significance in metastatic renal cell carcinoma (mRCC) patients. Neutrophilia and thrombocytosis are markers of systemic inflammation that accompanies cancer, while lymphopenia is related to dysfunctions of the immune system. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) thus seem particularly interesting from a clinical perspective...
March 23, 2019: Advances in Experimental Medicine and Biology
Sunil Munakomi, Amit Agrawal
There have been significant advancements in the management of intracerebral hemorrhage (ICH) stemming from new knowledge on its pathogenesis. Major clinical trials, such as Surgical Trial in Lobar Intracerebral Hemorrhage (STICH I and II), have shown only a small, albeit clinically relevant, advantage of surgical interventions in specific subsets of patients suffering from ICH. Currently, the aim is to use a minimally invasive and safe trajectory in removing significant brain hematomas with the aid of neuro-endoscopy or precise guidance through neuro-navigation, thereby avoiding a collateral damage to the surrounding normal brain tissue...
March 20, 2019: Advances in Experimental Medicine and Biology
Sherri M Biendarra-Tiegs, Frank J Secreto, Timothy J Nelson
Induced pluripotent stem cells (iPSCs) offer great promise in the areas of disease modeling, basic research, drug development, and regenerative medicine. Much of their value comes from the fact that they can be used to create otherwise inaccessible cell types, such as cardiomyocytes, which are genetically matched to a patient or any other individual of interest. A consistent issue plaguing the iPSC platform, however, involves excessive variability exhibited in the differentiated products. This includes discrepancies in genetic, epigenetic, and transcriptional features, cell signalling, the cell types produced from cardiac differentiation, and cardiomyocyte functionality...
March 10, 2019: Advances in Experimental Medicine and Biology
Thi Thuy Hang Tran, Duc Hinh Nguyen, Van Khanh Tran, Quy Linh Nguyen, Hong Anh Trinh, Long Hoang Luong, Van Anh Tran, Le Anh Tuan Pham, Thu Thuy Nguyen, Van Bang Nguyen, Thinh Huy Tran, Thanh Van Ta
BACKGROUND: The sequence polymorphism of mitochondrial DNA (mtDNA) hypervariable segment 1 (HV1) and hypervariable segment 2 (HV2) is studied and applied to genetic diversity and human evolution assessment, forensic genetics, consanguinity determination, and mitochondrial disease diagnosis. METHODS: The study identified the variations of HV1 and HV2 of 517 unrelated Vietnamese individuals in Kinh, Muong, Cham, and Khmer ethnic. We performed sequencing of two hypervariable segments of mitochondrial DNA: HV1 and HV2...
March 6, 2019: Advances in Experimental Medicine and Biology
Chi Dung Vu, Thanh Van Ta, Ngoc-Lan Nguyen, Huy-Hoang Nguyen, Thi Kim Lien Nguyen, Thinh Huy Tran, Van Khanh Tran
Inactivating mutations of the CYP21A2 gene, encoding for steroid synthesis, have been reported in patients with congenital adrenal hyperplasia (CAH). We report a case of an infant who were diagnosed with CAH and presented with the severe phenotype of CAH with symptoms such as increased testicular volume, elevated of 17-hydroxyprogesteron, testosterone and progesterone. In this study, we established an assay for the detection of unusual genetic in the CYP21A2 gene in the proband and his family. A novel nonsense mutation c...
March 6, 2019: Advances in Experimental Medicine and Biology
Cyryl Daroszewski, Małgorzata Stasiewicz, Ewa Jaźwińska-Tarnawska, Anna Rachwalik, Ewa Mura, Joanna Luboch-Kowal, Andrzej Dryś, Zdzisław A Bogucki, Anna Brzecka
The goal of this study was to explore quality of life in patients with advanced non-small-cell lung cancer (NSCLC) in an attempt to single out features that could help predict the possibility of non-completion of chemotherapy. The survey tool was the Quality of Life Questionnaire Core-30 (QLQ-C30) with the module Lung Cancer 13 (LC-13) developed by the European Organization for Research and Treatment of Cancer. The assessment of quality of life (QoL) was performed in 58 patients with advanced NSCLC before palliative chemotherapy and it was repeated in 43 patients who completed at least three cycles of chemotherapy...
March 2, 2019: Advances in Experimental Medicine and Biology
Janusz Skrzypecki, Huc Tomasz, Ciepiaszuk Karolina
Removal of lacrimal glands is used as a viable model of dry eye disease in rats. However, there is no uniform agreement on the disease severity following different variants of the procedure. The interpretation of the modeled dry eye disease also is biased by the interchangeable use of male and female rats. Therefore, this study seeks to define the features of dry eye disease following removal of the extraorbital lacrimal gland, with or without excision of the infraorbital lacrimal gland in male and female rats...
February 27, 2019: Advances in Experimental Medicine and Biology
S Kespohl, Monika Raulf
Asthmatic patients are suspected of having a higher risk of mold sensitization. Thus, precise diagnosis of fungal sensitization is important. Mold allergen extracts are difficult to standardize, but component-resolved allergy diagnosis may be an alternative to replace extract-based tests. In this research, asthmatic and non-asthmatic subjects were studied for their sensitization to Aspergillus fumigatus (Asp f), Cladosporium herbarum (Cla h), Penicillium chrysogenum (Pen ch), Alternaria alternata (Alt a), and Aspergillus versicolor (Asp v)...
February 20, 2019: Advances in Experimental Medicine and Biology
Nazmul Haque, Darius Widera, Noor Hayaty Abu Kasim
BACKGROUND: The response of stem cells to paracrine factors within the host's body plays an important role in the regeneration process after transplantation. The aim of this study was to determine the viability and paracrine factor profile of stem cells from human extracted deciduous teeth (SHED) pre-cultivated in media supplemented with either foetal bovine serum (FBS) or pooled human serum (pHS) in the presence of individual human sera (iHS). METHODS: SHED (n = 3) from passage 4 were expanded in FBS (FBS-SHED) or pHS (pHS-SHED) supplemented media until passage 7...
February 16, 2019: Advances in Experimental Medicine and Biology
Dominik Majewski, Katarzyna A Majewska, Barbara Kuznar-Kaminska, Marta Runowska, Tomasz Piorunek, Halina Batura-Gabryel, Mariusz Puszczewicz
Systemic sclerosis is a connective tissue disease characterized by tissue fibrosis leading to interstitial lung disease. Transforming growth factor-β (TGF-β) has been of interest as a potential diagnostic marker and also as a drug target in systemic sclerosis. The aim of this study was to assess the serum content of TGF-β1 in patients with systemic sclerosis and to assess its potential role in tissue fibrosis. The study included 30 patients, 5 men and 25 women, of the mean age of 46.9 ± 12.8 years, diagnosed with systemic sclerosis...
February 14, 2019: Advances in Experimental Medicine and Biology
Hanna Czajka, Szymon Czajka, Katarzyna Anna Dyląg, Elżbieta Borek, Ernest Kuchar
A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. One hundred and thirty eight (138) children, mean 24...
February 14, 2019: Advances in Experimental Medicine and Biology
Mariusz Chabowski, Judyta Łuczak, Krzysztof Dudek, Beata Jankowska-Polańska
Sleep disorders are common in patients with chronic obstructive pulmonary disease (COPD) and are associated with greater disease severity, more frequent exacerbations, greater use of emergency health care, and higher mortality. They may contribute to worsening of COPD course by reducing patients' adherence to treatment. The aim of this study was to evaluate quality of sleep in COPD patients and to assess the relationship between impaired sleep and adherence to inhalation therapy. The study included 106 COPD patients who were asked to answer the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Adherence to Refills and Medications Scale (ARMS)...
February 12, 2019: Advances in Experimental Medicine and Biology
Hüseyin Abdik, Ezgi Avsar Abdik, Ayşen Aslı Hızlı Deniz, Pakize Neslihan Taşlı, Fikrettin Şahin
In the past decade a number of different stem cell types have entered the clinical applications increasingly as a therapeutic option, due to their tissue maintenance capacity at the site where they localize. Although it was initially thought that conferral of resilience to damaged tissue largely depends on the stem cells themselves through orchestration of signaling among the local epithelial and immune systems at the injury site, recent findings point out that the remarkable regenerative capacity of stem cells is rather due to their nanovesicular products that emerge as the new active players of tissue repair processes...
February 8, 2019: Advances in Experimental Medicine and Biology
A Rybak, M Zarzecki, E Golabiewska, A Niechoda, A Holownia
Erlotinib is a widely used, reversible tyrosine kinase inhibitor (TKI), targeting pro-proliferative signaling of epidermal growth factor receptor (EGFR). The drug is approved for the first-line treatment of patients with metastatic non-small cell lung cancer with EGFR mutations. Extracellular glycans can affect EGFR expression, dimerization, phosphorylation, and EGF binding. In this study we investigated the effects of EGF and erlotinib on the cell cycle of naive and sialidase (alpha-neuraminidase)-pretreated human A549 alveolar epithelial cells...
February 8, 2019: Advances in Experimental Medicine and Biology
Ayşegül Mendi, Hacer Ulutürk, Mustafa Sancar Ataç, Derviş Yılmaz
Oromaxillofacial tissues (OMT) are composed of tooth and bone, together with nerves and blood vessels. Such a composite material is a huge source for mesenchymal stem cells (MSCs) that can be obtained with ease from extracted teeth, teeth structures and socket blood, flapped gingiva tissue, and mandibular/maxillar bone marrow. They offer a biological answer for restoring damaged dental tissues such as the regeneration of alveolar bone, prevention of pulp tissue defects, and dental structures. Dental tissue-derived mesenchymal stem cells share properties with bone marrow-derived mesenchymal stem cells and there is a considerable potential for these cells to be used in different stem cell-based therapies, such as bone and nerve regeneration...
February 7, 2019: Advances in Experimental Medicine and Biology
Joanna Waligóra, Maria Magdalena Bujnowska-Fedak
Advances in mobile technology constitute a promising and evolving trend that enables better access to health care especially for the elderly, disabled, and chronically ill. It overcomes geographical, temporal, and organizational barriers at low and affordable costs. The aim of the study was to evaluate the needs and expectations of Polish citizens and their attitudes toward mobile health (mHealth) services using mobile phones and communication devices in medical care and also to evaluate the sociodemographic factors affecting such behavioral processes...
February 7, 2019: Advances in Experimental Medicine and Biology
Selami Demirci, Alexis Leonard, Juan J Haro-Mora, Naoya Uchida, John F Tisdale
Sickle cell disease (SCD) is an inherited monogenic disorder resulting in serious mortality and morbidity worldwide. Although the disease was characterized more than a century ago, there are only two FDA approved medications to lessen disease severity, and a definitive cure available to all patients with SCD is lacking. Rapid and substantial progress in genome editing approaches have proven valuable as a curative option given plausibility to either correct the underlying mutation in patient-derived hematopoietic stem/progenitor cells (HSPCs), induce fetal hemoglobin expression to circumvent sickling of red blood cells (RBCs), or create corrected induced pluripotent stem cells (iPSCs) among other approaches...
February 5, 2019: Advances in Experimental Medicine and Biology
Özge Sezin Somuncu
Decellularized organs and tissues are effectively utilized in a diversity of regenerative medicine purposes, and the decellularization approaches employed differ as broadly as the tissues/organs of concern. Biological scaffold substances formed by extracellular matrix (ECM) are mostly produced with methods that include decellularization of tissues. Conservation of the multifaceted arrangement and three-dimensional (3D) construction of the ECM is very wanted but it is documented that almost every approach of decellularization cause disturbance of the organization and possible forfeiture of surface organization and conformation...
February 2, 2019: Advances in Experimental Medicine and Biology
Jakub Kucharz, Monika Budnik, Paulina Dumnicka, Maciej Pastuszczak, Beata Kuśnierz-Cabala, Tomasz Demkow, Katarzyna Popko, Pawel Wiechno
Patients with metastatic clear cell renal cell carcinoma (mRCC) typically receive systemic treatment with tyrosine kinase inhibitors (TKI). Side effects include the hand-foot syndrome (HFS), tiredness, nausea, decreased appetite, diarrhea, myelosuppression, and hypertension. This study seeks to define the relationship between the incidence of HFS after the first cycle of treatment with sunitinib as the first-line treatment for mRCC (50 mg/day, 6-week schedule: 4 weeks on and 2 weeks off) and progression-free survival...
January 31, 2019: Advances in Experimental Medicine and Biology
Aneta Czerwonogrodzka-Senczyna, Małgorzata Rumińska, Anna Majcher, Dominika Credo, Anna Jeznach-Steinhagen, Beata Pyrżak
Inappropriate dietary habits influence the development of excessive body weight. The role of added sugars, including fructose, notably is significant in this process. It is estimated that fructose intake has increased many times over the past two centuries. The aim of the study was to define the effect of fructose consumption on anthropometric indices and lipid metabolism in obese (body mass index (BMI) >30 kg/m2 ) children and adolescents. The study included 84 patients (47 girls and 37 boys) aged 7-18 years, divided into prepubertal, pubertal, and post-pubertal age groups...
January 31, 2019: Advances in Experimental Medicine and Biology
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