journal
https://read.qxmd.com/read/38364717/the-yes-associated-protein-1-yap1-inhibitor-celastrol-suppresses-the-ability-of-transforming-growth-factor-%C3%AE-to-activate-human-gingival-fibroblasts
#21
JOURNAL ARTICLE
Angha Naik, Pratyusha Chitturi, John Nguyen, Andrew Leask
OBJECTIVE: To determine whether celastrol, an inhibitor of the mechanosensitive transcriptional cofactor yes-associated protein-1 (YAP1), impairs the ability of TGFβ1 to stimulate fibrogenic activity in human gingival fibroblast cell line. DESIGN: Human gingival fibroblasts were pre-treated with celastrol or DMSO followed by stimulation with or without TGFβ1 (4 ng/ml). We then utilized bulk RNA sequencing (RNAseq), real-time polymerase chain reaction (RT-PCR), Western blot, immunofluorescence, cell proliferation assays to determine if celastrol impaired TGFβ1-induced responses in a human gingival fibroblast cell line...
February 5, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38335699/carbon-dots-combined-with-phytosphingosine-inhibit-acid-induced-demineralization-of-hydroxyapatite-in-vitro
#22
JOURNAL ARTICLE
Cuicui Fu, Henk S Brand, Kamran Nazmi, Arie Werner, Annina van Splunter, Floris J Bikker
OBJECTIVES: To study the effects of carbon dots (CDs), in combination with phytosphingosine (PHS), against acid-induced demineralization of hydroxyapatite in vitro. METHODS: CDs were generated from citric acid and urea by microwave heating. Transmission electron microscope (TEM), FT-IR, and fluorescence intensity were used to characterize the CDs. A hydroxyapatite (HAp) model was used to investigate the protective effects of CDs, PHS, and their combinations with and without a salivary pellicle against acid-induced demineralization in vitro...
February 5, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38335700/analysis-of-head-motions-during-food-intake-in-japanese-adults-using-a-new-motion-capture-system
#23
JOURNAL ARTICLE
Kohei Chinju, Yushi Yamamoto, Emi Inada, Yoichiro Iwashita, Hideo Sato
OBJECTIVE: A new motion capture system was developed to verify the hypothesis that "during food intake, head motion changes according to the properties of the food." DESIGN: Twenty healthy males and 20 healthy females with right-handed and normal occlusion participated in this study. The motion capture system used consisted of a Microsoft Xbox One Kinect Sensor® and a newly-developed program. Meatballs (solid), yogurt (paste), and water (fluid) were used as food samples...
February 3, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38309196/tfeb-regulates-the-odontoblastic-differentiation-of-dental-pulp-stem-cells-by-promoting-a-positive-feedback-loop-between-mitophagy-and-glycolysis
#24
JOURNAL ARTICLE
Yiming Li, Enli Yang, Yiming Geng, Mingyang Li, Xuan Wang, Dongsheng Zhang
OBJECTIVE: To evaluate the regulatory effect of transcription factor EB (TFEB) on the odontoblastic differentiation of dental pulp stem cells(DPSCs) in vivo and in vitro. DESIGNS: RNA-seq was used to detect differentially expressed genes in differentiated DPSCs. Lysosomes and the expression of the related gene TFEB were examined in DPSCs. DPSCs were then transfected with lentivirus for TFEB-overexpression. Cell proliferation was detected using CCK-8 and EdU assays, while cell differentiation was detected using ALP and ARS detection kits...
February 1, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38290225/resveratrol-is-an-inhibitory-polyphenol-of-epithelial-mesenchymal-transition-induced-by-fusobacterium-nucleatum
#25
JOURNAL ARTICLE
Jie Min, Chiho Mashimo, Takayuki Nambu, Hugo Maruyama, Hiroki Takigawa, Toshinori Okinaga
OBJECTIVE: Resveratrol is a natural phytoalexin that has anti-inflammatory properties, reverses doxorubicin resistance, and inhibits epithelial-mesenchymal transition (EMT) in many types of cancer cells. Fusobacterium nucleatum is reportedly enriched in oral squamous cell carcinoma (OSCC) tissues compared to adjacent normal tissues, sparking interest in the relationship between F. nucleatum and OSCC. Recently, F. nucleatum was shown to be associated with EMT in OSCC. In the present study, we aimed to investigate the effects of the natural plant compound resveratrol on F...
January 22, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38278126/association-between-alcohol-dehydrogenase-polymorphisms-rs1229984-rs1573496-rs1154460-and-rs284787-and-susceptibility-to-head-and-neck-cancers-a-systematic-review-and-meta-analysis
#26
REVIEW
Mohammad Moslem Imani, Mohamad Mehdi Moradi, Farzad Rezaei, Hamid Reza Mozaffari, Roohollah Sharifi, Mohsen Safaei, Fatemeh Azizi, Masoumeh Basamtabar, Zahra Sohrabi, Majid Shalchi, Masoud Sadeghi
OBJECTIVE: Head and neck cancer (HNC) is a prevalent and complex group of malignancies with increasing incidence globally. Alcohol dehydrogenases (ADHs) play a crucial role in alcohol metabolism, and their polymorphisms have been linked to HNC risk. This systematic review and meta-analysis aims to evaluate the association between ADH polymorphisms and susceptibility to HNCs, incorporating additional analyses and adding more studies to increase power and accuracy of the results. DESIGN: Subgroup analysis, meta-regression analysis, and sensitivity analyses were conducted to explore potential differences within the data and assess the stability of pooled odds ratios (ORs)...
January 22, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38278124/notum-plays-a-bidirectionally-modulatory-role-in-the-odontoblastic-differentiation-of-human-stem-cells-from-the-apical-papilla-through-the-wnt-%C3%AE-catenin-signaling-pathway
#27
JOURNAL ARTICLE
Qingxuan Zhao, Huihui Ren, Nan Wang, Xiaojing Yuan, Yuming Zhao, Quan Wen
OBJECTIVE: Notum is a secreted deacylase, which is crucial for tooth dentin development in mice. This study aimed to investigate the effect of NOTUM on the odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs), to reveal the potential value of NOTUM in pulp-dentin complex regeneration. DESIGN: The expression pattern of NOTUM in human tooth germs and during in vitro odontoblastic differentiation of hSCAPs was evaluated by immunohistochemical staining, and quantitative polymerase chain reaction, respectively...
January 20, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38266424/variation-in-enamel-prism-size-in-primate-molars
#28
JOURNAL ARTICLE
Ian Towle, Carolina Loch
OBJECTIVE: This study examines whether larger enamel prism diameters accommodate a greater enamel volume from the enamel-dentine junction (EDJ) to the outer-enamel surface (OES) in primate molars, and how prism size relates to enamel thickness and crown location. DESIGN: We assessed variation in enamel prism diameter in relation to crown location and enamel thickness in catarrhine lower molars (n = 14 species) and one platyrrhine. Prism diameter and enamel thickness were recorded in four locations (lingual lateral; lingual cuspal; buccal cuspal; buccal lateral), using a buccal-lingual section through the centre of the mesial cusps...
January 17, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38278125/association-between-raftlin-and-presepsin-levels-with-periodontal-healthy-and-disease-conditions
#29
JOURNAL ARTICLE
Eda Çetin Özdemir, Meral Uzunkaya, Hasan Gündoğar, Ergül Belge Kurutaş
OBJECTIVE: The aim of this study was to examine the association between Raftlin and Presepsin levels in periodontal healthy/diseases, hypothesizing a change in their levels. Also, the study aimed to determine their potential role in diagnosing and predicting the prognosis of periodontal diseases. DESIGN: A cross-sectional study design was used, including 20 periodontally healthy individuals, 21 gingivitis patients, and 21 periodontitis patients. Clinical measurements and gingival crevicular fluid (GCF) sample collection were conducted, and the levels of Raftlin and Presepsin were analyzed...
January 12, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38271891/nociceptive-and-histomorphometric-evaluation-of-the-effects-of-ozone-therapy-on-the-rat-masseter-muscle-in-a-carrageenan-model-of-myofascial-pain
#30
JOURNAL ARTICLE
Kelvin Borges Rocha de Souza, Lysianne Rodrigues de Almeida Guerra, Marcos Lázaro da Silva Guerreiro, Luciana Lyra Casais-E-Silva, Marcio Cajazeira Aguiar
OBJECTIVE: This study evaluated the effects of intramuscular ozone therapy on nociception, inflammation, and tissue damage caused by the injection of carrageenan in the masseter muscle of rats. DESIGN: Rat masseter muscles were injected with saline or carrageenan. Seventy-seven adult male rats were divided into six groups: Sal, saline; Car, carrageenan; Ibup + Sal, ibuprofen and saline; Ibup + Car, ibuprofen and carrageenan; O3 + Sal, ozone and saline; and O3 + Car, ozone and carrageenan...
January 12, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38232498/patterns-and-sexual-dimorphism-of-non-syndromic-hypodontia-among-a-french-orthodontic-population
#31
JOURNAL ARTICLE
Anaïs Cavare, Pierre-Hadrien Decaup, Marie-José Boileau, Elsa Garot
OBJECTIVES: This retrospective study aimed to estimate the prevalence of non-syndromic congenitally missing teeth (CMT) and to explore the frequency of CMT patterns in a French orthodontic population. In addition, the study sought to assess sex-based differences in CMT patterns. DESIGN: Panoramic radiographs of 4569 orthodontic patients between 9 and 21 years-old performed over a 16-year period (2006-2022) were examined to identify non-syndromic tooth agenesis, excluding third molars...
January 12, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38295615/oral-bacteriome-and-oral-potentially-malignant-disorders-a-systematic-review-of-the-associations
#32
REVIEW
Pamela Pignatelli, Maria Cristina Curia, Gianluca Tenore, Danilo Bondi, Adriano Piattelli, Umberto Romeo
INTRODUCTION: Periodontal bacteria can infiltrate the epithelium, activate signaling pathways, induce inflammation, and block natural killer and cytotoxic cells, all of which contribute to the vicious circle of carcinogenesis. It is unknown whether oral dysbiosis has an impact on the etiology or prognosis of OPMD. AIMS: Within this paradigm, this work systemically investigated and reported on the composition of oral microbiota in patients with oral potentially malignant disorders (OPMD) versus healthy controls...
January 8, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38241846/evaluation-of-the-differences-in-the-localization-of-the-lingula-mandibulae-according-to-pubertal-development-in-children-a-new-anthropological-and-forensic-approach
#33
JOURNAL ARTICLE
Hakan Eren, Berkant Sezer, Yeşim Deniz
OBJECTIVE: This study aims to investigate changes in lingula mandibulae localization before and after puberty and sex differences. DESIGN: 288 panoramic radiographs evaluated retrospectively were divided into four groups according to pubertal development: under and over 10 years old for females and under and over 11 years old for males. Four anatomic sites were used as reference points: (a) the anterior border of the ramus; (b) the posterior border of the ramus; (c) the deepest point of mandibular notch; and (d) the angulus mandibulae...
January 7, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38199116/autophagy-induced-by-hypoxia-in-pulpitis-is-mediated-by-hif-1%C3%AE-bnip3
#34
JOURNAL ARTICLE
Xiaohe Wang, Zeyu Wu, Yangyang Zhang, Bingjie Lian, Li Ma, Jin Zhao
OBJECTIVE: Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2 interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions. However, their roles in pulpitis are unclear. Therefore, the changes in inflammatory response and autophagy levels caused by hypoxia during pulpitis were evaluated. Additionally, the regulatory mechanism of HIF-1α/BNIP3 in cellular autophagy in pulpitis was explored. DESIGN: Pulp from dental pulp tissues of healthy individuals and patients with pulpitis (n = 10) were exposed and combined with a low oxygen simulation chamber to construct pulpitis (n = 6), hypoxia (n = 6), and hypoxia+pulpitis (n = 6) rat models...
January 5, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38211398/influence-of-the-radius-of-monson-s-sphere-and-excursive-occlusal-contacts-on-masticatory-function-of-dentate-subjects
#35
JOURNAL ARTICLE
Dominique Ellen Carneiro, Luiz Ricardo Marafigo Zander, Carolina Ruppel, Giancarlo De La Torre Canales, Rubén Auccaise-Estrada, Alfonso Sánchez-Ayala
OBJECTIVE: To determine the influence of the radius of Monson's sphere, the number of posterior laterotrusive, mediotrusive, and protrusive contacts, and the chewing rate on food comminution. DESIGN: Sixty healthy dentate subjects, aged 21.22 ± 2.30 years, were selected. The three-dimensional coordinates of the cusp tips of the lower canine, premolar, and molar teeth were identified from the subjects' digital models. Monson's sphere was designed using the simplex method for function minimisation by adjusting the coordinates on its surface...
January 4, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38171058/molecular-mechanisms-underlying-the-effect-of-tooth-shortening-on-memory-dysfunction-in-wistar-male-rat
#36
JOURNAL ARTICLE
Ali Esmaeili, Shiva Ebrahimpour, Kimiya Forouzandeh Hefshejani, Abolghasem Esmaeili
OBJECTIVE: We investigated the effects of molar tooth shortening on the mRNA expression of the AβPP/BACE1, BDNF/TrkB, and Bax/Bcl-2 signaling pathways in the Wistar male rat hippocampal regions. DESIGN: Four groups (n = 5 per group) of male Wistar rats (control, SRM (shortened right molar), SLM (shortened left molar), and SBM (shortened bilateral molar)) were used. RNA was isolated from the hippocampus and transformed into cDNA. Real-time quantitative PCR was used to evaluate the mRNA expression levels of AβPP, BACE1, Bax, Bcl-2, BDNF, and TrkB...
December 30, 2023: Archives of Oral Biology
https://read.qxmd.com/read/37980840/risk-of-head-and-neck-cancer-among-opium-users
#37
REVIEW
Elham Mohebbi, Zainab Alimoradi, Laura S Rozek, Azadeh Mohebbi, Elahe Jafari
OBJECTIVE: The scientific literature presents conflicting data on a possible causal relationship between opium users and the development of head and neck cancer (HNC). This study aimed to explore the risk of HNC among opium users is a narcotic addictive drug. DESIGN: A systematic review and meta-analysis encompassed academic databases and gray literature up to May 2023, focusing on epidemiologic observational studies that reported the effect size of the HNC risk and opium use...
January 2024: Archives of Oral Biology
https://read.qxmd.com/read/38183935/impact-of-obesity-on-the-structures-and-functions-of-the-stomatognathic-system-a-morphofunctional-approach
#38
JOURNAL ARTICLE
Isabela Hallak Regalo, Marcelo Palinkas, Ligia Maria Napolitano Gonçalves, Paulo Batista de Vasconcelos, Annalisa Cappella, Riccardo Solazzo, Claudia Lucia Pimenta Ferreira, Claudia Dolci, Simone Cecilio Hallak Regalo, Chiarella Sforza, Selma Siessere
OBJECTIVE: The prevalence of obesity is increasing significantly worldwide, raising great concern among health professionals. This observational study evaluated the electromyographic activity and thickness of the masseter and temporalis muscles, in addition to the maximum molar bite force, in obese and eutrophic subjects. METHODS: Sixty subjects were divided into three groups: I (7-12 years), II (13-20 years), III (21-40 years) and sex: with 10 men and 10 women for each group...
December 26, 2023: Archives of Oral Biology
https://read.qxmd.com/read/38160519/rodents-as-an-animal-model-for-studying-tooth-extraction-related-medication-related-osteonecrosis-of-the-jaw-assessment-of-outcomes
#39
REVIEW
Henrique Hadad, Henrique R Matheus, Sara I Pai, Francisley A Souza, Fernando P S Guastaldi
OBJECTIVE: To assess the outcomes of several rodent animal models for studying tooth extraction-related medication-related osteonecrosis of the jaw (MRONJ). DESIGN: After a search of the databases, 2004 articles were located, and 118 corroborated the inclusion factors (in vivo studies in rodents evaluating tooth extraction as a risk factor for the development of MRONJ). RESULTS: Numerous studies attempting to establish an optimal protocol to induce MRONJ were found...
December 26, 2023: Archives of Oral Biology
https://read.qxmd.com/read/38181490/biological-properties-of-stem-cells-from-the-apical-papilla-exposed-to-lipopolysaccharides-an-in-vitro-study
#40
JOURNAL ARTICLE
Cristina Bucchi, Ana Bucchi, Paulina Martínez-Rodríguez
OBJECTIVE: The aim of this study was to analyze the effect of lipopolysaccharides (LPS) on the biological properties of stem cells from the apical papilla (SCAPs), such as viability, adhesion to dentin, odontoblast-like differentiation, mineralization, and release of immunomodulatory cytokines. DESIGN: SCAPs were isolated from immature teeth of three donors (10 to 15 years old) and cultured in mineralizing media with or without 1 μg/mL lipopolysaccharide (LPS)...
December 22, 2023: Archives of Oral Biology
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