journal
https://read.qxmd.com/read/38829140/-acinetobacter-baumannii-satellite-phage-aci01-2-phanie-depends-on-a-helper-myophage-for-its-multiplication
#21
JOURNAL ARTICLE
Christine Pourcel, Christiane Essoh, Malika Ouldali, Paulo Tavares
We report the discovery of a satellite-helper phage system with a novel type of dependence on a tail donor. The Acinetobacter baumannii satellite podovirus Aci01-2-Phanie (short name Phanie) uses a phage phi29-like DNA replication and packaging mode. Its linear 11,885 bp dsDNA genome bears 171 bp inverted terminal repeats (ITR). Phanie is related to phage DU-PP-III from Pectobacterium and to members of the Astrithrvirus from Salmonella enterica . Together, they form a new clade of phages with 27% to 30% identity over the whole genome...
June 3, 2024: Journal of Virology
https://read.qxmd.com/read/38829139/flt3-agonist-enhances-immunogenicity-of-arenavirus-vector-based-simian-immunodeficiency-virus-vaccine-in-macaques
#22
JOURNAL ARTICLE
Archana Vidya Boopathy, Anurag Nekkalapudi, Janette Sung, Sophie Schulha, Debi Jin, Bhawna Sharma, Sarah Ng, Sabrina Lu, Raphaela Wimmer, Silpa Suthram, Sarah Ahmadi-Erber, Henning Lauterbach, Klaus K Orlinger, Magdeleine Hung, Brian Carr, Christian Callebaut, Romas Geleziunas, Michelle Kuhne, Sarah Schmidt, Brie Falkard
Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in nonhuman primates. Several studies have evaluated the use of immune modulators to further enhance vaccine-induced T-cell responses. The hematopoietic growth factor Flt3L drives the expansion of various bone marrow progenitor populations, and administration of Flt3L was shown to promote expansion of dendritic cell populations in spleen and blood, which are targets of arenaviral vectors...
June 3, 2024: Journal of Virology
https://read.qxmd.com/read/38829138/a-full-length-glycoprotein-mrna-vaccine-confers-complete-protection-against-severe-fever-with-thrombocytopenia-syndrome-virus-with-broad-spectrum-protective-effects-against-bandaviruses
#23
JOURNAL ARTICLE
Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan
UNLABELLED: Highly pathogenic viruses from family Phenuiviridae , which are mainly transmitted by arthropods, have intermittently sparked epidemics worldwide. In particular, tick-borne bandaviruses, such as severe fever with thrombocytopenia syndrome virus (SFTSV), continue to spread in mountainous areas, resulting in an average mortality rate as high as 10.5%, highlighting the urgency and importance of vaccine development. Here, an mRNA vaccine developed based on the full-length SFTSV glycoprotein, containing both the receptor-binding domain and the fusion domain, was shown to confer complete protection against SFTSV at a very low dose by triggering a type 1 helper T cell-biased cellular immune response in rodents...
June 3, 2024: Journal of Virology
https://read.qxmd.com/read/38829137/porcine-deltacoronavirus-nucleocapsid-protein-antagonizes-jak-stat-signaling-pathway-by-targeting-stat1-through-kpna2-degradation
#24
JOURNAL ARTICLE
Yating Hu, Chenlin Hao, Donghan Wang, Meng Guo, Hongyan Chu, Xiaohui Jin, Shaopo Zu, Xueyan Ding, Honglei Zhang, Hui Hu
Porcine deltacoronavirus (PDCoV) is an enteric pathogenic coronavirus that causes acute and severe watery diarrhea in piglets and has the ability of cross-species transmission, posing a great threat to swine production and public health. The interferon (IFN)-mediated signal transduction represents an important component of virus-host interactions and plays an essential role in regulating viral infection. Previous studies have suggested that multifunctional viral proteins encoded by coronaviruses antagonize the production of IFN via various means...
June 3, 2024: Journal of Virology
https://read.qxmd.com/read/38829136/dipeptidyl-peptidase-4-interacts-with-porcine-coronavirus-phev-spikes-and-mediates-host-range-expansion
#25
JOURNAL ARTICLE
Junchao Shi, Shiyu Hu, Hanlu Wei, Le Zhang, Yungang Lan, Jiyu Guan, Kui Zhao, Feng Gao, Wenqi He, Zi Li
Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, is prevalent in natural reservoir pigs and infects mice. This raises concerns about host jumping or spillover, but little is known about the cause of occurrence. Here, we revealed that dipeptidyl peptidase 4 (DPP4) is a candidate binding target of PHEV spikes and works as a broad barrier to overcome. Investigations of the host breadth of PHEV confirmed that cells derived from pigs and mice are permissive to virus propagation...
June 3, 2024: Journal of Virology
https://read.qxmd.com/read/38819171/identification-of-a-novel-neurovirulence-factor-encoded-by-the-cryptic-orphan-gene-ul31-6-of-herpes-simplex-virus-1
#26
JOURNAL ARTICLE
Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi
Although the herpes simplex virus type 1 (HSV-1) genome was thought to contain approximately 80 different protein coding sequences (CDSs), recent multi-omics analyses reported HSV-1 encodes more than 200 potential CDSs. However, few of the newly identified CDSs were confirmed to be expressed at the peptide or protein level in HSV-1-infected cells. Furthermore, the impact of the proteins they encode on HSV-1 infection is largely unknown. This study focused on a newly identified CDS, UL31.6. Re-analyzation of our previous chemical proteomics data verified that UL31...
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38819169/correction-for-su-et-al-japanese-encephalitis-virus-infection-initiates-endoplasmic-reticulum-stress-and-an-unfolded-protein-response
#27
JOURNAL ARTICLE
Hong-Lin Su, Ching-Len Liao, Yi-Ling Lin
No abstract text is available yet for this article.
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38819165/correction-for-huang-et-al-n-linked-glycans-and-k147-residue-on-hemagglutinin-synergize-to-elicit-broadly-reactive-h1n1-influenza-virus-antibodies
#28
JOURNAL ARTICLE
Ying Huang, Simon O Owino, Corey J Crevar, Donald M Carter, Ted M Ross
No abstract text is available yet for this article.
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38819164/correction-for-carter-et-al-design-and-characterization-of-a-computationally-optimized-broadly-reactive-hemagglutinin-vaccine-for-h1n1-influenza-viruses
#29
JOURNAL ARTICLE
Donald M Carter, Christopher A Darby, Bradford C Lefoley, Corey J Crevar, Timothy Alefantis, Raymond Oomen, Stephen F Anderson, Tod Strugnell, Guadalupe Cortés-Garcia, Thorsten U Vogel, Mark Parrington, Harold Kleanthous, Ted M Ross
No abstract text is available yet for this article.
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38819163/retraction-for-carter-et-al-elicitation-of-protective-antibodies-against-a-broad-panel-of-h1n1-viruses-in-ferrets-preimmune-to-historical-h1n1-influenza-viruses
#30
Donald M Carter, Christopher A Darby, Scott K Johnson, Michael A Carlock, Greg A Kirchenbaum, James D Allen, Thorsten U Vogel, Simon Delagrave, Joshua DiNapoli, Harold Kleanthous, Ted M Ross
No abstract text is available yet for this article.
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38819132/human-coronavirus-oc43-infection-remodels-connexin-43-mediated-gap-junction-intercellular-communication-in-vitro
#31
JOURNAL ARTICLE
Souvik Karmakar, Jayasri Das Sarma
β-coronaviruses cause acute infection in the upper respiratory tract, resulting in various symptoms and clinical manifestations. OC43 is a human β-coronavirus that induces mild clinical symptoms and can be safely studied in the BSL2 laboratory. Due to its low risk, OC43 can be a valuable and accessible model for understanding β-coronavirus pathogenesis. One potential target for limiting virus infectivity could be gap junction-mediated communication. This study aims to unveil the status of cell-to-cell communications through gap junctions in human β-coronavirus infection...
May 31, 2024: Journal of Virology
https://read.qxmd.com/read/38814068/migraine-inhibitor-olcegepant-reduces-weight-loss-and-il-6-release-in-sars-cov-2-infected-older-mice-with-neurological-signs
#32
JOURNAL ARTICLE
Shafaqat M Rahman, David W Buchholz, Brian Imbiakha, Mason C Jager, Justin Leach, Raven M Osborn, Ann O Birmingham, Stephen Dewhurst, Hector C Aguilar, Anne E Luebke
COVID-19 can cause neurological symptoms such as fever, dizziness, and nausea. However, such neurological symptoms of SARS-CoV-2 infection have been hardly assessed in mouse models. In this study, we infected two commonly used wild-type mouse lines (C57BL/6J and 129/SvEv) and a 129S calcitonin gene-related peptide (αCGRP) null-line with mouse-adapted SARS-CoV-2 and demonstrated neurological signs including fever, dizziness, and nausea. We then evaluated whether a CGRP receptor antagonist, olcegepant, a "gepant" antagonist used in migraine treatment, could mitigate acute neuroinflammatory and neurological signs of SARS-COV-2 infection...
May 30, 2024: Journal of Virology
https://read.qxmd.com/read/38814067/ido1-promotes-csfv-replication-by-mediating-tryptophan-metabolism-to-inhibit-nf-%C3%AE%C2%BAb-signaling
#33
JOURNAL ARTICLE
Feifan Zhao, Yaoyao Huang, Junzhi Ji, Xueyi Liu, Xiaowen Li, Linke Zou, Keke Wu, Xiao di Liu, Sen Zeng, Xinyan Wang, Wenshuo Hu, Yiwan Song, Zhimin Lu, Bolun Zhou, Peng Li, Weijun Wang, Mingqiu Zhao, Jinding Chen, Lin Yi, Shuangqi Fan
Tryptophan metabolism plays a crucial role in facilitating various cellular processes essential for maintaining normal cellular function. Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan (Trp) into kynurenine (Kyn), thereby initiating the degradation of Trp. The resulting Kyn metabolites have been implicated in the modulation of immune responses. Currently, the role of IDO1-mediated tryptophan metabolism in the process of viral infection remains relatively unknown. In this study, we discovered that classical swine fever virus (CSFV) infection of PK-15 cells can induce the expression of IDO1, thereby promoting tryptophan metabolism...
May 30, 2024: Journal of Virology
https://read.qxmd.com/read/38814066/higher-hiv-1-evolutionary-rate-is-associated-with-cytotoxic-t-lymphocyte-escape-mutations-in-infants
#34
JOURNAL ARTICLE
Jamirah Nazziwa, Sophie M Andrews, Mimi M Hou, Christian A W Bruhn, Miguel A Garcia-Knight, Jennifer Slyker, Sarah Hill, Barbara Lohman Payne, Dorothy Moringas, Philippe Lemey, Grace John-Stewart, Sarah L Rowland-Jones, Joakim Esbjörnsson
Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210 gag and 1,264 nef sequences longitudinally collected within 15 months after birth from 14 HIV-1 perinatally infected infants and their mothers were analyzed. The number of transmitted founder (T/F) viruses and associations between virus evolution, selection, CTL escape, and disease progression were determined...
May 30, 2024: Journal of Virology
https://read.qxmd.com/read/38809027/a-community-science-approach-to-public-health-and-public-trust-in-science
#35
COMMENT
Christine Marizzi, Paul Kehinde Ajayi, Rita McMahon, Philip S Meade
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of health literacy and trust in pandemic management. Collaborating with the community to prepare for pandemics is incredibly effective in fostering understanding and building trust in public health and scientific research.
May 29, 2024: Journal of Virology
https://read.qxmd.com/read/38809021/hexestrol-an-estrogen-receptor-agonist-inhibits-lassa-virus-entry
#36
JOURNAL ARTICLE
Zihan Zhang, Toru Takenaga, Sarah Katharina Fehling, Manabu Igarashi, Takatsugu Hirokawa, Yukiko Muramoto, Koji Yamauchi, Chiho Onishi, Masahiro Nakano, Shuzo Urata, Allison Groseth, Thomas Strecker, Takeshi Noda
Lassa virus (LASV) is the causative agent of human Lassa fever which in severe cases manifests as hemorrhagic fever leading to thousands of deaths annually. However, no approved vaccines or antiviral drugs are currently available. Recently, we screened approximately 2,500 compounds using a recombinant vesicular stomatitis virus (VSV) expressing LASV glycoprotein GP (VSV-LASVGP) and identified a P-glycoprotein inhibitor as a potential LASV entry inhibitor. Here, we show that another identified candidate, hexestrol (HES), an estrogen receptor agonist, is also a LASV entry inhibitor...
May 29, 2024: Journal of Virology
https://read.qxmd.com/read/38809020/rabv-induces-biphasic-actin-cytoskeletal-rearrangement-through-rac1-activity-modulation
#37
JOURNAL ARTICLE
Xiaomin Liu, Jing Xu, Maolin Zhang, Hualei Wang, Xin Guo, Mingxin Zhao, Ming Duan, Zhenhong Guan, Yidi Guo
Rabies virus (RABV) is highly lethal and triggers severe neurological symptoms. The neuropathogenic mechanism remains poorly understood. Ras-related C3 botulinum toxin substrate 1 (Rac1) is a Rho-GTPase that is involved in actin remodeling and has been reported to be closely associated with neuronal dysfunction. In this study, by means of a combination of pharmacological inhibitors, small interfering RNA, and specific dominant-negatives, we characterize the crucial roles of dynamic actin and the regulatory function of Rac1 in RABV infection, dominantly in the viral entry phase...
May 29, 2024: Journal of Virology
https://read.qxmd.com/read/38808973/subgenomic-flavivirus-rna-as-key-target-for-live-attenuated-vaccine-development
#38
REVIEW
Kristel Doets, Gorben P Pijlman
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.
May 29, 2024: Journal of Virology
https://read.qxmd.com/read/38785424/correction-for-domingo-et-al-puzzles-challenges-and-information-reservoir-of-sars-cov-2-quasispecies
#39
JOURNAL ARTICLE
Esteban Domingo, Brenda Martínez-González, Carlos García-Crespo, Pilar Somovilla, Ana Isabel de Ávila, María Eugenia Soria, Antoni Durán-Pastor, Celia Perales
No abstract text is available yet for this article.
May 24, 2024: Journal of Virology
https://read.qxmd.com/read/38785423/host-obesity-impacts-genetic-variation-in-influenza-a-viral-populations
#40
JOURNAL ARTICLE
Marissa Knoll, Rebekah Honce, Victoria Meliopoulos, Ernesto Alejandro Segredo-Otero, Katherine E E Johnson, Stacey Schultz-Cherry, Elodie Ghedin, David Gresham
Obesity is well established as a risk factor for many noncommunicable diseases; however, its consequences for infectious disease are poorly understood. Here, we investigated the impact of host obesity on influenza A virus (IAV) genetic variation using a diet-induced obesity ferret model and the A/Hong Kong/1073/1999 (H9N2) strain. Using a co-caging study design, we investigated the maintenance, generation, and transmission of intrahost IAV genetic variation by sequencing viral genomic RNA obtained from nasal wash samples over multiple days of infection...
May 24, 2024: Journal of Virology
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