journal
https://read.qxmd.com/read/38771044/a-cell-cycle-regulator-e2f2-and-glucocorticoid-receptor-cooperatively-transactivate-the-bovine-alphaherpesvirus-1-immediate-early-transcription-unit-1-promoter
#1
JOURNAL ARTICLE
Fouad S El-Mayet, Clinton Jones
UNLABELLED: Bovine alphaherpesvirus 1 (BoHV-1) infection causes respiratory tract disorders and immune suppression and may induce bacterial pneumonia. BoHV-1 establishes lifelong latency in sensory neurons after acute infection. Reactivation from latency consistently occurs following stress or intravenous injection of the synthetic corticosteroid dexamethasone (DEX), which mimics stress. The immediate early transcription unit 1 (IEtu1) promoter drives expression of infected cell protein 0 (bICP0) and bICP4, two viral transcriptional regulators necessary for productive infection and reactivation from latency...
May 21, 2024: Journal of Virology
https://read.qxmd.com/read/38771043/bacteriophage-cocktail-shows-no-toxicity-and-improves-the-survival-of-galleria-mellonella-infected-with-klebsiella-spp
#2
JOURNAL ARTICLE
Lucy Kelly, Eleanor Jameson
Klebsiella spp. are causative agents of healthcare-associated infections in patients who are immunocompromised and use medical devices. The antibiotic resistance crisis has led to an increase in infections caused by these bacteria, which can develop into potentially life-threatening illnesses if not treated swiftly and effectively. Thus, new treatment options for Klebsiella are urgently required. Phage therapy can offer an alternative to ineffective antibiotic treatments for antibiotic-resistant bacteria infections...
May 21, 2024: Journal of Virology
https://read.qxmd.com/read/38771042/sequence-polymorphisms-in-the-reovirus-%C3%AF-1-attachment-protein-modulate-encapsidation-efficiency-and-replication-in-mice
#3
JOURNAL ARTICLE
Olivia L Welsh, Alexa N Roth, Danica M Sutherland, Terence S Dermody
UNLABELLED: Many functions of viral attachment proteins are established, but less is known about the biological importance of viral attachment protein encapsidation efficiency. The mammalian orthoreovirus (reovirus) σ1 attachment protein forms filamentous trimers that incorporate into pentamers of the λ2 capsid protein. Reovirus strains vary in the efficiency of σ1 encapsidation onto progeny virions, which influences viral stability during entry into cells and the efficacy of tumor cell lysis...
May 21, 2024: Journal of Virology
https://read.qxmd.com/read/38767375/kaposi-sarcoma-associated-herpesvirus-complement-control-protein-kcp-and-glycoprotein-k8-1-are-not-required-for-viral-infection-in-vitro-or-in-vivo
#4
JOURNAL ARTICLE
Murali Muniraju, Lorraine Z Mutsvunguma, Ivana G Reidel, Gabriela M Escalante, Simeon Cua, Webster Musonda, Jonathan Calero-Landa, Mafalda A Farelo, Esther Rodriguez, Zhou Li, Javier Gordon Ogembo
UNLABELLED: Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, is the causal agent of Kaposi sarcoma, a cancer that appears as tumors on the skin or mucosal surfaces, as well as primary effusion lymphoma and KSHV-associated multicentric Castleman disease, which are B-cell lymphoproliferative disorders. Effective prophylactic and therapeutic strategies against KSHV infection and its associated diseases are needed. To develop these strategies, it is crucial to identify and target viral glycoproteins involved in KSHV infection of host cells...
May 20, 2024: Journal of Virology
https://read.qxmd.com/read/38767356/s309-car-nk-cells-bind-the-omicron-variants-in-vitro-and-reduce-sars-cov-2-viral-loads-in-humanized-ace2-nsg-mice
#5
JOURNAL ARTICLE
Minh Tuyet Ma, Qingkui Jiang, Chih-Hsiung Chen, Saiaditya Badeti, Xuening Wang, Cong Zeng, Deborah Evans, Brittany Bodnar, Salvatore A E Marras, Sanjay Tyagi, Preeti Bharaj, Ghassan Yehia, Peter Romanienko, Wenhui Hu, Shan-Lu Liu, Lanbo Shi, Dongfang Liu
UNLABELLED: Recent progress on chimeric antigen receptor (CAR)-NK cells has shown promising results in treating CD19-positive lymphoid tumors with minimal toxicities [including graft versus host disease (GvHD) and cytokine release syndrome (CRS) in clinical trials. Nevertheless, the use of CAR-NK cells in combating viral infections has not yet been fully explored. Previous studies have shown that CAR-NK cells expressing S309 single-chain fragment variable (scFv), hereinafter S309-CAR-NK cells, can bind to SARS-CoV-2 wildtype pseudotyped virus (PV) and effectively kill cells expressing wild-type spike protein in vitro ...
May 20, 2024: Journal of Virology
https://read.qxmd.com/read/38767352/an-mrna-lnp-based-lassa-virus-vaccine-induces-protective-immunity-in-mice
#6
JOURNAL ARTICLE
Mei Hashizume, Ayako Takashima, Masaharu Iwasaki
The mammarenavirus Lassa virus (LASV) causes the life-threatening hemorrhagic fever disease, Lassa fever. The lack of licensed medical countermeasures against LASV underscores the urgent need for the development of novel LASV vaccines, which has been hampered by the requirement for a biosafety level 4 facility to handle live LASV. Here, we investigated the efficacy of mRNA-lipid nanoparticle (mRNA-LNP)-based vaccines expressing the LASV glycoprotein precursor (LASgpc) or nucleoprotein (LCMnp) of the prototypic mammarenavirus, lymphocytic choriomeningitis virus (LCMV), in mice...
May 20, 2024: Journal of Virology
https://read.qxmd.com/read/38757985/classical-swine-fever-virus-non-structural-protein-4a-recruits-dihydroorotate-dehydrogenase-to-facilitate-viral-replication
#7
JOURNAL ARTICLE
Bing-Qian Zhao, Jing Chen, Jin-Xia Chen, Yan Cheng, Jiang-Fei Zhou, Ji-Shan Bai, Ding-Yi Mao, Bin Zhou
UNLABELLED: Mitochondria are energy producers in cells, which can affect viral replication by regulating the host innate immune signaling pathways, and the changes in their biological functions are inextricably linked the viral life cycle. In this study, we screened a library of 382 mitochondria-targeted compounds and identified the antiviral inhibitors of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the de novo synthesis pathway of pyrimidine ribonucleotides, against classical swine fever virus (CSFV)...
May 17, 2024: Journal of Virology
https://read.qxmd.com/read/38757972/targeting-host-o-linked-glycan-biosynthesis-affects-ebola-virus-replication-efficiency-and-reveals-differential-galnac-t-acceptor-site-preferences-on-the-ebola-virus-glycoprotein
#8
JOURNAL ARTICLE
Ieva Bagdonaite, Samir Abdurahman, Mattia Mirandola, Denis Pasqual, Martin Frank, Yoshiki Narimatsu, Hiren J Joshi, Sergey Y Vakhrushev, Cristiano Salata, Ali Mirazimi, Hans H Wandall
Ebola virus glycoprotein (EBOV GP) is one of the most heavily O-glycosylated viral glycoproteins, yet we still lack a fundamental understanding of the structure of its large O-glycosylated mucin-like domain and to what degree the host O-glycosylation capacity influences EBOV replication. Using tandem mass spectrometry, we identified 47 O-glycosites on EBOV GP and found similar glycosylation signatures on virus-like particle- and cell lysate-derived GP. Furthermore, we performed quantitative differential O-glycoproteomics on proteins produced in wild-type HEK293 cells and cell lines ablated for the three key initiators of O-linked glycosylation, GalNAc-T1, -T2, and -T3...
May 17, 2024: Journal of Virology
https://read.qxmd.com/read/38752754/the-genomic-and-phylogenetic-analysis-of-marseillevirus-cajuinensis-raises-questions-about-the-evolution-of-marseilleviridae-lineages-and-their-taxonomical-organization
#9
JOURNAL ARTICLE
Bruna Luiza de Azevedo, Victória Fulgêncio Queiroz, Isabella Luiza Martins de Aquino, Talita Bastos Machado, Felipe Lopes de Assis, Erik Reis, João Pessoa Araújo Júnior, Leila Sabrina Ullmann, Philippe Colson, Gilbert Greub, Frank Aylward, Rodrigo Araújo Lima Rodrigues, Jônatas Santos Abrahão
UNLABELLED: Marseilleviruses (MsV) are a group of viruses that compose the Marseilleviridae family within the Nucleocytoviricota phylum. They have been found in different samples, mainly in freshwater. MsV are classically organized into five phylogenetic lineages (A/B/C/D/E), but the current taxonomy does not fully represent all the diversity of the MsV lineages. Here, we describe a novel strain isolated from a Brazilian saltwater sample named Marseillevirus cajuinensis. Based on genomics and phylogenetic analyses, M...
May 16, 2024: Journal of Virology
https://read.qxmd.com/read/38752725/biologically-significant-interaction-of-human-herpesvirus-8-viral-interferon-regulatory-factor-4-with-ubiquitin-specific-protease-7
#10
JOURNAL ARTICLE
Zunlin Yang, John Nicholas
UNLABELLED: Human herpesvirus 8 (HHV-8), associated with Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease, encodes four interferon regulatory factor homologs, vIRFs 1-4, that interact with and inhibit various mediators of host-cell defense against virus infection. A cellular protein targeted by all the vIRFs is ubiquitin-specific protease 7 (USP7); while replication-modulatory and latently infected PEL-cell pro-viability phenotypes of USP7 targeting have been identified for vIRFs 1-3, the significance of the interaction of vIRF-4 with USP7 has remained undetermined...
May 16, 2024: Journal of Virology
https://read.qxmd.com/read/38747601/detection-of-clade-2-3-4-4b-highly-pathogenic-h5n1-influenza-virus-in-new-york-city
#11
JOURNAL ARTICLE
Philip S Meade, Pooja Bandawane, Kaitlyn Bushfield, Irene Hoxie, Karla R Azcona, Daneidy Burgos, Sadia Choudhury, Adama Diaby, Mariama Diallo, Kailani Gaynor, Aaron Huang, Kadiatou Kante, Shehryar N Khan, William Kim, Paul Kehinde Ajayi, Ericka Roubidoux, Sasha Nelson, Rita McMahon, Randy A Albrecht, Florian Krammer, Christine Marizzi
Highly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.4b were detected in North America in the winter of 2021/2022. These viruses have spread across the Americas, causing morbidity and mortality in both wild and domestic birds as well as some mammalian species, including cattle. Many surveillance programs for wildlife as well as commercial poultry operations have detected these viruses. In this study, we conducted surveillance of avian species in the urban environment in New York City. We detected highly pathogenic H5N1 viruses in six samples from four different bird species and performed whole-genome sequencing...
May 15, 2024: Journal of Virology
https://read.qxmd.com/read/38742902/linc08148-promotes-the-caveola-mediated-endocytosis-of-zika-virus-through-upregulating-transcription-of-src
#12
JOURNAL ARTICLE
Zhiting Huo, Xuanfeng Zhu, Qinyu Peng, Cancan Chen, Xiaoyi Yang, Changbai Huang, Yincheng Xiang, Qingju Tian, Jingyu Liu, Chao Liu, Ping Zhang
UNLABELLED: Long non-coding RNAs (lncRNAs) represent a new group of host factors involved in viral infection. Current study identified an intergenic lncRNA, LINC08148, as a proviral factor of Zika virus (ZIKV) and Dengue virus 2 (DENV2). Knockout (KO) or silencing of LINC08148 decreases the replication of ZIKV and DENV2. LINC08148 mainly acts at the endocytosis step of ZIKV but at a later stage of DENV2. RNA-seq analysis reveals that LINC08148 knockout downregulates the transcription levels of five endocytosis-related genes including AP2B1 , CHMP4C , DNM1 , FCHO1 , and Src ...
May 14, 2024: Journal of Virology
https://read.qxmd.com/read/38742901/optimization-of-quenched-fluorescent-peptide-substrates-of-sars-cov-2-3cl-pro-main-protease-mpro-from-proteomic-identification-of-p6-p6-active-site-specificity
#13
JOURNAL ARTICLE
Hugo Cesar Ramos de Jesus, Nestor Solis, Yoan Machado, Isabel Pablos, Peter A Bell, Reinhild Kappelhoff, Peter M Grin, Carlos A Sorgi, Georgina S Butler, Christopher M Overall
SARS-CoV-2 3C-like main protease (3CLpro ) is essential for protein excision from the viral polyprotein. 3CLpro inhibitor drug development to block SARS-CoV-2 replication focuses on the catalytic non-prime (P) side for specificity and potency, but the importance of the prime (P') side in substrate specificity and for drug development remains underappreciated. We determined the P6-P6' specificity for 3CLpro from >800 cleavage sites that we identified using Proteomic Identification of Cleavage site Specificity (PICS)...
May 14, 2024: Journal of Virology
https://read.qxmd.com/read/38742875/equine-herpesvirus-type-1-ehv-1-replication-at-the-upper-respiratory-entry-site-is-inhibited-by-neutralizing-ehv-1-specific-igg1-and-igg4-7-mucosal-antibodies
#14
JOURNAL ARTICLE
Naya A Eady, Camille Holmes, Christiane Schnabel, Susanna Babasyan, Bettina Wagner
Equine herpesvirus type 1 (EHV-1) is a contagious respiratory pathogen that infects the mucosa of the upper respiratory tract (URT). Mucosal immune responses at the URT provide the first line of defense against EHV-1 and are crucial for orchestrating immunity. To define host-pathogen interactions, we characterized B-cell responses, antibody isotype functions, and EHV-1 replication of susceptible (non-immune) and clinically protected (immune) horses after experimental EHV-1 infection. Nasal secretion and nasal wash samples were collected and used for the isolation of DNA, RNA, and mucosal antibodies...
May 14, 2024: Journal of Virology
https://read.qxmd.com/read/38742874/covert-rna-viruses-in-medflies-differ-in-their-mode-of-transmission-and-tissue-tropism
#15
JOURNAL ARTICLE
Luis Hernández-Pelegrín, Hannah-Isadora Huditz, Pablo García-Castillo, Norbert C A de Ruijter, Monique M van Oers, Salvador Herrero, Vera I D Ros
UNLABELLED: Numerous studies have demonstrated the presence of covert viral infections in insects. These infections can be transmitted in insect populations via two main routes: vertical from parents to offspring, or horizontal between nonrelated individuals. Thirteen covert RNA viruses have been described in the Mediterranean fruit fly (medfly). Some of these viruses are established in different laboratory-reared and wild medfly populations, although variations in the viral repertoire and viral levels have been observed at different time points...
May 14, 2024: Journal of Virology
https://read.qxmd.com/read/38717113/degradation-of-trim32-is-induced-by-rta-for-kaposi-s-sarcoma-associated-herpesvirus-lytic-replication
#16
JOURNAL ARTICLE
Yulin Zhang, Zhongwei Dong, Feng Gu, Yifei Xu, Ying Li, Wen Sun, Wutian Rao, Shujuan Du, Caixia Zhu, Yuyan Wang, Fang Wei, Qiliang Cai
UNLABELLED: TRIM32 is often aberrantly expressed in many types of cancers. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked with several human malignancies, including Kaposi's sarcoma and primary effusion lymphomas (PELs). Increasing evidence has demonstrated the crucial role of KSHV lytic replication in viral tumorigenesis. However, the role of TRIM32 in herpesvirus lytic replication remains unclear. Here, we reveal that the expression of TRIM32 is upregulated by KSHV in latency, and reactivation of KSHV lytic replication leads to the inhibition of TRIM32 in PEL cells...
May 8, 2024: Journal of Virology
https://read.qxmd.com/read/38717112/update-on-human-herpesvirus-7-pathogenesis-and-clinical-aspects-as-a-roadmap-for-future-research
#17
REVIEW
Rianne Verbeek, Linos Vandekerckhove, Jolien Van Cleemput
Human herpesvirus 7 (HHV-7) is a common virus that is associated with various human diseases including febrile syndromes, dermatological lesions, neurological defects, and transplant complications. Still, HHV-7 remains one of the least studied members of all human betaherpesviruses. In addition, HHV-7-related research is mostly confined to case reports, while in vitro or in vivo studies unraveling basic virology, transmission mechanisms, and viral pathogenesis are sparse. Here, we discuss HHV-7-related literature linking clinical syndromes to the viral life cycle, epidemiology, and viral immunopathogenesis...
May 8, 2024: Journal of Virology
https://read.qxmd.com/read/38712945/characterization-of-virus%C3%A2-host-recombinant-variants-of-the-hepatitis-e-virus
#18
JOURNAL ARTICLE
Olivia Paronetto, Claire Allioux, Chloé Diméglio, Lhorane Lobjois, Nicolas Jeanne, Noémie Ranger, Jérôme Boineau, Mélanie Pucelle, Sofia Demmou, Florence Abravanel, Sabine Chapuy-Regaud, Jacques Izopet, Sébastien Lhomme
UNLABELLED: Hepatitis E virus is a single-strand, positive-sense RNA virus that can lead to chronic infection in immunocompromised patients. Virus-host recombinant variants (VHRVs) have been described in such patients. These variants integrate part of human genes into the polyproline-rich region that could introduce new post-translational modifications (PTMs), such as ubiquitination. The aim of this study was to characterize the replication capacity of different VHRVs, namely, RNF19A, ZNF787, KIF1B, EEF1A1, RNA18, RPS17, and RPL6...
May 7, 2024: Journal of Virology
https://read.qxmd.com/read/38709106/human-coronavirus-oc43-nanobody-neutralizes-virus-and-protects-mice-from-infection
#19
JOURNAL ARTICLE
Amy Adair, Li Lynn Tan, Jackson Feng, Jason Girkin, Nathan Bryant, Mingyang Wang, Francesca Mordant, Li-Jin Chan, Nathan W Bartlett, Kanta Subbarao, Phillip Pymm, Wai-Hong Tham
UNLABELLED: Human coronavirus (hCoV) OC43 is endemic to global populations and usually causes asymptomatic or mild upper respiratory tract illness. Here, we demonstrate the neutralization efficacy of isolated nanobodies from alpacas immunized with the S1B and S1C domain of the hCoV-OC43 spike glycoprotein. A total of 40 nanobodies bound to recombinant OC43 protein with affinities ranging from 1 to 149 nM. Two nanobodies WNb 293 and WNb 294 neutralized virus at 0.21 and 1.79 nM, respectively...
May 6, 2024: Journal of Virology
https://read.qxmd.com/read/38709105/multiple-e3-ligases-act-as-antiviral-factors-against-sars-cov-2-via-inducing-the-ubiquitination-and-degradation-of-orf9b
#20
JOURNAL ARTICLE
Miao Yu, Jie Li, Wenying Gao, Zhaolong Li, Wenyan Zhang
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) open reading frame 9b (ORF9b) antagonizes the antiviral type I and III interferon (IFN) responses and is ubiquitinated and degraded via the ubiquitin-proteasome pathway. However, E3 ubiquitin ligases that mediate the polyubiquitination and degradation of ORF9b remain unknown. In this study, we identified 14 E3 ligases that specifically bind to SARS-CoV-2 ORF9b. Specifically, three E3 ligases, HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 (HUWE1), ubiquitin protein ligase E3 component n-recognin 4 (UBR4), and UBR5, induced K48-linked polyubiquitination and degradation of ORF9b, thereby attenuating ORF9b-mediated inhibition of the IFN response and SARS-CoV-2 replication...
May 6, 2024: Journal of Virology
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