Tumori | Page 4

Marco Chisari, Raffaella Sensi, Carlo Alfredo Clerici, Fulvia Angela Gariboldi, Filippo Spreafico, Veronica Biassoni, Elisabetta Schiavello, Patrizia Gasparini, Augusto Tommaso Caraceni, Andrea Ferrari, Maura Massimino
This study reports a case series of patients with upper limb neuromotor deficits following pediatric central nervous system tumor and treated with rehabilitative therapy according to action observation therapy (AOT). AOT is based on the "mirror neurons" system and had positive results in various non-oncologic neurologic pathologies. This study is the first experience in the oncology field, and included 6 patients, 4 of whom were fully evaluated at 6-month follow-up. In all patients, therapy showed improvement in all assessment tests...
October 10, 2019: Tumori
Kun Chen, Juan Wang, Jinzhen Dai, Ailin Luo, Yuke Tian, Zhonghui Guan, Xueren Wang
OBJECTIVE: To investigate the perioperative anesthetic management of patients diagnosed with renal cell carcinoma (RCC) metastasized into the renal vein or inferior vena cava (IVC) after undergoing radical nephrectomy to provide clinical evidence for rational anesthetic interventions. METHODS: A total of 81 patients with RCC extending into the renal vein or IVC, aged 17-73 years, undergoing radical nephrectomy were recruited. Preoperative status, intraoperative management, average operation time, average estimated blood loss, postanesthesia outcomes, and postoperative complications were retrospectively analyzed...
October 2019: Tumori
Georges Chahine, Tony Ibrahim, Tony Felefly, Abir El-Ahmadie, Pamela Freiha, Lionel El-Khoury, Nadine Khalife-Saleh, Khalil Saleh
INTRODUCTION: Brain metastases (BM) are rare in colorectal cancer (CRC) and are associated with a dismal prognosis. This work aims to report the rate of BM in CRC patients treated in a single institution, along with survival and prognostic factors. METHODS: Medical charts for patients with histologically proven CRC were retrospectively reviewed. RESULTS: A total of 538 patients were identified, of whom 33% developed any metastatic disease and 4...
October 2019: Tumori
Rosa Falcone, Lidia Strigari, Lorenzo Farina, Paolo Marchetti
No abstract text is available yet for this article.
September 30, 2019: Tumori
Jie Weng, Mengying Xie, Zhe Xu, Zhiyi Wang
No abstract text is available yet for this article.
September 9, 2019: Tumori
Lucia Mangone, Pamela Mancuso, Giovanna Tagliabue, Rosa Angela Filiberti, Giuliano Carrozzi, Silvia Iacovacci, Walter Mazzucco, Rosario Tumino, Pamela Minicozzi, Milena Sant, Paolo Giorgi Rossi
OBJECTIVE: To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I-III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area. METHODS: Data from the High Resolution Study conducted in 7 Italian cancer registries were used; they are a representative sample of incident cancers in the study period (2009-2013). Included were 3546 women aged <85 years (groups <50, 50-69, 70-64, and 75+) with stage I-III breast cancer at diagnosis who underwent surgery...
September 9, 2019: Tumori
Ying-Hui Tong, Ying He, Lu-Ying Hu, Yu-Jia Liu, Xiao-Wei Zheng, Jiao Sun, Yu Song, Yi-Wen Zhang, Luo Fang, Ping Huang
BACKGROUND: An integral and well-functioning vascular system is essential for tumor progression and chemotherapy infusion. However, the lumen integrity of the microvessels and its significance in prognosis has not been studied. In this study, we found that the proportion of collapsed microvessels is suggested to be a novel biomarker for predicting prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: In this study, immunohistochemical CD31 staining was performed to identify the microvessels in tumor specimens...
September 3, 2019: Tumori
Ines Gockel, Boris Jansen-Winkeln, Linda Haase, Stefan Niebisch, Yusef Moulla, Orestis Lyros, Florian Lordick, Katrin Schierle, Christian Wittekind, René Thieme
BACKGROUND: Patients with intestinal cancer (colorectal, appendiceal, and small bowel) with peritoneal metastases (PM) have a poor prognosis. We assessed whether pressurized intraperitoneal aerosol chemotherapy (PIPAC) together with systemic chemotherapy is an effective treatment option for these entities in palliative intent. METHODS: Between November 2015 and February 2018, prospective data registry was performed (NCT03100708). Thirteen patients with intestinal cancer (median age 61 years [range 49-77]) underwent 26 PIPAC procedures with a median number of 2 interventions per patient (range 1-6)...
August 30, 2019: Tumori
Federico Piccioni, Daniela Codazzi, Maria C Paleari, Paola Previtali, Gabriele Delconte, Luca Fumagalli, Renato Manzi, Marco Faustini, Laura Persiani, Maurilia Rizzi, Federico Sodi, Enzo Masci
INTRODUCTION: Endobronchial ultrasound (EBUS) is an endoscopic diagnostic procedure combining flexible fibrobronchoscopy with ultrasound techniques; it allows transbronchial needle aspiration biopsy for the diagnosis and staging of mediastinal masses. We present our preliminary experience with the use of the i-gel O2 supraglottic airway device for management of EBUS procedures. METHODS: An observational study on 39 patients who underwent EBUS under general anesthesia was performed...
August 28, 2019: Tumori
Selin Narter, Secil Hasdemir, Sahsine Tolunay, Sehsuvar Gokgoz
INTRODUCTION: Sclerosing adenosis is a form of adenosis characterized by lobulocentric architecture, glandular and stromal proliferation in which the stromal component compresses and distorts the glandular structures. Atypical epithelial proliferations such as atypical lobular hyperplasia, lobular carcinoma in situ, and ductal carcinoma in situ may accompany areas of sclerosing adenosis. We present a case of ductal carcinoma in situ and sclerosing adenosis with metastatic carcinoma on sentinel lymph node...
August 28, 2019: Tumori
Marco Benasso, Pierluigi Bonomo, Michela Buglione, Maria Grazia Ghi, Lisa Licitra, Stefano Maria Magrini, Marco Carlo Merlano, Livio Presutti, Graziana Ronzino, Daris Ferrari
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease often presenting at an already advanced stage. Cisplatin chemoradiotherapy is the standard treatment for locally advanced disease, although its efficacy varies according to different studies. Thus, treatment selection is a challenge, especially in older patients, who frequently have several comorbidities. Moreover, the majority of patients with recurrent and/or metastatic disease are unsuitable for local treatment, either surgery or radiation therapy...
August 28, 2019: Tumori
Silvia Tanzi, Silvia Di Leo, Elisa Mazzini, Mattia Castagnetti, Caterina Turrà, Carlo Peruselli, Massimo Costantini
BACKGROUND: Several approaches towards pain control for admitted cancer patients have been suggested by the literature without achieving satisfactory results. In this quality improvement project, we proposed a multicomponent intervention. MEASURES: A set of indicators was established for each component of the project. The feasibility of both the intervention and its evaluation system was measured. According to the literature review and the analysis of the local context, 5 active components were identified, piloted, and assessed: training of ward professionals, education of patients and nonprofessional caregivers, regular pain assessment, specialist-level pain consultation procedures, and involvement of hospital management...
August 28, 2019: Tumori
Giulia Galli, Claudia Proto, Mara Cossa, Barbara Valeri, Silvana Sdao, Diego Signorelli, Martina Imbimbo, Filippo de Braud, Marina Chiara Garassino, Giuseppe Lo Russo
INTRODUCTION: Immunotherapy has shown efficacy in the treatment of different malignancies. Nivolumab, an immune checkpoint inhibitor directed against programmed death-1, has been approved for non-small cell lung cancer (NSCLC) in pretreated patients. Although it is generally well-tolerated, immunotherapy may be complicated by a wide range of immune-mediated adverse events. We describe the case of an uncommon skin toxicity arising as alopecia universalis induced by nivolumab in a patient with NSCLC...
August 28, 2019: Tumori
Yasushi Domeki, Masanobu Nakajima, Masakazu Takahashi, Maiko Kikuchi, Haruka Yokoyama, Hideo Ogata, Kentaro Okamoto, Satoru Yamaguchi, Kinro Sasaki, Takashi Tsuchioka, Hiroyuki Kato
BACKGROUND: This study aimed to examine the treatment outcomes of patients with brain metastases from esophageal cancer. Brain metastases from esophageal cancer are rare and have a poorer prognosis than brain metastases from lung and breast cancer. METHODS: This study included patients who were diagnosed with and treated for esophageal cancer in our department and subsequently developed brain metastases between April 2010 and December 2014. We examined the differences in survival in patients based on receiving chemotherapy...
August 28, 2019: Tumori
Ilaria Ardoino, Stefano Signoroni, Enzo Malvicini, Maria Teresa Ricci, Elia M Biganzoli, Lucio Bertario, Savino Occhionorelli, Marco Vitellaro
BACKGROUND: The best surgical choice for patients with familial adenomatous polyposis (FAP) is still debated. No prospective trials have been carried out to evaluate the pros and cons of the recommended procedures: total colectomy (ileorectal anastomosis [IRA]) vs restorative proctocolectomy (ileal pouch-anal anastomosis [IPAA]). The aim of this study was to provide a basis for tailored precision surgery in patients with FAP. METHODS: We conducted a retrospective review of patients with FAP who underwent surgery and were registered in a dedicated database in Milan, Italy...
August 27, 2019: Tumori
Chiara Pellegrini, Augusto T Caraceni, Livia I E Bedodi, Raffaella Sensi, Simona Breggiè, Fulvia A Gariboldi, Cinzia Brunelli
OBJECTIVE: This study reviews the scientific literature to identify and describe which assessment tools (ATs) are used in pediatric oncology and neuro-oncology rehabilitation and which development neuropsychomotor (DNPM) ATs were built for children with central nervous system (CNS) tumors. METHODS: A systematic review was performed searching PubMed, CINAHL, PEDro, Science Direct, and Catalog of National Institute of Tumors databases and specialized journals. The search covered 7 years (2010-2017) and used relevant keywords in different combinations...
August 27, 2019: Tumori
Letizia Ferella, Anna Cavallo, Rosalba Miceli, Nicola Alessandro Iacovelli, Tommaso Giandini, Emanuele Pignoli, Giuseppina Calareso, Paolo Bossi, Carlo Resteghini, Giovanni Luca Gravina, Piero Nicolai, Paolo Castelnuovo, Cesare Piazza, Lisa Licitra, Carlo Fallai, Ester Orlandi
BACKGROUND: We evaluated the prognostic role of gross tumor volumes (GTVs) of primary tumor and positive lymph nodes on overall survival (OS) and progression-free survival (PFS) in locally advanced unresectable sinonasal cancer (SNC) treated with definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy. METHODS: Primary tumor GTV (GTV-T), pathologic neck nodes GTV (GTV-N), and positive retropharyngeal nodes GTV (GTV-RPN) of 34 patients with epithelial nonglandular SNC receiving IMRT with or without chemotherapy were retrospectively measured...
August 27, 2019: Tumori
Paolo Orsaria, Antonella Grasso, Rita Carino, Emanuele Caredda, Matteo Sammarra, Carlo Altomare, Carla Rabitti, Gabriella Gullotta, Giuseppe Perrone, Francesco Pantano, Oreste Claudio Buonomo, Vittorio Altomare
BACKGROUND: Most cases of breast lesions of uncertain malignant potential (B3) undergo surgical intervention. We aimed to analyze the outcome of B3 lesion subtypes in a large series of screen-detected cases. METHODS: We screened 2,986 core needle biopsies to classify B3 lesions. Positive predictive values (PPVs) for malignancy were calculated for a comprehensive risk characterization according to clinicopathologic and morphologic variables. RESULTS: B3 lesions comprised 35% atypical ductal hyperplasia (PPV = 20%), 16...
August 27, 2019: Tumori
Huan Wan, Bin Xu, Ni Zhu, Baozhong Ren
PURPOSE: The present study aims to investigate the efficacy and mechanisms of peroxisome proliferator-activated receptor γ coactivator 1-α agonist, as adjuvant to programmed death-1 (PD-1) blockade in hyporesponsive lung cancer cells-derived in vivo tumor model, using bezafibrate. METHODS: Mouse Lewis lung carcinoma (LLC) xenograft models were established and treated with programmed death-ligand 1 (PD-L1) monoclonal antibodies with or without bezafibrate. Tumors or peripheral blood of mice were harvested to investigate the quality, quantity, and function as well as energetic metabolism of cytotoxic T lymphocytes (CTLs) by flow cytometry or quantitative real-time polymerase chain reaction...
August 27, 2019: Tumori
Lijiang Sun, Ting Xu, Xiaoliang Yuan, Feng Liu, Fengju Guan, Dingwei Ye, Guiming Zhang
OBJECTIVE: This study aimed to investigate the relationship between obesity and pathologic features and biochemical recurrence in patients with prostate cancer (PCa) undergoing radical prostatectomy (RP) after neoadjuvant hormonal therapy (NHT). METHODS: A total of 422 consecutive patients with clinically localized PCa who received NHT before RP were retrospectively analyzed. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) regarding probability...
August 27, 2019: Tumori
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