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https://read.qxmd.com/read/30700226/incidence-of-rare-cancers-in-the-city-of-s%C3%A3-o-paulo-brazil
#41
Maria Teresa Bustamante-Teixeira, Maria do Rosário D O Latorre, Maximiliano R Guerra, Luana F Tanaka, Laura Botta, Annalisa Trama, Gemma Gatta
INTRODUCTION: Rare cancers are a challenge for clinical practice as well as for epidemiology and public health. Studies on this subject are few and limited to the study of cases with scarce epidemiologic information. This study aimed to evaluate the incidence of rare cancers and to compare the demographic, anatomic, and histologic characteristics of rare and nonrare (common) cancers. METHODS: Incidence data were obtained from the Population-based Cancer Registry of São Paulo, Brazil...
January 30, 2019: Tumori
https://read.qxmd.com/read/30674231/semaphorin-4d-promotes-the-proliferation-and-metastasis-of-bladder-cancer-by-activating-the-pi3k-akt-pathway
#42
Jian-Jun Lu, Yao-Wu Su, Chao-Jun Wang, Di-Feng Li, Liang Zhou
The present study aimed to investigate the role of semaphorin 4D (Sema4D) in bladder cancer cell proliferation and metastasis in vivo and in vitro. Effects of Sema4D modulation on cancer cell viability and clonogenic abilities were assessed by MTT assay and colony formation assay. Cell apoptosis, cell cycle analysis, transwell assays, and wound-healing assays were also assayed. A mouse model of bladder cancer was established to observe the tumorigenesis in vivo. Our data showed that Sema4D was 4-fold upregulated in clinical bladder cancer tissues relative to noncancerous ones and differentially expressed in bladder cancer cell lines...
January 24, 2019: Tumori
https://read.qxmd.com/read/30592233/on-the-diagnosis-of-malignant-pleural-mesothelioma-a-necropsy-based-study-of-171-cases-1997-2016
#43
Pietro Gino Barbieri
No abstract text is available yet for this article.
December 28, 2018: Tumori
https://read.qxmd.com/read/30580656/carfilzomib-induced-tumor-lysis-syndrome-in-relapsed-multiple-myeloma-a-report-of-two-cases
#44
Esra Terzi Demirsoy, Elif Birtas Atesoglu, Necmi Eren, Ayfer Gedük, Ozgur Mehtap, Pınar Tarkun, Abdullah Hacıhanefioğlu
BACKGROUND: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, and hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies such as Burkitt lymphoma and acute leukemia. TLS has rarely been observed in multiple myeloma (MM). CASE REPORT: We present 2 patients with relapsed MM who developed TLS after the first cycle of carfilzomib treatment...
December 23, 2018: Tumori
https://read.qxmd.com/read/30558495/role-of-contrast-enhanced-spectral-mammography-in-the-post-biopsy-management-of-b3-lesions-preliminary-results
#45
Giulia Bicchierai, Jacopo Nori, Diego De Benedetto, Cecilia Boeri, Ermanno Vanzi, Simonetta Bianchi, Maninderpal Kaur Gill, Donatello Cirone, Vittorio Miele
PURPOSE: To evaluate the role of contrast-enhanced spectral mammography (CESM) in the post biopsy management of breast lesions classified as lesions of uncertain malignant potential (B3) by core needle biopsy and vacuum-assisted biopsy (VAB). METHODS: The local ethics committee approved this retrospective study and for this type of study formal consent is not required. A total of 42 B3 lesions in 40 women aged 41-77 years were included in our study. All patients underwent CESM 2-3 weeks after the biopsy procedure and surgical excision was subsequently performed within 60 days of the CESM procedure...
December 17, 2018: Tumori
https://read.qxmd.com/read/30514181/irinotecan-toxicity-during-treatment-of-metastatic-colorectal-cancer-focus-on-pharmacogenomics-and-personalized-medicine
#46
Adam Paulík, Jana Nekvindová, Prof Stanislav Filip
Colorectal cancer, one of the most frequent types of cancer worldwide, has a high mortality rate. Irinotecan (CPT-11) has been approved for the treatment of advanced or metastatic disease either as a single agent or, more commonly, as part of combined chemotherapeutic regimens. Treatment with irinotecan is often accompanied by severe toxicity (e.g. neutropenia and diarrhea) that can result in treatment interruption or cessation, thus jeopardizing the patient's prognosis and quality of life. Irinotecan is bioactivated into its metabolite SN-38, which is subsequently detoxified by uridine diphosphate-glucuronosyl transferases (mainly UGT1A1)...
December 5, 2018: Tumori
https://read.qxmd.com/read/30514177/bag3-contributes-to-hgf-mediated-cell-proliferation-migration-and-invasion-via-the-egr1-pathway-in-gastric-cancer
#47
Jae Chang Lee, Sung Ae Koh, Kyung Hee Lee, Jae-Ryong Kim
INTRODUCTION: Bcl2-associated athanogene 3 (BAG3) is elevated in several types of cancers. However, the role of BAG3 in progression of gastric cancer is unknown. Therefore, the present study aims to find out the role of BAG3 in hepatocyte growth factor (HGF)-mediated tumor progression and the molecular mechanisms by which HGF regulates BAG3 expression. METHODS: BAG3 mRNA and protein were measured using reverse transcription polymerase chain reaction and Western blot in the 2 human gastric cancer cell lines, NUGC3 and MKN28, treated with or without HGF...
December 4, 2018: Tumori
https://read.qxmd.com/read/30484385/unexpected-postpneumonectomy-exertion-induced-acute-right-heart-failure
#48
Jacopo Colombo, Iryna Arendar, Ugo Pastorino, Daniela Codazzi
INTRODUCTION: Thoracic surgery can have serious side effects. Accurate preoperative evaluation to assess which patients with anatomically resectable disease are suitable candidates for surgery is mandatory. CASE DESCRIPTION: A 58-year-old man, scheduled for left pneumonectomy for lung cancer, passed all the preoperative examinations suggested by guidelines and underwent the surgery. Three days after pneumonectomy, he experienced hemorrhagic shock and subsequent acute respiratory distress syndrome...
November 28, 2018: Tumori
https://read.qxmd.com/read/30484384/chemoradiation-in-female-patients-with-anal-cancer-patient-reported-outcome-of-acute-and-chronic-side-effects
#49
Stefan A Koerber, Ben Seither, Alla Slynko, Matthias F Haefner, David Krug, Jakob Liermann, Sebastian Adeberg, Klaus Herfarth, Juergen Debus, Florian Sterzing
INTRODUCTION: We evaluated acute and chronic side effects of 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) in female patients with anal carcinoma and accessed correlations between dosimetric parameters and the considered toxicities. METHODS: For 70 women with anal cancer treated at our department, acute and chronic side effects and quality of life (QoL) were evaluated with questionnaires using the Common Terminology Criteria for Adverse Events (CTCAE v...
November 28, 2018: Tumori
https://read.qxmd.com/read/30474503/time-to-systemic-treatment-and-prognosis-in-patients-with-recurrent-and-metastatic-head-and-neck-squamous-cell-cancer
#50
Marco Siano, Vittoria Espeli, Markus Joerger
BACKGROUND: Delay of systemic treatment in recurrent/metastatic head and neck squamous cell cancer (r/mHNSCC) has never been assessed. Whether time span to start systemic treatment affects survival and whether referral to a medical oncologist is important has not been explored. METHODS: We analyzed our head and neck database to assess the prognostic impact of time between diagnosis of r/mHNSCC and start of systemic treatment (time to treatment [TTT]). Secondarily, we assessed the prognostic impact of time to referral to a medical oncologist (referral time)...
November 26, 2018: Tumori
https://read.qxmd.com/read/30474502/patients-understanding-of-clinical-research-an-italian-cancer-patient-survey
#51
Britt Rudnas, Emanuela Montanari, Monia Dall'Agata, Elisabetta Petracci, Oriana Nanni
INTRODUCTION: Patients' awareness of clinical research and their involvement in clinical trials is of great importance, but it is difficult to estimate the extent of knowledge on the research being undertaken. METHODS: We evaluated the level of knowledge about clinical research using a self-reporting survey distributed to 967 adult patients with cancer attending the Departments of Medical Oncology and Onco-Haematology Units of IRST IRCCS and 4 hospitals in the region of Emilia-Romagna, Italy...
November 26, 2018: Tumori
https://read.qxmd.com/read/30392443/meeting-with-triumph-and-disaster-osimertinib-in-t790m-unknown-cns-progression-in-egfr-mutated-non-small-cell-lung-cancer
#52
Francesco Facchinetti, Francesca Bozzetti, Roberta Minari, Giovanni Ceccon, Teresa Zielli, Irene Florindo, Girolamo Crisi, Marcello Tiseo
INTRODUCTION: Treatment paradigms for EGFR-mutated non-small cell lung cancer (NSCLC) have successfully evolved since the introduction of osimertinib. The detection of EGFR T790M mutation in plasma or tumor samples obtained at disease progression to first-/second-generation EGFR inhibitors is mandatory for osimertinib prescription. Nevertheless, pharmacokinetics properties of osimertinib guarantee its usefulness in central nervous system (CNS) disease even in the case of T790M-negative or unknown status...
November 5, 2018: Tumori
https://read.qxmd.com/read/30352536/from-the-seventh-floor-to-seventh-heaven
#53
Laura Veneroni, Paola Gaggiotti, Davide Ciceri, Edoardo Rosati, Maura Massimino, Andrea Ferrari
No abstract text is available yet for this article.
October 24, 2018: Tumori
https://read.qxmd.com/read/30270769/primary-sphenoid-lymphoma-focus-on-imaging
#54
Davide Facchinelli, Enrico Boninsegna, Marco Barillari, Giancarlo Mansueto, Mauro Krampera, Dino Veneri
Primary lymphoma of the sphenoid is an extremely rare pathology, therefore it is difficult to hypothesize and the imaging characteristics are not well-known. Here we report the imaging features in computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scan of a 44-year-old patient who presented with severe headache. CT and MRI showed a sphenoid sinus mass that suggested rhinopharyngeal lesion or a chordoma. However, biopsy from the mass histologically proved it to be Diffuse large B-cell lymphoma and PET examinations revealed increased fluorodeoxyglucose uptake around the sphenoid bone and multiple spinal lesions...
October 1, 2018: Tumori
https://read.qxmd.com/read/30185117/extensive-intraperitoneal-lavage-to-eliminate-intraperitoneal-tumor-cells-in-gastrectomy-with-d2-lymphadenectomy-for-gastric-cancer
#55
Ulrich Ronellenfitsch, Kristina Ernst, Christina Mertens, Marcus J Trunk, Philipp Ströbel, Alexander Marx, Peter Kienle, Stefan Post, Kai Nowak
INTRODUCTION: Survival in gastric cancer is often limited by peritoneal carcinomatosis, which supposedly develops from serosal tumor infiltration or tumor cell spread during gastrectomy with lymphadenectomy. To eliminate peritoneal tumor cells, extensive intraperitoneal lavage (EIPL) has been suggested. Impressive results have been achieved in Japanese trials. In this trial, we assessed EIPL in Western patients. METHODS: This prospective trial included patients with non-metastatic gastric adenocarcinoma undergoing gastrectomy with D2 lymphadenectomy...
October 2018: Tumori
https://read.qxmd.com/read/30086700/denosumab-in-patients-with-aneurysmal-bone-cysts-a-case-series-with-preliminary-results
#56
Emanuela Palmerini, Pietro Ruggieri, Andrea Angelini, Stefano Boriani, Domenico Campanacci, Giuseppe M Milano, Marilena Cesari, Anna Paioli, Alessandra Longhi, Massimo E Abate, Guido Scoccianti, Silvia Terzi, Giulia Trovarelli, Alessandro Franchi, Piero Picci, Stefano Ferrari, Martina Piccinni Leopardi, Michela Pierini
PURPOSE: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC. METHODS: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Patients underwent radiologic disease assessment every 3 months. Symptoms and adverse events were noted. RESULTS: Nine patients were identified (6 male, 3 female), with a median age of 17 years (range 14-42 years)...
October 2018: Tumori
https://read.qxmd.com/read/29986637/equipment-staffing-and-provision-of-radiotherapy-in-lombardy-italy-results-of-three-surveys-performed-between-2012-and-2016
#57
Mauro F Palazzi, Carlo Soatti, Barbara A Jereczek-Fossa, Luigi F Cazzaniga, Paolo Antognoni, Gianstefano Gardani, Marcello Amadori, Ambrogia Baio, Giancarlo Beltramo, Mario Bignardi, Stefano Bracelli, Alberto Buffoli, Simona Castiglioni, Gianpiero Catalano, Nadia Di Muzio, Carlo Fallai, Laura Fariselli, Paolo Frata, Alberto Gramaglia, Corrado Italia, Giovanni Ivaldi, Fabrizio Lombardi, Stefano M Magrini, Simonetta Nava, Enrico Sarti, Luciano Scandolaro, Marta Scorsetti, Francesco Stiglich, Roberto Tortini, Riccardo Valdagni, Francesca Valvo, Vittorio Vavassori, Elena L Sbicego, Sandro Tonoli, Roberto Orecchia
INTRODUCTION: Several efforts are being implemented at the European level to measure provision of up-to-date radiation treatments across the continent. METHODS: A snapshot survey involving all radiation oncology centers within Lombardy, Italy, was performed in 2012 and repeated in 2014 and 2016, in cooperation with regional governmental officers. Centers were asked to provide detailed information concerning all individual patients being treated on the index day, and to report data on available local resources...
October 2018: Tumori
https://read.qxmd.com/read/29739299/grp137-promotes-cell-proliferation-and-metastasis-through-regulation-of-the-pi3k-akt-pathway-in-human-ovarian-cancer
#58
Li-Qian Zhang, Su-Qing Yang, Xiang-Dong Qu, Xian-Jun Chen, Hong-Sheng Lu, Ying Wang
PURPOSE: Ovarian cancer is one of the leading causes of death for women worldwide. The present study aims to investigate the role of G protein-coupled receptor 137 (GPR137) in the biological activities of ovarian cancer cells. METHODS: (QUERY: Please supply Methods for Abstract). RESULTS: G protein-coupled receptor 137 was highly expressed in clinical ovarian cancer tissues and exhibited the highest protein levels in SKOV3 cells and OVCAR3 cells...
October 2018: Tumori
https://read.qxmd.com/read/29714662/safety-of-concurrent-adjuvant-radiotherapy-and-chemotherapy-for-locally-advanced-soft-tissue-sarcoma
#59
Daniela Greto, Mauro Loi, Calogero Saieva, Cristina Muntoni, Camilla Delli Paoli, Carlotta Becherini, Cinzia Ciabatti, Marco Perna, Domenico Campanacci, Francesca Terziani, Giovanni Beltrami, Guido Scoccianti, Pierluigi Bonomo, Icro Meattini, Isacco Desideri, Gabriele Simontacchi, Monica Mangoni, Lorenzo Livi
INTRODUCTION: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS). METHODS: A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria...
October 2018: Tumori
https://read.qxmd.com/read/29192741/taribo-trial-targeted-therapy-with-or-without-nephrectomy-in-metastatic-renal-cell-carcinoma-liquid-biopsy-for-biomarkers-discovery
#60
RANDOMIZED CONTROLLED TRIAL
Elena Verzoni, Raffaele Ratta, Paolo Grassi, Roberto Salvioni, Silvia Stagni, Rosanna Montone, Giovanni Fucà, Vera Cappelletti, Carolina Reduzzi, Ugo De Giorgi, Giuseppe Procopio
PURPOSE: Two randomized trials in the cytokine era showed that cytoreductive nephrectomy (CN) had a role in metastatic renal cell carcinoma (mRCC), increasing life expectancy. The survival benefit of tyrosine kinase inhibitors (TKIs), including first-line sunitinib and pazopanib, in mRCC has been demonstrated, but the majority of patients enrolled in the pivotal phase III studies had undergone nephrectomy. Therefore it is unknown if similar survival benefit with targeted agents could be achieved without CN...
October 2018: Tumori
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