Tumori | Page 2

Ginevra Lolli, Alessandro Broccoli, Vittorio Stefoni, Lisa Argnani, Ornella Leone, Michele Cavo, Pier Luigi Zinzani
BACKGROUND: B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder consisting of clonal proliferation and accumulation of small, mature, CD5-positive B-lymphocytes in the blood, bone marrow, and lymphoid tissues. Among extranodal localizations, cardiac involvement is extremely rare: to our knowledge, there are no findings reported in the literature of concomitant B-CLL diagnosis in the context of atrial myxoma (so-called collision tumours) and the best strategy to treat these malignancies is unclear...
March 12, 2020: Tumori
Ghina Fakhri, Majd Al Assaad, Arafat Tfayli
Lung cancer remains the leading cause of cancer death in both men and women worldwide. Tobacco smoking remains the single most important factor. Recent research has focused on the role of nutrition and dietary habits on lung tumorigenesis. With many individual reports on separate dietary aspects, no single review is available in the literature that summarizes the updated studies. To our knowledge, this is the first review that comprehensively reviews the updated literature on the effect of dietary habits on lung cancer...
March 4, 2020: Tumori
Carla Minoia, Alessia Bari, Luca Nassi, Rita Banzi, Chiara Gerardi, Valentina Lenti, Marco Calabrese, Michele Spina, Attilio Guarini
Several outpatient models for the follow-up of cancer survivors have been developed worldwide. A multidisciplinary approach is often necessary to guarantee the best monitoring of long-term toxicities. Guidelines also indicate a close education on healthy lifestyles. In this context, we have analyzed the Italian follow-up modalities of lymphoma survivors, with the aim to have a starting line to hypothesize and plan the best model for Italian hematology centers.
March 2, 2020: Tumori
Pratik Tripathi, Weifeng Guo, Shengxiang Rao, Mengsu Zeng, Daoyu Hu
INTRODUCTION: Extramural vascular invasion (EMVI) has been recommended as an independent prognostic factor for poor overall survival rate in rectal cancer and can be used as a potential biomarker. Early prediction of prevalence of synchronous metastasis can elevate the disease-free survival rate. We aimed to evaluate the magnetic resonance imaging (MRI)-detected EMVI (mrEMVI) scoring system in predicting distant metastasis in T3 rectal cancer. METHODS: Patients with postoperative histopathologically confirmed T3 rectal cancer without previous treatment from July 2014 to December 2015 were enrolled in this study...
March 2, 2020: Tumori
Alessandra Raimondi, Pierangela Sepe, Melanie Claps, Marco Maccauro, Gianluca Aliberti, Filippo Pagani, Giulia Apollonio, Giovanni Randon, Giorgia Peverelli, Ettore Seregni, Elena Verzoni, Giuseppe Procopio
INTRODUCTION: Therapeutic decision-making in metastatic castration-resistant prostate cancer (mCRPC) represents an open challenge. Radium-223 is approved for patients with symptomatic bone metastases, no visceral involvement, progressing after at least 2 lines of systemic therapy, or ineligible for any other systemic treatment. METHODS: We performed a retrospective, observational study on patients with mCRPC treated with radium-223 at our institution outside of clinical trials, to assess the safety and activity in a real-world population...
March 2, 2020: Tumori
Veronica Grigoletto, Arianna Tagarelli, Catia Atzeni, Giovanni Cecchetto, Paolo Indolfi, Maria Debora De Pasquale, Francesco De Leonardis, Beatrice Coppadoro, Silvia Sorbara, Stefano Chiaravalli, Andrea Ferrari, Gianni Bisogno
INTRODUCTION: Pleuropulmonary blastoma (PPB) is a rare, aggressive mesenchymal tumor of childhood. The Italian Tumori Rari in Età Pediatrica (TREP) Registry was the first in Europe dedicated to prospective data collection on rare pediatric tumors. We analyzed data from an Italian series of patients with PPB, focusing on the role of the TREP Project. METHODS: We considered patients aged 0-14 with histologically confirmed diagnosis, registered in population-based cancer registries (before 2000) or the TREP Registry (2000 to 2014), and analyzed data on clinical characteristics, treatment, and outcome...
April 2020: Tumori
Marco Rispoli, Rosario Salvi, Antonio Cennamo, Davide Di Natale, Giovanni Natale, Ilernando Meoli, Maria Rosaria Gioia, Marianna Esposito, Moana Rossella Nespoli, Mario De Finis, Salvatore Buono, Antonio Corcione, Sabrina Lavoretano, Andrea Bianco, Alfonso Fiorelli, Carlo Curcio, Fabio Perrotta
OBJECTIVE: To investigate the effectiveness of a home-based preoperative rehabilitation program for improving preoperative lung function and surgical outcome of patients with chronic obstructive pulmonary disease (COPD) undergoing lobectomy for cancer. METHODS: This was a prospective, observational, single-center study including 59 patients with mild COPD who underwent lobectomy for lung cancer. All patients attended a home-based preoperative rehabilitation program including a minimum of 3 sessions each week for 4 weeks...
February 23, 2020: Tumori
Luca Boldrini, Antonio Piras, Giuditta Chiloiro, Rosa Autorino, Francesco Cellini, Davide Cusumano, Bruno Fionda, Andrea D'Aviero, Maura Campitelli, Fabio Marazzi, M Balducci, Vincenzo Valentini, Maria Antonietta Gambacorta
OBJECTIVE: Magnetic resonance-guided radiotherapy (MRgRT) represents an innovative approach for personalized radiotherapy treatments and its applications are being explored in various anatomical sites to fully understand its potential advantages. This study describes the first clinical experience of MRgRT application in patients with locally advanced cervical cancer (LACC) undergoing neoadjuvant chemoradiotherapy. The feasibility of the technique is evaluated and its toxicity profile and clinical outcomes are reported...
February 17, 2020: Tumori
Teresa Beninato, Giuseppe Lo Russo, Marina Chiara Garassino, Filippo De Braud, Marco Platania
INTRODUCTION: Patients with cancer have higher risk of thrombosis compared to the general population and particularly lung adenocarcinoma is considered at high risk for venous thromboembolism. Some targetable oncogenic drivers are supposed to further increase this risk. CASE DESCRIPTION: A 35-year-old man who had developed a recurrent venous thromboembolism and pulmonary embolism (PE) was diagnosed with ROS1 rearranged non-small cell lung cancer (NSCLC). While molecular examinations were ongoing, he developed progressive respiratory failure...
February 17, 2020: Tumori
Enqi Wu, Guangwen An, Ritu Wu, Yuanyu Tang, Qing Li, Jinhua Wang, Yaqin Ling, Jia You
OBJECTIVE: To investigate the prevalence of human papillomavirus (HPV) in archival head and neck cancer (HNC) collected from the Tong-Liao area, which is located in east Inner Mongolia, China. METHODS: The presence of HPV in 54 HNCs and 25 benign biopsies was detected and the sequence variation of the E6 gene in HPV-positive samples was analyzed to determine their lineage/sublineage classification. RESULTS: HPV was detected in only 4 out of 54 HNCs and no benign biopsies were found to be HPV-positive...
February 17, 2020: Tumori
Giuseppe Gaipa, Eugenio Erba, Marco Danova, Giuliano Mazzini, Adriano Venditti, Barbara Buldini, Giorgina Specchia, Oscar Maglia, Annalisa Kunkl, Maria Matilde Ciriello, Mario Arpinati, Francesco Mannelli, Francesco Lanza, Roberta Riccioni, Vanna Pistotti, Giovanni Apolone
OBJECTIVE: Acute leukemia (AL) is a broad, heterogeneous group of malignant diseases. The diagnostic workup of AL is based on several clinical and laboratory findings, including flow cytometric immunophenotyping. However, the role of this assay in the diagnosis of AL has not been systematically investigated. The aim of this study was to determine the accuracy and utility of flow cytometric immunophenotyping in the identification, characterization, and staging of AL. METHODS: We performed a systematic selection and classification of the literature since 1980, focused on flow cytometric immunophenotyping of AL...
February 14, 2020: Tumori
Luigi Ventura, Maura Scarlattei, Letizia Gnetti, Enrico Maria Silini, Maurizio Rossi, Marcello Tiseo, Nicola Sverzellati, Giovanni Bocchialini, Luca Musini, Valeria Balestra, Luca Ampollini, Michele Rusca, Paolo Carbognani, Livia Ruffini
OBJECTIVE: To evaluate the prognostic role of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) measured by FDG-positron emission tomography (PET)/computed tomography (CT) in patients with primary lung adenocarcinoma undergoing surgical resection. METHODS: All consecutive patients undergoing curative surgery for primary lung adenocarcinoma at the Thoracic Surgery Unit of the University Hospital of Parma between January 2009 and December 2014 were retrospectively analyzed...
February 14, 2020: Tumori
Lucia Bonomi, Anna Cecilia Bettini, Ermenegildo Arnoldi, Alessandra Chirco, Laura Ghilardi, Ornella Manara, Marco Roscigno, Luigi Filippo Da Pozzo, Carlo Alberto Tondini
BACKGROUND: Meningeal carcinomatosis is rare in patients with kidney cancer and treatment options are limited. Few patients treated with systemic approaches have been reported. We describe a case of complete remission of leptomeningeal metastasis in a patient with renal cell carcinoma treated with nivolumab. To our knowledge, this is the first report of nivolumab safety and efficacy in this particular site of metastasis. CASE PRESENTATION: Our patient was a 60-year-old Caucasian man with bone and lung metastases from renal cell carcinoma...
February 11, 2020: Tumori
Ying Zhang, Beili Jia, Jing Li, Xiaomei Xu
INTRODUCTION: An elderly patient with advanced small cell lung cancer who had a history of smoking and who had previously had tuberculosis and chronic kidney disease relapsed after classical treatment with etoposide combined with carboplatin. METHODS: The patient was given chemotherapy again, with albumin-bound paclitaxel, etoposide capsules, apatinib, and other treatment. The last medication was apatinib. RESULTS: After treatment with anlotinib, the patient has survived for 15 months with good quality of life...
February 7, 2020: Tumori
Katarzyna Kozak, Artur Kowalik, Aleksandra Gos, Bartosz Wasag, Iwona Lugowska, Monika Jurkowska, Natalia Krawczynska, Hanna Kosela-Paterczyk, Tomasz Switaj, Paweł Teterycz, Anna Klimczak, Janusz A Siedlecki, Małgorzata Chlopek, Joanna Kalisz, Janusz Limon, Piotr Rutkowski
OBJECTIVE: We assessed the status of the BRAF V600E mutation in cell-free circulating tumor DNA (cfDNA) isolated from the plasma of patients with metastatic melanoma treated with the BRAF inhibitor vemurafenib, collected at different time points during therapy to evaluate the sensitivity and specificity of quantitative polymerase chain reaction and droplet digital polymerase chain reaction (ddPCR) and the correlation between the level of plasma cfDNA p.V600E and the long-term clinical outcome...
February 6, 2020: Tumori
Maria Caterina Pallotti, Marianna Ricci, Romina Rossi, Lorenzo Cecconetto, Domenico Barone, Marco Maltoni
INTRODUCTION: Palliative care (PC) aims to treat symptoms independently of the disease. In many medical disciplines, including oncology, there is an emphasis on personalizing treatment, identifying the most effective therapeutic option by studying the genetic heritage of the patient and the molecular characteristics of the disease. PC, on the other hand, encompasses the overall (physical and spiritual) well-being of the patient and his or her caregivers. The increasing use of early PC and its integration with oncology could represent a fruitful collaboration among specialists...
February 3, 2020: Tumori
Apollonia Verrengia, Cristina Sigismondi, Eva Iannacone, Adriano Bellia, Luisa Busci, Gaetano Trezzi, Chiara Malandrino, Andrea Gianatti, Luigi Frigerio
INTRODUCTION: The optimal postoperative adjuvant treatment for stage III endometrial cancer (EC) is controversial. The aim of the study was to evaluate the impact of cytoreductive surgery (CRS) and adjuvant chemoradiotherapy (CRT) on relapse-free survival (RFS) and overall survival (OS) in stage III EC. METHODS: Data on 36 patients with stage III EC were reviewed. A review of the literature was performed. RESULTS: Median follow-up was 31 months (range 3-195)...
February 3, 2020: Tumori
Daniela Alterio, Marta Tagliabue, Matteo Muto, Stefano Zorzi, Stefania Volpe, Sara Gandini, Daniela Sibio, Ömer Bayır, Giulia Marvaso, Annamaria Ferrari, Roberto Bruschini, Maria Cossu Rocca, Lorenzo Preda, Roberta Marangoni, Anna Starzynska, Sabrina Vigorito, Mohssen Ansarin, Barbara Alicja Jereczek-Fossa
OBJECTIVE: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). METHODS: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded...
January 30, 2020: Tumori
Guozhong Lai, Na Guo, Yu Jiang, Jielan Lai, Yi Li, Renchun Lai
OBJECTIVE: To assess whether the duration of one-lung ventilation (OLV) affects postoperative pulmonary complications after McKeown esophagectomy for esophageal cancer. METHODS: A retrospective analysis of data stored in a database for esophageal cancer was carried out to identify predictors of postoperative pulmonary complications in patients undergoing McKeown esophagectomy at Sun Yat-sen University Cancer Center between 2010 and 2012. RESULTS: Patients in the OLV ⩾150 minutes group had a higher incidence of postoperative pulmonary complications than those in the OLV <150 minutes group (18...
January 22, 2020: Tumori
Marta Giussani, Chiara Maura Ciniselli, Alessandra Macciotta, Rossella Panella, Paolo Verderio, Chiara Bonini, Daniele Morelli
BACKGROUND: Immunofixation electrophoresis of urinary proteins, coupled with densitometric analysis, is the gold standard method for determining urinary monoclonal free light chains (FLCs), i.e. Bence Jones protein. Recently, immunochemical methods have been developed for Bence Jones protein quantification, but no such method has been widely adopted. This study evaluated a new antibody-based immunoturbidimetry method for urinary FLC quantification, using immunofixation electrophoresis as reference...
January 20, 2020: Tumori
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