Jung-Hoon Kwon, Jin-Yong Noh, Jei-Hyun Jeong, Sol Jeong, Sun-Hak Lee, Yu-Jin Kim, Seong-Su Yuk, Dong-Hun Lee, You-Chan Bae, Seok-Chan Park, Kyung-Hyun Lee, Eun-Kyoung Lee, Yu-Na Lee, Youn-Jeong Lee, Chang-Seon Song
H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus...
January 15, 2019: Virology