Kristen A Clarkson, Chad K Porter, Kawsar R Talaat, Melissa C Kapulu, Wilbur H Chen, Robert W Frenck, A Louis Bourgeois, Robert W Kaminski, Laura B Martin
Shigella-controlled human infection models (CHIMs) are an invaluable tool utilized by the vaccine community to combat one of the leading global causes of infectious diarrhea, which affects infants, children and adults regardless of socioeconomic status. The impact of shigellosis disproportionately affects children in low- and middle-income countries (LMICs) resulting in cognitive and physical stunting, perpetuating a cycle that must be halted. Shigella-CHIMs not only facilitate the early evaluation of enteric countermeasures and up-selection of the most promising products but also provide insight into mechanisms of infection and immunity that are not possible utilizing animal models or in vitro systems...
May 27, 2022: Current Topics in Microbiology and Immunology