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Caries Research

Katia Regina Vasconcelos, Juliana Arid, Silvane Evangelista, Sara Oliveira, André Luiz Dutra, Lea Assed Bezerra Silva, Raquel Assed Bezerra Segato, Alexandre Rezende Vieira, Paulo Nelson-Filho, Erika Calvano Küchler
The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil. Den tal caries and DDE data were collected through clinical examination from 216 children. Genomic DNA was extracted from saliva, and genotyping of selected polymorphisms in MMP8 (rs17099443 and rs3765620), MMP13 (rs478927 and rs2252070), and MMP20 (rs1784418) was performed using TaqMan chemistry and endpoint analysis...
February 13, 2019: Caries Research
Fernanda Raposo, Ana Cristina de Carvalho Rodrigues, Érica Negrini Lia, Soraya Coelho Leal
AIM: This study aimed to investigate the prevalence of hypersensitivity in molar-incisor hypomineralization (MIH)-affected molars through a census carried out in 8-year-old schoolchildren. METHODS: Examinations were conducted by a calibrated examiner, using the Nyvad criteria for caries diagnosis and a new criterion for MIH assessment. For hypersensitivity assessment, all MIH-affected molars were included. Nonaffected molars from the same child were used as controls...
January 24, 2019: Caries Research
Ana Karine Macedo Teixeira, Angelo Giuseppe Roncalli, Luiz Roberto Augusto Noro
OBJECTIVE: To investigate the impact of the family's socioeconomic trajectory on the oral health status of young people in the city of Sobral, Ceará, Brazil, and test the hypotheses of the life course theory. METHODS: This is a cohort study conducted in 2000, 2006, and 2012. In the third wave, 482 individuals between 17 and 21 years of age were examined and interviewed. The outcomes analyzed were the trajectory of tooth decay (decayed teeth in 2012 and cavity reoccurrence) and the trajectory of dental assistance (immediate dental assistance and untreated caries)...
January 16, 2019: Caries Research
Eva-Karin Bergström, Thomas Davidson, Ulla Moberg Sköld
Since 2008, FRAMM has been a guideline for caries prevention for all 3- to 15-year-olds in the Västra Götaland Region in Sweden and a predominant part is school-based fluoride varnish applications for all 12- to 15-year-olds. The aims were to evaluate dental health-economic data among 12- to 15-year-olds, based on the approximal caries prevalence at the age of 12, and to evaluate cost-effectiveness. Caries data for 13,490 adolescents born in 1993 who did not take part and 11,321 adolescents born in 1998 who followed this guideline were extracted from dental records...
January 16, 2019: Caries Research
Jin Xiao, Naemah Alkhers, Dorota T Kopycka-Kedzierawski, Ronald J Billings, Tong Tong Wu, Daniel A Castillo, Linda Rasubala, Hans Malmstrom, Yanfang Ren, Eli Eliav
Despite the advancement of early childhood caries (ECC) prediction and treatment, ECC remains a significant public health burden in need of more effective preventive strategies. Pregnancy is an ideal period to promote ECC prevention given the profound influence of maternal oral health and behaviors on children's oral health. However, studies have shown debatable results with respect to the effectiveness of ECC prevention by means of prenatal intervention. Therefore, this study systematically reviewed the scientific evidence relating to the association between prenatal oral health care, ECC incidence, and Streptococcus mutans carriage in children...
January 10, 2019: Caries Research
Zerrin Abbasoğlu, Diego G Bussaneli, İlknur Tanboğa, Indiara W Henn, Adriana Modesto, Alexandre R Vieira
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of unequal contributions of risk factors and protective factors that influence the disease. The aim of this study was to assess if the X chromosome region previously linked to caries was associated with ECC. Two hundred and fifty-nine unrelated children with no chronic illnesses from 2 to 5 years of age who had no systemic fluoride consumption were evaluated using a cross-sectional design...
December 21, 2018: Caries Research
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December 14, 2018: Caries Research
Ann-Catrin André Kramer, Aldina Pivodic, Magnus Hakeberg, Anna-Lena Östberg
The objective was to investigate the variability in dental caries experience in Swedish children and adolescents, at two different area levels: dental clinics and SAMS (small areas for market statistics), with respect to multiple individual socioeconomic factors (SES). Records of manifest caries using the DMFT indices (decayed, missing, filled teeth, dependent variables) were collected from electronic dental records for 300,988 individuals aged 3-19 years (97.3% coverage) from the Region Västra Götaland, Sweden...
2019: Caries Research
Branca Heloisa Oliveira, Anjana Rajendra, Analia Veitz-Keenan, Richard Niederman
OBJECTIVES: To investigate whether silver diamine fluoride (SDF) is effective in preventing new caries lesions in primary teeth when compared to placebo or active treatments. METHODS: Systematic review (CRD42016036963) of controlled clinical trials. Searches were performed in 9 electronic databases, 5 registers of ongoing trials, and reference lists of identified review articles. Two researchers carried out data extraction and quality appraisal independently. The primary outcome was the difference in caries increment (decayed, missing, and filled surfaces or teeth - dmfs or dmft) between SDF and control groups...
2019: Caries Research
Aline A Sampaio, Samilly E Souza, Antônio P Ricomini-Filho, Altair A Del Bel Cury, Yuri W Cavalcanti, Jaime A Cury
Streptococcus mutans are considered the most cariogenic bacteria, but it has been suggested that Candida albicans could increase their cariogenicity. However, the effect of this dual-species microorganisms' combination on dentine caries has not been experimentally evaluated. Biofilms of C. albicans, S. mutans and C. albicans + S. mutans (n = 12/biofilm) were grown in ultra-filtered tryptone yeast extract broth culture medium for 96 h on root dentine slabs of known surface hardness and exposed 8 times per day for 3 min to 10% sucrose...
November 16, 2018: Caries Research
Sávio J C Bezerra, Samira H João-Souza, Idalina V Aoki, Alessandra B Borges, Anderson T Hara, Taís Scaramucci
The aim of this study was to evaluate the anti-erosive effect of solutions containing sodium fluoride (F: 225 ppm F-), stannous chloride (Sn: 800 ppm Sn2+), and some film-forming polymers (Gantrez: Poly [methylvinylether-alt-maleic anhydride]; PGA: propylene glycol alginate; Plasdone: poly[vinylpyrrolidone]; and CMC: carboxymethylcellulose). Solutions were tested in an erosion-remineralization cycling model, using enamel and dentin specimens (n = 10, for each substrate). Distilled water was the negative control...
October 25, 2018: Caries Research
Fernanda Tomazoni, Mario Vianna Vettore, Fausto Medeiros Mendes, Thiago Machado Ardenghi
The relationship between dental caries and sense of coherence (SOC) has not been substantiated in children and adolescents, particularly among those with a low socioeconomic status. The aim of this study was to investigate the association between SOC and dental caries in schoolchildren from a low socioeconomic background. A random sample of 356 8- to 14-year-old schoolchildren enrolled in public schools from the poorest region of Santa Maria, a southern city in Brazil, was selected. Dental examinations were performed to assess dental plaque and dental caries (DMF-S and dmf-s indexes)...
October 25, 2018: Caries Research
Lenita Marangoni-Lopes, Gabriela Rovai-Pavan, Carolina Steiner-Oliveira, Marinês Nobre-Dos-Santos
OBJECTIVE: We aimed to evaluate whether radiotherapy causes changes in the mineral composition, hardness, and morphology of enamel and dentin of primary teeth. MATERIALS AND METHODS: Thirty specimens of primary teeth were subjected to radiotherapy. At baseline and after 1,080, 2,160, and 3,060 cGy, the specimens were subjected to microhardness, FT-Raman spectroscopy, and scanning electron microscopy (SEM) analysis. The pH of artificial saliva was determined, as were the calcium and phosphate concentrations...
October 12, 2018: Caries Research
Nebu Philip
The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime...
October 8, 2018: Caries Research
F Vida Zohoori, Anne Maguire, E Angeles Martinez-Mier, Marília Afonso Rabelo Buzalaf, Roy Sanderson, George J Eckert
The aim was to compare potential methods for fluoride analysis in microlitre-volume plasma samples containing nano-gram amounts of fluoride. METHODS: A group of 4 laboratories analysed a set of standardised biological samples as well as plasma to determine fluoride concentration using 3 methods. In Phase-1, fluoride analysis was carried out using the established hexamethyldisiloxane (HMDS)-diffusion method (1 mL-aliquot/analysis) to obtain preliminary measurement of agreement between the laboratories...
October 8, 2018: Caries Research
Marcelle Danelon, Luhana G Garcia, Juliano P Pessan, Amanda Passarinho, Emerson R Camargo, Alberto C B Delbem
OBJECTIVE: To evaluate the remineralizing potential of a conventional toothpaste (1,100 ppm F) supplemented with nano-sized sodium hexametaphosphate (HMPnano) in artificial caries lesions in situ. DESIGN: This double-blinded crossed study was performed in 4 phases of 3 days each. Twelve subjects used palatal appliances containing 4 bovine enamel blocks with artificial caries lesions. Volunteers were randomly assigned into the following treatment groups: no F/HMP/HMPnano (Placebo); 1,100 ppm F (1100F); 1100F plus 0...
October 2, 2018: Caries Research
Yoshimi Nakayama, Hirofumi Ohnishi, Mitsuru Mori
Severe early childhood caries (S-ECC) has serious consequences for primary dentition, affecting the overall health, well-being, and quality of life of the child. The aim of this study was to investigate the association of risk factors, including environmental tobacco smoke (ETS), with S-ECC in 3-year-old Japanese children by a cross-sectional study. Study subjects were 2,825 children aged 3 years old. Of these individuals, after excluding the study subjects with missing values, a total of 2,277 children were included in the present analysis...
October 2, 2018: Caries Research
Alexandra Mussolino Queiroz, Claudia María Carpio Bonilla, Regina Guenka Palma-Dibb, Harley Francisco Oliveira, Paulo Nelson-Filho, Léa Assed Bezerra Silva, Marília Pacífico Lucisano, Francisco Wanderley Garcia Paula-Silva
The objectives of this study were to investigate changes in the activity and expression of matrix metalloproteinase (MMP)-2 and MMP-9 in permanent teeth with or without exposure to radiotherapy, and the role of proteinase inhibitors in their inactivation. In situ zymography and immunofluorescence assays were performed to evaluate the activity and expression of two key gelatinases (MMP-2 and MMP-9) in sections of permanent molars, assigned to irradiated and nonirradiated subgroups. Dental fragments were exposed to radiation at a dose of 2 Gy fractions for 5 consecutive days until a cumulative dose of 60 Gy was reached...
September 26, 2018: Caries Research
Joana Christina Carvalho, Ulrich Schiffner
This review assesses the development of oral health habits and status in European adults (35-44 years old) and senior citizens (65-74 years old) over the period of 1996-2016. There seem to be good opportunities for improving oral health habits by brushing twice daily with fluoride toothpaste among adults, as only 33-85% reported doing so. Caries experience was extensive among adults (≥92%). In adults of 23 countries, the mean DMFT score ranged from 6.6 to 17.6 (median 12.1). In senior citizens of 21 countries, the mean DMFT score varied from 14...
September 18, 2018: Caries Research
Mariana Bezamat, Kathleen Deeley, Shahryar Khaliq, Ariadne Letra, Rafaela Scariot, Renato M Silva, Megan L Weber, Diego G Bussaneli, Paula C Trevilatto, Alejandro J Almarza, Hongjiao Ouyang, Alexandre R Vieira
The purpose of this cohort study was to identify associations between combined oral and bone disease phenotypes and genes present in cell regulatory pathways. The studied pathways play important roles in cellular growth, proliferation, differentiation, and homeostasis. DNA samples extracted from whole saliva of 3,912 individuals were genotyped and these data analyzed according to dental caries experience, periapical lesions, periodontitis, osteoporosis, or temporomandibular joint discomfort. Samples were obtained from the Dental Registry and DNA Repository project at the University of Pittsburgh...
September 11, 2018: Caries Research
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