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Journal of Comparative Pathology

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https://read.qxmd.com/read/30691611/the-bicuspid-condition-of-the-aortic-valve-does-not-alter-the-incidence-of-accessory-coronary-artery-ostia-in-syrian-hamsters-mesocricetus-auratus
#1
M C Fernández, M T Soto-Navarrete, A C Durán, V Sans-Coma, B Fernández
In man and Syrian hamsters (Mesocricetus auratus), the prevalence of anomalies in the origin of the coronary arteries is significantly higher in individuals with bicuspid than with normal aortic valves. In hamsters, the incidence of accessory ostia is similar in individuals with normal and anomalous coronary arteries, all of them possessing a normal (tricuspid) aortic valve. In order to evaluate whether or not the presence of bicuspid aortic valves alters the incidence of accessory ostia, 1,050 hearts from hamsters with bicuspid valves were examined...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691610/canine-cutaneous-haemangiosarcoma-biomarkers-and-survival
#2
D F Nóbrega, V F Sehaber, R Madureira, A P F R L Bracarense
Haemangiosarcoma (HSA) is a malignant tumour of vascular endothelial cells. It is common in dogs, but rare in other species, and may arise in any tissue. A dermal location of canine HSA has been associated with short survival and recurrence after surgical excision. Solar radiation has been proposed as a predisposing factor in shorthaired dogs with light skin pigmentation. There are no studies relating the expression of immunohistochemical markers to survival of dogs with cutaneous haemangiosarcoma (cHSA). Such data could contribute to establishing prognostic factors and new therapies based on the expression of target molecules...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691609/inflammatory-mediators-in-the-mesenteric-lymph-nodes-site-of-a-possible-intermediate-phase-in-the-immune-response-to-feline-coronavirus-and-the-pathogenesis-of-feline-infectious-peritonitis
#3
A J Malbon, M L Meli, E N Barker, A D Davidson, S Tasker, A Kipar
Feline infectious peritonitis (FIP) is an almost invariably fatal feline coronavirus (FCoV)-induced disease thought to arise from a combination of viral mutations and an overexuberant immune response. Natural initial enteric FCoV infection may remain subclinical, or result in mild enteric signs or the development of FIP; cats may also carry the virus systemically with no adverse effect. This study screened mesenteric lymph nodes (MLNs), the presumed first site of FCoV spread from the intestine regardless of viraemia, for changes in the transcription of a panel of innate immune response mediators in response to systemic FCoV infection and with FIP, aiming to identify key pathways triggered by FCoV...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691608/somatostatin-receptor-2-expression-in-canine-meningioma
#4
G Foiani, G Guelfi, E Chiaradia, F Mancini, C Trivelli, G Vitellozzi, E Lepri, M T Mandara
The neuropeptide somatostatin (SST) plays an important regulatory role in the proliferation of normal and neoplastic cells. Five subtypes of somatostatin receptors (SSTRs), SSTR1-SSTR5, have been identified in human tumours. The SSTR2 subtype is identified most commonly in meningiomas. Long half-life SST analogues are now recommended for the systemic treatment of unresectable or radiation-refractory recurrent human meningiomas. In this study, SSTR2 expression was evaluated in 46 canine meningiomas; in 21 cases this was by immunohistochemistry and in 25 cases by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR)...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691607/immunohistochemical-profile-of-ameloblastic-carcinoma-arising-from-an-amyloid-producing-odontogenic-tumour-in-a-miniature-dachshund
#5
U Z Izzati, Y Hidaka, T Hirai, R Yamaguchi
A 13-year-old female miniature dachshund was presented with a centrally-located sublingual mass in the rostral mandibular region. The focally ulcerated growth completely covered the left (305) and right (405) premolar teeth and partially covered the right canine teeth (404). A punch biopsy sample revealed neoplastic proliferation of odontogenic epithelium arranged in irregular cords with frequent comedo-like necrosis. Following the initial diagnosis of ameloblastic carcinoma, a bilateral rostral hemimandibulectomy was performed...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691606/chronic-basophilic-leukaemia-in-a-dog
#6
D Azakami, A Saito, K Ochiai, T Ishiwata, K Takahashi, N Kaji, D Kaji, N Kaji, M Michishita
A 13-year-old neutered female mixed-breed dog with a clinical history of emaciation, inappetence and vomiting for 2 months was presented. Blood tests showed marked leucocytosis with increased neutrophil and basophil count, mild thrombocytosis and anaemia. Seven days after the initial visit, the dog died and was submitted for necropsy examination. Grossly, the bone marrow was red in colour and hepatomegaly and splenomegaly with discolouration were observed. A bone marrow smear showed an increased proportion of basophilic lineage cells...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691605/a-descriptive-study-of-lectin-histochemistry-of-the-placenta-in-cattle-following-inoculation-of-neospora-caninum
#7
M A Dorsch, M G de Yaniz, F Fiorani, Y P Hecker, A C Odeón, E L Morrell, C M Campero, C G Barbeito, D P Moore
The aim of this study was to describe the lectin-binding pattern in the placentas of cows infected experimentally with Neospora caninum. Four cows were inoculated intravenously with 1 × 108 tachyzoites of the NC-1 strain of N. caninum at 150 ± 7 days of pregnancy. Two control cows were administered a placebo. An indirect fluorescence antibody test (IFAT) was performed on serum samples obtained before and after the inoculation. The cows were killed at 30 and 37 days post inoculation. Samples of placenta were taken for histopathology and lectin histochemistry...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691604/neoplasia-in-captive-panthera-species
#8
H M Kloft, E C Ramsay, M M Sula
This retrospective study identified the spectrum of neoplasia diagnoses, prevalence rates and the contribution of neoplasia to death or humane destruction within Panthera species housed at a large cat sanctuary. Biopsy and necropsy reports from January 2002 to December 2017 were examined and histological material from cases diagnosed with neoplasia was reviewed. One hundred and sixty-eight neoplasms were diagnosed in 108 large felids: 70 tigers (Panthera tigris), 26 lions (Panthera leo), three ligers (P. leo × P...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691603/cerebral-and-cardiac-congenital-malformations-in-neonatal-west-indian-manatees-trichechus-manatus
#9
V L Carvalho, K R Groch, J L Catão-Dias, A C O Meirelles, C P N Silva, A N B Monteiro, J Díaz-Delgado
Strandings of live new-born West Indian manatees (WIMs; Trichechus manatus) are one of the main challenges for the conservation of this species in Brazil, particularly in the northeastern states. Congenital malformations (CMs) are rare in sirenians. We identified CMs in two of 19 stranded WIMs that were rescued, rehabilitated and subjected to complete pathological examinations in Ceará and Rio Grande do Norte States between 1992 and 2017. In case 1, dilation of the cerebral lateral and fourth ventricles with abundant cerebrospinal fluid (internal hydrocephalus), was diagnosed...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691602/feline-lymphoma-and-a-high-correlation-with-feline-leukaemia-virus-infection-in-brazil
#10
T G Cristo, G Biezus, L F Noronha, L H H S Pereira, J A Withoeft, L V Furlan, L S Costa, S D Traverso, R A Casagrande
Lymphoma is the most important haemopoietic tumour in cats and has been associated with feline leukaemia virus (FeLV) infection. In Brazil, no studies have established a correlation between FeLV infection and lymphoma. The aim of this study was to characterize lymphomas arising in cats in Brazil anatomically and microscopically, and to correlate these data with FeLV infection as determined by immunohistochemistry for the FeLV gp70 antigen. Fifty-three cats with lymphoma were evaluated. The mean age of junior, prime, mature, senior and geriatric cats was 1...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691601/pancreatic-choristoma-in-a-canine-gallbladder
#11
Y Abou Monsef, S Atalay Vural, O Kutsal
A 1.5-year-old male Siberian Husky dog was presented with a history of progressive twitching and tetraplegia. The dog was humanely destroyed and at necropsy examination an incidental intramural white lesion measuring 10 × 15 × 5 mm was observed in the gallbladder. Histologically, the mass consisted of pancreatic tissue located in the tunica adventitia of the gallbladder. Immunohistochemistry revealed that the islets of Langerhans were positive for insulin, but negative for glucagon. In addition, the dog had non-suppurative meningoencephalitis associated with canine distemper virus infection...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30691600/primary-osteoma-cutis-in-the-interscapular-region-of-a-dog
#12
S-H Woo, D-M Go, S-H Lee, S-S Han, D-Y Kim
A 9-year-old neutered male Shih Tzu was presented with three contiguous firm nodules in the subcutaneous tissue of the interscapular region. Histopathological examination revealed that the nodules consisted of mature lamellar bone with a Haversian system, with no apparent lesion around the bone. Clinical examination revealed that the dog had no underlying disease and no history of trauma at the lesion site. Based on these findings and on the medical history, a diagnosis of primary osteoma cutis was made. Osteoma cutis is rare in both human and veterinary medicine, and most dogs reported to have secondary osteoma cutis...
January 2019: Journal of Comparative Pathology
https://read.qxmd.com/read/30503578/the-journal-of-comparative-pathology-educational-trust-2018-awards
#13
EDITORIAL
M J Day
No abstract text is available yet for this article.
November 28, 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30503577/histopathological-findings-in-the-viscera-of-malformed-neotropical-viperids
#14
M P N Carvalho, S S Sant'Anna, J Díaz-Delgado, K F Grego, I C V P Gogone, N G T Queiroz-Hazarbassanov, J L Catão-Dias
Congenital malformations (CMs) or developmental abnormalities are pathological processes defined as morphological defects that originate during embryonic stages. A wide variety of CMs is observed in reptiles, most of which are incompatible with normal life. Characterization of CMs and their pathogenesis are of great importance for the conservation of reptiles, including neotropical viperids (NVs). External CMs are often reported in these species, but little is known about concomitant microscopical findings in the viscera of malformed individuals...
November 28, 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30503576/expression-of-three-adipokines-adiponectin-leptin-and-resistin-in-normal-canine-skin-a-pilot-study
#15
T Brément, C Cossec, C Roux, A C Knol, B Dréno, A Khammari, P Bourdeau, V Bruet
Adipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and systemic inflammatory conditions. We aimed to evaluate the expression of three adipokines (i.e...
November 28, 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30502801/evaluation-of-histological-immunohistochemical-clinical-and-genetic-prognostic-factors-associated-with-the-response-of-canine-mast-cell-tumours-to-glucocorticotherapy
#16
R Dos Santos Horta, G Eunice Lavalle, L Narducci Monteiro, F B T M Alves Dos Reis, M de Pádua Costa, A Giuliano, G Dantas Cassali, J Dobson
Mast cell tumours (MCTs) are one of the most frequent neoplasms in dogs. Glucocorticoids (GCs) are widely used in the management of this disease, although no guidelines for their use have been established. The aim of this study was to evaluate the correlation of MCT prognostic factors with measurable response to GCs. This retrospective study included 60 dogs treated with prednisone or prednisolone prior to surgical biopsy of MCT. Incisional or excisional biopsy was performed 7-14 days after initiation of GC therapy...
November 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30502800/zygomycosis-due-to-mucor-racemosus-associated-with-a-circovirus-infection-in-a-blue-tit-cyanistes-caeruleus
#17
A Schmitz, R Korbel, M Rinder
In spring 2014, several wild passeriform garden birds were found severely ill or dead, all with severe periocular swellings. A blue tit (Cyanistes caeruleus) showing severe depression was humanely destroyed and sent for necropsy examination. In this bird, the lower eyelids were sagging, red and oedematous. Microscopical examination revealed marked infiltration of the eyelid tissue with fungal hyphae (stained by periodic acid-Schiff) without any inflammatory reaction. Polymerase chain reaction followed by sequencing identified Mucor racemosus and a so far unknown circovirus...
November 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30502799/tumour-to-tumour-metastasis-phenomenon-metastatic-prostatic-adenocarcinoma-within-an-anaplastic-oligodendroglioma-in-the-brain-of-a-dog
#18
C Ros, F Fernández-Flores, C de la Fuente, D Pi, S Añor, M Planellas, M Pumarola
A 10-year-old entire male French bulldog was presented following clusters of generalized tonic-clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Computed tomography of the thorax and abdomen was consistent with disseminated metastatic disease. The dog was humanely destroyed and subjected to necropsy examination...
November 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30502798/pathological-characterization-of-lymphoma-with-pulmonary-involvement-in-cats
#19
R V Leite-Filho, W Panziera, M B Bandinelli, S P Pavarini
Studies evaluating histological patterns of lung infiltration by lymphoma in cats are lacking. We evaluated retrospectively the histological patterns of 125 necropsy cases of feline lymphoma collected over a 12-year period. Of the 125 cases, 16 showed lung infiltration (12.8%). Nine cats were female, seven cats were male and all were of mixed breed. Gross lesions observed in the lungs consisted of masses (25%) and nodules (18.7%); however, the majority of cases (56.2%) did not show any gross abnormality. Peribronchial-vascular infiltration (93...
November 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30502797/primary-meningeal-rhabdomyosarcoma-of-the-spinal-cord-of-a-young-dog-with-neuromelanocytosis-and-multiple-cutaneous-neurofibromas
#20
L L Hoon-Hanks, C B Frank, E F Edmondson
A 7-week-old male black Labrador retriever puppy was presented for post-mortem examination following progressive hindlimb paralysis and multiple masses within the skin. A highly compressive and infiltrative intradural mass was found within the T9-T11 spinal cord. Microscopical and immunohistochemical analysis revealed features compatible with spindle cell rhabdomyosarcoma (RMS). The adjacent spinal cord had numerous melanin-containing cells, arranged in small nodules, predominantly within the grey matter (proposed term of 'micronodular neuromelanocytosis') and the left lateral thorax had multifocal dermal neurofibromas...
November 2018: Journal of Comparative Pathology
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