Siyu Li, Geng Wang, Yan Ren, Xinyue Liu, Yixuan Wang, Jianing Li, Hua Liu, Jiaqiang Yang, Jingjun Xing, Yanru Zhang, Canxia He, Suling Xu, Xin Hou, Na Li
V-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, including neutrophils, monocytes, macrophages, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs)...
February 29, 2024: Biochemical Pharmacology