journal
https://read.qxmd.com/read/37726545/neonatal-resuscitation-with-continuous-chest-compressions-and-high-frequency-percussive-ventilation-in-preterm-lambs
#1
JOURNAL ARTICLE
Evan Giusto, Deepika Sankaran, Amy Lesneski, Houssam Joudi, Morgan Hardie, Victoria Hammitt, Lida Zeinali, Satyan Lakshminrusimha, Payam Vali
BACKGROUND: Cerebral oxygen delivery (cDO2 ) is low during chest compressions (CC). We hypothesized that gas exchange and cDO2 are better with continuous CC with high frequency percussive ventilation (CCC + HFPV) compared to conventional 3:1 compressions-to-ventilation (C:V) resuscitation during neonatal resuscitation in preterm lambs with cardiac arrest induced by umbilical cord compression. METHODS: Fourteen lambs in cardiac arrest were randomized to 3:1 C:V resuscitation (90CC + 30 breaths/min) per the Neonatal Resuscitation Program guidelines or CCC + HFPV (120CC + HFPV continuously)...
September 19, 2023: Pediatric Research
https://read.qxmd.com/read/37726544/early-cardiac-function-and-death-severe-bronchopulmonary-dysplasia-and-pulmonary-hypertension-in-extremely-preterm-infants
#2
JOURNAL ARTICLE
Shiran S Moore, Gabriela De Carvalho Nunes, Adrian Dancea, Punnanee Wutthigate, Jessica Simoneau, Marc Beltempo, Guilherme Sant'Anna, Gabriel Altit
BACKGROUND: Association between early cardiac function and neonatal outcomes are scarcely reported. The aim of the current study was to describe this association with death, severe bronchopulmonary dysplasia (BPD) and BPD-related pulmonary hypertension (PH). METHODS: Retrospective cohort study of infants <29 weeks born between 2015 and 2019. Infants with clinically acquired echocardiography at ≤21 days after birth were included and data were extracted by an expert masked to outcomes...
September 19, 2023: Pediatric Research
https://read.qxmd.com/read/37726543/the-prevalence-and-impact-of-small-intestine-bacterial-overgrowth-in-biliary-atresia-patients
#3
JOURNAL ARTICLE
Jia-Feng Wu, Ping-Huei Tseng, Hsiu-Hao Chang, Che-Ming Chiang, Wen-Hsi Lin, Wen-Ming Hsu, Mei-Hwei Chang
BACKGROUND: Acute cholangitis is an ominous complication in biliary atresia (BA) patients. We investigated the prevalence of small intestine bacterial overgrowth (SIBO) in BA patients and its role in predicting acute cholangitis. METHODS: There are 69 BA patients with native liver recruited into this study prospectively. They received hydrogen and methane-based breath testing (HMBT) to detect SIBO after recruitment and were followed prospectively in our institute...
September 19, 2023: Pediatric Research
https://read.qxmd.com/read/37723215/reply-to-correspondence
#4
LETTER
Maureen Monaghan, Stephanie Norman, Marcin Gierdalski, Adriana Marques, James E Bost, Roberta L DeBiasi
No abstract text is available yet for this article.
September 18, 2023: Pediatric Research
https://read.qxmd.com/read/37709853/maternal-periconceptional-folic-acid-supplementation-and-risk-for-fetal-congenital-genitourinary-system-defects
#5
JOURNAL ARTICLE
Zixi Pang, Lei Jin, Jie Zhang, Wenying Meng, Di Wang, Lei Jin
BACKGROUND: Taking folic acid supplementation could reduce the risk of neural tube defects for offspring in the maternal periconceptional period, but the relationship between folic acid use and other birth defects remains unclear, such as genitourinary system birth defects. METHODS: The data from a Prenatal Health Care System and Birth Defects Surveillance System in Tongzhou, Beijing, China, were collected from 2013 to 2018. We adjusted for differences in characteristics between comparison groups using propensity score inverse probability weighting and assessed associations with Poisson regression modeling...
September 15, 2023: Pediatric Research
https://read.qxmd.com/read/37704709/outcomes-assessments-should-reflect-the-dynamic-and-contextual-nature-of-early-childhood-development
#6
JOURNAL ARTICLE
Jonathan S Litt, Paige Terrien Church
No abstract text is available yet for this article.
September 13, 2023: Pediatric Research
https://read.qxmd.com/read/37700164/novel-pathogenic-gata6-variant-associated-with-congenital-heart-disease-diabetes-mellitus-and-necrotizing-enterocolitis
#7
JOURNAL ARTICLE
Jun Yasuhara, Sathiya N Manivannan, Uddalak Majumdar, David M Gordon, Patrick J Lawrence, Mona Aljuhani, Katherine Myers, Corey Stiver, Amee M Bigelow, Mark Galantowicz, Hiroyuki Yamagishi, Kim L McBride, Peter White, Vidu Garg
BACKGROUND: Pathogenic GATA6 variants have been associated with congenital heart disease (CHD) and a spectrum of extracardiac abnormalities, including pancreatic agenesis, congenital diaphragmatic hernia, and developmental delay. However, the comprehensive genotype-phenotype correlation of pathogenic GATA6 variation in humans remains to be fully understood. METHODS: Exome sequencing was performed in a family where four members had CHD. In vitro functional analysis of the GATA6 variant was performed using immunofluorescence, western blot, and dual-luciferase reporter assay...
September 12, 2023: Pediatric Research
https://read.qxmd.com/read/37700163/safety-and-efficacy-of-adding-postbiotics-in-infant-formula-a-systematic-review-and-meta-analysis
#8
Xifeng Liang, Yu Li, Zhijiao Zhao, Ru Ding, Jing Sun, Cheng Chi
Postbiotics, as emerging products, were added to infant formula, but their safety and efficacy are unclear. To clarify this issue, we wrote this meta-analysis. We searched PubMed, Embase, Web of Science and ProQuest from its establishment to February 2023. The review was registered on PROSPERO database (CRD42022352405). The effects of infant formula with and without postbiotics were compared, and the incidence of serious adverse events (SAEs), digestive symptoms, concentration of stool secretory immunoglobulin A (SIgA), and growth and development indexes were analyzed...
September 12, 2023: Pediatric Research
https://read.qxmd.com/read/37700162/unmasking
#9
JOURNAL ARTICLE
Michele Kong, Chelsea Brown
No abstract text is available yet for this article.
September 12, 2023: Pediatric Research
https://read.qxmd.com/read/37700161/neurodevelopmental-and-behavioral-outcomes-of-very-preterm-infants-latent-profile-analysis-in-the-environmental-influences-on-child-health-outcomes-echo-program
#10
JOURNAL ARTICLE
Marie Camerota, Elisabeth C McGowan, Judy Aschner, Annemarie Stroustrup, T Michael O'Shea, Julie A Hofheimer, Robert M Joseph, Rashelle Musci, Genevieve Taylor, Brian S Carter, Jennifer Check, Lynne M Dansereau, Semsa Gogcu, Jennifer B Helderman, Charles R Neal, Steven L Pastyrnak, Lynne M Smith, Carmen J Marsit, Barry M Lester
BACKGROUND: Very preterm infants are at high risk for neurodevelopmental impairments. We used a child-centered approach (latent profile analysis [LPA]) to describe 2-year neurobehavioral profiles for very preterm infants based on cognitive, motor, and behavioral outcomes. We hypothesized that distinct outcome profiles would differ in the severity and co-occurrence of neurodevelopmental and behavioral impairment. METHODS: We studied children born <33 weeks' gestation from the Environmental influences on Child Health Outcomes Program with at least one neurobehavioral assessment at age 2 (Bayley Scales of Infant and Toddler Development, Child Behavior Checklist, Modified Checklist for Autism in Toddlers, cerebral palsy diagnosis)...
September 12, 2023: Pediatric Research
https://read.qxmd.com/read/37696979/advancing-brain-mri-as-a-prognostic-indicator-in-hypoxic-ischemic-encephalopathy
#11
LETTER
Yvonne W Wu, Jessica L Wisnowski, Hannah C Glass, Amit M Mathur, Yi Li, Sarah E Monsell, Sandra E Juul, Robert C McKinstry
No abstract text is available yet for this article.
September 11, 2023: Pediatric Research
https://read.qxmd.com/read/37689774/predictive-and-diagnostic-measures-for-kernicterus-spectrum-disorder-a-prospective-cohort-study
#12
JOURNAL ARTICLE
Rose Gelineau-Morel, Fatima Usman, Saadatu Shehu, Hung-Wen Yeh, Mohammad A Suwaid, Mohammed Abdulsalam, Yasir Jibril, Katherine M Satrom, Steven M Shapiro, Timothy P Zinkus, Hayden W Head, Tina M Slusher, Jean-Baptiste Le Pichon, Zubaida L Farouk
BACKGROUND: Kernicterus spectrum disorder (KSD) resulting from neonatal hyperbilirubinemia remains a common cause of cerebral palsy worldwide. This 12-month prospective cohort study followed neonates with hyperbilirubinemia to determine which clinical measures best predict KSD. METHODS: The study enrolled neonates ≥35 weeks gestation with total serum bilirubin (TSB) ≥ 20 mg/dl admitted to Aminu Kano Hospital, Nigeria. Clinical measures included brain MRI, TSB, modified bilirubin-induced neurologic dysfunction (BIND-M), Barry-Albright Dystonia scale (BAD), auditory brainstem response (ABR), and the modified KSD toolkit...
September 9, 2023: Pediatric Research
https://read.qxmd.com/read/37689773/the-neural-exposome-influences-the-preterm-fetal-to-neonatal-connectome
#13
JOURNAL ARTICLE
Mark S Scher
No abstract text is available yet for this article.
September 9, 2023: Pediatric Research
https://read.qxmd.com/read/37684431/national-pediatrician-scientist-collaborative-workgroup-comment-on-new-acgme-requirements-impact-on-pediatric-physician-scientists
#14
JOURNAL ARTICLE
Daniel J Moore, Weston Powell, Debra Boyer, Katherine Bline, Lyndsay Harshman, Andrew Nowalk, Audrea Burns, Jordan S Orange
BACKGROUND: The ACGME recently released its recommendation for updates to the program requirements for pediatrics. These updates proposed changes to allocation of resident clinical time and a greater emphasis on individualization. The potential impact of these changes on the training of physician-scientists is discussed. METHODS: Discussion of the proposed changes was held within the members of the National Pediatrician-Scientist Collaborative Workgroup, a group that represents scientists, trainees, program directors, chairs, and physician-scientist educators at nearly 30 residency programs from across the US with a focus on understanding and developing optimal approaches to physician-scientist training...
September 8, 2023: Pediatric Research
https://read.qxmd.com/read/37684430/rectal-temperature-after-hypoxia-ischemia-predicts-white-matter-and-cortical-pathology-in-the-near-term-ferret
#15
JOURNAL ARTICLE
Olivia R White, Kylie A Corry, Daniel H Moralejo, Janessa B Law, Jessica M Snyder, Ulrike Mietzsch, Sandra E Juul, Thomas R Wood
BACKGROUND: Neonatal encephalopathy (NE) remains a common cause of infant morbidity and mortality. Neuropathological corollaries of NE associated with acute hypoxia-ischemia include a central injury pattern involving the basal ganglia and thalamus, which may interfere with thermoregulatory circuits. Spontaneous hypothermia (SH) occurs in both preclinical models and clinical hypoxic-ischemic NE and may provide an early biomarker of injury severity. To determine whether SH predicts the degree of injury in a ferret model of hypoxic-ischemic NE, we investigated whether rectal temperature (RT) 1 h after insult correlated with long-term outcomes...
September 8, 2023: Pediatric Research
https://read.qxmd.com/read/37679518/age-related-cytokine-imbalance-in-the-thymus-in-sudden-infant-death-syndrome-sids
#16
JOURNAL ARTICLE
Dong Qu, Vanessa Preuss, Lars Hagemeier, Lena Radomsky, Kerstin Beushausen, Jana Keil, Schaumann Nora, Benedikt Vennemann, Christine S Falk, Michael Klintschar
BACKGROUND: Sudden infant death syndrome (SIDS) has been considered to be triggered by a combination of underlying immune dysregulation and infections. The thymus is a crucial lymphatic organ responsible for T cell development in infancy. We hypothesized that an altered thymic immune status may be detectable by intrathymic cytokine profiling in SIDS. METHODS: 27 cytokines in protein lysates of thymus tissue and thymus weights were assessed in 26 SIDS cases and 16 infants who died of other reasons...
September 7, 2023: Pediatric Research
https://read.qxmd.com/read/37674025/impact-of-low-level-prenatal-alcohol-exposure-and-maternal-stress-on-autonomic-regulation
#17
JOURNAL ARTICLE
Jessie R Maxwell, Jared DiDomenico, Melissa H Roberts, Lidia Enriquez Marquez, Rajani Rai, Joanne Weinberg, Sandra W Jacobson, Julia Stephen, Ludmila N Bakhireva
BACKGROUND: Prenatal alcohol exposure (PAE) impacts the neurodevelopment of the fetus, including the infant's ability to self-regulate. Heart rate variability (HRV), that is, the beat-to-beat variability in heart rate, is a non-invasive measurement that can indicate autonomic nervous system (ANS) function/dysfunction. METHODS: The study consisted of a subset of our ENRICH-2 cohort: 80 participants (32 PAE and 48 Controls) who had completed three visits during pregnancy...
September 6, 2023: Pediatric Research
https://read.qxmd.com/read/37674024/the-tyranny-of-acronyms-in-medical-journal-articles
#18
JOURNAL ARTICLE
Tonse N K Raju
No abstract text is available yet for this article.
September 6, 2023: Pediatric Research
https://read.qxmd.com/read/37674023/effects-of-fetal-growth-restriction-on-the-perinatal-neurovascular-unit-and-possible-treatment-targets
#19
REVIEW
Bing Anthony Wu, Kirat K Chand, Alexander Bell, Suzanne L Miller, Paul B Colditz, Atul Malhotra, Julie A Wixey
The neurovascular unit (NVU) within the brain is a multicellular unit that synergistically acts to maintain blood-brain barrier function and meet cerebral metabolic demand. Recent studies have indicated disruption to the NVU is associated with neuropathology in the perinatal brain. Infants with fetal growth restriction (FGR) are known to be at increased risk of neurodevelopmental conditions including motor, learning, and behavioural deficits. There are currently no neuroprotective treatments for these conditions...
September 6, 2023: Pediatric Research
https://read.qxmd.com/read/37674022/childhood-growth-outcomes-2-years-after-hypertensive-versus-normotensive-pregnancy-a-p4-study
#20
JOURNAL ARTICLE
Megan L Gow, Priya Vakil, Lynne Roberts, Greg Davis, Joseph M Khouri, Ana Dosen, Mark A Brown, Maria E Craig, Amanda Henry
BACKGROUND: Intrauterine exposure to hypertensive disorders of pregnancy, including gestational hypertension (GH) and preeclampsia (PE), may influence infant growth and have long-term health implications. This study aimed to compare growth outcomes of infants exposed to a normotensive pregnancy (NTP), GH, or PE from birth to 2 years. METHODS: Infants were children of women enroled in the prospective Postpartum Physiology, Psychology and Paediatric (P4) cohort study who had NTP, GH or PE...
September 6, 2023: Pediatric Research
journal
journal
21602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.