Caterina Strisciuglio, Alessandra Vitale, Francesco Perna, Federica Garziano, Pasquale Dolce, Serena Vitale, Teresa Micillo, Franca Oglio, Michele Miraglia Del Giudice, Giuseppe Matarese, Carmen Gianfrani
BACKGROUND: In children with an allergy to cow's milk proteins (CMA), the altered composition of intestinal microbiota influences the immune tolerance to milk proteins (CMP). This study aims to investigate the effect of probiotics on the phenotype and activation status of peripheral basophils and lymphocytes in a pediatric CMA cohort. METHODS: CMA children underwent 45 days of treatment with Bifidobacteria. The basophil degranulation and the immune phenotype of B cells, T helper cells, and regulatory T cells were analyzed in peripheral blood at diagnosis (T0), after a 45-day probiotic treatment (T1), and 45 days after the probiotic wash-out (T2)...
March 23, 2023: Pediatric Research