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Planta Medica

Vamshi K Manda, Mona H Haron, Tahir M Mir, Bharathi Avula, Mohammad K Ashfaq, Saqlain Haider, Amar G Chittiboyina, Ikhlas A Khan, Shabana I Khan
Aegeline is claimed to be a biologically active constituent of Aegle marmelos . Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products. However, the consumption of aegeline-containing supplements such as OxyELITE Pro and VERSA-1 has been linked to multiple cases of acute and chronic liver failure. This study was carried out to evaluate the pharmacokinetics and tissue distribution of aegeline in ND4 mice...
February 12, 2019: Planta Medica
Daiani Cristina Savi, Rodrigo Aluizio, Chirlei Glienke
Brazil has an extraordinary biodiversity, and for many years, has been classified as the first of 17 countries with a mega diversity, with 22% of the total plants in the world (more than 55 000 species). Considering that some endophytes are host-specific, the incomparable plant diversity found in Brazil encompasses an immeasurable variety of habitats and may represent a repository of unexplored species. As a result of the endophyte-host interaction, plant-associated microorganisms have an enormous biosynthetic potential to produce compounds with novelties in structure and bioactivity...
February 11, 2019: Planta Medica
Risto O Juvonen, Filip Novák, Eleni Emmanouilidou, Seppo Auriola, Juri Timonen, Aki T Heikkinen, Jenni Küblbeck, Moshe Finel, Hannu Raunio
Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes in vitro and in humans in vivo . Oxidation of scoparone to isoscopoletin via 6-O-demethylation was the major metabolic pathway in liver microsomes from humans, mouse, rat, pig and dog, whereas 7-O-demethylation to scopoletin was the main reaction in rabbit...
February 8, 2019: Planta Medica
Si Sun, Le Liu, Xiaojun Tian, Yanghongyun Guo, Yingkang Cao, Yunqing Mei, Changhua Wang
Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the Epimedium plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. In this study, we investigated the potential protective effect of icariin on high glucose-induced detrimental effects on vascular endothelial cells. Human umbilical venous endothelial cells were incubated in media containing 5...
January 31, 2019: Planta Medica
Phanit Songvut, Pajaree Chariyavilaskul, Mayuree H Tantisira, Phisit Khemawoot
The aim of this study was to investigate the safety and pharmacokinetic profiles of a newly developed, standardized extract of Centella asiatica (ECa 233) capsule in healthy Thai volunteers. This study was designed as an open-labeled, 2-sequence dosage, single- and repeated-dose study investigated under fasting conditions. Plasma concentrations of the parent compounds and their relative acid metabolites were measured and pharmacokinetic parameters were calculated using noncompartmental analysis. Tolerability was assessed based on physical examinations, monitoring of vital signs, clinical laboratory tests, and any observed adverse events...
January 30, 2019: Planta Medica
Nada M Abdel-Wahab, Sebastian Scharf, Ferhat C Özkaya, Tibor Kurtán, Attila Mándi, Mostafa A Fouad, Mohamed S Kamel, Werner E G Müller, Rainer Kalscheuer, Wenhan Lin, Georgios Daletos, Weaam Ebrahim, Zhen Liu, Peter Proksch
A new cyclic pentapeptide, cotteslosin C (1: ), a new aflaquinolone, 22-epi-aflaquinolone B (3: ), and two new anthraquinones (9: and 10: ), along with thirty known compounds (2, 4:  - 8, 11:  - 34: ) were isolated from a co-culture of the sponge-associated fungus Aspergillus versicolor with Bacillus subtilis . The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14: ), averufin (16: ), and sterigmatocyctin (19: ) by factors of 1...
January 30, 2019: Planta Medica
An-Dong Wang, Chao-Jie Xie, Yun-Qiang Zhang, Mei-Chen Li, Xia Wang, Jian-Yu Liu, Yong-Nan Xu
Two new α -tetralonyl glucosides, (4 S )-4,5,8-trihydroxy- α -tetralone-5- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (1: ) and (4 S )-4,8-dihydroxy- α -tetralone-4- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (2: ), together with eight known compounds (3:  - 10: ) were isolated from the green walnut husks of Juglans mandshurica . The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments...
January 28, 2019: Planta Medica
Jasmin Seiwerth, Georgia Tasiopoulou, Julia Hoffmann, Ute Wölfle, Kay Schwabe, Karl-Werner Quirin, Christoph Mathis Schempp
The anti-inflammatory properties of the topical herbal composition VEL-091604 with gentian root, licorice root, and willow bark extract were assessed in a randomized, prospective, placebo-controlled, double-blind ultraviolet (UV)-erythema test study with 42 healthy volunteers in comparison to 1% hydrocortisone acetate. The efficacy and tolerability of VEL-091604 cream 2 times daily over 2 wk was evaluated in an open-label, prospective proof of concept study in 10 subjects with atopic dermatitis using a lesional SCORAD severity score...
January 28, 2019: Planta Medica
Ivica Jeremic, Sasa Petricevic, Vanja Tadic, Dragana Petrovic, Jelena Tosic, Zeljka Stanojevic, Milan Petronijevic, Sasenka Vidicevic, Vladimir Trajkovic, Aleksandra Isakovic
Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast and endometrial cancer as well as a risk for cardiovascular and thromboembolic disease. Therefore, certain natural compounds with positive metabolic effects may be considered as a possible alternative or adjunctive treatment in patients not willing to take estrogens or patients with contraindications for estrogens...
January 28, 2019: Planta Medica
Yulin Ren, A Douglas Kinghorn
Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as potential anticancer agents. In the present review, the anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic derivatives, including examples of lupane-, oleanane-, ursane-, and cucurbitane-type pentacyclic triterpenoids, along with dammarane-type tetracyclic triterpenes including ginsenosides and their sapogenins and dichapetalins, which have been characterized as antitumor leads from higher plants...
January 18, 2019: Planta Medica
Bao-Jun Zhang, Wen-Wei Fu, Rong Wu, Jin-Ling Yang, Cai-Yun Yao, Bing-Xiong Yan, Hong-Sheng Tan, Chang-Wu Zheng, Zhi-Jun Song, Hong-Xi Xu
Six new prenylated xanthones (1: -6: ) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1: and 15: -17: showed moderate inhibitory effects on tumor cell growth, with IC50 s ranging from 3.7 to 14.7 µM.
January 16, 2019: Planta Medica
Abraham Giacoman-Martínez, Francisco J Alarcón-Aguilar, Alejandro Zamilpa, Sergio Hidalgo-Figueroa, Gabriel Navarrete-Vázquez, Rebeca García-Macedo, Rubén Román-Ramos, Julio C Almanza-Pérez
Hibiscus sabdariffa is a medicinal plant consumed as a diuretic and anti-obesity remedy. Several pharmacological studies have shown its beneficial effects in metabolism. Peroxisome proliferator-activated receptors δ and γ may play a role in the actions of H. sabdariffa. These nuclear receptors regulate lipid and glucose metabolism and are therapeutic targets for type 2 diabetes. This research aimed to perform a phytochemical study guided by a bioassay from H. sabdariffa to identify compounds with peroxisome proliferator-activated receptor δ and peroxisome proliferator-activated receptor γ agonist activity, supported by messenger ribonucleic acid expression, molecular docking, lipid accumulation, and an antihyperglycemic effect...
January 16, 2019: Planta Medica
Elsayed A Ibrahim, Mei Wang, Mohamed M Radwan, Amira S Wanas, Chandrani G Majumdar, Baharthi Avula, Yan-Hong Wang, Ikhlas A Khan, Suman Chandra, Hemant Lata, Ghada M Hadad, Randa A Abdel Salam, Amany K Ibrahim, Safwat A Ahmed, Mahmoud A ElSohly
Terpenes are the major components of the essential oils present in various Cannabis sativa L. varieties. These compounds are responsible for the distinctive aromas and flavors. Besides the quantification of the cannabinoids, determination of the terpenes in C. sativa strains could be of importance for the plant selection process. At the University of Mississippi, a GC-MS method has been developed and validated for the quantification of terpenes in cannabis plant material, viz., α -pinene, β -pinene, β- myrcene, limonene, terpinolene, linalool, α -terpineol, β -caryophyllene, α -humulene, and caryophyllene oxide...
January 15, 2019: Planta Medica
Sahar Mofidi Tabatabaei, Samad Nejad Ebrahimi, Peyman Salehi, Ali Sonboli, Marzieh Tabefam, Marcel Kaiser, Matthias Hamburger, Mahdi Moridi Farimani
A phytochemical investigation of extracts from flowers and aerial parts of Tanacetum sonbolii afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The in vitro antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4: and 5: showed IC50 values of 5...
January 8, 2019: Planta Medica
Chiu-Mei Lin, Bao-Wei Wang, Wei-Jen Fang, Chun-Ming Pan, Kou-Gi Shyu, Sheng-Wen Hou
Catalpol, an iridoid glycoside, is an isolated natural product of Rehmannia glutinosa , which has been reported to have antidiabetic properties. This study investigated the vascular protective effects of catalpol in hyperglycemic rats with balloon-injured carotid arteries. Balloon injury stress led to the upregulation of monocyte chemoattractant protein-1 expression in rats with streptozotocin-induced diabetes. Western blotting and real-time PCR were performed. In situ hybridization, immunohistochemistry, and confocal analyses were employed...
January 4, 2019: Planta Medica
Baknoon Ham, Myungsuk Kim, Yang-Ju Son, Sungyul Chang, Sang Hoon Jung, Chu Won Nho, Man Jae Kwon
Pterocarpus santalinus has been traditionally used as a medicinal plant owing to its anti-inflammatory, anthelmintic, tonic, antihyperglycemic, and diaphoretic properties. We hypothesized that P. santalinus might have therapeutic potential in alleviating allergy and atopic dermatitis. Thus, we investigated the inhibitory effects of P. santalinus extract against allergic responses and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like dorsal skin lesions using immunoglobulin E-sensitized rat basophilic leukemia-2H3 mast cells and NC/Nga mice...
January 4, 2019: Planta Medica
Shao-Fang Xing, Lin-Hua Liu, Ma-Li Zu, Man Lin, Xin-Fang Zhai, Xiang-Lan Piao
Damulin B, a dammarane-type saponin from steamed Gynostemma pentaphyllum , exhibits the strongest activity against human lung carcinoma A549 cells among the isolated active saponins. In this study, the structure-activity relationship of a series of saponin compounds was discussed. The inhibitory effect of damulin B on human lung cancer A549 and H1299 cells was investigated from apoptosis, cell cycle, and migration aspects. In vitro , human lung cancer cells were more susceptible to damulin B treatment than human normal fibroblasts...
December 18, 2018: Planta Medica
Stefanie Santos, Christian Haslinger, Kristian Klaic, Maria T Faleschini, Mónica Mennet, Olivier Potterat, Ursula von Mandach, Matthias Hamburger, Ana Paula Simões-Wüst
Bryophyllum pinnatum has been used since the 1970s to prevent premature labour, first in anthroposophic hospitals and, more recently, also in the main Swiss perinatal centres. However, it is not known which compounds in B. pinnatum leaves contribute to the tocolytic effect. Here we studied the effects of a flavonoid-enriched fraction, the corresponding flavonoid aglycon mixture, a bufadienolide-enriched fraction, and B. pinnatum leaf press juice on human myometrial contractility in vitro . The strength (area under the curve and amplitude) and frequency of contractions were recorded using strips of human myometrium mounted in an organ bath system...
December 18, 2018: Planta Medica
Yi Ling Teo, Wei Fun Cheong, Amaury Cazenave-Gassiot, Shanshan Ji, Susan Logan, Zhi Xing Kelvin Lee, Jun Li, Kok Yong Seng, Lawrence Soon-U Lee, Eu Leong Yong
Leaves of the Epimedium plant are traditionally consumed for bone health and other indications. The aim of this study was to establish the safety and pharmacokinetics of the metabolites of prenylflavonoids (icariin, icariside I, icariside II, icaritin, and desmethylicaritin) following single doses of a defined Epimedium prenylflavonoid extract in humans. A single oral dose of 370, 740, or 1110 mg of a standardized Epimedium prenylflavonoid extract was administered to 30 healthy male subjects in a randomized, placebo-controlled trial...
December 6, 2018: Planta Medica
Mariam Gaid, Jendrik Füller, Christel Müller-Goymann
The hyperforin content of Hypericum perforatum herb was repeatedly reported to be responsible for a multitude of pharmacological activities. Our recent report about the hyperforin accumulation in in vitro root cultures of H. perforatum provides an alternative perspective to achieve constant product quality and to serve the rapidly growing market. In this study, the antiproliferative effect of a petroleum ether extract from the in vitro root cultures was investigated. When normalized to 1 µM hyperforin content, the extract reduced the viability of human keratinocytes (HaCaT) and human dermal fibroblast monolayers to 33 and 36%, respectively, after 72 h of incubation...
December 4, 2018: Planta Medica
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