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Bratislavské Lekárske Listy

H Kazimoglu, E Uysal, M Dokur, H R Gunerkan
OBJECTIVE: We aimed to evaluate the relationship between neutrophil lymphocyte ratio and the most common bacterial urinary tract infections after transplantation. We also assessed the frequency of bacterial infections, e.g. Escherichia coli, Klebsiella, and Enterococcus in the urinary tract, and determined the important factors affecting neutrophil/lymphocyte ratio (N/L). METHODS: We compared the percentage of neutrophils (NE%), percentage of lymphocytes (Lym%), and N/L, along with blood urea nitrogen (BUN), creatinine, and white blood cells (WBC) in all patients before and after renal transplantation...
2019: Bratislavské Lekárske Listy
D Filipova, T Dostalova, V Filipi, M Kaminek
OBJECTIVES: We sought to objectivize the overall alveolar bone thickness changes in lower incisors after orthodontic intervention. BACKGROUND: The effect of orthodontic treatment on the cortical bone, specifically the clinical implications of proclination-induced change, have long been a matter of dispute. METHODS: Cone-beam computed tomographs of 58 patients were obtained before and after treatment and labial cortical bone thickness and overall alveolus width were measured in sagittal sections in the distance of 3, 6, 9 and 12 mm apically from the cemento-enamel junction...
2019: Bratislavské Lekárske Listy
H Saleh, L Sadeghi
Alzheimer's disease (AD) is an advanced neurodegenerative disorder greatly accompanied by acetylcholinesterase (AChE) activation and amyloid plaque deposition. Tetrahydrodeoxycorticosterone (THDOC) is an endogenous neurosteroid that is reduced in AD patient according to previous results. It has neuroprotective effects and plays important role in neurological diseases. By considering AChE role in AD, this study investigated THDOC effects on catalytic and non-catalytic functions of the enzyme. Inhibitory effect of THDOC on hydrolytic activity of AChE was confirmed by in vitro assay (IC50 = 5...
2019: Bratislavské Lekárske Listy
M Bagheri, K Khadem-Vatani, M H Seyed-Mohammad-Zad, I Abdi Rad, A Rostamzadeh, B Rahimi, S Mahmoudi-Nejad
OBJECTIVES: Present investigation was carried out to evaluate the mRNA level of TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2) in peripheral-blood cells in patients with premature CAD over healthy controls. BACKGROUND: TNFα as a pleiotropic cytokine could be concerned in cardiovascular pathophysiology regarding its special effects on endothelial cells. TNFα exerts its activities through its receptors, TNFR1 and TNFR2. METHODS: Totally, 40 patients with premature CAD and 40 healthy controls were studied...
2019: Bratislavské Lekárske Listy
M F Heidari, S S Arab, A Noroozi-Aghideh, H Tebyanian, A M Latifi
OBJECTIVE: Organophosphorus Acid Anhydrolase (OPAA) is used as one of the most important enzymes in the decontamination process of organophosphate compounds. In this study, we aimed to evaluate the effects of amino acid substitution in OPAA's substrate-binding site on its catalytic activity using the rational engineering strategy. METHODS: The native and three mutant forms of OPAA enzyme including 4ZWP, 4ZWU and Mut6 were studied using the docking technique toward parathion, paraoxon and R-VX compounds...
2019: Bratislavské Lekárske Listy
C R Oncel, I S Ovey
OBJECTIVE: We investigated the role of selenium in bevacizumab induced cardiotoxicity and involvement of transient receptor potential vanilloid 1 (TRPV1) channels in cardiomyocytes. MATERIALS AND METHODS: All cells (Human cardiomyocyte cell line) were cultured at 37 °C. We divided the cells into seven groups as control, bevacizumab, bevacizumab + capsazepin, bevacizumab + selenium, bevacizumab + selenium + capsazepin, selenium and selenium + capsazepin groups. Cells in the groups were stimulated with capsaicin and inhibited with capsazepin in related experiments for activation and inactivation of TRPV1 channels, respectively...
2019: Bratislavské Lekárske Listy
E Atay, M Guzel, R Amanvermez, M T Demir, A K Erenler, E Ozgen, M Yucel
OBJECTIVES: We aimed to compare the plasma levels of biomarkers such as: serum Gal-3, H-FABP, cTnI, and CK-MB in patients, who were admitted to the emergency room with chest pain, and to determine whether these biomarkers have early diagnostic value of acute coronary syndrome (ACS). METHODS: The study was performed in 60 patients aged ≥ 18 years, who were admitted to emergency room. These patients were divided into 3 groups: patients with STEMI (group I, n = 20), patients with NSTEMI (group II, n = 20), and patients with USAP (group III, n = 20)...
2019: Bratislavské Lekárske Listy
B Mravec, J Dubravicky, M Tibensky, L Horvathova
Preclinical data have shown that neurotransmitters released in peripheral tissues from nerve endings may influence carcinogenesis, affect the tumor microenvironment, and directly potentiate both proliferation and migration of cancer cells. This stimulatory role of the nervous system in cancer initiation and progression has also been documented by clinical studies investigating the effect of attenuated signaling from nerves innervating cancer tissue. However, compared to preclinical studies, clinical studies are rarer and some of them have ambiguous results...
2019: Bratislavské Lekárske Listy
H Aygun, S S Gul
OBJECTIVE: We aimed to determine the possible protective effects of melatonin and agomelatine on an animal model of adriamycin nephrotoxicity by 99mTc DMSA renal scintigraphy and biochemical methods. METHODS: Ten weeks old 49 male Wistar rats were randomly separated into seven groups; namely control (CON), adriamycin (ADR), melatonin (MEL), agomelatine (AGO), melatonin + adriamycin (MEL+ADR), agomelatine + adriamycin (AGO+ADR) and melatonin + agomelatine + adriamycin (MEL+AGO+ADR) groups...
2019: Bratislavské Lekárske Listy
F Motevalli, A Khodaei, M Anvari, A Bolhassani
BACKGROUND: Protein fusion technology was widely used to improve expression, purification and solubility of the recombinant proteins expressed in E. coli for in vitro/in vivo delivery. METHODS: We developed a method for successful expression of soluble +36GFP-A2-E7 protein in E. coli and its effective delivery into mammalian cells. At first, the plasmid harboring +36GFP-A2-E7 was transformed into E. coli Rosetta competent cells. Then, the recombinant protein fused to histidine tag was expressed and purified using affinity chromatography...
2019: Bratislavské Lekárske Listy
R Baylarov, R Baylarova, A Berdeli, R Bayramov, E Haziyev
OBJECTIVES: The aim of the study was to determine the mutation of the podocin gene (NPHS2) in children with minimal changes diseases (steroid sensitive nephrotic syndrome (NS)) and steroid resistant NS. BACKGROUND: Despite the fact that the role of genetic factors is a well-known phenomenon, in NS there are still unknown aspects that are yet to be discovered. NS, type 2 is caused by NPHS2 gene and is characterised with proteinuria, minimal change disease on renal biopsy, poor response to steroid treatment, etc...
2019: Bratislavské Lekárske Listy
P E Ekmekci, M D Guner
Medical sciences and medical technologies are developing in an enormous pace. The number of multi-site and multi- cultural clinical trials is increasing in line with this development. Yet, the increase in number brought about a problem, namely that of inconsistencies in institutional review board (IRB) decisions. The efforts to develop a comprehensive and systematic framework for the decision-making procedure of IRB members were ineffective and ended up in form of lists containing general principles of research ethics...
2019: Bratislavské Lekárske Listy
J G Castillo, J Slezak, D L Reich
No abstract text is available yet for this article.
2019: Bratislavské Lekárske Listy
Z Bagheri-Hosseinabadi, H Ghasemi Hamidabadi, M Nazm Bojnordi
INTRODUCTION: This study examined the process of deriving mature oligodendrocytes from human dental pulp stem cells (hDPSCs) via addition of cerebrospinal fluid (CSF). METHODS: The hDPSCs were cultured in the presence of retinoic acid and CSF. The oligodendrocytes were confirmed using immunocytochemistry for specific glial markers, namely Olig2 and MBP markers. RESULTS: The differentiated oligodendrocytes were immunopositive for Olig2 and MBP markers at the end of induction phase...
2019: Bratislavské Lekárske Listy
I S Ovey, C R Oncel
OBJECTIVES: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential vanilloid 1 (TRPV1) channels are found in cardiomyocyte cells and they are activated by reactive oxygen species. We investigated the effects of digoxin toxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through TRPV1 channels and modulator role of melatonin in cardiomyocytes...
2019: Bratislavské Lekárske Listy
M Demir, U Yilmaz, C Colak, Y Cigremis, F Ozyalin, I Tekedereli, S Sandal
Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart...
2019: Bratislavské Lekárske Listy
S Colak, A Omma, S C Sandikci, C Yucel, T Omma, T Turhan
OBJECTIVES: To examine the relationship between disease activity and vaspin, neutrophil gelatinase-associated lipocalin (NGAL) and apolipoprotein levels in patients with psoriatic arthritis (PsA). BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, which is related with psoriasis. Adipokines are the mediators which play a role in metabolic homeostasis and inflammatory conditions. METHODS: The levels of vaspin, NGAL, apolipoproteins and their correlations with disease activity were compared in 50 psoriatic arthritis patients and 36 healthy controls...
2019: Bratislavské Lekárske Listy
R Atic, E Deveci
OBJECTIVES: The diabetic foot is an important and destructive complication of diabetes. This study examined 65 individuals (35 males, 30 females) diagnosed with diabetic foot with open wounds on their feet. METHODS: After washing the foot with isotonic solution, the wound was debrided and the excised tissues (diabetic dermis) were fixed with neutral buffered 10 % formalin solution. Specimens stained with haematoxylin-eosin, endothelin-1 (ET-1), nuclear factor kappa B (NF-κB), and ADAM 15 antibodies were used to examine angiogenesis, cytokine activity, and the extracellular matrix, respectively...
2019: Bratislavské Lekárske Listy
V I Martemyanov, N Y Poddubnaya
BACKGROUND: Hypernatremia supports the movement of water from the intracellular to the intercellular space. This shift leads to cells shrinkage and disruption of intracellular processes, representing risk factors of morbidity and mortality in clinical circumstances. On the other hand, hypernatremia triggers protective mechanisms that counteract damage of cells. OBJECTIVES: To determine in experiments in vivo the ranges of sodium content regulation in the blood plasma of carp characterizing the norm and hypernatremia...
2019: Bratislavské Lekárske Listy
E Nagyova, J Radvanszky, M Hyblova, V Simovicova, E Goncalvesova, F W Asselbergs, L Kadasi, T Szemes, G Minarik
OBJECTIVES: For the first time we used targeted next-generation sequencing to detect candidate pathogenic variants in Slovak cardiomyopathy patients. BACKGROUND: Targeted next-generation sequencing is considered to be the best practice in genetic diagnostics of cardiomyopathies. However, in Slovakia, with high cardiomyopathies prevalence of 1/440, the current diagnostic tests are still based on Sanger sequencing of a few genes. Consequently, little is known about the exact contribution of pathogenic variants in known cardiomyopathy genes in Slovak patients...
2019: Bratislavské Lekárske Listy
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