journal
https://read.qxmd.com/read/37041720/comparison-of-ahiflower-oil-containing-stearidonic-acid-to-a-high-alpha-linolenic-acid-flaxseed-oil-at-two-dietary-levels-on-omega-3-enrichment-of-egg-yolk-and-tissues-in-laying-hens
#21
JOURNAL ARTICLE
Ahmed S A El-Zenary, Robert G Elkin, Kevin J Harvatine
Enrichment of egg yolks with very long chain omega-3 fatty acids (VLCn-3 FA) is of interest because of their beneficial effects on human health. The ability of Ahiflower® oil (AHI; Buglossoides arvensis), which is naturally rich in stearidonic acid (SDA), and a high-alpha-linolenic acid (ALA) flaxseed (FLAX) oil to enrich eggs and tissues of laying hens with VLCn-3 FA was investigated. Forty 54-week-old Hy-Line W-36 White Leghorn hens were fed a diet that contained soybean oil (control; CON) or AHI or FLAX oils at 7...
April 11, 2023: Lipids
https://read.qxmd.com/read/36960737/equal-bioavailability-of-omega-3-pufa-from-calanus-oil-fish-oil-and-krill-oil-a-12-week-randomized-parallel-study
#22
JOURNAL ARTICLE
Franziska Vosskötter, Milena Burhop, Andreas Hahn, Jan Philipp Schuchardt
The bioavailability of long-chain omega-3 polyunsaturated fatty acids (n3 PUFA) can be affected by the form in which they are bound. An alternative source of n3 PUFA is Calanus finmarchicus oil (CO), which, unlike fish oil (FO) and krill oil (KO), contains fatty acids primarily bound as wax esters. Recent studies have shown that n3 PUFA from CO are bioavailable to humans, but CO has not been compared to other marine oils such as FO or KO. Therefore, the aim of this study was to investigate the influence of 12 weeks supplementation with CO, FO and KO on the long-term n3 PUFA status in healthy volunteers...
March 24, 2023: Lipids
https://read.qxmd.com/read/36942837/effects-of-fatty-acid-ethanol-amine-fa-ea-derivatives-on-lipid-accumulation-and-inflammation
#23
JOURNAL ARTICLE
Mengyu Li, Xiaoqing Huang, Mengxian Huang, Wenhui Jin, Zhuan Hong, Yucang Zhang, Hua Fang, Weizhu Chen
This study aimed to investigate the effect of fatty acid-ethanol amine (FA-EA) derivatives (L1-L10) on the mitigation of intracellular lipid accumulation and downregulation of pro-inflammatory cytokines in vitro. First, the series of FA-EA derivatives were synthesized and characterized. Then, their cytotoxic, intracellular lipid accumulation and inhibition of pro-inflammatory cytokines were evaluated. The oil red O staining experiment showed that the tested compounds L4, L6, L8, L9, and L10 could reduce intracellular lipid accumulation induced by palmitic acid (PA)...
March 21, 2023: Lipids
https://read.qxmd.com/read/36849669/ceramide-concentrations-in-liver-plasma-and-very-low-density-lipoproteins-of-humans-with-severe-obesity
#24
JOURNAL ARTICLE
Kelli A Lytle, Jin Ook Chung, Nikki C Bush, Jessica M Triay, Michael D Jensen
We investigated the relationships between ceramide species concentrations in liver, plasma and very low-density lipoproteins (VLDL) particles of humans with obesity as well as the relationships between hepatic fat content and hepatic ceramide concentrations and proportional distribution. Twenty-five obese (body mass index >35 kg/m2 ) adults participated in this study. Plasma, VLDL and hepatocellular ceramide concentrations were measured by liquid chromatography/tandem mass spectrometry. The proportionate distribution of measured ceramide species differed between liver, whole plasma and the VLDL fraction...
February 27, 2023: Lipids
https://read.qxmd.com/read/36708255/hypoxia-increases-cellular-levels-of-phosphatidic-acid-and-lysophospholipids-in-undifferentiated-caco-2-cells
#25
JOURNAL ARTICLE
Yoshibumi Shimizu, Keiko Tamiya-Koizumi, Toshihiko Tsutsumi, Mamoru Kyogashima, Reiji Kannagi, Soichiro Iwaki, Mineyoshi Aoyama, Akira Tokumura
Cancer cells are known to survive in a hypoxic microenvironment by altering their lipid metabolism as well as their energy metabolism. In this study, Caco-2 cells derived from human colon cancer, were found to have elevated intracellular levels of phosphatidic acid and its lysoform, lysophosphatidic acid (LPA), under hypoxic conditions. Our results suggested that the elevation of LPA in Caco-2 cells was mainly due to the combined increases in cellular levels of lysophosphatidylcholine and lysophosphatidylethanolamine by phospholipase A2 and subsequent hydrolysis to LPA by lysophospholipase D...
January 28, 2023: Lipids
https://read.qxmd.com/read/36271748/serum-and-diet-long-chain-omega-3-fatty-acid-nutritional-status-in-chinese-elite-athletes
#26
JOURNAL ARTICLE
Qiuping Zhang, Qian Xu, Huajun Tian, Yudan Chu, Jun Qiu, Mengwei Sun
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are essential for improving the health and performance of athletes. The present study aimed to evaluate the nutritional status of omega-3 PUFAs in Chinese elite athletes by both dietary intake analysis and serum biomarker detection. A cross-sectional analysis of data from 54 elite athletes (24 men and 30 women) from Shanghai professional sports teams was conducted. A food frequency questionnaire (FFQ) was employed to analyze dietary intake, and gas chromatography-mass spectrometry (GC-MS/MS) was conducted to measure serum biomarkers of PUFAs...
January 2023: Lipids
https://read.qxmd.com/read/36544247/enriched-pufa-environment-of-leishmania-infantum-promastigotes-promotes-the-accumulation-of-lipid-mediators-and-favors-parasite-infectivity-towards-j774-murine-macrophages
#27
JOURNAL ARTICLE
Marine Leroux, Hana Bouazizi-Ben Messaoud, Céline Luquain-Costaz, Lars P Jordheim, Pauline Le Faouder, Marie-Paule Gustin, Karim Aoun, Philippe Lawton, Samira Azzouz-Maache, Isabelle Delton
Leishmania parasites are the causative agents of visceral or cutaneous leishmaniasis in humans and of canine leishmaniosis. The macrophage is the predilected host cell of Leishmania in which the promastigote stage is transformed into amastigote. We previously showed changes in the fatty acid composition (FA) of lipids in two strains of Leishmania donovani upon differentiation of promastigote to amastigote, including increased proportions of arachidonic acid (AA) and to a less extent of docosahexaenoic acid (DHA)...
December 21, 2022: Lipids
https://read.qxmd.com/read/36408796/geometrical-and-positional-isomers-of-unsaturated-furan-fatty-acids-in-food
#28
JOURNAL ARTICLE
Franziska Müller, Tim Hammerschick, Walter Vetter
Furan fatty acids (FuFA) are important antioxidants found in low concentrations in many types of food. In addition to conventional FuFA which normally feature saturated carboxyalkyl and alkyl chains, a few previous studies indicated the FuFA co-occurrence of low shares of unsaturated furan fatty acids (uFuFA). For their detailed analysis, the potential uFuFA were enriched by centrifugal partition chromatography (CPC) or countercurrent chromatography (CCC) followed by silver ion chromatography from a 4,7,10,13,16,19-docosahexaenoic acid ethyl ester oil, a 5,8,11,14,17-eicosapentaenoic acid ethyl ester oil and a latex glove extract...
November 21, 2022: Lipids
https://read.qxmd.com/read/35908848/%C3%AE-linolenic-acid-interconversion-is-sufficient-as-a-source-of-longer-chain-%C3%AF-3-polyunsaturated-fatty-acids-in-humans-an-opinion
#29
REVIEW
Graham C Burdge
α-linolenic acid (αLNA) conversion into the functionally important ω-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), has been regarded as inadequate for meeting nutritional requirements for these PUFA. This view is based on findings of small αLNA supplementation trials and stable isotope tracer studies that have been interpreted as indicating human capacity for EPA and, in particular, DHA synthesis is limited. The purpose of this review is to re-evaluate this interpretation...
November 2022: Lipids
https://read.qxmd.com/read/36289559/olive-oil-promotes-the-survival-and-migration-of-dermal-fibroblasts-through-nrf2-pathway-activation
#30
JOURNAL ARTICLE
Bianca C de S Ribeiro, Regina V de C Faria, Jeane de S Nogueira, Samuel Santos Valença, Lin Chen, Bruna Romana-Souza
Olive oil has beneficial effects on skin wound healing due to its anti-inflammatory and antioxidant properties; however, the mechanism by which olive oil promotes wound healing is unclear. We evaluated the mechanisms involved in Nrf2 pathway activation by olive oil and its role in cell survival and migration in mouse dermal fibroblasts in a short-term exposition. Our data demonstrated that olive oil and oleic acid promoted reactive oxygen species (ROS) production, while olive oil and hydroxytyrosol stimulated nuclear factor erythroid 2-related factor 2 (Nrf2) activation...
October 26, 2022: Lipids
https://read.qxmd.com/read/36253942/antibiotics-administration-alleviates-the-high-fat-diet-induced-obesity-through-altering-the-lipid-metabolism-in-young-mice
#31
JOURNAL ARTICLE
Shiyue Luo, Hongyang Zhang, Xuejun Jiang, Yinyin Xia, Shixin Tang, Xinhao Duan, Wei Sun, Min Gao, Chengzhi Chen, Zhen Zou, Lixiao Zhou, Jingfu Qiu
Currently, there is a global trend of rapid increase in obesity, especially among adolescents. The antibiotics cocktails (ABX) therapy is commonly used as an adjunctive treatment for gut microbiota related diseases, including obesity. However, the effects of broad-spectrum antibiotics alone on young obese hosts have rarely been reported. In the present study, the 3-week-old C57BL/6J male mice fed a high-fat diet (HFD) were intragastric administration with ampicillin, vancomycin, metronidazole or neomycin for 30 days...
October 17, 2022: Lipids
https://read.qxmd.com/read/36195466/gc-ms-analysis-of-oxysterols-and-their-formation-in-cultivated-liver-cells-hepg2
#32
JOURNAL ARTICLE
Elisabeth Koch, Mustafa Bagci, Michael Kuhn, Nicole M Hartung, Malwina Mainka, Katharina M Rund, Nils Helge Schebb
Oxysterols play a key role in many (patho)physiological processes and they are potential biomarkers for oxidative stress in several diseases. Here we developed a rapid gas chromatographic-mass spectrometry-based method for the separation and quantification of 11 biologically relevant oxysterols bearing hydroxy, epoxy, and dihydroxy groups. Efficient chromatographic separation (resolution ≥ 1.9) was achieved using a medium polarity 35%-diphenyl/65%-dimethyl polysiloxane stationary phase material (30 m × 0...
October 4, 2022: Lipids
https://read.qxmd.com/read/36114729/hydrolysis-of-polyhydroxy-polyunsaturated-fatty-acid-glycerophosphocholines-by-group-iia-v-and-x-secretory-phospholipases-a-2
#33
JOURNAL ARTICLE
Arnis Kuksis, Waldemar Pruzanski
It is widely accepted that unesterified polyunsaturated ω-6 and ω-3 fatty acids (PUFA) are converted through various lipoxygenases, cyclooxygenases, and cytochrome P450 enzymes to a range of oxygenated derivatives (oxylipins), among which the polyhydroxides of unesterified PUFA have recently been recognized as cell signaling molecules with anti-inflammatory and pro-resolving properties, known as specialized pro-resolving mediators (SPMs). This study investigates the mono-, di-, and trihydroxy 16:0/PUFA-GPCs, and the corresponding 16:0/SPM-GPC, in plasma lipoproteins...
September 17, 2022: Lipids
https://read.qxmd.com/read/36098349/glucocorticoids-decrease-thermogenic-capacity-and-increase-triacylglycerol-synthesis-by-glycerokinase-activation-in-the-brown-adipose-tissue-of-rats
#34
JOURNAL ARTICLE
Ana Paula Assis, Karine Emanuelle Silva, Natalia Lautherbach, Henrique Jorge Novaes Morgan, Maria Antonieta Rissato Garófalo, Neusa Maria Zanon, Luiz Carlos Carvalho Navegantes, Valéria Ernestânia Chaves, Isis do Carmo Kettelhut
Although it is well established that glucocorticoids inactivate thermogenesis and promote lipid accumulation in interscapular brown adipose tissue (IBAT), the underlying mechanisms remain unknown. We found that dexamethasone treatment (1 mg/kg) for 7 days in rats decreased the IBAT thermogenic activity, evidenced by its lower responsiveness to noradrenaline injection associated with reduced content of mitochondrial proteins, respiratory chain protein complexes, noradrenaline, and the β3 -adrenergic receptor...
September 13, 2022: Lipids
https://read.qxmd.com/read/36098332/ergosterol-increases-7-dehydrocholesterol-a-cholesterol-precursor-and-decreases-cholesterol-in-human-hepg2-cells
#35
JOURNAL ARTICLE
Naoko Kuwabara, Miho Ohta-Shimizu, Fumiko Fuwa, Eriko Tomitsuka, Shinji Sato, Saori Nakagawa
Current treatment approaches for hyperlipidemia rely mainly on reducing the cholesterol level by inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which is involved in the presqualene pathway of cholesterol biosynthesis. Finding a compound that instead targets the postsqualene pathway could aid in the treatment of hyperlipidemia and synergistically reduce the cholesterol level when used in conjunction with HMGCR inhibitors. Ergosterol is a fungal sterol that is converted to brassicasterol by 7-dehydrocholesterol reductase (DHCR7)...
September 13, 2022: Lipids
https://read.qxmd.com/read/36054018/phosphatidylinositol-4-5-bisphosphate-specific-phospholipase-c-%C3%AE-1-selectively-binds-dipalmitoyl-and-distearoyl-phosphatidic-acids-via-lys946-and-lys951
#36
JOURNAL ARTICLE
Fumi Hoshino, Maika Nakayama, Masataka Furuta, Chiaki Murakami, Ayumu Kato, Fumio Sakane
Phospholipase C (PLC) β1 hydrolyzes 1-stearoyl-2-arachidonoyl (18:0/20:4)-phosphatidylinositol (PtdIns) 4,5-bisphosphate to produce diacylglycerol, which is converted to phosphatidic acid (PtdOH), in the PtdIns cycle and plays pivotal roles in intracellular signal transduction. The present study identified PLCβ1 as a PtdOH-binding protein using PtdOH-containing liposomes. Moreover, the comparison of the binding of PLCβ1 to various PtdOH species, including 14:0/14:0-PtdOH, 16:0/16:0-PtdOH, 16:0/18:1-PtdOH, 18:0/18:1-PtdOH, 18:0/18:0-PtdOH, 18:1/18:1-PtdOH, 18:0/20:4-PtdOH, and 18:0/22:6-PtdOH, indicated that the interaction of PLCβ1 with 16:0/16:0-PtdOH was the strongest...
September 2, 2022: Lipids
https://read.qxmd.com/read/35799422/the-13-c-octanoic-acid-breath-test-for-gastric-emptying-quantification-a-focus-on-nutrition-and-modeling
#37
REVIEW
Johanna von Gerichten, Marwan H Elnesr, Joe E Prollins, Ishanki A De Mel, Alan Flanagan, Jonathan D Johnston, Barbara A Fielding, Michael Short
Gastric emptying (GE) is the process of food being processed by the stomach and delivered to the small intestine where nutrients such as lipids are absorbed into the blood circulation. The combination of an easy and inexpensive method to measure GE such as the CO2 breath test using the stable isotope [13 C]octanoic acid with semi-mechanistic modeling could foster a wider application in nutritional studies to further understand the metabolic response to food. Here, we discuss the use of the [13 C]octanoic acid breath test to label the solid phase of a meal, and the factors that influence GE to support mechanistic studies...
July 7, 2022: Lipids
https://read.qxmd.com/read/35778866/correlation-between-adipocyte-fatty-acid-binding-protein-and-glucose-dysregulation-is-closely-associated-with-obesity-and-metabolic-syndrome-a-cohort-of-han-chinese-population-from-yunnan-plateau
#38
JOURNAL ARTICLE
Juan Huang, Guo Chen, Qiao Zhang, Yanjiao Wang, Qiong Meng, Fang Xu, Xuehui Zhang, Wei Zou, Fei Mi, Jianzhong Yin
The present study investigated the correlation of plasma A-FABP with glucose dysregulation under different body mass index (BMI) and metabolic states in a Han Chinese population from Yunnan plateau. We cross-sectionally analyzed data from the China Multi Ethnic Cohort, Yunnan province. Participants were divided into two groups. Group A contained 297 obese individuals with metabolic syndrome (MetS). Group B contained 326 age-, sex-, and region-matched normal BMI subjects without MetS. Glucose dysregulation was defined as elevated fasting plasma glucose (FPG) (FPG ≥ 5...
July 2022: Lipids
https://read.qxmd.com/read/35778847/structurally-engineered-fatty-acid-1024-sefa-1024-improves-diet-induced-obesity-insulin-resistance-and-fatty-liver-disease
#39
JOURNAL ARTICLE
Jordon D Secor, Bennet S Cho, Lumeng J Yu, Amy Pan, Victoria H Ko, Duy T Dao, Michael Feigh, Lorenzo Anez-Bustillos, Gillian L Fell, David A Fraser, Kathleen M Gura, Mark Puder
Obesity is a global epidemic that drives morbidity and mortality through cardiovascular disease, diabetes, and non-alcoholic fatty liver disease (NAFLD). No definitive therapy has been approved to improve glycemic control and treat NAFLD in obese patients. Here, we investigated a semi-synthetic, long chain, structurally-engineered fatty acid-1024 (SEFA-1024), as a treatment for obesity-induced hyperglycemia, insulin-resistance, and fatty liver disease in rodent models. A single dose of SEFA-1024 was administered to evaluate glucose tolerance and active glucagon-like peptide 1 (GLP-1) in lean rats in the presence and absence of a DPP-4 inhibitor...
July 1, 2022: Lipids
https://read.qxmd.com/read/35661171/validation-of-lipid-profile-measurement-methods-and-establishment-of-reference-values-in-a-sub-saharan-african-population
#40
JOURNAL ARTICLE
Cécile Danielle Tang Tsana, Guy Sadeu Wafeu, Vicky Jocelyne Ama Moor, Bertille Elodie Edinga-Melengue, Jan René Nkeck, Georges Nguefack-Tsague
Validated reference values and procedures are needed to ensure optimal diagnosis of dyslipidemia in sub-Saharan Africa. We aimed to validate an analysis method and establish reference intervals of lipid profile parameters in Cameroonians using this method. On a cross-sectional study conducted from November 2019 to August 2020 in Yaoundé, we have analyzed blood samples with Cobas® 6000. We subscribed to ASQUALAB's External Quality Assessments (EQA) and Outsourced Internal Quality Controls (IQC). Reproducibility, repeatability, correctness accuracy and uncertainty were evaluated using IQC...
June 3, 2022: Lipids
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