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Scandinavian Journal of Gastroenterology

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https://read.qxmd.com/read/30739520/incidence-of-diverticular-bleeding-a-population-based-study
#1
G D Olafsson, J P Hreinsson, E S Björnsson
OBJECTIVE: To determine the incidence of diverticular bleeding (DB) and examine the time trend of the incidence. Furthermore to study prognosis with regard to therapy and rebleeding. METHODS: A retrospective, population-based study of patients with DB in a National University Hospital from 2006 to 2016. Patients were identified in an electronically stored colonoscopy database. Definite diverticular bleeding was defined as active bleeding, a nonbleeding visible vessel or adherent clot...
February 10, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30739519/adalimumab-in-the-treatment-of-chronic-pouchitis-a-randomized-double-blind-placebo-controlled-trial
#2
Mie Dilling Kjær, Niels Qvist, Inge Nordgaard-Lassen, Lisbet Ambrosius Christensen, Jens Kjeldsen
BACKGROUND: Pouchitis is a complication of ileal pouch-anal anastomosis and occurs in up to 50% of patients 10 years after IPAA with 10% developing refractory pouchitis. OBJECTIVE: To evaluate the effect of a TNF-α inhibitor (Adalimumab) in the treatment of refractory pouchitis. MATERIALS AND METHODS: A multicenter, randomized double-blind, placebo-controlled trial includes patients with refractory pouchitis for more than 4 weeks despite antibiotic treatment...
February 10, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30739515/fluoropyrimidine-induced-intestinal-mucosal-injury-is-associated-with-the-severity-of-chemotherapy-related-diarrhea
#3
Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Satoshi Harada, Haruhiko Ozaki, Noriaki Sugawara, Yuki Hirata, Toshifumi Yamaguchi, Tetsuji Terazawa, Kazuki Kakimoto, Takayuki Kii, Masahiro Goto, Kazuhide Higuchi
BACKGROUND AND AIM: Although the fluoropyrimidines are effective chemotherapeutic agents for malignant gastrointestinal tumors, they sometimes cause enteritis with diarrhea. Severe treatment-related diarrhea may result in chemotherapy discontinuation. We investigated the relationship between diarrhea severity and fluoropyrimidine-induced small intestinal mucosal injury. METHODS: We performed small bowel capsule endoscopy in patients undergoing chemotherapy including fluoropyrimidine for a malignant tumor between May 2017 and June 2018 and analyzed the relationship between the endoscopic findings and diarrhea severity...
February 10, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30735443/indirect-comparison-of-vedolizumab-and-adalimumab-for-biologic-naive-patients-with-ulcerative-colitis
#4
Axel U Dignass, Britta Siegmund, Ralf Goertz, Gundula Schneidewind, Lena Fanter
AIM: Indirect comparison of efficacy and safety of vedolizumab with adalimumab in biologic-naïve patients with moderate to severe ulcerative colitis (UC). METHODS: Vedolizumab is a gut-selective medication for moderate to severe UC. Since no comparative trials are available for direct comparison of vedolizumab vs adalimumab in UC, a systematic review of literature databases was conducted to identify randomized, placebo-controlled trials of the two drugs in patients with moderate to severe UC after failure of conventional treatment...
February 8, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30731044/22-gauge-biopsy-needles-have-a-better-histological-diagnostic-yield-in-the-discrimination-of-specific-pancreatic-solid-neoplasms
#5
Hongxue Jiang, Jiefang Guo, Kaixuan Wang, Huiyun Zhu, Jie Chen, Can Xu, Dong Wang, Zhendong Jin
BACKGROUND: To overcome the limitations of using cytological specimen alone for the diagnosis of challenging pancreatic lesions, biopsy needles have been developed to procure histological specimens during EUS, especially for the discrimination of several specific pancreatic tumors requiring adequate histological samples. The aim of this study was to compare the diagnostic yield of EUS-guided 22-gauge (G) fine needle aspiration (FNA) needles and 22G fine needle biopsy (FNB) needles for sampling pancreatic masses...
February 7, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30714430/eus-guided-trans-esophageal-drainage-of-a-mediastinal-necrotic-fluid-collection-using-the-axios-electrocautery-enhanced-delivery-system%C3%A2
#6
Margherita Pizzicannella, Monica Pandolfi, Gianluca Andrisani, Marianna Signoretti, Margareth Martino, Roberta Rea, Francesco Maria Di Matteo
Mediastinal collection secondary to necrotic acute pancreatitis, is an extremely rare event caused by the posterior rupture of the pancreatic duct into the retroperitoneal space with the penetration of the pancreatic fluid through the diaphragmatic orifices. Infection of the necrotic collection may occur with a consequent substantial increase of the mortality rate. Due to the rarity of this severe condition, no consensus is known about the management of infected mediastinal necrotic collections. We reported the case of a 61-year-old male who was critically unwell secondary to a large mediastinal necrotic collections after necrotic acute pancreatitis with no improvement after surgery...
February 3, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30700194/long-term-treatment-with-stimulant-laxatives-clinical-evidence-for-effectiveness-and-safety
#7
Mia Noergaard, Jon Traerup Andersen, Espen Jimenez-Solem, Mikkel Bring Christensen
OBJECTIVES: Bisacodyl and sodium picosulfate are classified both as stimulant laxatives, approved for short-term treatment of constipation and sold without prescription (OTC). Stimulant laxatives are associated with harmful long-term colonic effects and possible carcinogenic risk - and evidence support that these agents are used for longer periods. We aimed to compile and review the clinical trial evidence describing the effectiveness and safety of long-term treatment (>14 continuous days) with stimulant laxatives...
January 31, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30700174/long-term-gastric-cancer-risk-in-male-smokers-with-atrophic-corpus-gastritis
#8
Anna A Nieminen, Jukka Kontto, Pauli Puolakkainen, Jarmo Virtamo, Arto Kokkola
OBJECTIVES: The aim of this study was to evaluate long-term gastric cancer risk in male smokers with and without atrophic gastritis. MATERIALS AND METHODS: A total of 22,346 elderly male smokers participated in the Helsinki Gastritis Study between the years 1989 and 1993. Serum pepsinogen I (PGI) was measured for the men, and 2,132 men with low PGI (<25 µg/L; a marker of atrophic corpus gastritis) were invited to undergo gastroscopy because of increased gastric cancer risk...
January 31, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30700170/changes-in-inflammatory-bowel-disease-subtype-during-follow-up-and-over-time-in-44-302-patients
#9
Åsa H Everhov, Michael C Sachs, Petter Malmborg, Caroline Nordenvall, Pär Myrelid, Hamed Khalili, Maria Elmberg, Anders Ekbom, Johan Askling, Gustav Jakobsson, Jonas Halfvarson, Jonas F Ludvigsson, Ola Olén
AIM: To investigate inflammatory bowel disease (IBD) register-based subtype classifications over a patient's disease course and over time. METHODS: We examined International Classification of Diseases coding in patients with ≥2 IBD diagnostic listings in the National Patient Register 2002-2014 (n = 44,302). RESULTS: 18% of the patients changed diagnosis (17% of adults, 29% of children) during a median follow-up of 3.8 years. Of visits with diagnoses of Crohn's disease (CD) or ulcerative colitis (UC), 97% were followed by the same diagnosis, whereas 67% of visits with diagnosis IBD-unclassified (IBD-U) were followed by another IBD-U diagnosis...
January 31, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30700163/risk-factors-for-chronic-and-recurrent-pancreatitis-after-first-attack-of-acute-pancreatitis
#10
Berglind A Magnusdottir, Maria B Baldursdottir, Evangelos Kalaitzakis, Einar S Björnsson
OBJECTIVE: To study the outcome of acute pancreatitis and risk factors for recurrent and chronic pancreatitis in a population based cohort of patients with first-time acute pancreatitis. METHODS: All patients with first-time acute pancreatitis from 2006-2015 in Iceland were retrospectively evaluated. Medical records were scrutinized and relevant data extracted. RESULTS: 1102 cases of first-time acute pancreatitis were identified: mean age 56yr, 46% female, 41% biliary, 21% alcohol, 26% idiopathic, 13% other causes, mean follow-up 4yr...
January 31, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30678499/the-future-of-nanomedicine-in-optimising-the-treatment-of-inflammatory-bowel-disease
#11
Lauren J Mohan, Jacqueline S Daly, Barbara M Ryan, Zebunnissa Ramtoola
There have been major advancements in the treatment of inflammatory bowel disease (IBD) over the past three decades. However despite significant progress, the best available treatments continue to demonstrate variable efficacy in patients and are associated with adverse effects. Therefore there remains an unmet clinical need for ongoing therapeutic advances for IBD. In recent years nanomedicines have emerged as promising diagnostic and therapeutic tools. Nanoparticles in particular show promise to facilitate targeted oral drug delivery in IBD...
January 24, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30676120/proton-pump-inhibitor-use-is-associated-with-elevated-faecal-calprotectin-levels-a-cross-sectional-study-on-subjects-referred-for-colonoscopy
#12
David Lundgren, Vincy Eklöf, Richard Palmqvist, Johan Hultdin, Pontus Karling
OBJECTIVES: Faecal Calprotectin (FC) is a sensitive marker for gut inflammation. However, slightly elevated FC levels are also common in subjects without inflammation. We investigated the association between FC and clinical factors including concomitant use of medical therapy in patients with a normal colonoscopy. MATERIAL AND METHODS: Out-patients (n = 1263) referred for colonoscopy, performed FC test (CALPRO) the day before the start of bowel preparation. All subjects answered questionnaires that included questions on the present and past health history, concomitant medical treatment and gastrointestinal symptoms (GSRS)...
January 24, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30676114/benefit-of-high-negative-pressure-during-endoscopic-ultrasound-guided-fine-needle-aspiration-with-standard-22-gauge-needles-for-pancreatic-lesions-a-retrospective-comparative-study
#13
Junya Sato, Hirotoshi Ishiwatari, Keiko Sasaki, Shinya Fujie, Junichi Kaneko, Tatsunori Satoh, Hiroyuki Matsubayashi, Yoshihiro Kishida, Masao Yoshida, Sayo Ito, Noboru Kawata, Kenichiro Imai, Naomi Kakushima, Kohei Takizawa, Kinichi Hotta, Hiroyuki Ono
OBJECTIVES: Few studies are available on high negative pressure (HNP) during endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). This study compared the diagnostic yield between HNP and normal negative pressure (NNP) during EUS-FNA for solid pancreatic masses. METHODS: Consecutive patients with pancreatic masses who underwent EUS-FNA using a 22-G needle with either HNP or NNP for both the first and second passes were retrospectively examined for diagnostic yield...
January 24, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30668177/targets-for-interventions-for-faecal-incontinence-in-inflammatory-bowel-disease-a-systematic-review
#14
Hannah Proudfoot, Christine Norton, Micol Artom, Eve Didymus, Sylwia Kubasiewicz, Bernadette Khoshaba
OBJECTIVE: Prevalence of faecal incontinence is greater in patients with inflammatory bowel disease than in the general population. It is a major concern for patients with inflammatory bowel disease, even when disease is in remission. It is underreported and negatively affects quality of life. We explored the evidence on the associations of faecal incontinence in inflammatory bowel disease and the effectiveness of interventions. MATERIAL AND METHODS: Databases searched in October 2017: Web of Science, MEDLINE, EMBASE, CINAHL, PsycINFO, British Nursing Index and Scopus...
January 22, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30663515/low-fecal-calprotectin-predicts-clinical-remission-in-crohn-s-disease-patients-the-simple-answer-to-a-challenging-question
#15
Sara Monteiro, Francisca Dias de Castro, Sílvia Leite, Maria João Moreira, José Cotter
BACKGROUND AND AIM: Fecal calprotectin (FC) is a noninvasive marker of intestinal inflammation. Predicting relapses in Crohn's disease (CD) patients can allow earlier changes in therapy. The aim of this study was to evaluate the role of FC in predicting relapse in CD patients in clinical remission within six months follow-up. METHODS: Patients with CD who were in clinical remission at least ≥3 months were included in this study. The first FC sample during the remission period was evaluated and was used as the baseline value...
January 20, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30663454/predictive-value-of-the-red-blood-cell-distribution-width-to-platelet-ratio-for-hepatic-fibrosis
#16
Ding Yuyun, Tao Zhihua, Wang Haijun, Liao Zhaoping, Zhu Xiaoli, Xu Wenfang, Jin Faxiang, Liu Hongmei
AIMS: The red blood cell distribution width-to-platelet ratio (RPR) has been reported to be an indicator of hepatic fibrosis in patients with chronic hepatitis B (HBV), nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C (HCV). However, no research has explored the RPR in all patients with hepatic fibrosis. There is a recognized need to establish whether the RPR could assess hepatic fibrosis and reflect the severity of fibrosis, regardless of the patient's etiology. METHODS: Quantitative data from 1282 patients who underwent liver biopsy between January 2010 and December 2014 at the Second Affiliated Hospital of Zhejiang University School of Medicine were included...
January 20, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30663451/personalised-medicine-in-inflammatory-bowel-diseases-a-patient-survey
#17
Myriam Choukour, Joelle Kivits, Angela Baker, Cedric Baumann, Francis Guillemin, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
January 20, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30663442/galectin-4-is-a-biomarker-for-early-recurrence-and-death-after-surgical-resection-for-pancreatic-ductal-adenocarcinoma
#18
Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Roland Andersson
BACKGROUND: Galectins are a group of carbohydrate-binding proteins that are involved in neoplastic development and progression. In a previous mass spectrometry-based study, we identified galectin 4 as a down-regulated protein in short-term survivors of pancreatic cancer. This study was performed to validate the prognostic value of galectin 4 in a larger cohort of pancreatic cancer patients undergoing surgical resection. METHODS: Galectin 4 expression was evaluated by tissue microarrays and immunohistochemistry in 140 patients with surgically resected pancreatic cancer...
January 20, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30650313/outcome-of-peroral-endoscopic-myotomy-poem-in-treatment-naive-patients-a-systematic-review
#19
Helge Evensen, Vendel Kristensen, Lene Larssen, Olav Sandstad, Truls Hauge, Asle W Medhus
OBJECTIVES: Achalasia is a primary motility disorder of the esophagus characterized by aperistalsis and failure of lower esophageal sphincter (LES) relaxation. Treatment of achalasia aims at reducing LES pressure. The common treatment modalities are laparoscopic Heller myotomy and pneumatic dilatation, but during the last decade, a promising treatment, per oral endoscopic myotomy (POEM), has been introduced. The aim of the present study was to perform a systematic review of the literature to assess the outcome of POEM in treatment-naive patients...
January 16, 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/30650312/real-world-data-on-effectiveness-safety-and-therapeutic-drug-monitoring-of-vedolizumab-in-patients-with-inflammatory-bowel-disease-a-single-center-cohort
#20
Lydia C T Buer, Bjørn A Moum, Milada Cvancarova, David J Warren, Nils Bolstad, Asle W Medhus, Marte L Høivik
BACKGROUND AND AIMS: The efficacy of vedolizumab (VDZ) has been demonstrated in clinical trials. The aim of this report is to evaluate the long-term effectiveness and safety of VDZ in a real-world cohort and to explore possible associations between concentration measurements of VDZ and treatment effectiveness. METHODS: This is a prospective clinical follow-up including all adult patients with ulcerative colitis (UC) and Crohn's disease (CD) treated with VDZ from October 2014 until September 2017 at a single center in Norway...
January 16, 2019: Scandinavian Journal of Gastroenterology
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