Journals Scandinavian Journal of Gastro...

Scandinavian Journal of Gastroenterology
B A J Kertzman, F J Amelung, H E Bolkenstein, E C J Consten, W A Draaisma
BACKGROUND: Recurrences or persistent symptoms after an initial episode of diverticulitis are common, yet surgical treatment is rarely performed. Current guidelines lack clear recommendations on whether or not to operate, even though recent studies suggest an improved quality of life following surgery. The aim of this study is therefore to compare quality of life in patients with recurrent or ongoing diverticulitis treated conservatively versus surgically, giving a more definitive answer to the question of whether or not to operate on these patients...
April 13, 2024: Scandinavian Journal of Gastroenterology
Zihao Wang, Tianxiang Jiang, Mingchun Mu, Chaoyong Shen, Zhaolun Cai, Haining Chen, Bo Zhang
BACKGROUND: Intramural hematoma of the small bowel is a rare yet acute gastrointestinal condition typically linked with impaired coagulation function, often posing diagnostic challenges. It is principally encountered in patients undergoing prolonged anticoagulant therapy, specifically warfarin. CASE PRESENTATION: We reported a case of intramural hematoma associated with warfarin use. The patient was admitted to hospital with abdominal pain and had received anticoagulant therapy with warfarin 2...
April 10, 2024: Scandinavian Journal of Gastroenterology
Hyun Jin Lee, Yun Seo, Chang Kyo Oh, Ji Min Lee, Hyun Ho Choi, Tae-Geun Gweon, Sung-Hak Lee, Dae Young Cheung, Jin Il Kim, Soo-Heon Park, Han Hee Lee
OBJECTIVES: While endoscopic resection of rectal neuroendocrine tumors (NETs) has significantly increased, long-term data on risk factors for recurrence are still lacking. Our aim is to analyze the long-term outcomes of patients with rectal NETs after endoscopic resection through risk stratification. METHODS: In this multicenter retrospective study, we included patients who underwent endoscopic resection of rectal NETs from 2009 to 2018 and were followed for ≥12 months at five university hospitals...
April 8, 2024: Scandinavian Journal of Gastroenterology
Chao Gao, Guanpo Zhang, Jin Zheng, Yunmeng Zheng, Wulian Lin, Guilin Xu, Yixiang You, Dazhou Li, Wen Wang
OBJECTIVE: To study and compare the value of the Kyoto classification risk scoring system and the modified Kyoto classification risk scoring system based on linked color imaging (LCI) in predicting the risk of early gastric cancer. METHODS: One hundred and fifty patients with pathologically confirmed non-cardia early gastric cancer by endoscopic LCI and 150 non-gastric cancer patients matched for age and gender were included. Basic patient data and whole gastric endoscopic images under LCI were collected, and the images were scored according to the LCI-based Kyoto classification risk scoring system and the LCI-based modified Kyoto classification risk scoring system...
April 5, 2024: Scandinavian Journal of Gastroenterology
Lone Larsen, Anne Estrup Olesen, Alev Büyükuslu Nayeb, Simon Grøntved, Anne Lund Krarup
OBJECTIVES: Early biological treatment in patients with inflammatory bowel disease (IBD) is important in disease control. Previous studies have suggested that patients with IBD from Non-Academic Hospitals were less likely to receive biologics. The aims of this study were (1) to use the granular data in the clinical database, GASTROBIO, to study detailed differences in time from IBD diagnosis to first administration of biologics, hospital admission, and surgery in patients referred to Academic Hospitals versus to Non-Academic Hospitals, and (2) to explore differences in disease extent, behavior, and indication for biological treatment...
April 3, 2024: Scandinavian Journal of Gastroenterology
Cecilia Jönsson, Martin Bergram, Stergios Kechagias, Patrik Nasr, Mattias Ekstedt
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition worldwide. There is an urgent need to develop new biomarkers to assess disease severity and to define patients with a progressive phenotype. Activin A is a new promising biomarker with conflicting results about liver fibrosis. In this study we investigate levels of Activin A in patients with biopsy proven MASLD. We assess levels of Activin A in regard to fibrosis stage and genetic variant I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3)...
April 2, 2024: Scandinavian Journal of Gastroenterology
Mimoza Gjela, Anders Askeland, Maiken Mellergaard, Asbjørn Mohr Drewes, Aase Handberg, Jens Brøndum Frøkjær
OBJECTIVES: Intra-pancreatic fat deposition (IPFD) is suspected to be associated with various medical conditions. This study aimed to assess pancreatic fat content in lean and obese individuals, characterize obese individuals with and without IPFD, and explore the underlying mechanisms. MATERIALS AND METHODS: Sixty-two obese individuals without diabetes and 35 lean controls underwent magnetic resonance imaging (MRI) using proton density fat fraction (PDFF) maps to evaluate pancreatic and hepatic fat content, and visceral adipose tissue (VAT) content...
April 1, 2024: Scandinavian Journal of Gastroenterology
Jussi Rauma, Stefan Jansson, Yang Cao, Michiel A van Nieuwenhoven
OBJECTIVES: Irritable bowel syndrome (IBS) is a common functional gastrointestinal condition. A respectful patient-doctor relationship with good communication is crucial for optimal treatment. Q-methodology is a combination of qualitative and quantitative methods used to study subjectivity. The aim of this study was to compare viewpoints on IBS between patients with IBS and general practitioners (GPs). METHODS: We conducted a Q-methodology study by including 30 patients and 30 GPs...
April 1, 2024: Scandinavian Journal of Gastroenterology
Ali Kiasat, Stefanie Prast-Nielsen, Susanne Rautiainen, Lars Engstrand, Fredrik Andersson, Johan Lindberg, Ina Schuppe-Koistinen, Anna Löf Granström, Ulf O Gustafsson
BACKGROUND: In addition to facilitating lipid digestions, bile acids (BA) are signalling molecules acting on receptors on immune cells and along the gastrointestinal (GI) tract. The aim of this study was to assess if altered bile acid profiles in plasma are associated with Crohn's disease (CD). METHOD: This cross-sectional study included individuals (aged ≥18 years) referred for colonoscopy at a tertiary centre in Stockholm between 2016 and 2019. All participants received bowel preparation, completed a lifestyle questionnaire and provided blood samples for analysis...
March 20, 2024: Scandinavian Journal of Gastroenterology
Shellie J Radford, Buraq Abdul-Aema, Chris Tench, Paul Leighton, Jane Coad, Gordon W Moran
BACKGROUND: Imaging is used to monitor disease activity in small bowel Crohn's disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, patient burden and limited access are significant. It is as yet uncertain if small bowel intestinal ultrasound (IUS) may be a quicker, more acceptable, and cheaper alternative for monitoring patients with CD. METHODS: A clinical service evaluation of imaging pathways was undertaken at a single NHS site in England, United Kingdom...
March 19, 2024: Scandinavian Journal of Gastroenterology
Philippe Onana Ndong, Jean-Michel Gonzalez, Ana Beyrne, Marc Barthet, Veronique Vitton
INTRODUCTION: The prevalence of esophageal motor disorders (EMD) in PPI-refractory gastroesophageal reflux disease (GERD) is substantial. However, limited data exist on their impact on the efficacy of endoscopic treatments like anti-reflux mucosectomy (ARMS). This study aimed to evaluate the influence of EMD on ARMS efficacy in patients with PPI-refractory GERD. METHOD: This single-center retrospective study enrolled patients with refractory GERD treated with ARMS-b (anti-reflux mucosectomy band-ligation)...
March 18, 2024: Scandinavian Journal of Gastroenterology
Mei-Juan Hao, Zhi-Yuan Cheng, Ye Gao, Lei Xin, Chu-Ting Yu, Ting-Lu Wang, Zhao-Shen Li, Luo-Wei Wang
Oesophageal squamous cell carcinoma (ESCC) is a common malignant tumour of the gastrointestinal tract. Early detection and access to appropriate treatment are crucial for the long-term survival of patients. However, limited diagnostic and monitoring methods are available for identifying early stage ESCC. Endoscopic screening and surgical resection are commonly used to diagnose and treat early ESCC. However, these methods have disadvantages, such as high recurrence, lethality, and mortality rates. Therefore, methods to improve early diagnosis of ESCC and reduce its mortality rate are urgently required...
March 11, 2024: Scandinavian Journal of Gastroenterology
Doğan Barut, Ezgi Kıran Taşcı, Bora Kunay, Burcu Güven, Betül Aksoy, Yeliz Çağan Appak, Miray Karakoyun, Funda Çetin, Ayşe Selimoğlu, Huseyin Onay, Sema Aydoğdu
BACKGROUND: Congenital sucrase-isomaltase deficiency (CSID) is a rare inherited carbohydrate malabsorption disorder caused by sucrase-isomaltase ( SI ) gene variants. In CSID, an autosomal recessively inherited disease, symptoms can also be seen in individuals with heterozygous mutations. METHODS: The variant spectrum was evaluated retrospectively in individuals who presented with chronic diarrhea between 2014 and 2022 and had undergone genetic testing of the SI gene considering CSID due to diet-related complaints...
March 8, 2024: Scandinavian Journal of Gastroenterology
Anette Mertz Nielsen, Klaus Theede, Lise Lotte Gluud, Marianne Kiszka-Kanowitz
OBJECTIVE: The long-term outcome of thiopurine therapy in patients with ulcerative colitis (UC) enrolled in prospective trials have not been evaluated. We aimed to assess the effects of optimised thiopurine maintenance therapy for UC. METHODS: Long-term data were obtained from patients from our center enrolled in two randomised, prospective, open-label, controlled studies comprising 66 thiopurine-naïve moderate-to-severe patients with UC consisting of a low dose azathioprine (AZA)/allopurinol combination or AZA monotherapy...
March 5, 2024: Scandinavian Journal of Gastroenterology
Niklas Mattila, Maxim Mazanikov, Marianne Udd, Leena Kylänpää, Outi Lindström, Pertti Pere, Reino Pöyhiä, Matti Ristikankare
OBJECTIVES: The benefits of topical pharyngeal anesthesia for gastroscopy remain under debate. Articaine, a local anesthetic with fast onset and offset of action as well as low systemic toxicity, could be a promising choice for topical anesthesia. The objective of this study was to assess whether topical pharyngeal anesthesia with articaine is beneficial in sedated gastroscopy. MATERIALS AND METHODS: This randomized double-blinded cross-over study included nine volunteers who underwent two gastroscopies under conscious sedation...
March 5, 2024: Scandinavian Journal of Gastroenterology
Yiting Hu, Zhongfei Luo, Siyi Cai, Qinfen Xie, Shusen Zheng
BACKGROUND: Hepatocellular carcinoma (HCC) is the most malignant cancer worldwide. Sorafenib (SRF) is a common therapeutic drug used for patients with advanced HCC. Nevertheless, drug resistance frequently occurs in patients treated with sorafenib. Glycyrrhizic acid (GRA) is a natural compound that is identified to exhibit anti-cancer effects. In this work, we aimed to investigate the effects of GRA on SRF-resistant HCC cells and the potential regulatory mechanisms. METHODS: We established SRF-resistant HCC cell lines and administrated GRA treatment...
March 1, 2024: Scandinavian Journal of Gastroenterology
Matin Sepehrinia, Hossein Pourmontaseri
No abstract text is available yet for this article.
February 28, 2024: Scandinavian Journal of Gastroenterology
Jóngerð Midjord, Kári Rubek Nielsen, Amanda Gratton Vang, Marin Strøm, Søren Lophaven, Turid Hammer, Johan Burisch
BACKGROUND: The association between inflammatory bowel disease (IBD) and malignancy remains disputed despite many observational studies. The Faroese population exhibits the highest occurrence of IBD in the world. This study aimed to investigate the cancer risk in Faroese IBD patients in a nationwide IBD cohort. METHODS: This study included all IBD patients diagnosed in the Faroe Islands between 1960 and 2020. Clinical demographics and cancer diagnoses were retrieved from patient files and the Faroese cancer registry...
February 26, 2024: Scandinavian Journal of Gastroenterology
Aryoung Kim, Heejung Kim, Eun Ran Kim, Ji Eun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim
BACKGROUND AND AIMS: Diagnostic colonoscopy plays a central role in colorectal cancer screening programs. We analyzed the risk factors for perforation during diagnostic colonoscopy and discussed the treatment outcomes. METHODS: We performed a retrospective analysis of risk factors and treatment outcomes of perforation during 74,426 diagnostic colonoscopies between 2013 and 2018 in a tertiary hospital. RESULTS: A total of 19 perforations were identified after 74,426 diagnostic colonoscopies or sigmoidoscopies, resulting in a standardized incidence rate of 0...
February 21, 2024: Scandinavian Journal of Gastroenterology
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