Pratibha Gaur, Mansour Seaf, Nirit Trabelsi, Orly Marcu, Daria Gafarov, Ora Schueler-Furman, Ofer Mandelboim, Micha Ben-Zimra, Francesca Levi-Schaffer
Staphylococcus aureus (SA) and its exotoxins activate eosinophils (Eos) and mast cells (MCs) via CD48, a GPI-anchored receptor belonging to the Signaling Lymphocytes Activation Molecules (SLAM) family. 2B4 (CD244), an immuno-regulatory transmembrane receptor also belonging to the SLAM family, is the high affinity ligand for CD48. 2B4 is expressed on several leukocytes including NK cells, T cells, basophils, monocytes, dendritic cells (DCs) and Eos. In the Eos and MCs crosstalk carried out by physical and soluble interactions (named the 'Allergic Effector Unit', AEU), 2B4-CD48 binding plays a central role...
August 16, 2023: Clinical and Experimental Immunology