journal
https://read.qxmd.com/read/38375873/epigenetic-reprogramming-in-the-transition-from-pluripotency-to-totipotency
#1
REVIEW
Qingsheng Han, Ru Ma, Na Liu
Mammalian development commences with the zygote, which can differentiate into both embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote and embryos around zygotic genome activation (ZGA) (two-cell embryo stage in mice and eight-cell embryo in humans) are totipotent cells. Epigenetic modifications undergo extremely extensive changes during the acquisition of totipotency and subsequent development of differentiation. However, the underlying molecular mechanisms remain elusive...
February 20, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38372068/m-6-a-induced-trib3-regulates-hippo-pathway-through-interacting-with-lats1-to-promote-the-progression-of-lung-adenocarcinoma
#2
JOURNAL ARTICLE
Jiamei Wu, Tingzhuang Yi, Chenyi Zhuo, Duanduan Wang, Ming Zhang, Rui Hu, Dan Wu, Guoxin Hou, Yutong Xing
Recent studies have indicated that dysregulation of the Hippo/Yes-associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of Hippo signaling in LUAD is of great significance. Elevated levels of TRIB3, a pseudo kinase, have been observed in certain lung malignancies and are associated with an unfavorable prognosis. Our research aims to investigate whether increased TRIB3 levels enhance the malignant characteristics of LUAD cells and tumor progression through its interaction with the Hippo signaling pathway...
February 19, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38358001/mechanical-strain-regulates-osteogenesis-via-antxr1-lncrna-h19-wnt-%C3%AE-catenin-axis
#3
JOURNAL ARTICLE
Lifei Liu, Jianmin Guo, Xiaoyang Tong, Miao Zhang, Xi Chen, Mei Huang, Chenyu Zhu, Samuel Bennett, Jiake Xu, Jun Zou
Alleviating bone loss is an essential way to prevent osteoporotic fractures. Proper exercise improves bone density without the side effects of long-term medications, but the mechanism is unclear. Our study explored the role of Antxr1/LncRNA H19/Wnt/β-catenin axis in the process of exercise-mediated alleviation of bone loss. Here we discovered that moderate-intensity treadmill exercise alleviates bone loss caused by ovariectomy and ameliorates bone strength accompanied by an increased lncRNA H19 expression...
February 15, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38348695/magp2-promotes-osteogenic-differentiation-during-fracture-healing-through-its-crosstalk-with-the-%C3%AE-catenin-pathway
#4
JOURNAL ARTICLE
Zhiguang Chen, Qi Zhao, Lianghong Chen, Songlan Gao, Lingshuai Meng, Yingjie Liu, Yu Wang, Tiegang Li, Jinqi Xue
Osteogenic differentiation is important for fracture healing. Microfibrial-associated glycoprotein 2 (MAGP2) is found to function as a proangiogenic regulator in bone formation; however, its role in osteogenic differentiation during bone repair is not clear. Here, a mouse model of critical-sized femur fracture was constructed, and the adenovirus expressing MAGP2 was delivered into the fracture site. Mice with MAGP2 overexpression exhibited increased bone mineral density and bone volume fraction (BV/TV) at Day 14 postfracture...
February 13, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38345408/identification-of-binding-partners-that-facilitate-membrane-type-5-matrix-metalloproteinase-mt5-mmp-processing-of-amyloid-precursor-protein
#5
JOURNAL ARTICLE
Hongjie Wang, Madepalli K Lakshmana, Gregg B Fields
One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular deposits of amyloid beta (Aβ) peptide. In addition to Aβ as the core component of the amyloid plaque, the amyloid precursor protein (APP) processing fragment Aβ was also found accumulated around the plaque. The APPη pathway, mainly mediated by membrane-type 5 matrix metalloproteinase (MT5-MMP), represents an important factor in AD pathogenesis. The proamyloidogenic features of MT5-MMP could result from interactions with APP when trafficking between organelles, so determination of the location within the cell of APPη cleavage and interacting proteins of MT5-MMP affecting this process will be of priority in understanding the role of MT5-MMP in AD...
February 12, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38345407/abnormal-stress-promotes-intervertebral-disc-degeneration-through-wtap-ythdf2-dependent-timp3-m6a-modification
#6
JOURNAL ARTICLE
Daokuan Gao, Quanlai Zhao, Chen Liu, Yu Zhang, Liang Xiao
Mechanical environment worsening is an important predisposing factor that accelerates intervertebral disc degeneration (IDD), but its specific regulatory mechanisms remain unclear. In this study, we reveal the molecular mechanisms of WTAP/YTHDF2-mediated m6A modification in abnormal stress-induced intervertebral disc (IVD) matrix degradation. WTAP expression in human nucleus pulposus cells was elevated under tension. Similarly, high WTAP expression was detected in severe degenerated human and rat nucleus pulposus tissues...
February 12, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38345361/expression-of-cell-surface-zinc-transporter-liv1-in-triple-negative-breast-cancer-is-an-indicator-of-poor-prognosis-and-therapy-failure
#7
JOURNAL ARTICLE
Roshni Saravanan, Vaishnavi Balasubramanian, Sandhya Sundaram, Bhawna Dev, Pavithra Vittalraj, Ravi Shankar Pitani, Gouthaman Shanmugasundaram, Suresh Kumar Rayala, Ganesh Venkatraman
Triple negative breast cancers (TNBC) are an aggressive molecular subtype of breast carcinoma (BC) identified by the lack of receptor expression for estrogen, progesterone, & human epidermal growth factor receptor-2. Lack of tangible drug targets warrants further research in TNBC. LIV1, is a zinc (Zn) transporter known to be overexpressed in few cancer types including BCs. Recently, in the United States of America, FDA approved the use of a new drug targeting LIV1, antibody drug conjugate SGN-LIV1A for treatment of TNBC patients...
February 12, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38327128/role-of-c-fos-in-dna-damage-repair
#8
REVIEW
Haiyang Yao, Yilun Wu, Yiming Zhong, Chenxuan Huang, Zimo Guo, Yinpeng Jin, Xianli Wang
c-Fos, a member of the immediate early gene, serves as a widely used marker of neuronal activation induced by various types of brain damage. In addition, c-Fos is believed to play a regulatory role in DNA damage repair. This paper reviews the literature on c-Fos' involvement in the regulation of DNA damage repair and indicates that genes of the Fos family can be induced by various forms of DNA damage. In addition, cells lacking c-Fos have difficulties in DNA repair. c-Fos is involved in tumorigenesis and progression as a proto-oncogene that maintains cancer cell survival, which may also be related to DNA repair...
February 7, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38327035/ring-finger-e3-ligase-rnf138-inhibits-osteoblast-differentiation-by-negatively-regulating-runx2-protein-turnover
#9
JOURNAL ARTICLE
Vishal Upadhyay, Anil Kumar Singh, Shivani Sharma, Arppita Sethi, Swati Srivastava, Sangita Chowdhury, Shumaila Siddiqui, Naibedya Chattopadhyay, Arun Kumar Trivedi
A few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription factor and thereby regulate bone formation. The regulation of Runx2 expression and function are controlled both at the transcriptional and posttranslational levels. Really interesting new gene (RING) finger ubiquitin ligases of which RNF138 is a member are important players in the ubiquitin-proteasome system, contributing to the regulation of protein turnover and cellular processes. Here, we demonstrated that RNF138 negatively correlated with Runx2 protein levels in osteopenic ovariectomized rats which implied its role in bone loss...
February 7, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38317581/tiliroside-is-a-new-potential-therapeutic-drug-for-osteoporosis-in-mice
#10
Kai Li, Yu Xiao, Ziyi Wang, Fangsheng Fu, Siyuan Shao, Fangming Song, Jinmin Zhao, Xixi Lin, Qian Liu, Jiake Xu
No abstract text is available yet for this article.
February 5, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38317568/protective-effect-of-extractive-and-biotechnological-chondroitin-in-insulin-amyloid-and-advanced-glycation-end-product-induced-toxicity
#11
(no author information available yet)
No abstract text is available yet for this article.
February 5, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38310632/circular-rna-rsf1-promotes-inflammatory-and-fibrotic-phenotypes-of-irradiated-hepatic-stellate-cell-by-modulating-mir-146a-5p
#12
(no author information available yet)
No abstract text is available yet for this article.
February 4, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38310630/cyanidin-chloride-inhibits-ovariectomy-induced-osteoporosis-by-suppressing-rankl-mediated-osteoclastogenesis-and-associated-signaling-pathways
#13
(no author information available yet)
No abstract text is available yet for this article.
February 4, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38310622/molecular-characterization-of-autophagic-and-apoptotic-signaling-induced-by-sorafenib-in-liver-cancer-cells
#14
María A Rodríguez-Hernández, Raúl González, Ángel J de la Rosa, Paloma Gallego, Raquel Ordóñez, Elena Navarro-Villarán, Laura Contreras, Mario Rodríguez-Arribas, Javier González-Gallego, José M Álamo-Martínez, Luís M Marín-Gómez, José A Del Campo, José L Quiles, José M Fuentes, Jesús de la Cruz, José L Mauriz, Francisco J Padillo, Jordi Muntané
No abstract text is available yet for this article.
February 4, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38310614/galangin-ameliorates-cardiac-remodeling-via-the-mek1-2-erk1-2-and-pi3k-akt-pathways
#15
Hui-Bo Wang, Si-Hui Huang, Man Xu, Jun Yang, Jian Yang, Ming-Xin Liu, Chun-Xia Wan, Hai-Han Liao, Di Fan, Qi-Zhu Tang
No abstract text is available yet for this article.
February 4, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38308838/nrf2-prevents-diabetic-cardiomyopathy-via-antioxidant-effect-and-normalization-of-glucose-and-lipid-metabolism-in-the-heart
#16
JOURNAL ARTICLE
Ge Yang, Qihe Zhang, Chao Dong, Guowen Hou, Jinjie Li, Xin Jiang, Ying Xin
Metabolic disorders and oxidative stress are the main causes of diabetic cardiomyopathy. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) exerts a powerful antioxidant effect and prevents the progression of diabetic cardiomyopathy. However, the mechanism of its cardiac protection and direct action on cardiomyocytes are not well understood. Here, we investigated in a cardiomyocyte-restricted Nrf2 transgenic mice (Nrf2-TG) the direct effect of Nrf2 on cardiomyocytes in DCM and its mechanism. In this study, cardiomyocyte-restricted Nrf2 transgenic mice (Nrf2-TG) were used to directly observe whether cardiomyocyte-specific overexpression of Nrf2 can prevent diabetic cardiomyopathy and correct glucose and lipid metabolism disorders in the heart...
February 3, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38308657/dynamic-changes-of-endothelial-and-stromal-cilia-are-required-for-the-maintenance-of-corneal-homeostasis
#17
JOURNAL ARTICLE
Hua Ni, Lamei Li, Die Hu, Mulin Yang, Difei Wang, Hongbo Ma, Weiwen Bu, Jia Yang, Li-E Zhu, Denghui Zhai, Ting Song, Song Yang, Quanlong Lu, Dengwen Li, Jie Ran, Min Liu
Primary cilia are distributed extensively within the corneal epithelium and endothelium. However, the presence of cilia in the corneal stroma and the dynamic changes and roles of endothelial and stromal cilia in corneal homeostasis remain largely unknown. Here, we present compelling evidence for the presence of primary cilia in the corneal stroma, both in vivo and in vitro. We also demonstrate dynamic changes of both endothelial and stromal cilia during corneal development. In addition, our data show that cryoinjury triggers dramatic cilium formation in the corneal endothelium and stroma...
February 3, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38308646/c-peptide-in-diabetes-a-player-in-a-dual-hormone-disorder
#18
REVIEW
Ali Dakroub, Ali Dbouk, Aref Asfour, Suzanne A Nasser, Ahmed F El-Yazbi, Amirhossein Sahebkar, Assaad A Eid, Rabah Iratni, Ali H Eid
C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide protects endothelial cells by activating AMP-activated protein kinase α, thus suppressing the activity of NAD(P)H oxidase activity and reducing reactive oxygen species (ROS) generation. It also prevents apoptosis by regulating hyperglycemia-induced p53 upregulation and mitochondrial adaptor p66shc overactivation, as well as reducing caspase-3 activity and promoting expression of B-cell lymphoma-2...
February 3, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38308641/ubc9-mediated-sumoylation-of-lamin-b1-enhances-dna-damage-induced-nuclear-dna-leakage-and-autophagy-after-spinal-cord-injury
#19
JOURNAL ARTICLE
Yun-Peng Fan, Jun-Sheng Lou, Meng-Ran Jin, Cong-Hui Zhou, Hong-Hao Shen, Chun-Yan Fu, Xing-Jia Mao, Ying-Ying Chen, Jin-Jie Zhong, Lin-Lin Wang, Jun-Song Wu
Recent studies have shown that nucleophagy can mitigate DNA damage by selectively degrading nuclear components protruding from the nucleus. However, little is known about the role of nucleophagy in neurons after spinal cord injury (SCI). Western blot analysis and immunofluorescence were performed to evaluate the nucleophagy after nuclear DNA damage and leakage in SCI neurons in vivo and NSC34 expression in primary neurons cultured with oxygen-glucose deprivation (OGD) in vitro, as well as the interaction and colocalization of autophagy protein LC3 with nuclear lamina protein Lamin B1...
February 3, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38304971/high-glucose-promotes-osteogenic-differentiation-of-human-lens-epithelial-cells-through-hypoxia-inducible-factor-hif-activation
#20
JOURNAL ARTICLE
Haneen Ababneh, Enikő Balogh, Dávid Máté Csiki, Gréta Lente, Ferenc Fenyvesi, Andrea Tóth, Viktória Jeney
Cataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two- to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia. Hydroxyapatite deposition is present in cataractous lenses that could be the consequence of osteogenic differentiation and calcification of lens epithelial cells (LECs). We hypothesised that hyperglycaemia might promote the osteogenic differentiation of human LECs (HuLECs)...
February 2, 2024: Journal of Cellular Physiology
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