Mathieu Dallaire, Alexandra Houde-Thibeault, Jérôme Bouchard-Tremblay, Enafa Anais Wotto, Sharlène Côté, Claudia Santos Oliveira, Suzy Ngomo, Rubens A da Silva
BACKGROUND: Parkinson's Disease (PD), a neurodegenerative condition, affects normal aging and leads to reduced motor abilities. In addition, frailty syndrome can increase vulnerability and risks of undesirable effects such as disease progression, falls, disability, and premature death among individuals with PD. AIMS: To assess the impact of frailty on balance and gait parameters in older with PD and to determine if sex mediates these measures. METHODS: Twenty-seven (27) participants (n = 18 men; n = 10 frail) performed 4 balance tasks on a force platform (eyes opened/closed in bipodal/semi-tandem position) while linear center of pressure (COP) parameters were calculated...
January 10, 2024: Experimental Gerontology
Ting Liu, Na Li, Jingjing Pu, Caihong Zhang, Kun Xu, Wenting Wang, Linsheng Liu, Lihong Gao, Xiaonan Xu, Jiying Tan
Alzheimer's disease (AD) is the leading cause of dementia and is rapidly becoming one of the most costly, fatal diseases, which is typically discovered in the late stage of molecular pathology, at which point medication intervention is irreversible. As a result, there is an urgent need for a low-cost, least-invasive way of screening cognitive impairment, with the goal of identifying persons at risk of AD. Mild cognitive impairment (MCI) has been described as a transitional state between normal cognitive aging and AD...
January 10, 2024: Experimental Gerontology
Ziqiang Fan, Yingdong Tong, Ziyue Yang, Shuai Wang, Tiantian Huang, Deying Yang, Qingyong Ni, Mingwang Zhang, Diyan Li, Mingyao Yang, Xiaolan Fan
Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is also a known risk factor for many chronic diseases. Recent research has shown that senolytics can extend the lifespans and health spans of model organisms, and they have also been demonstrated effective in treating age-related diseases. In this study, we conducted a high-throughput screening of 156 drugs that targeted the PI3K/AKT/mTOR pathway to identify potential senolytic medications. Among these drugs, PF-04691502 was selected for further investigation to understand its molecular mechanism of action...
January 6, 2024: Experimental Gerontology
Zhe Luan, Shihui Fu, Shirui Qi, Congyong Li, Jun Chen, Yiming Zhao, Hanwen Zhang, Junling Wu, Zhizhuang Zhao, Jiaqi Zhang, Yi Chen, Wei Zhang, Yujia Jing, Shufang Wang, Gang Sun
BACKGROUND: Sex differences in health status and life expectancy are widely accepted to exist. The mechanisms underlying it are still poorly understood. In this study, we aimed to clarify the influences and contributions of sex on the gut microbiome in healthy centenarians and to explore the different roles played by the gut microbiome in healthy aging between the sexes. RESULTS: Taking covariates of different dimensions into account (social demographics, anthropometry, the activities of daily living, dietary structure, mental state, blood tests, lifestyle and disease history), our data showed that sex was one of the most significant covariates affecting the gut microbiome of healthy centenarians at both the species and Kyoto Encyclopedia of Genes and Genomes Orthology (KO) levels...
January 5, 2024: Experimental Gerontology
Aaron Colverson, Stephanie Barsoum, Ronald Cohen, John Williamson
Brain aging and common conditions of aging (e.g., hypertension) affect networks important in organizing information, processing speed and action programming (i.e., executive functions). Declines in these networks may affect timing and could have an impact on the ability to perceive and perform musical rhythms. There is evidence that participation in rhythmic musical activities may help to maintain and even improve executive functioning (near transfer), perhaps due to similarities in brain regions underlying timing, musical rhythm perception and production, and executive functioning...
January 2, 2024: Experimental Gerontology
Zhaoyang Yin, Qinghua Cheng, Chao Wang, Bin Wang, Guoping Guan, Jian Yin
BACKGROUND: Sarcopenia is an age-related condition that causes loss of skeletal muscle mass and disability. Sarcopenia is closely related to the prognosis of patients suffering osteoporotic thoraco-lumbar compression fractures (OTLCF). The purpose of this study was to investigate the effect of sarcopenia on the efficacy of percutaneous kyphoplasty (PKP) in the treatment of older adults with OTLCF surgery and postoperative mortality. METHODS: From February 2016 to June 2019, 101 patients who met the inclusion and exclusion criteria were included in this study...
January 2, 2024: Experimental Gerontology
Lu Lu Guo, Ru Yu Yan, Zheng Du, Han Bing Li, Gen Lin Li, Su Hui Wu
BACKGROUND: Intestinal stem cells (ISCs) are the reservoir source of various types of intestinal cells, and the decline of stem cell function in the gut may be a potential factor for aging-related disease. The present study aimed to explore the regulatory mechanisms of Panax ginseng C.A.Meyer (Araliaceae, Panax genus) that could restore gut aging by enhancing intestinal function and regulating ISCs in aging mice based on the Wnt/β-catenin signaling pathway. METHODS: A total of 60 ICR male mice were randomly divided into control, model, metformin, and ginseng water decoction (GWD) 3...
December 20, 2023: Experimental Gerontology
Estela Calatayud, Bárbara Oliván-Blázquez, Marta Sánchez Peña, Alejandra Aguilar-Latorre, Olga Tena-Bernal
BACKGROUND: The global population is experiencing accelerated biopsychosocial aging. Cognitive impairment is frequently associated with functional impairment in basic and instrumental daily living activities. To maintain optimal cognitive and functional functioning, health professionals recommend that older adults participate in cognitive training. AIMS: This study examines the cognitive and functional evolution of older adults with and without Intellectual Disability and the factors associated with favourable evolution following the intervention of a multicomponent programme based on the human occupational model and the person-centred care model...
December 19, 2023: Experimental Gerontology
Yujie Tang, Xiaojin Feng, Na Liu, Yuan Zhou, Yadi Wang, Zhenna Chen, Yongping Liu
OBJECTIVE: To investigate the association between systemic immune inflammation index (SII) and all-cause or cardiovascular diseases (CVDs) mortality in US adults with different diabetic status based on the National Health and Nutrition Examination Survey (NHANES) database. STUDY DESIGN AND SETTING: Adults with follow-up data in the NHANES 1999-2018 cycles were included in this study. The SII was calculated based on blood cells counts (including neutrophils, lymphocytes, and platelets) measured in the laboratory data...
December 19, 2023: Experimental Gerontology
Mingming Deng, Ye Lu, Xuelian Li, Xiaoming Zhou, Gang Hou
BACKGROUND: Little is known about the association between sarcopenia and multimorbidity among middle-aged and older adults. This study investigated whether sarcopenia is associated with multimorbidity in middle-aged and older Chinese individuals. MATERIALS AND METHODS: A total of 12,760 participants from China Health and Retirement Longitudinal Study (CHARLS) 2015, with data on 14 specified chronic diseases and sarcopenia status were included in the cross-sectional analysis...
December 19, 2023: Experimental Gerontology
Taichi Nishikawa, Ryosuke Takeda, Tetsuya Hirono, Masamichi Okudaira, Toshiyuki Ohya, Kohei Watanabe
AIMS: The purpose of this study was to investigate differences in the acute response after resistance exercise between young and older adults. METHODS: Seventeen young and 18 older adults performed a single session of resistance exercise, consisting of 3 sets of 10 isometric knee extensions. Maximal voluntary contraction (MVC), motor unit (MU) activity of the vastus lateralis, and electrically elicited torque of the knee extensor were measured before and after the resistance exercise...
December 15, 2023: Experimental Gerontology
Shuli Wang, Mulan Li, Pengcheng Liu, Yaning Dong, Ruishuang Geng, Tihua Zheng, Qingyin Zheng, Bo Li, Peng Ma
Age-related hearing loss (ARHL) is a common neurodegenerative disease. Its molecular mechanisms have not been fully elucidated. In the present study, we obtained differential mRNA expression in the cochlea of 2-month-old miR-29a+/+ mice and miR-29a-/- mice by RNA-seq. Gene ontology (GO) analysis was used to identify molecular functions associated with hearing in miR-29a-/- mice, including being actin binding (GO: 0003779) and immune processes. We focused on the intersection of differential genes, miR-29a target genes and the sensory perception of sound (GO:0007605) genes, with six mRNA at this intersection, and we selected Col1a1 as our target gene...
December 14, 2023: Experimental Gerontology
Kefeng Wu, Pan Wang, Luming Deng, Yancai Li, Qian Zhang, Haiyan Hou, Yuzhen Zhu, Hua Ye, Si Mei, Liao Cui
Type 2 diabetes (T2D) is a common chronic disease, characterized by persistent hyperglycemia and insulin resistance. This disorder is associated with decreased bone quality and an elevated risk of bone fractures. However, evidence on the relationship between systemic metabolic change and the development of type 2 diabetic osteoporosis (T2DOP) remains elusive. Herein, we investigate the changes of bone metabolites with bone loss in db/db mice (an animal model of T2DOP exhibited bone loss with age progression), and explore the potential metabolic mechanism underlying type 2 diabetes and osteoporosis...
December 12, 2023: Experimental Gerontology
Hung-Chen Chang, Xiaojun Wang, Xuchao Gu, Shuai Jiang, Wenhao Wang, Tao Wu, Maoqing Ye, Xinkai Qu, Zhijun Bao
BACKGROUND: Secretory factors linked to lymphogenesis, such as vascular endothelial growth factor C (VEGF-C), angiopoietin like protein 4 (ANGPTL4), and activin A (ACV-A), have been recognized as potential markers of chronic inflammatory status and age-related diseases. Furthermore, these factors may also be linked to frailty. The primary objective of this study was to examine the serum VEGF-C, ANGPTL4, and ACV-A levels in young individuals, healthy older individuals, and older individuals with pre-frailty and frailty, and to determine their association with pro-inflammatory factor levels...
December 11, 2023: Experimental Gerontology
Pedro Gargallo, Eva Tamayo, Pablo Jiménez-Martínez, Alvaro Juesas, Jose Casaña, Josep C Benitez-Martinez, Javier Gene-Morales, Julio Fernandez-Garrido, Guillermo T Saez, Juan C Colado
PURPOSE: This study aimed to explore the effects of 20 weeks of multicomponent or power training with elastic bands (EBs) on metabolic and inflammatory blood parameters, body composition, anthropometry, and physical function in older women with metabolic syndrome (MS). METHODS: Ninety participants were randomly assigned to a multicomponent (MCG; n = 30), power (PG; n = 30), or a control group (CG; n = 30). The MCG performed balance, slow-speed strength, and aerobic training, twice per week...
December 5, 2023: Experimental Gerontology
Rola S Zeidan, Taylor McElroy, Laxmi Rathor, Matthew S Martenson, Yi Lin, Robert T Mankowski
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of life (lifespan). The average life expectancy has significantly increased during the last few decades. A longer lifespan has been accompanied by an increase in frailty and decreased independence in older adults, with major differences existing between men and women. For example, women tend to live longer than men but also experience higher rates of frailty and disability...
December 2, 2023: Experimental Gerontology
Xinyue Tang, Haoran Dai, Yuehong Hu, Wenbin Liu, Qihan Zhao, Hanxue Jiang, Zhendong Feng, Naiqian Zhang, Hongliang Rui, Baoli Liu
Membranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
November 30, 2023: Experimental Gerontology
Hui Kong, Juan-Juan Han, Leonid Kapilevich, Xin-An Zhang
The immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as well as new ideas and molecular targets for the prevention and treatment of these diseases...
November 30, 2023: Experimental Gerontology
Tobias Gaemelke, Marie-Louise K Jørgensen, Morten Riemenschneider, Ulrik Dalgas, Lars G Hvid
BACKGROUND: The prevalence of older (>60 years) people with multiple sclerosis (pwMS) is increasing. This introduces numerous challenges, as both MS and ageing independently contribute to the deterioration of neuromuscular function. AIM: The aim was to compare the neuromuscular function in pwMS and healthy controls (HC) across three age groups: young, middle-aged, and old. METHODS: Using a cross-sectional study design, the maximal muscle strength (Fmax) and rate of force development (RFD) of the knee extensors (KE) and plantar flexors (PF) were assessed using an isokinetic dynamometer...
November 27, 2023: Experimental Gerontology
E Johnson, T J Ellmers, T Muehlbauer, S R Lord, M W Hill
The purpose of this study was to explore the effects of arm movements on postural control when standing under different sensory conditions in healthy young and older adults. Fifteen young (mean ± SD age; 21.3 ± 4.2 years) and 15 older (mean ± SD age; 73.3 ± 5.0 years) adults completed the modified Romberg test, which uses four task manipulations (i.e. eyes open and eyes closed on a firm and foam surface) to compromise the fidelity of sensory feedback mechanisms...
November 26, 2023: Experimental Gerontology
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