journal
https://read.qxmd.com/read/38729334/testing-the-involvement-of-low-level-visual-representations-during-spoken-word-processing-with-non-western-students-and-meditators-practicing-sudarshan-kriya-yoga
#21
JOURNAL ARTICLE
Veeky Baths, Mayur Jartarkar, Shagun Sood, Ashley G Lewis, Markus Ostarek, Falk Huettig
Previous studies, using the Continuous Flash Suppression (CFS) paradigm, observed that (Western) university students are better able to detect otherwise invisible pictures of objects when they are presented with the corresponding spoken word shortly before the picture appears. Here we attempted to replicate this effect with non-Western university students in Goa (India). A second aim was to explore the performance of (non-Western) meditators practicing Sudarshan Kriya Yoga in Goa in the same task. Some previous literature suggests that meditators may excel in some tasks that tap visual attention, for example by exercising better endogenous and exogenous control of visual awareness than non-meditators...
May 8, 2024: Brain Research
https://read.qxmd.com/read/38729333/from-aberrant-neurodevelopment-to-neurodegeneration-insights-into-the-hub-gene-associated-with-autism-and-alzheimer-s-disease
#22
JOURNAL ARTICLE
Yu Fu, Guang-Ming Xie, Rong-Qi Liu, Jun-Ling Xie, Jing Zhang, Jun Zhang
No abstract text is available yet for this article.
May 8, 2024: Brain Research
https://read.qxmd.com/read/38729332/veliparib-exerts-protective-effects-in-intracerebral-hemorrhage-mice-by-inhibiting-the-inflammatory-response-and-accelerating-hematoma-resolution
#23
JOURNAL ARTICLE
Yiwei Fu, Rongrong Liu, Yuexin Zhao, Yuhan Xie, Honglei Ren, Yu Wu, Bohao Zhang, Xiuju Chen, Ying Guo, Yang Yao, Wei Jiang, Ranran Han
Poly (ADP-ribose) polymerase (PARP) inhibitors have potent anti-inflammatory effects, including the suppression of brain microglial activation. Veliparib, a well-known PARP1/2 inhibitor, exhibits particularly high brain penetration, but its effects on stroke outcome is unknown. Here, the effects of veliparib on the short-term outcome of intracerebral hemorrhage (ICH), the most lethal type of stroke, were investigated. Collagenase-induced mice ICH model was applied, and the T2-weighted magnetic resonance imaging was performed to evaluate lesion volume...
May 8, 2024: Brain Research
https://read.qxmd.com/read/38729331/ficus-platyphylla-alleviates-seizure-severity-and-neurobehavioral-comorbidities-in-pentylenetetrazole-kindled-rats-via-modulation-of-oxidative-stress
#24
JOURNAL ARTICLE
Ben A Chindo, Musa I Yakubu, Abdulfatai A Jimoh, Peter M Waziri, Idris Abdullahi, Godwin I Ayuba, Axel Becker
PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP...
May 8, 2024: Brain Research
https://read.qxmd.com/read/38723740/a-comparative-study-of-the-dorsolateral-prefrontal-cortex-targeting-approaches-for-transcranial-magnetic-stimulation-treatment-insights-from-the-healthy-control-data
#25
JOURNAL ARTICLE
Megumi Kinjo, Shiori Honda, Masataka Wada, Shinichiro Nakajima, Shinsuke Koike, Yoshihiro Noda
Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) is an established treatment for medication-resistant depression. Several targeting methods for the left DLPFC have been proposed including identification with resting-state functional magnetic resonance imaging (rs-fMRI) neuronavigation, stimulus coordinates based on structural MRI, or electroencephalography (EEG) F3 site by Beam F3 method. To date, neuroanatomical and neurofunctional differences among those approaches have not been investigated on healthy subjects, which are structurally and functionally unaffected by psychiatric disorders...
May 7, 2024: Brain Research
https://read.qxmd.com/read/38718851/the-microtubule-dynamin-binding-inhibitor-peptide-phdp5-rescues-spatial-learning-and-memory-deficits-in-alzheimer-s-disease-model-mice
#26
JOURNAL ARTICLE
Chia-Jung Chang, Zacharie Taoufiq, Hiroshi Yamada, Takei Kohji, Takami Tomiyama, Tomohiro Umeda, Tetsuya Hori, Tomoyuki Takahashi
Dynamin is a microtubule (MT) binding protein playing a key role in vesicle endocytosis. In a brain slice model, tau loaded in presynaptic terminals assembles MTs, thereby impairing vesicle endocytosis via depletion of cytosolic dynamin. The peptide PHDP5, derived from the pleckstrin homology domain of dynamin 1, inhibits dynamin-MT interaction and rescues endocytosis and synaptic transmission impaired by tau when co-loaded in presynaptic terminals. We tested whether in vivo administration of PHDP5 could rescue their learning/memory deficits observed in Alzheimer's disease (AD) model mice...
May 6, 2024: Brain Research
https://read.qxmd.com/read/38714228/abnormal-global-and-local-connectivity-in-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis-a-resting-state-functional-mri-study
#27
JOURNAL ARTICLE
Huachun Huang, Zexiang Chen, Binglin Fan, Dongying Huang, Zhuoyan Qiu, Cuimi Luo, Jinou Zheng
OBJECTIVE: We decided to investigate the changes of global and local connectivity in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis patients based on eigenvector centrality (EC) and regional homogeneity (ReHo). We sought new biomarkers to identify the patients based on multivariate pattern analysis (MVPA). METHODS: Functional MRI (fMRI) was performed on all participants. EC, ReHo and MVPA were used to analyze the fMRI images. The correlation between the global or local connectivity and neuropsychology tests was detected...
May 5, 2024: Brain Research
https://read.qxmd.com/read/38714227/gray-matter-volume-and-corresponding-covariance-connectivity-are-biomarkers-for-major-depressive-disorder
#28
JOURNAL ARTICLE
Xiao Hu, Bochao Cheng, Yuyin Tang, Tong Long, Yan Huang, Pei Li, Yu Song, Xiyang Song, Kun Li, Yijie Yin, Xijian Chen
The major depressive disorder (MDD) is a common and severe mental disorder. To identify a reliable biomarker for MDD is important for early diagnosis and prevention. Given easy access and high reproducibility, the structural magnetic resonance imaging (sMRI) is an ideal method to identify the biomarker for depression. In this study, sMRI data of first episode, treatment-naïve 66 MDD patients and 54 sex-, age-, and education-matched healthy controls (HC) were used to identify the differences in gray matter volume (GMV), group-level, individual-level covariance connections...
May 5, 2024: Brain Research
https://read.qxmd.com/read/38705557/spinal-lipocalin-2-as-a-factor-in-the-development-of-central-post-stroke-pain
#29
JOURNAL ARTICLE
Kazuo Nakamoto, Shogo Tokuyama
Central poststroke pain (CPSP) is a type of central neuropathic pain whose mechanisms remain unknown. Recently, we showed that activated astrocytes and microglial cells are present in the spinal cord of CPSP model mice. Activated glial cells exacerbate cerebral ischemic pathology by increasing the expression of inflammatory factors. However, the involvement of spinal glial cells in CPSP remains unknown. We hypothesized that spinal glial cell-derived molecules cause hyperexcitability or promoted the development of CPSP...
May 3, 2024: Brain Research
https://read.qxmd.com/read/38705556/potential-correlations-between-asymmetric-disruption-of-functional-connectivity-and-metabolism-in-major-depressive-disorder
#30
JOURNAL ARTICLE
Yu Yang, Haibiao Ye, Haohao Yan, Chunguo Zhang, Wenxuan Li, Zhijian Li, Huang Jing, Xiaoling Li, Jiaquan Liang, Guojun Xie, Wenting Liang, Yangpan Ou, Xuesong Li, Wenbin Guo
OBJECTIVE: Previous research has suggested a connection between major depressive disorder (MDD) and certain comorbidities, including gastrointestinal issues, thyroid dysfunctions, and glycolipid metabolism abnormalities. However, the relationships between these factors and asymmetrical alterations in functional connectivity (FC) in adults with MDD remain unclear. METHOD: We conducted a study on a cohort of 42 MDD patients and 42 healthy controls (HCs). Participants underwent comprehensive clinical assessments, including evaluations of blood lipids and thyroid hormone levels, as well as resting-state functional magnetic resonance imaging (Rs-fMRI) scans...
May 3, 2024: Brain Research
https://read.qxmd.com/read/38705555/the-neuroprotective-effect-of-diosgenin-in-the-rat-valproic-acid-model-of-autism
#31
JOURNAL ARTICLE
Mohammad Reza Naghdi, Reza Ahadi, Ali Motamed Nezhad, Faeze Sadat Ahmadi Tabatabaei, Mansoureh Soleimani, Razieh Hajisoltani
BACKGROUND AND AIM: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with two core behavioral symptoms restricted/repetitive behavior and social-communication deficit. The unknown etiology of ASD makes it difficult to identify potential treatments. Valproic acid (VPA) is an anticonvulsant drug with teratogenic effects during pregnancy in humans and rodents. Prenatal exposure to VPA induces autism-like behavior in both humans and rodents. This study aimed to investigate the protective effects of Diosgenin in prenatal Valproic acid-induced autism in rats...
May 3, 2024: Brain Research
https://read.qxmd.com/read/38702024/remimazolam-inhibits-postoperative-cognitive-impairment-after-cardiopulmonary-bypass-by-alleviating-neuroinflammation-and-promoting-microglia-m2-polarization
#32
JOURNAL ARTICLE
Tao Wen, Jing Wen, Cuicui Yao
Postoperative cognitive impairment (POCD) is a complication of cardiopulmonary bypass (CPB). Remimazolam is an ultra-short acting benzodiazepine that can be used for anesthesia or sedation during surgery. This study investigated the role of remimazolam in inflammasome activation and microglia polarization using CPB rat model and lipopolysaccharide (LPS)-induced microglia model. The cognitive function of rats was evaluated by Morris water maze. TUNEL assay was performed to detect apoptosis. Inflammatory cytokines concentration were analyzed by enzyme-linked immunosorbent assay...
May 1, 2024: Brain Research
https://read.qxmd.com/read/38688382/investigating-the-effects-of-thymus-vulgaris-essential-oil-allium-cepa-extract-and-their-active-compounds-thymol-and-quercetin-on-expression-profile-of-genes-related-to-alzheimer-s-disease-in-pc12-model-cell
#33
JOURNAL ARTICLE
Saba Foroughi, Kahin Shahanipour, Ramesh Monajemi, Ali Mohammad Ahadi
Thymus vulgaris and Allium cepa are plants with great medicinal importance. Thymol monoterpene and quercetin, which are present in these plants, have anti-Alzheimer's and antioxidant effects. The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively...
April 28, 2024: Brain Research
https://read.qxmd.com/read/38685372/nrf2-expression-mitochondrial-fission-and-neuronal-apoptosis-in-the-prefrontal-cortex-of-methamphetamine-abusers-and-rats
#34
JOURNAL ARTICLE
Qian-Yun Nie, Gen-Meng Yang, Peng Zhang, Wen-Juan Dong, Di Jing, Zhen-Ping Hou, Yan-Xia Peng, Yang Yu, Li-Hua Li, Shi-Jun Hong
Methamphetamine (MA), a representative amphetamine-type stimulant, is one of the most abused drugs worldwide. Studies have shown that MA-induced neurotoxicity is strongly associated with oxidative stress and apoptosis. While nuclear factor E2-related factor 2 (Nrf2), an antioxidant transcription factor, is known to exert neuroprotective effects, its role in MA-induced dopaminergic neuronal apoptosis remains incompletely understood. In the present study, we explored the effects of MA on the expression levels of Nrf2, dynamin-related protein 1 (Drp1), mitofusin 1 (Mfn1), cytochrome c oxidase (Cyt-c), and cysteine aspartate-specific protease 3 (Caspase 3), as well as the correlations between Nrf2 and mitochondrial dynamics and apoptosis...
April 27, 2024: Brain Research
https://read.qxmd.com/read/38685371/vocal-and-tongue-exercise-in-early-to-mid-stage-parkinson-disease-using-the-pink1-rat
#35
JOURNAL ARTICLE
J D Hoffmeister, C K Broadfoot, N E Schaen-Heacock, S A Lechner, M N Krasko, A F Nisbet, J Russell, J Szot, T J Glass, N P Connor, C A Kelm-Nelson, M R Ciucci
Vocal and swallowing deficits are common in Parkinson disease (PD). Because these impairments are resistant to dopamine replacement therapies, vocal and lingual exercise are the primary treatment, but not all individuals respond to exercise and neural mechanisms of treatment response are unclear. To explore putative mechanisms, we used the progressive Pink1-/- rat model of early to mid-stage PD and employed vocal and lingual exercises at 6- and 10-months of age in male Pink1-/- and wild type (WT) rats. We hypothesized that vocal and lingual exercise would improve vocal and tongue use dynamics and increase serotonin (5HT) immunoreactivity in related brainstem nuclei...
April 27, 2024: Brain Research
https://read.qxmd.com/read/38679314/swallowing-like-activity-elicited-in-neonatal-rat-medullary-slice-preparation
#36
JOURNAL ARTICLE
Takahide Kondo, Tadashi Yamanishi, Takahiro Nishio, Yusuke Yokota, Tetsuya Seikai, Akifumi Enomoto, Takeshi Harada, Tadataka Tsuji, Susumu Tanaka
Swallowing is induced by a central pattern generator in the nucleus tractus solitarius (NTS). We aimed to create a medullary slice preparation to elucidate the neural architecture of the central pattern generator of swallowing (Sw-CPG) and record its neural activities. Experiments were conducted on 2-day-old Sprague-Dawley rats (n = 46). The brainstem-spinal cord was transected at the pontomedullary and cervicothoracic junctions; the medulla was sliced transversely at thicknesses of 600, 700, or 800 μm...
April 26, 2024: Brain Research
https://read.qxmd.com/read/38679313/systemic-inflammation-in-a%C3%AE-1-40-induced-alzheimer-s-disease-model-new-translational-opportunities
#37
JOURNAL ARTICLE
Anastasiia Nefodova, Mariia Rudyk, Roman Dovhyi, Taisa Dovbynchuk, Nataliia Dzubenko, Ganna Tolstanova, Larysa Skivka
Alzheimer disease (AD) is the most frequent cause of dementia, and the most common neurodegenerative disease, which is characterized by memory impairment, neuronal death, and synaptic loss in the hippocampus. Sporadic late-onset AD, which accounts for over 95 % of disease cases, is a multifactorial pathology with complex etiology and pathogenesis. Nowadays, neuroinflammation is considered the third most important component of AD pathogenesis in addition to amyloid peptide generation and deposition. Neuroinflammation is associated with the impairment of blood-brain barrier and leakage of inflammatory mediators into the periphery with developing systemic inflammatory responses...
April 26, 2024: Brain Research
https://read.qxmd.com/read/38679312/human-midbrain-brainstem-classification-according-to-the-prosomeric-model
#38
JOURNAL ARTICLE
Alberth Patricio Munoz-Gualan, Abuzer Güngör, Phillip Cem Cezayirli, Serdar Rahmanov, Muhammet Enes Gurses, Luis Puelles, Uğur Türe
This study reevaluates the conventional understanding of midbrain anatomy and neuroanatomical nomenclature in the context of recent genetic and anatomical discoveries. The authors assert that the midbrain should be viewed as an integral part of the forebrain due to shared genetic determinants and evolutionary lineage. The isthmo-mesencephalic boundary is recognized as a significant organizer for both the caudal midbrain and the isthmo-cerebellar area. The article adopts the prosomeric model, redefining the whole brain as neuromeres, offering a more precise depiction of brain development, including processes like proliferation, neurogenesis, cell migration, and differentiation...
April 26, 2024: Brain Research
https://read.qxmd.com/read/38677451/dichotic-listening-and-interhemispheric-integration-after-callosotomy-a-systematic-review
#39
JOURNAL ARTICLE
René Westerhausen
The right-ear advantage (REA) for recalling dichotically presented auditory-verbal stimuli has been traditionally linked to the dominance of the left cerebral hemisphere for speech processing. Early studies on patients with callosotomy additionally found that the removal of the corpus callosum leads to a complete extinction of the left ear, and consequently the today widely used models to explain the REA assume a central role of callosal axons for recalling the left-ear stimulus in dichotic listening. However, later dichotic-listening studies on callosotomy patients challenge this interpretation, as many patients appear to be able to recall left-ear stimuli well above chance level, albeit with reduced accuracy...
April 25, 2024: Brain Research
https://read.qxmd.com/read/38677450/role-of-intracranial-bone-marrow-mesenchymal-stem-cells-in-stroke-recovery-a-focus-on-post-stroke-inflammation-and-mitochondrial-transfer
#40
REVIEW
Jiang Ming, Yidong Liao, Wenxue Song, Zili Wang, Junshuan Cui, Longcai He, Guangtang Chen, Kaya Xu
Stem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mechanism by which BMSCs regulate inflammation remains unclear and requires further study...
April 25, 2024: Brain Research
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