Paula Lemes Dos Santos Sanna, Liebert Bernardes Carvalho, Camila Cristina Dos Santos Afonso, Kassia de Carvalho, Rogério Aires, Jennyffer Souza, Marcel Rodrigues Ferreira, Alexander Birbrair, Maria Martha Bernardi, Alexandra Latini, Rodrigo A Foganholi da Silva
Caffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2 A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum...
March 15, 2024: Brain Research