journal
https://read.qxmd.com/read/38531465/il-6-mediates-olfactory-dysfunction-in-a-mouse-model-of-allergic-rhinitis
#1
JOURNAL ARTICLE
Xiao-Yu Song, Qi Sun, Shi-Zhuang Wei, Han-Rui Wang, Yao Wang, Wen-Bin Zhang, Chao Ren, Xi-Cheng Song, Ya-Kui Mou
BACKGROUND: Immune-inflammatory response is a key element in the occurrence and development of olfactory dysfunction (OD) in patients with allergic rhinitis (AR). As one of the core factors in immune-inflammatory responses, interleukin (IL)-6 is closely related to the pathogenesis of allergic diseases. It may also play an important role in OD induced by diseases, such as Sjögren's syndrome and coronavirus disease 2019. However, there is no study has reported its role in OD in AR...
March 24, 2024: Brain Research
https://read.qxmd.com/read/38527712/exploring-the-neuroprotective-role-of-physical-activity-in-cerebral-small-vessel-disease
#2
REVIEW
Maria E Anderson, Eleanor J Wind, Lisa S Robison
Cerebral Small Vessel Disease (cSVD) is a common neurological finding characterized by abnormalities of the small blood vessels in the brain. Previous research has established a strong connection between cSVD and stroke, as well as neurodegenerative disorders, notably Alzheimer's disease (AD) and other dementias. As the search for effective interventions continues, physical activity (PA) has emerged as a potential preventative and therapeutic avenue. This review synthesizes the human and animal literature on the influence of PA on cSVD, highlighting the importance of determining optimal exercise protocols, considering aspects such as intensity, duration, timing, and exercise type...
March 23, 2024: Brain Research
https://read.qxmd.com/read/38521161/myeloperoxidase-to-high-density-lipoprotein-ratio-potential-predictor-of-severity-and-outcome-in-patients-with-acute-ischemic-stroke
#3
JOURNAL ARTICLE
Penghong Li, Cailang Niu, Xueqing Du, Mina Zhao, Haobo Wang, Debo Yang, Yuan Li, Wei Jing
OBJECTIVE: As a new marker of inflammation and lipid metabolism, the ratio of myeloperoxidase to high density lipoprotein (MPO/HDL) has been reported in the field of cardiovascular disease. However, the effect of MPO/HDL on acute ischemic stroke (AIS) is not clear. The purpose of this study was to explore the prognostic value of MPO/HDL level in patients with AIS. METHODS: This study conducted a retrospective analysis of 363 patients diagnosed with AIS. Stroke severity was assessed by National Institutes of Health Stroke Scale (NIHSS)...
March 21, 2024: Brain Research
https://read.qxmd.com/read/38521160/mitochondria-targeting-peptide-ss-31-attenuates-ferroptosis-via-inhibition-of-the-p38-mapk-signaling-pathway-in-the-hippocampus-of-epileptic-rats
#4
JOURNAL ARTICLE
Xue Liu, Fei-Yu Wang, Song Chi, Tao Liu, Hai-Lin Yang, Ru-Jie Zhong, Xiao-Yu Li, Jing Gao
Ferroptosis is a newly identified form of non-apoptotic regulated cell death (RCD) andplaysanimportantrole in epileptogenesis. The p38 mitogen-activated protein kinase (p38 MAPK) pathway has been confirmed to be involved in ferroptosis. The mitochondria-targeting antioxidant Elamipretide (SS-31) can reduce the generation of lipid peroxidation and the buildup of reactive oxygen species (ROS). Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO)...
March 21, 2024: Brain Research
https://read.qxmd.com/read/38519009/neuropsychiatric-symptoms-profile-and-markers-of-alzheimer-disease-type-pathology-in-patients-with-lewy-body-dementias
#5
JOURNAL ARTICLE
Chaofan Geng, Leilei Tan, Chenchen
BACKGROUND: To determine whether Lewy body dementia (LBD) patients with likely copathology of Alzheimer's disease (AD) exhibit greater neuropsychiatric symptom (NPS) compared to those without likely AD-type copathology. METHODS: We enrolled 69 individuals diagnosed with Lewy body dementia (LBD), comprising both dementia with Lewy bodies (DLB) (n = 36) and Parkinson's disease dementia (PDD) (n = 33). These participants had accessible cerebrospinal fluid (CSF) markers related to Alzheimer's disease (AD) and cognitive data...
March 20, 2024: Brain Research
https://read.qxmd.com/read/38519008/age-related-changes-in-meningeal-lymphatic-function-are-closely-associated-with-vascular-endothelial-growth-factor-c-expression
#6
JOURNAL ARTICLE
Qi Liu, Cheng Wu, Qian Ding, Xiang-Yu Liu, Ni Zhang, Jun-Hui Shen, Zi-Tong Ou, Tuo Lin, Hong-Xiang Zhu, Yue Lan, Guang-Qing Xu
Meningeal lymphatic vessels (MLVs) have crucial roles in removing metabolic waste and toxic proteins from the brain and transporting them to the periphery. Aged mice show impaired meningeal lymphatic function. Nevertheless, as the disease progresses, and significant pathological changes manifest in the brain, treating the condition becomes increasingly challenging. Therefore, investigating the alterations in the structure and function of MLVs in the early stages of aging is critical for preventing age-related central nervous system degenerative diseases...
March 20, 2024: Brain Research
https://read.qxmd.com/read/38513996/diagnosing-schizophrenia-using-deep-learning-novel-interpretation-approaches-and-multi-site-validation
#7
JOURNAL ARTICLE
Tingting Weng, Yuemei Zheng, Yingying Xie, Wen Qin, Li Guo
Schizophrenia is a profound and enduring mental disorder that imposes significant negative impacts on individuals, their families, and society at large. The development of more accurate and objective diagnostic tools for schizophrenia can be expedited through the employment of deep learning (DL), that excels at deciphering complex hierarchical non-linear patterns. However, the limited interpretability of deep learning has eroded confidence in the model and restricted its clinical utility. At the same time, if the data source is only derived from a single center, the model's generalizability is difficult to test...
March 19, 2024: Brain Research
https://read.qxmd.com/read/38513995/towards-understanding-sex-differences-in-autism-spectrum-disorders
#8
REVIEW
Karen Q Leow, Mary A Tonta, Jing Lu, Harold A Coleman, Helena C Parkington
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability and potential comorbidities often lead to diagnostic and therapeutic challenges. This review addresses the biological basis of ASD, focusing on the sex differences in gene expression and hormonal influences. ASD is more commonly diagnosed in males at a ratio of 4:1, indicating a potential oversight in female-specific ASD research and a risk of underdiagnosis in females...
March 19, 2024: Brain Research
https://read.qxmd.com/read/38499234/variants-in-3p24-3-predicts-the-risk-of-early-neurological-deterioration-in-large-artery-atherosclerotic-stroke
#9
JOURNAL ARTICLE
Xiaoya Huang, Qiang Ye, Zhenguo Zhu, Yanyan Chen, Niange Xia, Rongrong Chen, Wujun Geng, Zusen Ye
The rate of early neurological deterioration (END) differs in different subtypes of ischaemic stroke. Previous studies showed PLCL2 gene is a novel susceptibility locus for the occurrence of atherosclerosis and thrombotic events. The objective of this research is to examine the efficacy that PLCL2 may have on the risk of END in large artery atherosclerotic (LAA) stroke. Tagged single nucleotide polymorphisms (SNPs) were identified by a strategy of fine-mapping. The genotyping of the selected SNPs was performed by SNPscan...
March 16, 2024: Brain Research
https://read.qxmd.com/read/38493572/mu-erd-reflects-action-understanding-but-the-effect-is-small
#10
JOURNAL ARTICLE
Lawrence Paul Behmer
Since the mid-2000's, many researchers have provided evidence that mu-ERD measured at the motor cortex may reflect the collective activation of upstream brain regions associated with the human mirror system during action observation paradigms; however, several recent papers have called these findings into question. Our study represents an effort to address these criticisms. In our study, participants watched videos in which the type of grip an actor used to grasp a coffee mug either conveyed the goal with 100 % certainty (unambiguous-goal trials), or offered no predictive information (ambiguous-goal trials)...
March 16, 2024: Brain Research
https://read.qxmd.com/read/38494099/the-relationship-between-oxidative-stress-markers-and-1h-magnetic-resonance-spectroscopy-findings-in-obsessive-compulsive-disorder
#11
JOURNAL ARTICLE
Fatma Subaşı Turgut, Mahmut Bulut, Salih Hattapoğlu, Mehmet Güneş, Mehmet Cemal Kaya, Faysal Ekici, Mehmet Guli Çetinçakmak, İbrahim Kaplan, Murad Atmaca
INTRODUCTION: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls' orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). METHODS: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65...
March 15, 2024: Brain Research
https://read.qxmd.com/read/38494098/adora2a-downregulation-promotes-caffeine-neuroprotective-effect-against-lps-induced-neuroinflammation-in-the-hippocampus
#12
JOURNAL ARTICLE
Paula Lemes Dos Santos Sanna, Liebert Bernardes Carvalho, Camila Cristina Dos Santos Afonso, Kassia de Carvalho, Rogério Aires, Jennyffer Souza, Marcel Rodrigues Ferreira, Alexander Birbrair, Maria Martha Bernardi, Alexandra Latini, Rodrigo A Foganholi da Silva
Caffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2 A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum...
March 15, 2024: Brain Research
https://read.qxmd.com/read/38492841/poly-rc-binding-protein-1-alleviates-neurotoxicity-in-6-ohda-induced-sh-sy5y-cells-and-modulates-glial-cells-in-neuroinflammation
#13
JOURNAL ARTICLE
Ling-Yun Ma, Bingbing Jia, Haoming Geng, Jiantao Liang, Lirong Huo
BACKGROUND: Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the loss of dopaminergic neurons and neuroinflammation. Previous research has identified the involvement of Poly (rC)-binding protein 1 (PCBP1) in certain degenerative diseases; however, its specific mechanisms in PD remain incompletely understood. METHODS: In this study, 6-OHDA-induced neurotoxicity in the cell lines SH-SY5Y, BV-2 and HA, was used to evaluate the protective effects of PCBP1...
March 14, 2024: Brain Research
https://read.qxmd.com/read/38490145/corrigendum-to-potential-biomaterials-and-experimental-animal-models-for-inventing-new-drug-delivery-approaches-in-the-neurodegenerative-disorder-multiple-sclerosis-brain-res-1822-2023-148674
#14
Dnyandev G Gadhave, Vrashabh V Sugandhi, Sruthi Sarvepalli, Chandrakant R Kokare
No abstract text is available yet for this article.
March 14, 2024: Brain Research
https://read.qxmd.com/read/38484924/lpcat3-exacerbates-early-brain-injury-and-ferroptosis-after-subarachnoid-hemorrhage-in-rats
#15
JOURNAL ARTICLE
Jiahui Hao, Tong Wang, Cheng Cao, Xiang Li, Haiying Li, Heng Gao, Jinquan Li, Haitao Shen, Gang Chen
AIMS: Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is known to play a pivotal role in lipid metabolism, but its role in the early brain injury (EBI) following subarachnoid hemorrhage (SAH) remains unclear. This study provides insights into LPCAT3 expression alterations and functional implications in EBI following SAH. METHODS: SAH models of adult male Sprague-Dawley (SD) rats were established by intravascular perforation. Lentivirus vectors were administered by intracerebroventricular injection (i...
March 12, 2024: Brain Research
https://read.qxmd.com/read/38479491/dynamic-monitoring-of-radiation-induced-white-matter-microstructure-injury-in-nasopharyngeal-carcinoma-via-high-angular-resolution-diffusion-imaging
#16
JOURNAL ARTICLE
Tiansheng Li, Yihao Guo, Xin Jin, Tao Liu, Gang Wu, Weiyuan Huang, Feng Chen
PURPOSE: To investigate white matter microstructural abnormalities caused by radiotherapy in nasopharyngeal carcinoma (NPC) patients using MRI high-angular resolution diffusion imaging (HARDI). METHODS: We included 127 patients with pathologically confirmed NPC: 36 in the pre-radiotherapy group, 29 in the acute response period (post-RT-AP), 23 in the early delayed period (post-RT-ED) group, and 39 in the late-delayed period (post-RT-LD) group. HARDI data were acquired for each patient, and dispersion parameters were calculated to compare the differences in specific fibre bundles among the groups...
March 11, 2024: Brain Research
https://read.qxmd.com/read/38471645/microstructural-abnormality-of-white-matter-tracts-in-rheumatoid-arthritis
#17
JOURNAL ARTICLE
Zeyu Liu, Bo Hou, Hui You, Chen Yu, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Qian Wang, Feng Feng
BACKGROUND: Structural and functional brain imaging studies have reported abnormalities of gray matter morphology and functional activities in patients with rheumatoid arthritis (RA). However, it is largely unknown whether patients with RA show alterations of white matter microstructural organization. OBJECTIVES: To automatically identify alteration of white matter microstructure in patients with RA and further examine how this alteration associates with clinical characteristics...
March 10, 2024: Brain Research
https://read.qxmd.com/read/38471644/ligation-of-cervical-lymphatic-vessels-decelerates-blood-clearance-and-worsens-outcomes-after-experimental-subarachnoid-hemorrhage
#18
JOURNAL ARTICLE
Shi-Qiao Luo, Sheng-Qing Gao, Mao-Xing Fei, Xue-Wang, Yan-Sun, Ran-Zhao, Yan-Ling Han, Han-Dong Wang, Meng-Liang Zhou
Subarachnoid hemorrhage (SAH) is characterized by the extravasation of blood into the subarachnoid space, in which erythrocyte lysis is the primary contributor to cell death and brain injuries. New evidence has indicated that meningeal lymphatic vessels (mLVs) are essential in guiding fluid and macromolecular waste from cerebrospinal fluid (CSF) into deep cervical lymph nodes (dCLNs). However, the role of mLVs in clearing erythrocytes after SAH has not been completely elucidated. Hence, we conducted a cross-species study...
March 10, 2024: Brain Research
https://read.qxmd.com/read/38460718/symmetric-unipedal-balance-in-quiet-stance-and-dynamic-tasks-in-older-individuals
#19
JOURNAL ARTICLE
Paola Janeiro Valenciano, Victória Emiliano Castan, Pedro Henrique Martins Monteiro, Luis Augusto Teixeira
Previous evidence of increased difference of muscular strength between the dominant and non-dominant legs in older adults suggests the possibility of dissimilar balance control between the legs (between-leg asymmetry) associated with aging. In the current investigation, we evaluated between-leg asymmetries in older adults when performing quiet and dynamic balance tasks. Fifty-two physically active and healthy older adults within the age range of 60 to 80 years were recruited. Participants performed balance tasks in unipedal stance, including quiet standing and cyclic sway (rhythmic oscillation) of the non-supporting leg in the anteroposterior or mediolateral directions, producing foot displacements with amplitudes of 20 cm paced in 1 Hz through a metronome...
March 7, 2024: Brain Research
https://read.qxmd.com/read/38458308/children-s-early-signs-and-developmental-trajectories-of-psychotic-like-experiences
#20
JOURNAL ARTICLE
Luxia Jia, Ziqian Wei, Juan Wang, Xuan Zhang, Huagen Wang, Runsen Chen, Xiaoqian Zhang
INTRODUCTION: Children who experience persistent psychotic-like experiences (PLEs) are at a higher risk of developing psychotic disorder later in life. The developmental trajectories of PLEs are influenced by various factors. Therefore, it is important to identify early characteristics that can distinguish and predict between different developmental trajectories of PLEs. METHODS: Using PLEs scores from the Adolescent Brain Cognitive Development (ABCD) data across three waves, we categorized participants into five distinct PLEs trajectories groups: persistent group (n = 47), remitting group (n = 185), increasing group (n = 117), remittent group (n = 21), and no PLEs group (n = 4,476)...
March 6, 2024: Brain Research
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