journal
https://read.qxmd.com/read/38609032/palmatine-improves-cognitive-dysfunction-in-alzheimer-s-disease-model-rats-through-autophagy-pathway-and-regulation-of-gut-microbiota
#1
JOURNAL ARTICLE
Lu Han, Weijia Chen, Jianming Li, Yan Zhao, Ying Zong, Zhongmei He, Rui Du
Alzheimer's disease (AD) is a primary degenerative encephalopathy that first appeared as a decline in memory and learning skills. Over time, the condition's severity grew. Palmatine (Pal) alleviates Alzheimer's disease symptoms, which has neuroprotective benefits. Numerous investigations have demonstrated a close relationship among AD and gut structure changes. The aim of the research was investigating whether the improvement of Pal on AD is linked to regulating gut flora and autophagy. First, we used Aβ1-40 to induce apoptosis in HT22 cells...
April 10, 2024: Brain Research
https://read.qxmd.com/read/38609031/association-of-impulsive-behavior-and-cerebrospinal-fluid-plasma-oxidation-and-antioxidation-ratio-in-chinese-men
#2
JOURNAL ARTICLE
Xiaoning Jiang, Xiaoli Han, Tiantian Kong, Yan Wu, Ligang Shan, Zhuqing Yang, Yanlong Liu, Fan Wang
OBJECTIVES: Impulsive behavior is the precursor of many psychiatric and neurological conditions. High levels of impulsive behavior will increase health risk behavior and related injuries. Impulsive behavior is produced and regulated by central and peripheral biological factors, and oxidative stress (OS) can aggravate it. However, previous studies only showed that impulsive behavior was related to the level of the peripheral OS. Therefore, this study aims to clarify the relationship between OS and impulsive behavior in the brain and peripheral blood...
April 10, 2024: Brain Research
https://read.qxmd.com/read/38609030/effects-of-sleep-deprivation-on-anxiety-depressive-like-behavior-and-neuroinflammation
#3
JOURNAL ARTICLE
Dandan Cao, Yi Zhao, Yuting Wang, Dongyun Wei, Minhao Yan, Shijie Su, Huashan Pan, Qi Wang
BACKGROUND: Depression is defined by a persistent low mood and disruptions in sleep patterns, with the WHO forecasting that major depression will rank as the third most prevalent contributor to the global burden of disease by the year 2030. Sleep deprivation serves as a stressor that triggers inflammation within the central nervous system, a process known as neuroinflammation. This inflammatory response plays a crucial role in the development of depression by upregulating the expression of inflammatory mediators that contribute to symptoms such as anxiety, hopelessness, and loss of pleasure...
April 10, 2024: Brain Research
https://read.qxmd.com/read/38609029/disruption-of-sphingomyelin-synthase-2-gene-alleviates-cognitive-impairment-in-a-mouse-model-of-alzheimer-s-disease
#4
JOURNAL ARTICLE
Osamu Uchiumi, Jingyu Zou, Sachiko Yamaki, Yoshie Hori, Munenori Ono, Ryo Yamamoto, Nobuo Kato
The membrane raft accommodates the key enzymes synthesizing amyloid β (Aβ). One of the two characteristic components of the membrane raft, cholesterol, is well known to promote the key enzymes that produce amyloid-β (Aβ) and exacerbate Alzheimer's disease (AD) pathogenesis. Given that the raft is a physicochemical platform for the sound functioning of embedded bioactive proteins, the other major lipid component sphingomyelin may also be involved in AD. Here we knocked out the sphingomyelin synthase 2 gene (SMS2) in 3xTg AD model mice by hybridization, yielding SMS2KO mice (4S mice)...
April 10, 2024: Brain Research
https://read.qxmd.com/read/38604558/implicit-and-explicit-motor-imagery-ability-after-sci-moving-the-elbow-makes-the-difference
#5
JOURNAL ARTICLE
Sébastien Mateo, Aymeric Guillot, Sonia Henkous, Anthony Gelis, Sébastien Daligault, Gilles Rode, Christian Collet, Franck Di Rienzo
Cervical spinal cord injury (SCI) causes dramatic sensorimotor deficits that restrict both activity and participation. Restoring activity and participation requires extensive upper limb rehabilitation focusing elbow and wrist movements, which can include motor imagery. Yet, it remains unclear whether MI ability is impaired or spared after SCI. We investigated implicit and explicit MI ability in individuals with C6 or C7 SCI (SCIC6 and SCIC7 groups), as well as in aged- and gender-matched controls without SCI...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38604557/oral-application-of-magnesium-l-threonate-alleviates-radicular-pain-by-inhibiting-neuro-inflammation-dependent-central-sensitization-of-rats
#6
JOURNAL ARTICLE
Siyuan Li, Hongjian Yi, Fuli Yuan, Xuejuan Zhang, Yi Zhong, Yangliang Huang
BACKGROUND: We have reported neuro-inflammation is involved in radicular pain by enhancing the efficiency of pain synaptic transmission in spinal level. Recently, peers' studies have confirmed that magnesium deficiency leads to neuro-inflammation, thus contributes to memory and emotional deficits and pain hypersensitivity in antineoplastic agents treated rats. In this study, we explore the effect of oral application of magnesium-L-threonate (L-TAMS) in radicular pain induced by lumbar disc herniation (LDH) of rats and the possible mechanisms...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38604556/inhibition-of-endoplasmic-reticulum-stress-attenuates-morphine-protracted-abstinence-induced-anxiety-like-behaviors-in-the-male-mice
#7
JOURNAL ARTICLE
Lu Liu, Jie Wu, Changlin Zhang, Tong Cao, Yongli Lu, Zhi He, Zicheng Li
The anxiety caused by morphine protracted abstinence is considered to be an important factor contributes to drug-seeking and relapse. Endoplasmic reticulum (ER) stress plays important roles in many kinds of mental disorders including drug addiction and anxiety, but it is unclear whether ER stress is involved in anxiety-like behaviors induced by morphine withdrawal. In this study, by using behavioral test, western blot, immunofluorescence, electron transmission microscope, we found that: (1) Inhibition of endoplasmic reticulum stress by 4-Phenylbutyric acid (4-PBA) could attenuate anxiety-like behaviors induced by morphine withdrawal...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38604555/function-and-mechanism-exploring-of-icariin-in-schizophrenia-through-network-pharmacology
#8
JOURNAL ARTICLE
Bing Liu, Chengqiang Wang, Ruyuan Liu, Weilai Xiang, Chang Yang, Di Li
This study aims to explore the therapeutic effect and possible mechanisms of icariin in schizophrenia. SD rats were divided into five groups, a control group, a MK801-induced schizophrenia model group, and three icariin treatment groups, with twelve rats in each group. Morris water maze and open field were used to observe the spatial learning and memory ability of rats. Compared with the control group, rats in the MK801-induced model group showed an increase in stereotypic behavior score, distance of spontaneous activities, escape latency, malondialdehyde (MDA) content, and IL-6, IL-1β, TNF-α expression, but a decrease in platform crossing times and superoxide dismutase (SOD) activity (P < 0...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38604554/effects-of-environmental-enrichment-on-glut-expression-in-the-visual-cortex-of-amblyopic-rats
#9
JOURNAL ARTICLE
Juan Xie, Yue Luo, Lingjun Wei, Haobo Fan, Ying Wang, Qian Wang, Yunchun Zou, Yuehan Luo, Yangyu Tang
OBJECTIVE: To investigate the potential changes of glucose metabolism and glucose transporter protein (GLUT) in the visual cortex of formally deprived amblyopic rats, as well as the effects of enriched environments on the levels of nerve conduction and glucose metabolism in the visual cortex of amblyopic rats. METHODS: 36 rats were randomly divided into three groups: CON + SE (n = 12), MD + SE (n = 12) and MD + EE (n = 12)...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38599511/targeting-vdac-a-potential-therapeutic-approach-for-mitochondrial-dysfunction-in-alzheimer-s-disease
#10
REVIEW
Yaqian Yang, Xiaotao Jia, Xinmao Yang, Jie Wang, Yan Fang, Xiaoping Ying, Meiqian Zhang, Jing Wei, Yanfang Pan
Mitochondrial dysfunction has been implicated in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder characterized by progressive cognitive decline. Voltage-dependent anion channel (VDAC), a protein located in the outer mitochondrial membrane, plays a critical role in regulating mitochondrial function and cellular energy metabolism. Recent studies have identified VDAC as a potential therapeutic target for Alzheimer's disease. This article aims to provide an overview of the role of VDAC in mitochondrial dysfunction, its association with Alzheimer's disease, and the potential of targeting VDAC for developing novel therapeutic interventions...
April 8, 2024: Brain Research
https://read.qxmd.com/read/38599510/manipulation-of-%C3%AE-4%C3%AE-%C3%AE-gaba-a-receptors-alters-synaptic-pruning-in-layer-3-prelimbic-prefrontal-cortex-and-impairs-temporal-order-recognition-implications-for-schizophrenia-and-autism
#11
JOURNAL ARTICLE
Sheryl S Smith, Safae Benanni, Quiana Jones, Lindsay Kenney, Matthew Evrard
Temporal order memory is impaired in autism spectrum disorder (ASD) and schizophrenia (SCZ). These disorders, more prevalent in males, result in abnormal dendritic spine pruning during adolescence in layer 3 (L3) medial prefrontal cortex (mPFC), yielding either too many (ASD) or too few (SCZ) spines. Here we tested whether altering spine density in neural circuits including the mPFC could be associated with impaired temporal order memory in male mice. We have shown that α4βδ GABAA receptors (GABARs) emerge at puberty on spines of L5 prelimbic mPFC (PL) where they trigger pruning...
April 8, 2024: Brain Research
https://read.qxmd.com/read/38588847/lesions-of-the-lateral-habenula-excite-dopamine-neurons-in-the-ventral-tegmental-area-and-serotonin-neurons-in-the-dorsal-raphe-nuclei-in-hemiparkinsonian-rats
#12
JOURNAL ARTICLE
Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo Li
The lateral habenula (LHb) projects to the ventral tegmental area (VTA) and dorsal raphe nuclei (DRN) that deliver dopamine (DA) and serotonin (5-HT) to cortical and limbic regions such as the medial prefrontal cortex (mPFC), hippocampus and basolateral amygdala (BLA). Dysfunctions of VTA-related mesocorticolimbic dopaminergic and DRN-related serotonergic systems contribute to non-motor symptoms in Parkinson's disease (PD). However, how the LHb affects the VTA and DRN in PD remains unclear. Here, we used electrophysiological and neurochemical approaches to explore the effects of LHb lesions on the firing activity of VTA and DRN neurons, as well as the levels of DA and 5-HT in related brain regions in unilateral 6-ydroxydopamie (6-OHDA)-induced PD rats...
April 6, 2024: Brain Research
https://read.qxmd.com/read/38588846/m1-type-microglia-derived-exosomes-contribute-to-blood-brain-barrier-damage
#13
JOURNAL ARTICLE
Wen Jiang, Yan Wu, Ailan Pang, Peiyao Li, Song Mei
BACKGROUND: As a key substance for intercellular communication, exosomes could be a potential strategy for stroke treatment. Activated microglia disrupt the integrity of blood-brain barrier (BBB) to facilitate the stroke process. Hence, this study was designed to investigate the effect of microglia-derived exosomes on BBB cell model injury and to explore the underlying molecular mechanisms. METHODS: M1 polarization of BV2 cells was induced with LPS and their derived exosomes were isolated...
April 6, 2024: Brain Research
https://read.qxmd.com/read/38582416/temporal-expression-of-brainstem-neurotrophic-proteins-following-mild-traumatic-brain-injury
#14
JOURNAL ARTICLE
Jacob I McPherson, Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, John J Leddy, Kirkwood E Personius
BDNF, a neurotrophic factor, and its receptors have been implicated in the pathophysiology of mild traumatic brain injury (mTBI). The brainstem houses many vital functions, that are also associated with signs and symptoms of mTBI, but has been understudied in mTBI animal models. We determined the extent to which neurotrophic protein and associated receptor expression is affected within the brainstem of adult rats following mTBI. Their behavioral function was assessed and temporal expression of the 'negative' regulators of neuronal function (p75, t-TrkB, and pro-BDNF) and 'positive' neuroprotective (FL-TrkB and m-BDNF) protein isoforms were determined via western blot and immunohistochemistry at 1, 3, 7, and 14 post-injury days (PID) following mTBI or sham (control) procedure...
April 4, 2024: Brain Research
https://read.qxmd.com/read/38582415/edaravone-dexborneol-attenuates-cognitive-impairment-in-a-rat-model-of-vascular-dementia-by-inhibiting-hippocampal-oxidative-stress-and-inflammatory-responses-and-modulating-the-nmda-receptor-signaling-pathway
#15
JOURNAL ARTICLE
Hui Guo, Haodong Li, Zhisheng Jia, Shuyu Ma, Jin Zhang
Exploring the intricate pathogenesis of Vascular Dementia (VD), there is a noted absence of potent treatments available in the current medical landscape. A new brain-protective medication developed in China, Edaravone dexboeol (EDB), has shown promise due to its antioxidant and anti-inflammatory properties, albeit with a need for additional research to elucidate its role and mechanisms in VD contexts. In a research setup, a VD model was established utilizing Sprague-Dawley (SD) rats, subjected to permanent bilateral typical carotid artery occlusion (2VO)...
April 4, 2024: Brain Research
https://read.qxmd.com/read/38582414/spinal-bestrophin-1-and-anoctamin-1-channels-have-a-pronociceptive-role-in-the-tactile-allodynia-induced-by-rem-sleep-deprivation-in-rats
#16
JOURNAL ARTICLE
Carlos J Martínez-Magaña, Paulina A Muñoz-Castillo, Janet Murbartián
Bestrophin-1 and anoctamin-1 are members of the calcium-activated chloride channels (CaCCs) family and are involved in inflammatory and neuropathic pain. However, their role in pain hypersensitivity induced by REM sleep deprivation (REMSD) has not been studied. This study aimed to determine if anoctamin-1 and bestrophin-1 are involved in the pain hypersensitivity induced by REMSD. We used the multiple-platform method to induce REMSD. REM sleep deprivation for 48 h induced tactile allodynia and a transient increase in corticosterone concentration at the beginning of the protocol (12 h) in female and male rats...
April 4, 2024: Brain Research
https://read.qxmd.com/read/38582413/alkaloids-as-drug-leads-in-alzheimer-s-treatment-mechanistic-and-therapeutic-insights
#17
REVIEW
Md Rezaul Islam, Shopnil Akash, Mohammed Murshedul Islam, Nadia Sarkar, Ajoy Kumer, Sandip Chakraborty, Kuldeep Dhama, Majed Ahmed Al-Shaeri, Yasir Anwar, Polrat Wilairatana, Abdur Rauf, Ibrahim F Halawani, Fuad M Alzahrani, Haroon Khan
Alzheimer's disease (AD) has few effective treatment options and continues to be a major global health concern. AD is a neurodegenerative disease that typically affects elderly people. Alkaloids have potential sources for novel drug discovery due to their diverse chemical structures and pharmacological activities. Alkaloids, natural products with heterocyclic nitrogen-containing structures, are considered potential treatments for AD. This review explores the neuroprotective properties of alkaloids in AD, focusing on their ability to regulate pathways such as amyloid-beta aggregation, oxidative stress, synaptic dysfunction, tau hyperphosphorylation, and neuroinflammation...
April 4, 2024: Brain Research
https://read.qxmd.com/read/38580047/role-of-electrophysiological-activity-and-interactions-of-lateral-habenula-in-the-development-of-depression-like-behavior-in-a-chronic-restraint-stress-model
#18
JOURNAL ARTICLE
Chang Wang, Yuting Sun, Yanjie Xing, Kezhou Liu, Kedi Xu
Closed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and brain network characteristics during the formation of a chronic restraint stress (CRS) model...
April 3, 2024: Brain Research
https://read.qxmd.com/read/38580046/neurobehavioral-and-molecular-changes-in-a-rodent-model-of-acth-induced-hpa-axis-dysfunction
#19
JOURNAL ARTICLE
Farhanah N Sallie, Leandrie Pienaar, Andrea Lubbe, Sanelisiwe Xhakaza, Srinivasa R Manne, Beatriz G de la Torre, Fernando Albericio, William Mu Daniels, Aletta Me Millen, Sooraj Baijnath
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is linked to the pathophysiology of depression. Although exogenous adrenocorticotropic hormone (ACTH) is associated with a depressive-like phenotype in rodents, comprehensive neurobehavioral and mechanistic evidence to support these findings are lacking. Sprague-Dawley rats (male, n = 30; female, n = 10) were randomly assigned to the control (male, n = 10) or ACTH (male, n = 20; female n = 10) groups that received saline (0...
April 3, 2024: Brain Research
https://read.qxmd.com/read/38575106/transcriptomic-insights-into-multiple-system-atrophy-from-a-plp-%C3%AE-synuclein-transgenic-mouse-model
#20
JOURNAL ARTICLE
L Nicholson, I S Piras, M D DeBoth, A Siniard, A Heras-Garvin, N Stefanova, M J Huentelman
Multiple system atrophy (MSA) is a rare, neurodegenerative disorder with rapid motor and non-motor symptom progression. MSA is characterized by protein aggregations of α-synuclein found in the cytoplasm of oligodendrocytes. Despite this pathological hallmark, there is still little known about the cause of this disease, resulting in poor treatment options and quality of life post-diagnosis. In this study, we investigated differentially expressed genes (DEGs) via RNA-sequencing of brain samples from a validated PLP-α-synuclein transgenic mouse model, identifying a total of 40 DEGs in the PLP group compared to wild-type (WT), with top detected genes being Gm15446, Mcm6, Aldh7a1 and Gm3435...
April 2, 2024: Brain Research
journal
journal
21333
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.