Hirohito Iimori, Sachiko Nishina, Osamu Hieda, Toshiaki Goseki, Noriko Nishikawa, Sadao Suzuki, Akiko Hikoya, Miwa Komori, Hiroko Suzuki, Tomoyo Yoshida, Shion Hayashi, Takafumi Mori, Akiko Kimura, Takeshi Morimoto, Yukiko Shimizu, Takashi Negishi, Tamami Shimizu, Yoshimi Yokoyama, Yoshiko Sugiyama, Noriyuki Azuma, Miho Sato
PURPOSE: To describe clinical presentations of acquired comitant esotropia and digital device use in children, adolescents, and young adults without neurological problems. STUDY DESIGN: Multicenter prospective observational study. METHODS: Patients with acquired comitant esotropia, without intracranial diseases aged 5-35 years at the time of visit, who were seen at pre-registered facilities within 1 year of onset were enrolled. The duration from the onset of symptoms and the time of digital device usage approximately 1 month before onset and their lifestyles were surveyed...
September 11, 2023: Japanese Journal of Ophthalmology
Osamu Hieda, Takahiro Hiraoka, Takashi Fujikado, Satoshi Ishiko, Satoshi Hasebe, Hidemasa Torii, Hiroshi Takahashi, Shiro Tanaka, Shigeru Kinoshita
PURPOSE: Having previously demonstrated the efficacy of 0.01% atropine eye drops for inhibiting progression of childhood myopia, we conducted additional analyses to assess post-treatment changes in myopia progression. STUDY DESIGN: Analysis of follow-up data from a previously reported randomized controlled trial METHODS: A mixed-effects model was used to compare intergroup changes in spherical equivalent (SE) and axial length (AL) at 1 month and 12 months after discontinuation of 2-year treatment with atropine or placebo in 167 school-age children...
September 2023: Japanese Journal of Ophthalmology
Mitsuru Sawa, Masaharu Mizuochi, Kazunori Matsumura, Makoto Aihara, Satoru Yamagami, Hidetoshi Yamashita, Toshikatsu Kaburaki
No abstract text is available yet for this article.
August 21, 2023: Japanese Journal of Ophthalmology
Rei Sakata, Shiro Mizoue, Keiji Yoshikawa, Misato Adachi, Shinji Ohkubo, Naoki Hamada, Tomoko Naito, Tomoyuki Muramatsu, Takeshi Hara, Ryo Asato, Makoto Aihara
PURPOSE: A brimonidine tartrate 0.1%/brinzolamide 1% fixed-dose combination (BBFC) was recently approved for glaucoma and ocular hypertension treatment in Japan. We investigated the efficacy and safety of BBFC used concomitantly with prostaglandin analogs (PG) or a PG/beta-blocker fixed-dose combination (PG/beta FC). STUDY DESIGN: This was a prospective, open-label, multicenter study. PATIENTS AND METHODS: We enrolled Japanese patients with open-angle glaucoma...
August 19, 2023: Japanese Journal of Ophthalmology
Kenji Kashiwagi, Kentaro Ouchi, Yoshiyuki Shibasaki, Masaki Suginaka
PURPOSE: To investigate the treatment persistence of carteolol hydrochloride/latanoprost fixed-combination ophthalmic solution (CAR/LAT) and other β-blocker/prostanoid FP receptor agonist fixed-combination ophthalmic solutions (BB/FP) in the treatment of glaucoma. STUDY DESIGN: Retrospective observational cohort study. METHODS: A retrospective observational cohort study using JMDC Claims Database. Patients aged 20 years or older diagnosed with glaucoma between February 1, 2017, and March 31, 2020, and prescribed CAR/LAT or another BB/FP were included...
August 19, 2023: Japanese Journal of Ophthalmology
Hatice Tekcan, Mehmet Serhat Mangan, Gökhan Celik, Serhat Imamoglu
PURPOSE: To compare the differences in anterior segment parameters between eyes with primary angle closure (PAC) with and without gonioscopically-visualized ciliary body processes (CBP). STUDY DESIGN: Prospective, observational, comparative clinical study. METHODS: Detailed ocular examinations and gonioscopy were performed in 89 eyes of 89 patients with PAC to determine the visibility of the CBP. Anterior chamber depth (ACD), anterior chamber width, lens thickness (LT), lens vault (LV) and pupil diameter were determined using ultrasound biomicroscopy...
August 19, 2023: Japanese Journal of Ophthalmology
Shin Hatou, Shigeto Shimmura
The cornea is a pioneering area of regenerative medicine, and Japanese researchers have led the world in this field. In Japan, 3 different epithelial sheet regenerative medicine products have been approved for corneal epithelial stem cell deficiency, and the first-in-human studies of cultured corneal endothelial cell suspension transplants, induced pluripotent stem cell (iPS cell)-derived corneal epithelial sheet transplants, and iPS cell-derived corneal endothelial substitute cell transplants were all conducted and reported globally for the first time by Japanese researchers...
August 14, 2023: Japanese Journal of Ophthalmology
Shuhei Kimura, Mio Morizane Hosokawa, Yusuke Shiode, Ryo Matoba, Yuki Kanzaki, Yasuhito Goto, Keisuke Kanenaga, Etsuji Suzuki, Yuki Morizane
PURPOSE: To identify a method for accurately measuring preoperative axial length (AL) in cases of rhegmatogenous retinal detachment (RRD). STUDY DESIGN: Retrospective study. METHODS: This retrospective study included 83 eyes of 83 patients who underwent vitrectomy for RRD and had both preoperative and postoperative data for AL. Preoperative AL measurements for the affected eye were obtained using ultrasound (aUS-AL) and compared with those for affected and fellow eyes measured using optical biometry (aOB-AL and fOB-AL, respectively)...
August 10, 2023: Japanese Journal of Ophthalmology
Soichiro Yamamoto, Yohei Kuroki, Toshihiro Ide, Shin Tanaka, Rintaro Hirahara, Ayako Takamori, Tomohisa Nishimura, Kiyoshi Suzuma, Kazuaki Kadonosono, Hiroshi Enaida
PURPOSE: To customize a passive surgery support robot for ophthalmic surgery and preliminarily evaluate its performance. STUDY DESIGN: Prospective observational study. METHODS: The range of motion of the arm was analyzed during ophthalmic surgery and, based on this analysis, a commercially available passive robot was customized for surgical support for ophthalmic surgery; following which a prototype robot was constructed. To examine the effects on the brachial muscle during surgical operations with and without the prototype robot, surface electromyograms of the biceps and triceps were analyzed after performing continuous curvilinear capsulorrhexis (CCC) and suturing the sclerocorneal wound in a cataract surgery simulation...
August 10, 2023: Japanese Journal of Ophthalmology
Shin-Ichi Manabe, Akira Hirata, Tadamichi Akagi, Ken Hayashi
PURPOSE: This study aimed to introduce a new technique for lowering intraocular pressure (IOP) using a multi-stent system after the implantation of a Baerveldt glaucoma implant (BGI) and evaluate its clinical effectiveness. STUDY DESIGN: Prospective case series. METHODS: Six patients with uncontrolled refractory glaucoma were enrolled between December 2021 and May 2022. Six 6-0 nylon sutures were preoperatively inserted into the tube of a BGI...
August 4, 2023: Japanese Journal of Ophthalmology
Ryo Asaoka, Hiroshi Murata
Timely treatment is essential in the management of glaucoma. However, subjective assessment of visual field (VF) progression is not recommended, because it can be unreliable. There are two types of artificial intelligence (AI) strong and weak (machine learning). Weak AIs can perform specific tasks. Linear regression is a method of weak AI. Using linear regression in the real-world clinic has enabled analyzing and predicting VF progression. However, caution is still required when interpreting the results, because whenever the number of VF data sets investigated is small, the predictions can be inaccurate...
August 4, 2023: Japanese Journal of Ophthalmology
Islam Y Swaify, Haytham E Nasr, Rania A El Essawy, Kareem B Elessawy
PURPOSE: To assess the efficacy and safety of periocular injections of methotrexate versus triamcinolone in the management of active thyroid-associated orbitopathy. STUDY DESIGN: Prospective, double-masked, randomized clinical trial. METHODS: Participants with bilateral active, moderate-to-severe thyroid-associated orbitopathy were randomly assigned to receive three periocular injections of 7.5 mg methotrexate in one orbit and three periocular injections of 20 mg triamcinolone in the contralateral orbit...
August 4, 2023: Japanese Journal of Ophthalmology
Mayumi Nagata, Hiroyuki Matsushima, Koichiro Mukai, Tadashi Senoo, Okihiro Nishi
PURPOSE: To verify the anterior capsule opacification (ACO) and contraction (ACC) of the ZCB00V intraocular lens (IOL), made of the same material as the AR40e with a high ACC rate. STUDY DESIGN: Retrospective cohort study. METHODS: We evaluated 35 patients at 1 week, 1, 3 and 6 months post phacoemulsification with either a ZCB00V (n = 35) or FY-60AD (n = 34) IOL implantation. The ACC rate was calculated using retroillumination images of the anterior segment, and the ACO was measured using anterior segment photographs and image analysis software...
August 3, 2023: Japanese Journal of Ophthalmology
Yurie Shimizu, Koichiro Shinji, Kaori Mitoma, Yoshiaki Kiuchi, Taiichiro Chikama
PURPOSE: To evaluate the efficacy of azithromycin hydrate ophthalmic solution for the treatment of internal hordeolum and meibomitis with or without phlyctenular keratitis. STUDY DESIGN: Retrospective study. METHODS: Patients diagnosed with internal hordeolum or meibomitis were prescribed azithromycin hydrate ophthalmic solution twice daily for 2 days and then once daily for 12 days. Depending on the presence of meibomitis-related keratoconjunctivitis (MRKC), we further divided the patients with meibomitis into three subgroups: meibomitis alone (non-MRKC group), meibomitis with non-phlyctenular MRKC (non-phlyctenular group), and meibomitis with phlyctenular MRKC (phlyctenular group)...
July 16, 2023: Japanese Journal of Ophthalmology
Kaori Mitoma, Tai-Ichiro Chikama, Ryotaro Toda, Yuki Yuasa, Yoshiaki Kiuchi
PURPOSE: To determine the usefulness of smears in the diagnosis of infectious keratitis by comparing smears and 2 different culture methods. STUDY DESIGN: Retrospective, observational study. METHODS: The foci of 73 patients diagnosed with infectious keratitis at Hiroshima University Hospital between July 2011 and September 2015 were abraded, and smear microscopy and culturing were performed. The microorganism detection rates and other parameters were compared...
July 13, 2023: Japanese Journal of Ophthalmology
Hirotaka Ochi, Takuji Kurimoto, Akiko Yamagami, Katsutoshi Goto, Atsushi Miki, Manami Kawai, Hitoshi Ishikawa, Mitsuhiro Matsuzaki, Miho Kondo, Yoshihito Mochizuki, Akiko Kimura, Tomoyuki Maekubo, Hideki Chuman, Satoshi Ueki, Makoto Nakamura
PURPOSE: To study the spatial association of magnetic resonance imaging (MRI) contrast enhancement (CE) areas with visual field defect (VFD) asymmetry in initial cases of optic neuritis (ON) with altitudinal hemianopsia (AH) with reference to nonarteritic anterior ischemic optic neuropathy (NAION) with AH. STUDY DESIGN: Multicenter, cross-sectional study. METHODS: The present study comprised 19 ON patients and 20 NAION patients with AH who underwent orbital contrast fat-suppressed MRI...
July 5, 2023: Japanese Journal of Ophthalmology
Hideaki Toyokuni, Mari Sakamoto, Kaori Ueda, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
PURPOSE: To evaluate the reproducibility of the imo binocular random single-eye test (BRSET) and Humphrey Field Analyzer (HFA) monocular test in patients with glaucoma. STUDY DESIGN: Retrospective observational study. METHODS: We measured the visual fields (VF) of patients with glaucoma using the BRSET and HFA. All tests were repeated two months later. Mean sensitivity (MS), mean deviation (MD), sensitivity at each test location, and reliability indices were compared between the test days...
July 1, 2023: Japanese Journal of Ophthalmology
Shiro Amano, Jun Shimazaki, Norihiko Yokoi, Yuichi Hori, Reiko Arita
No abstract text is available yet for this article.
July 2023: Japanese Journal of Ophthalmology
Toshikatsu Kaburaki, Kazuki Taoka
Intraocular lymphoma (IOL) is a rare malignant intraocular lymphocytic tumor that mimics uveitis. IOL is anatomically classified into vitreoretinal lymphoma (VRL) and uveal lymphoma; most IOLs are VRLs, while uveal lymphoma is rare. VRL is highly malignant, with 60%-85% of patients developing central nervous system (CNS) lymphoma; primary VRL (PVRL) is an ocular disease with poor prognosis. We aimed to review the management and both current and future treatments for VRL. VRL diagnosis is based on the results of cytopathological examination using vitreous biopsy...
July 2023: Japanese Journal of Ophthalmology
Asahi Fujita, Yohei Hashimoto, Akira Okada, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara
PURPOSE: Understanding the practice patterns and costs of glaucoma care in real-world clinical settings is important for optimizing medical expenses. However, glaucoma treatment trends and associated costs in Japan are unknown. We aimed to unveil glaucoma treatment trends and costs using a large administrative claims database in Japan. STUDY DESIGN: Retrospective cohort study. METHODS: We included patients diagnosed with glaucoma between April 2014 and March 2021 using the DeSC database...
June 24, 2023: Japanese Journal of Ophthalmology
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