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International Journal of Cancer. Journal International du Cancer

https://read.qxmd.com/read/38613405/comprehensive-characterization-of-somatic-mutations-associated-with-chimeric-rnas-in-human-cancers
#1
JOURNAL ARTICLE
Yuting Wang, Meng Shu, Tianqiang Wang, Tongxin He, Jiapei Yuan, Yang Yang
Chimeric RNAs, which can arise from gene recombination at the DNA level or non-canonical splicing events at the RNA level, have been identified as important roles in human tumors. Dysregulated gene expression caused by somatic mutations and altered splicing patterns of oncogenes or tumor suppressor genes can contribute to the development of tumors. Therefore, investigating the formation mechanism of chimeric RNAs via somatic mutations is critical for understanding tumor pathogenesis. This project is the first to propose studying the association between somatic single nucleotide variants and chimeric RNAs, identifying around 2900 somatic SNVs affecting chimeric RNAs in pan-cancer level...
April 13, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38608177/chemotherapy-versus-chemotherapy-plus-immune-checkpoint-inhibitors-for-the-first-line-treatment-of-unresectable-thymic-carcinoma-a-multicenter-retrospective-study
#2
JOURNAL ARTICLE
Baishen Zhang, Yao Liu, Zhiting Chen, Jing Chen, Hui Yu, Meichen Li, Shudong Ma, Chao Cheng, Likun Chen
Thymic carcinoma (TC) is a rare malignant tumor with a poor prognosis, and there is currently limited data on the use of immunotherapy in patients with unresectable TC. In this study, data of patients with unresectable TC diagnosed from January 2017 were retrospectively collected from multiple centers. Treatment response, progression-free survival (PFS), overall survival (OS), survival-independent prognostic factor, and adverse events (AEs) were further analyzed. As a result, a total of 93 patients with unresectable TC were enrolled, of which 54 received first-line chemotherapy, and 39 received chemotherapy plus immune checkpoint inhibitors (ICIs)...
April 12, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38608173/prevalence-of-survivors-of-childhood-cancer-based-on-a-population-based-cancer-registry-in-osaka-japan
#3
JOURNAL ARTICLE
Haruka Kudo, Kayo Nakata, Toshitaka Morishima, Mizuki Shimadzu Kato, Yoshihiro Kuwabara, Akihisa Sawada, Hiroyuki Fujisaki, Yoshiko Hashii, Isao Miyashiro
Although the survival rate of patients with childhood cancer has greatly improved, long-term survivors face specific problems such as the late effects of cancer treatment. In this study, we estimated the number of people who had experienced childhood cancer to predict their needs for medical care and social resources. Using data from the population-based Osaka Cancer Registry, we identified children aged 0-14 years who were diagnosed with cancer between 1975 and 2019. We estimated the prevalence on December 31, 2019, and the 5- and 10-year prevalence (i...
April 12, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38602070/circulating-micrornas-in-association-with-pancreatic-cancer-risk-within-5%C3%A2-years
#4
JOURNAL ARTICLE
Cong Wang, Hui Cai, Qiuyin Cai, Jie Wu, Rachael Stolzenberg-Solomon, Xingyi Guo, Claire Zhu, Yu-Tang Gao, Jordan Berlin, Fei Ye, Wei Zheng, Veronica Wendy Setiawan, Xiao-Ou Shu
Early detection is critical for improving pancreatic cancer prognosis. Our study aims to identify circulating microRNAs (miRNAs) associated with pancreatic cancer risk. The two-stage study used plasma samples collected ≤5 years prior to cancer diagnosis, from case-control studies nested in five prospective cohort studies. The discovery stage included 185 case-control pairs from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Replication stage samples comprised 277 pairs from Shanghai Women's Health Study/Shanghai Men's Health Study, Southern Community Cohort Study, and Multiethnic Cohort Study...
April 11, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38602058/exploring-the-tumor-genomic-landscape-of-aggressive-prostate-cancer-by-whole-genome-sequencing-of-tissue-or-liquid-biopsies
#5
JOURNAL ARTICLE
Simone Weiss, Philippe Lamy, Maria Rusan, Maibritt Nørgaard, Benedicte Parm Ulhøi, Michael Knudsen, Christine Gaasdal Kassentoft, Leila Farajzadeh, Jørgen Bjerggaard Jensen, Jakob Skou Pedersen, Michael Borre, Karina Dalsgaard Sørensen
Treatment resistance remains a major issue in aggressive prostate cancer (PC), and novel genomic biomarkers may guide better treatment selection. Circulating tumor DNA (ctDNA) can provide minimally invasive information about tumor genomes, but the genomic landscape of aggressive PC based on whole-genome sequencing (WGS) of ctDNA remains incompletely characterized. Thus, we here performed WGS of tumor tissue (n = 31) or plasma ctDNA (n = 10) from a total of 41 aggressive PC patients, including 11 hormone-naïve, 15 hormone-sensitive, and 15 castration-resistant patients...
April 11, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38602045/field-experience-with-the-8-hpv-type-oncoprotein-test-for-cervical-cancer-screening-among-hpv-positive-women-living-with-and-without-hiv-in-lmics
#6
JOURNAL ARTICLE
Laura Downham, Mary Luz Rol, Mathilde Forestier, Pilar Romero, Laura Mendoza, Pamela Mongelós, María Alejandra Picconi, María Celeste Colucci, Valeria Mariel Padin, Ana Paula Flores, Michael Zúñiga, Annabelle Ferrera, Yessy Cabrera, Marcela Farfan Crispín, Arianis Tatiana Ramirez, Londiwe Cele, Halimatou Diop-Ndiaye, Dianke Samaté, Pascaline Manga, Fadimatou Bintou Thiam, Maria Isabel Rodriguez, Jyoshma P DSouza, Victoria Nyawira Nyaga, Mamadou Diop, Motshedisi Sebitloane, Gloria Inés Sánchez, Carolina Teran, Alejandro Calderon, Carolina Wiesner, Raul Murillo, Rolando Herrero, Armando Baena, Maribel Almonte
Overexpression of HPV-oncoproteins E6 and E7 is necessary for HPV-driven cervical carcinogenesis. Hence, these oncoproteins are promising disease-specific biomarkers. We assessed the technical and operational characteristics of the 8-HPV-type OncoE6/E7 Cervical Test in different laboratories using cervical samples from HPV-positive women living with (WLWH) and without HIV. The 8-HPV-type OncoE6/E7 Test (for short: "OncoE6/E7 test") was performed in 2833 HIV-negative women and 241 WLWH attending multicentric studies in Latin America (ESTAMPA study), and in Africa (CESTA study)...
April 11, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38598851/effects-of-ambient-temperature-relative-humidity-and-absolute-humidity-on-risk-of-nasopharyngeal-carcinoma-in-china
#7
JOURNAL ARTICLE
Wenyi Di, Jiamin Yu, Dan Zong, Yizhi Ge, Yujie Zhang, Xin Chen, Xia He
Nasopharyngeal carcinoma (NPC) has a unique geographic distribution. It is unknown whether meteorological factors are related to the incidence of NPC. To investigate the effect of ambient temperature, relative humidity (RH), and absolute humidity (AH) on the incidence of NPC, we collected the incidence rate of NPC in 2016 and meteorological data from 2006 to 2016 from 484 cities and counties across 31 provinces in China. Generalized additive models with quasi-Poisson regression and generalized linear models with natural cubic splines were employed respectively to elucidate the nonlinear relationships and specify the partial linear relationships...
April 10, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38594805/prognosis-and-immunotherapy-efficacy-in-dmmr-mss-colorectal-cancer-patients-and-an-msi-status-predicting-model
#8
JOURNAL ARTICLE
Xinhui Fu, Jinglin Huang, Junling Zhu, Xinjuan Fan, Chao Wang, Weihao Deng, Xiaoli Tan, Zhiting Chen, Yacheng Cai, Hanjie Lin, Guannan Wang, Ning Zhang, Yongmin Zhu, Ji Chen, Huanmiao Zhan, Shuhui Huang, Yongzhen Fang, Yuhua Li, Yan Huang
The inconsistency between mismatch repair (MMR) protein immunohistochemistry (IHC) and microsatellite instability PCR (MSI-PCR) methods has been widely reported. We aim to investigate the prognosis and the effect of immunotherapy in dMMR by IHC but MSS by MSI-PCR (dMMR&MSS) colorectal cancer (CRC) patients. A microsatellite instability (MSI) predicting model was established to help find dMMR&MSS patients. MMR and MSI states were detected by the IHC and MSI-PCR in 1622 CRC patients (ZS6Y-1 cohort). Logistic regression analysis was used to screen clinical features to construct an MSI-predicting nomogram...
April 9, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38577898/differences-in-survival-and-recurrence-of-colorectal-cancer-by-stage-across-population-based-european-registries
#9
JOURNAL ARTICLE
Anne-Marie Bouvier, Valérie Jooste, Roberto Lillini, Rafael Marcos-Gragera, Alexander Katalinic, Paolo Giorgi Rossi, Guy Launoy, Véronique Bouvier, Marcela Guevara, Eva Ardanaz, Elisabetta Rapiti Aylward, Kaire Innos, Miguel Rodríguez Barranco, Milena Sant
Recurrence after colorectal cancer resection is rarely documented in the general population while a key clinical determinant for patient survival. We identified 8785 patients with colorectal cancer diagnosed between 2010 and 2013 and clinically followed up to 2020 in 15 cancer registries from seven European countries (Bulgaria, Switzerland, Germany, Estonia, France, Italy, and Spain). We estimated world age-standardized net survival using a flexible cumulative excess hazard model. Recurrence rates were calculated for patients with initially resected stage I, II, or III cancer in six countries, using the actuarial survival method...
April 5, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38577882/clinical-efficacy-of-tumor-organoid-guided-cancer-therapy-for-locally-advanced-unresectable-or-metastatic-breast-cancer
#10
JOURNAL ARTICLE
Ying-Yi Lin, Hong-Fei Gao, Hong Li, Qiong Hu, Bo-le Du, Sheng Li, Fang-Ping Xu, Min-Yi Cheng, Jia-Chen Zou, Xing-Xing Zheng, Teng Zhu, Kun Wang
Patient-derived organoids (PDOs) may facilitate treatment selection. This retrospective cohort study evaluated the feasibility and clinical benefit of using PDOs to guide personalized treatment in metastatic breast cancer (MBC). Patients diagnosed with MBC were recruited between January 2019 and August 2022. PDOs were established and the efficacy of customized drug panels was determined by measuring cell mortality after drug exposure. Patients receiving organoid-guided treatment (OGT) were matched 1:2 by nearest neighbor propensity scores with patients receiving treatment of physician's choice (TPC)...
April 5, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38577820/antibodies-against-high-risk-human-papillomavirus-proteins-as-markers-for-noncervical-hpv-related-cancers-in-a-black-south-african-population-according-to-hiv-status
#11
JOURNAL ARTICLE
Mwiza Gideon Singini, Mazvita Muchengeti, Freddy Sitas, Wenlong Carl Chen, Jean-Damien Combes, Tim Waterboer, Gary M Clifford
Human papillomavirus (HPV) proteins may elicit antibody responses in the process toward HPV-related malignancy. However, HPV seroepidemiology in noncervical HPV-related cancers remains poorly understood, particularly in populations with a high prevalence of human immunodeficiency virus (HIV). Using a glutathione S-transferase-based multiplex serology assay, antibodies against E6, E7 and L1 proteins of HPV16 and HPV18 were measured in sera of 535 cases of noncervical HPV-related cancers (anal (n = 104), vulval (n = 211), vaginal (n = 49), penile (n = 37) and oropharyngeal (n = 134)) and 6651 non-infection-related cancer controls, from the Johannesburg Cancer Study that recruited Black South African with newly diagnosed cancer between 1995 and 2016...
April 5, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38568397/trends-in-the-incidence-of-colorectal-cancer-in-sub-saharan-africa-a-population-based-registry-study
#12
JOURNAL ARTICLE
Laura Moen, Biying Liu, Phiona Bukirwa, Tatenda Chingonzoh, Eric Chokunonga, Anne Finesse, Ann Korir, Bojang Lamin, Cesaltina Ferreira Lorenzoni, Shyam S Manraj, Guy N'Da, Anani Wencesl Severin Odzebe, Olufemi Ogunbiyi, Nontuthuzelo I M Somdyala, Magdalena Packzowski, Donald M Parkin
In sub-Saharan Africa, colorectal cancer (CRC) has historically been considered a rare disease, although some previous studies have suggested that the incidence is increasing. We examine time trends in the incidence of CRC using data from 12 population-based cancer registries in 11 countries of sub-Saharan Africa that were able to provide time series data for periods of 12 or more years, or with earlier data with which recent rates may be compared. Age-standardized incidence rates were highest in the higher-income countries, and were increasing in all of the populations studied, and these increases were statistically significant in all but three...
April 3, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38567797/time-specific-impact-of-trace-metals-on-breast-density-of-adolescent-girls-in-santiago-chile
#13
JOURNAL ARTICLE
Claire E Kim, Ana Pereira, Alexandra M Binder, Chitra Amarasiriwardena, John A Shepherd, Camila Corvalan, Karin B Michels
Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV)...
April 3, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38561936/clinical-outcomes-of-coronavirus-disease-in-patients-with-breast-cancer-treated-with-granulocyte-colony-stimulating-factor-following-chemotherapy-triangulation-of-evidence-using-population-based-cohort-and-mendelian-randomization-analyses
#14
JOURNAL ARTICLE
Yali Wang, Weifeng Cai, Peng He, Qindong Cai, Jinhua Huang, Shougui Liu, Minyan Chen, Lili Chen, Yuxiang Lin, Jialin Hou, Jing Li, Chengbin Fu, Zhonghua Han, Hui Han, Shunguo Lin, Chunsen Xu, Fangmeng Fu, Chuan Wang
Recombinant human granulocyte colony-stimulating factor (G-CSF) administration in patients with cancer and coronavirus disease (COVID-19) remains controversial. Concerns exist that it may worsen COVID-19 outcomes by triggering an inflammatory cytokine storm, despite its common use for managing chemotherapy-induced neutropenia (CIN) or febrile neutropenia post-chemotherapy. Here, we determined whether prophylactic or therapeutic G-CSF administration following chemotherapy exacerbates COVID-19 progression to severe/critical conditions in breast cancer patients with COVID-19...
April 1, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38561928/indications-of-sustained-delay-of-colorectal-cancer-diagnoses-in-germany-during-the-first-2%C3%A2-years-of-the-covid-19-pandemic
#15
LETTER
Hermann Brenner, Lisa Weber, Rafael Cardoso, Thomas Heisser, Michael Hoffmeister, Bernd Holleczek
No abstract text is available yet for this article.
April 1, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38556848/restorabite%C3%A2-phase-ii-trial-of-jaw-stretching-exercises-using-a-novel-device-for-patients-with-trismus-following-head-and-neck-cancer
#16
JOURNAL ARTICLE
Emma Charters, Kai Cheng, Masako Dunn, Caleb Heng, Jamie Loy, Virginia Ricketts, Aaron Luo, Yee Mon Aung, Will Lewin, Dale Howes, Timothy Manzie, Boyang Wan, Jonathan Clark
Patients treated for oral cancer, may experience restricted mouth opening (trismus). Barriers such as cost have limited the utilization of traditional jaw stretching devices, and consequently, patients experience problems with swallowing, oral care, communication, and cancer surveillance. The safety and efficacy of Restorabite™, a new device designed to overcome these barriers, is evaluated prospectively over 12 months. This phase II investigator-led trial included patients with chronic trismus underwent 10-weeks of trismus therapy using Restorabite™...
March 31, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38554278/correction-to-real-world-treatment-patterns-for-palbociclib-plus-an-aromatase-inhibitor-or-an-aromatase-inhibitor-alone-for-patients-with-metastatic-breast-cancer-in-the-flatiron-database
#17
(no author information available yet)
No abstract text is available yet for this article.
March 30, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38554131/baseline-breast-tissue-characteristics-determine-the-effect-of-tamoxifen-on-mammographic-density-change
#18
JOURNAL ARTICLE
Marike Gabrielson, Mattias Hammarström, Jenny Bergqvist, Kristina Lång, Ann H Rosendahl, Signe Borgquist, Roxanna Hellgren, Kamila Czene, Per Hall
Tamoxifen prevents recurrence of breast cancer and is also approved for preventive, risk-reducing, therapy. Tamoxifen alters the breast tissue composition and decreases the mammographic density. We aimed to test if baseline breast tissue composition influences tamoxifen-associated density change. This biopsy-based study included 83 participants randomised to 6 months daily intake of placebo, 20, 10, 5, 2.5, or 1 mg tamoxifen. The study is nested within the double-blinded tamoxifen dose-determination trial Karolinska Mammography Project for Risk Prediction of Breast Cancer Intervention (KARISMA) Study...
March 30, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38554129/access-to-colorectal-cancer-screening-in-populations-in-china-2020-a-coverage-focused-synthesis-analysis
#19
JOURNAL ARTICLE
Yan-Jie Li, Xin Wang, Yu-Jie Wu, Xin-Yi Zhou, Jibin Li, Jiangmei Qin, Wanghong Xu, Jie-Bin Lew, Wanqing Chen, Ju-Fang Shi
In populations in China, colorectal cancer (CRC) screening can be mainly accessed through organized screening, opportunistic screening, and physical examination. This screening intervention is found to be effective but the exact coverage rate is difficult to measure. Based on data from published articles, official websites, and available program reports, the screening coverage rate and related indicators were quantified. A rapid review was then conducted to estimate the overall and the breakdown coverage rates of the sub-type screening services, by leveraging the numbers of articles and the by-type median sample sizes...
March 30, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38554127/use-of-5-alpha-reductase-inhibitors-and-risk-of-gastrointestinal-cancers-in-men-with-benign-prostatic-hyperplasia-a-population-based-cohort-study
#20
JOURNAL ARTICLE
Niamh Doherty, Chris Cardwell, Peter Murchie, Christopher Hill, Laurent Azoulay, Blánaid Hicks
Pre-clinical evidence suggests that 5-alpha reductase inhibitors (5ARi's), prescribed in the treatment of benign prostatic hyperplasia, reduce colorectal and gastro-oesophageal cancer incidence via action on the male hormonal pathway. However, few studies to date have investigated this association at the population level. Our study aimed to investigate the risk of colorectal and gastro-oesophageal cancers with the use of 5ARi's. We conducted a retrospective cohort study of new users of 5ARi's and alpha-blockers among patients with benign prostatic hyperplasia in the UK Clinical Practice Research Datalink...
March 30, 2024: International Journal of Cancer. Journal International du Cancer
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