Johannes M A Kusters, Brenda Diergaarde, Andrew Ness, Maarten F Schim van der Loeff, Janneke C M Heijne, Lea Schroeder, Katrina Hueniken, James D McKay, Gary J Macfarlane, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Antonio Agudo, Laia Alemany, Wolfgang Ahrens, Claire M Healy, David I Conway, Max Robinson, Christina Canova, Ivana Holcátová, Lorenzo Richiardi, Ariana Znaor, Miranda Pring, Steve Thomas, D Neil Hayes, Geoffrey Liu, Rayjean J Hung, Paul Brennan, Andrew F Olshan, Shama Virani, Tim Waterboer
A growing proportion of head and neck cancer (HNC), especially oropharyngeal cancer (OPC), is caused by human papillomavirus (HPV). There are several markers for HPV-driven HNC, one being HPV early antigen serology. We aimed to investigate the diagnostic accuracy of HPV serology and its performance across patient characteristics. Data from the VOYAGER consortium was used, which comprises five studies on HNC from North America and Europe. Diagnostic accuracy, that is, sensitivity, specificity, Cohen's kappa and correctly classified proportions of HPV16 E6 serology, was assessed for OPC and other HNC using p16INK4a immunohistochemistry (p16), HPV in situ hybridization (ISH) and HPV PCR as reference methods...
September 11, 2023: International Journal of Cancer. Journal International du Cancer