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International Journal of Cancer. Journal International du Cancer

https://read.qxmd.com/read/37728489/anal-cancer-screening-results-from-18-to-34-year-old-men-who-have-sex-with-men-living-with-hiv
#1
JOURNAL ARTICLE
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M Gaisa
Men who have sex with men living with HIV (MSM LWH) are at highest risk for human papillomavirus (HPV)-associated anal cancer. There is no consensus on the optimal screening initiation age. This study aimed to assess the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, which is a currently proposed screening age threshold. Between 2014 and 2020, 1255 18-to-34-year-old MSM LWH underwent anal cytology screening. 916 were co-tested for high-risk HPV (HR-HPV). 467 underwent high-resolution anoscopy (HRA) and biopsy...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37728485/tumor-cell-expressed-lipolysis-stimulated-lipoprotein-receptor-negatively-regulates-t-cell-function
#2
JOURNAL ARTICLE
Masashi Funauchi, Satoshi Serada, Kosuke Hiramatsu, Eiji Funajima, Mizuki Kanda, Yoshikazu Nagase, Satoshi Nakagawa, Tomoharu Ohkawara, Minoru Fujimoto, Yuji Suzuki, Yutaka Ueda, Tadashi Kimura, Tetsuji Naka
Lipolysis-stimulated lipoprotein receptor (LSR) is known as a lipoprotein receptor. LSR is expressed in various solid tumors, including epithelial ovarian, gastric, and colon cancers. High LSR expression is significantly associated with poor prognosis, but its role in cancer has not been fully elucidated. LSR belongs to the Ig protein superfamily, which is conserved in B7 family. Here, we assessed LSR as a novel immune checkpoint molecule. We developed a novel anti-LSR antibody (#27-6 mF-18) that defects antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity activity...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37728483/evaluating-interactions-of-polygenic-risk-scores-and-nat2-genotypes-with-tobacco-smoking-in-bladder-cancer-risk
#3
JOURNAL ARTICLE
Pranoti Pradhan, Guochong Jia, Nikhil K Khankari, Wei Zheng
Tobacco smoking is the most important risk factor for bladder cancer. Previous studies have identified the N-acetyltransferase (NAT2) gene in association with bladder cancer risk. The NAT2 gene encodes an enzyme that metabolizes aromatic amines, carcinogens commonly found in tobacco smoke. In our study, we evaluated potential interactions of tobacco smoking with NAT2 genotypes and polygenic risk score (PRS) for bladder cancer, using data from the UK Biobank, a large prospective cohort study. We used Cox proportional hazards models to measure the strength of the association...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37728072/geographic-sex-and-socioeconomic-disparities-in-esophageal-cancer-incidence-in-china-a-population-based-study
#4
JOURNAL ARTICLE
Xianhui Ran, Hongmei Zeng, Rongshou Zheng, Kexin Sun, Bingfeng Han, Shaoming Wang, Ru Chen, Li Li, Wenqiang Wei, Jie He
Geographic and sex differences in esophageal cancer have been reported in China, but data are lacking at the local level. We aimed to investigate geographic and sex disparities in esophageal cancer incidence among Chinese counties and whether county-level socioeconomic status was associated with these variations. We obtained esophageal cancer data from 2015 to 2017 for 782 counties from population-based cancer registries in China. We calculated age-standardized incidence rates and male-to-female incidence rate ratios (IRRs) by county...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37727982/telomere-dysfunction-in-tert-knockout-mice-delays-braf-v600e-induced-melanoma-development
#5
JOURNAL ARTICLE
Jinglong Zhang, Fan Zhang, Kenneth I Porter, Panshak P Dakup, Shuwen Wang, Gavin P Robertson, Shobhan Gaddameedhi, Jiyue Zhu
Telomerase activation is a crucial step in melanomagenesis, often occurring because of ultraviolet radiation (UVR)-induced mutations at the telomerase gene (TERT) promoter and rendering TERT transcription in response to the activated Raf-MAP kinase pathway by BRAFV600E mutation. Due to the excessively long telomeres in mice, this process does not occur during melanomagenesis in mouse models. To investigate the impact of telomere dysfunction on melanomagenesis, BrafV600E was induced in generations 1 and 4 (G1 and G4) of Tert-/- mice...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37724848/atypical-non-v600e-braf-mutations-in-metastatic-colorectal-cancer-in-population-and-real-world-cohorts
#6
JOURNAL ARTICLE
Emerik Osterlund, Ari Ristimäki, Markus J Mäkinen, Soili Kytölä, Juha Kononen, Per Pfeiffer, Leena-Maija Soveri, Mauri Keinänen, Halfdan Sorbye, Luís Nunes, Tapio Salminen, Lasse Nieminen, Aki Uutela, Päivi Halonen, Annika Ålgars, Jari Sundström, Raija Kallio, Raija Ristamäki, Annamarja Lamminmäki, Hanna Stedt, Eetu Heervä, Teijo Kuopio, Tobias Sjöblom, Helena Isoniemi, Bengt Glimelius, Pia Osterlund
BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, co-mutations and prognostic and predictive role. These were compared between mutational groups of mCRC patients collected from three Nordic population-based or real-world cohorts. Pathology of aBRAFmt was studied. The study included 1449 mCRC patients with 51 (3%) aBRAFmt, 182 (13%) BRAF-V600Emt, 456 (31%) RAS&BRAF wild-type (wt) and 760 (52%) RASmt tumours...
September 19, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37718333/21-gene-expression-assay-and-clinical-outcomes-of-premenopausal-patients-with-hormone-receptor-positive-breast-cancer
#7
JOURNAL ARTICLE
Jaewon Hyung, Sae Byul Lee, Jisun Kim, Hee Jeong Kim, BeomSeok Ko, Jong Won Lee, Byung-Ho Son, Hee Jin Lee, Gyungyub Gong, Hyehyun Jeong, Jae Ho Jeong, Jeong Eun Kim, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim
The prognostic role of the recurrence score (RS) based on the 21-gene expression assay in premenopausal women is not well delineated, and we investigated the association of outcomes and the RS in premenopausal patients who had 21-gene expression assay at Asan Medical Center, Seoul, Korea, between June 2005 and July 2018. Invasive breast cancer-free survival (IBCFS) by STEEP version 2.0 was compared according to the RS and clinical risk factors. A total of 554 patients were included in our study and 116 patients (20...
September 17, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37715472/the-impact-of-the-temporal-sequence-of-cranial-radiotherapy-and-platin-based-chemotherapy-on-hearing-impairment-in-pediatric-and-adolescent-cns-and-head-and-neck-cancer-patients-a-report-from-the-pancarelife-consortium
#8
JOURNAL ARTICLE
Sergiu Scobioala, Ross Parfitt, Peter Matulat, Julianne Byrne, Thorsten Langer, Fabian M Troschel, Amélie E Hesping, Eva Clemens, Peter Kaatsch, Desiree Grabow, Melanie Kaiser, Claudia Spix, Leontien C Kremer, Gabriele Calaminus, Katja Baust, Claudia E Kuehni, Annette Weiss, Sven Strebel, Rahel Kuonen, Susanne Elsner, Riccardo Haupt, Maria-Luisa Garré, Bernd Gruhn, Tomas Kepak, Katerina Kepakova, Jeanette Falck Winther, Line Kenborg, Catherine Rechnitzer, Henrik Hasle, Jarmila Kruseova, Ales Luks, Herwig Lackner, Stefan Bielack, Jörn-Dirk Beck, Heribert Jürgens, Marry M van den Heuvel-Eibrink, Oliver Zolk, Hans Theodor Eich, Antoinette Am Zehnhoff-Dinnesen
The impact of the temporal sequence by which cranial radiotherapy (CRT) and platin-based chemotherapy (PCth) are administered on sensorineural hearing loss (SNHL) in pediatric and adolescent central nervous system (CNS) and head-and-neck (HN) cancer patients has not yet been studied in detail. We examined the ototoxic effects of sequentially applied CRT and PCth. This study included children and adolescents with CNS and HN tumors who participated in the multicountry PanCareLIFE (PCL) consortium. Audiological outcomes were compared between patients who received CRT prior to PCth and those who received it afterwards...
September 15, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37715464/efficacy-of-thermal-ablation-for-treatment-of-biopsy-confirmed-high-grade-cervical-precancer-among-women-living-with-hiv-in-kenya
#9
JOURNAL ARTICLE
Chemtai Mungo, Cirilus Ogollah Osongo, Jeniffer Ambaka, Jackton Omoto, Craig R Cohen
The World Health Organization recommends thermal ablation (TA) as an alternative to cryotherapy within "screen-and-treat" cervical cancer programs in low- and middle-income countries (LMICs), including among women living with HIV (WLWH). Data on TA efficacy among WLWH are limited, however. We conducted a clinical trial to evaluate efficacy of TA for treatment of biopsy-confirmed cervical intraepithelial neoplasia grades 2 and 3 (CIN2/3) among WLWH in Kenya. Nonpregnant HPV-positive WLWH age 25 to 65 years underwent colposcopy-directed biopsy, and same-day treatment with TA, if eligible...
September 15, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37715370/state-of-the-science-and-future-directions-for-research-on-hiv-and-cancer-summary-of-a-joint-workshop-sponsored-by-iarc-and-nci
#10
REVIEW
Eric A Engels, Meredith S Shiels, Ruanne V Barnabas, Julia Bohlius, Paul Brennan, Jessica Castilho, Stephen J Chanock, Megan A Clarke, Anna E Coghill, Jean-Damien Combes, Scott Dryden-Peterson, Gypsyamber D'Souza, Satish Gopal, Antoine Jaquet, Kathryn Lurain, Alain Makinson, Jeffrey Martin, Mazvita Muchengeti, Robert Newton, Fred Okuku, Jackson Orem, Joel M Palefsky, Ramya Ramaswami, Hilary A Robbins, Keith Sigel, Sylvia Silver, Gita Suneja, Robert Yarchoan, Gary M Clifford
An estimated 38 million people live with human immunodeficiency virus (HIV) worldwide and are at excess risk for multiple cancer types. Elevated cancer risks in people living with HIV (PLWH) are driven primarily by increased exposure to carcinogens, most notably oncogenic viruses acquired through shared transmission routes, plus acceleration of viral carcinogenesis by HIV-related immunosuppression. In the era of widespread antiretroviral therapy (ART), life expectancy of PLWH has increased, with cancer now a leading cause of co-morbidity and death...
September 15, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37707172/incidence-trends-of-primary-liver-cancer-in-different-geographical-regions-of-china-from-1978-to-2012-and-projections-to-2032-an-age-period-cohort-analysis
#11
JOURNAL ARTICLE
Lin Jiang, Ningxuan Zhao, Minghan Xu, Jiao Pei, Yidie Lin, Qiang Yao, Meijing Hu, Cairong Zhu
China accounted for 45.3% of new cases of primary liver cancer (PLC) worldwide in 2020. While variations in PLC incidence between different regions of China and decreasing incidence in overall China have been reported, incidence patterns have not been thoroughly explored by region. We examined the nearly status and temporal trends of PLC incidence in different geographical regions in China and project future trends. The age-standardized incidence rate (ASR) was estimated for 1978 to 2012 by different geographical regions and gender in China...
September 14, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37700602/qrt-pcr-analysis-of-ceacam5-klk6-slc35d3-muc2-and-postn-in-colon-cancer-lymph-nodes-an-improved-method-for-assessment-of-tumor-stage-and-prognosis
#12
JOURNAL ARTICLE
Gudrun Lindmark, Lina Olsson, Basel Sitohy, Anne Israelsson, Joel Blomqvist, Sara Kero, Tamer Roshdy, Mattias Söderholm, Annamaria Turi, Jessica Isaksson, Thorbjörn Sakari, Michiel Dooper, George Dafnis, Pehr Forsberg, Susanne Skovsted, Maria Walldén, Chih-Han Kung, Martin Rutegård, Johanna Nordmyr, Måns Muhrbeck, Sten Hammarström, Marie-Louise Hammarström
One fourth of colorectal cancer patients having curative surgery will relapse of which the majority will die. Lymph node (LN) metastasis is the single most important prognostic factor and a key factor when deciding on postoperative treatment. Presently, LN metastases are identified by histopathological examination, a subjective method analyzing only a small LN volume and giving no information on tumor aggressiveness. To better identify patients at risk of relapse we constructed a qRT-PCR test, ColoNode, that determines levels of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN mRNAs...
September 12, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37699232/removal-of-gemcitabine-induced-senescent-cancer-cells-by-targeting-glutaminase1-improves-the-therapeutic-effect-in-pancreatic-ductal-adenocarcinoma
#13
JOURNAL ARTICLE
Keisuke Oyama, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Tadafumi Asaoka, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Insufficient cancer treatment can induce senescent cancer cell formation and treatment resistance. The characteristics of induced senescent cancer (iSnCa) cells remain unclear. Pancreatic ductal adenocarcinoma (PDAC) has a low and nondurable response rate to current treatments. Our study aimed to analyze the properties of iSnCa cells and the relationship between cellular senescence and prognosis in PDAC. We evaluated the characteristics of gemcitabine-induced senescent cancer cells and the effect of senescence-associated secretory phenotype (SASP) factors released by iSnCa cells on surrounding PDAC cells...
September 12, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37694922/long-term-follow-up-of-cervical-cancer-incidence-after-normal-cytological-findings
#14
JOURNAL ARTICLE
Jiangrong Wang, Henrik Edvardsson, Björn Strander, Bengt Andrae, Pär Sparén, Joakim Dillner
An increase in cervical cancer incidence in Sweden from 2014 to 2015 has been attributed to an increase in false-negative cytological findings before cancer diagnoses. Years later, we performed a long-term follow-up to investigate whether the problem persisted. At each calendar year from 2016 to 2020, we identified women with prior normal cervical screening results through linkage to the Swedish National Cervical Screening Registry. We reported their incidence rates (IRs) of invasive cervical cancer in consecutive years and compared the IRs over time...
September 11, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37694915/nonchromosomal-birth-defects-and-risk-of-childhood-acute-leukemia-an-assessment-in-15%C3%A2-000-leukemia-cases-and-46%C3%A2-000-controls-from-the-childhood-cancer-and-leukemia-international-consortium
#15
JOURNAL ARTICLE
Philip J Lupo, Tiffany M Chambers, Beth A Mueller, Jacqueline Clavel, John D Dockerty, David R Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E Heck, Claire Infante-Rivard, Alice Y Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D Bailey, Ana M Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S Pombo-de-Oliveira, Wafaa M Rashed, Eve Roman, Joachim Schüz, Catharina Wesseling, Logan G Spector, Michael E Scheurer
Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire-based and three registry-based case-control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia...
September 11, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37694774/identification-of-pre-diagnostic-lipid-sets-associated-with-liver-cancer-risk-using-untargeted-lipidomics-and-chemical-set-analysis-a-nested-case-control-study-within-the-atbc-cohort
#16
JOURNAL ARTICLE
Dinesh K Barupal, Mark L Ramos, Andrea A Florio, William A Wheeler, Stephanie J Weinstein, Demetrius Albanes, Oliver Fiehn, Barry I Graubard, Jessica L Petrick, Katherine A McGlynn
In pre-disposed individuals, a reprogramming of the hepatic lipid metabolism may support liver cancer initiation. We conducted a high-resolution mass spectrometry based untargeted lipidomics analysis of pre-diagnostic serum samples from a nested case-control study (219 liver cancer cases and 219 controls) within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Out of 462 annotated lipids, 158 (34.2%) were associated with liver cancer risk in a conditional logistic regression analysis at a false discovery rate (FDR) <0...
September 11, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37694289/diagnostic-accuracy-of-hpv16-early-antigen-serology-for-hpv-driven-oropharyngeal-cancer-is-independent-of-age-and-sex
#17
JOURNAL ARTICLE
Johannes M A Kusters, Brenda Diergaarde, Andrew Ness, Maarten F Schim van der Loeff, Janneke C M Heijne, Lea Schroeder, Katrina Hueniken, James D McKay, Gary J Macfarlane, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Antonio Agudo, Laia Alemany, Wolfgang Ahrens, Claire M Healy, David I Conway, Max Robinson, Christina Canova, Ivana Holcátová, Lorenzo Richiardi, Ariana Znaor, Miranda Pring, Steve Thomas, D Neil Hayes, Geoffrey Liu, Rayjean J Hung, Paul Brennan, Andrew F Olshan, Shama Virani, Tim Waterboer
A growing proportion of head and neck cancer (HNC), especially oropharyngeal cancer (OPC), is caused by human papillomavirus (HPV). There are several markers for HPV-driven HNC, one being HPV early antigen serology. We aimed to investigate the diagnostic accuracy of HPV serology and its performance across patient characteristics. Data from the VOYAGER consortium was used, which comprises five studies on HNC from North America and Europe. Diagnostic accuracy, that is, sensitivity, specificity, Cohen's kappa and correctly classified proportions of HPV16 E6 serology, was assessed for OPC and other HNC using p16INK4a immunohistochemistry (p16), HPV in situ hybridization (ISH) and HPV PCR as reference methods...
September 11, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37688376/glycolysis-regulation-in-tumor-associated-macrophages-its-role-in-tumor-development-and-cancer-treatment
#18
REVIEW
Guangyi Jiang, Junjie Hong, Lu Sun, Haibin Wei, Wangang Gong, Shu Wang, Jianqing Zhu
Tumor-associated macrophages constitute the main cell population in the tumor microenvironment and play a crucial role in regulating the microenvironment composition. Emerging evidence has revealed that the metabolic profile determines the tumor-associated macrophage phenotype. Tumor-associated macrophage function is highly dependent on glucose metabolism, with glycolysis being the major metabolic pathway. Recent reports have demonstrated diversity in glucose flux of tumor-associated macrophages and complex substance communication with cancer cells...
September 8, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37682630/gynaecologic-and-breast-cancers-in-women-living-with-hiv-in-south-africa-a-record-linkage-study
#19
JOURNAL ARTICLE
Tafadzwa G Dhokotera, Mazvita Muchengeti, Maša Davidović, Eliane Rohner, Victor Olago, Matthias Egger, Julia Bohlius
Breast and gynaecologic cancers account for approximately half of all cancers diagnosed amongst women in South Africa, many of whom also live with HIV. We aimed to determine the incidence of and risk factors for developing breast and gynaecologic cancers in women living with HIV (WLHIV) in South Africa. This is a longitudinal analysis of the South African HIV Cancer Match study including women aged ≥15 years with two or more HIV-related laboratory tests. We used Cox proportional hazard models to determine the association of Human Papilloma Virus (HPV)-related and hormone-related gynaecologic cancer with patient- and municipal-level characteristics...
September 8, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37676657/madcam-1-targeting-strategy-can-prevent-colitic-cancer-carcinogenesis-and-progression-via-suppression-of-immune-cell-infiltration-and-inflammatory-signals
#20
JOURNAL ARTICLE
Naoya Ozawa, Takehiko Yokobori, Katsuya Osone, Erkhem-Ochir Bilguun, Haruka Okami, Yuki Shimoda, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Munenori Ide, Hiroomi Ogawa, Takashi Yao, Tetsunari Oyama, Ken Shirabe, Hiroshi Saeki
Chronic inflammation caused by infiltrating immune cells can promote colitis-associated dysplasia/colitic cancer in ulcerative colitis (UC) by activating inflammatory cytokine signalling through the IL-6/p-STAT3 and TNFα/NF-κB pathways. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expressed on high endothelial venules promotes the migration of immune cells from the bloodstream to the gut via interaction with α4β7 integrin expressed on the immune cells. MAdCAM-1, has therefore drawn interest as a novel therapeutic target for treating active UC...
September 7, 2023: International Journal of Cancer. Journal International du Cancer
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