Igor V Ukrainets, Mykola Y Golik, Lyudmila V Sidorenko, Valentina I Korniyenko, Lina A Grinevich, Galina Sim, Olga V Kryvanych
In accordance with the principles of "me-too" technique, the preparative method for obtaining has been proposed, and the synthesis of a large series of new N -(arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1 H -pyrrolo[3,2,1- ij ]quinoline-5-carboxamides as structurally close analogs of tricyclic pyrrolo- and pyridoquinoline diuretics has been carried out. All target compounds were obtained with high yields and purity by amidation of ethyl ester of the corresponding 2-methyl-pyrroloquinoline-5-carboxylic acid with arylalkylamines in boiling ethanol...
August 29, 2018: Scientia Pharmaceutica