Aki Tsuchiyagaito, Masaya Misaki, Namik Kirlic, Xiaoqian Yu, Stella M Sánchez, Gabe Cochran, Jennifer L Stewart, Ryan Smith, Kate D Fitzgerald, Michael L Rohan, Martin P Paulus, Salvador M Guinjoan
INTRODUCTION: Repetitive negative thinking (RNT) is a cognitive process focusing on self-relevant and negative experiences, leading to a poor prognosis of major depressive disorder (MDD). We previously identified that connectivity between the precuneus/posterior cingulate cortex (PCC) and right temporoparietal junction (rTPJ) was positively correlated with levels of RNT. OBJECTIVE: In this double-blind, randomized, sham-controlled, proof-of-concept trial, we employed real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) to delineate the neural processes that may be causally linked to RNT and could potentially become treatment targets for MDD...
January 11, 2023: Psychotherapy and Psychosomatics