David Brenes, Mila P Salcedo, Jackson B Coole, Yajur Maker, Alex Kortum, Richard A Schwarz, Jennifer Carns, Imran S Vohra, Julio C Possati-Resende, Marcio Antoniazzi, Bruno de Oliveira Fonseca, Karen C Borba Souza, Iara V Vidigal Santana, Flavia Fazzio Barbin, Regis Kreitchmann, Nirmala Ramanujam, Kathleen M Schmeler, Rebecca Richards-Kortum
OBJECTIVE: Early detection and treatment of cervical precancers can prevent disease progression. However, in low-resource communities with a high incidence of cervical cancer, high equipment costs and a shortage of specialists hinder preventative strategies. This manuscript presents a low-cost multiscale in vivo optical imaging system coupled with a computer-aided diagnostic system that could enable accurate, real-time diagnosis of high-grade cervical precancers. METHODS: The system combines portable colposcopy and high-resolution endomicroscopy (HRME) to acquire spatially registered widefield and microscopy videos...
March 20, 2024: IEEE Transactions on Bio-medical Engineering