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JOURNAL ARTICLE
Nicholas A Wachowski, James A Pippin, Keith Boehm, Sumei Lu, Michelle E Leonard, Elisabetta Manduchi, Ursula W Parlin, Martin Wabitsch, Alessandra Chesi, Andrew D Wells, Struan F A Grant, Matthew C Pahl
AIMS/HYPOTHESIS: Genome-wide association studies (GWAS) have identified hundreds of type 2 diabetes loci, with the vast majority of signals located in non-coding regions; as a consequence, it remains largely unclear which 'effector' genes these variants influence. Determining these effector genes has been hampered by the relatively challenging cellular settings in which they are hypothesised to confer their effects. METHODS: To implicate such effector genes, we elected to generate and integrate high-resolution promoter-focused Capture-C, assay for transposase-accessible chromatin with sequencing (ATAC-seq) and RNA-seq datasets to characterise chromatin and expression profiles in multiple cell lines relevant to type 2 diabetes for subsequent functional follow-up analyses: EndoC-BH1 (pancreatic beta cell), HepG2 (hepatocyte) and Simpson-Golabi-Behmel syndrome (SGBS; adipocyte)...
September 6, 2024: Diabetologia
#22
LETTER
Jan W Eriksson, Maria J Pereira, Giovanni Fanni, Ulf Risérus, Mark Lubberink, Håkan Ahlström
No abstract text is available yet for this article.
September 5, 2024: Diabetologia
#23
LETTER
Roy Taylor
No abstract text is available yet for this article.
September 5, 2024: Diabetologia
#24
LETTER
Decio L Eizirik, Priscila L Zimath, Xiaoyan Yi, Arturo Roca Rivada, Sarah J Richardson
No abstract text is available yet for this article.
September 5, 2024: Diabetologia
#25
Moshe Phillip, Peter Achenbach, Ananta Addala, Anastasia Albanese-O'Neill, Tadej Battelino, Kirstine J Bell, Rachel E J Besser, Ezio Bonifacio, Helen M Colhoun, Jennifer J Couper, Maria E Craig, Thomas Danne, Carine de Beaufort, Klemen Dovc, Kimberly A Driscoll, Sanjoy Dutta, Osagie Ebekozien, Helena Elding Larsson, Daniel J Feiten, Brigitte I Frohnert, Robert A Gabbay, Mary P Gallagher, Carla J Greenbaum, Kurt J Griffin, William Hagopian, Michael J Haller, Christel Hendrieckx, Emile Hendriks, Richard I G Holt, Lucille Hughes, Heba M Ismail, Laura M Jacobsen, Suzanne B Johnson, Leslie E Kolb, Olga Kordonouri, Karin Lange, Robert W Lash, Åke Lernmark, Ingrid Libman, Markus Lundgren, David M Maahs, M Loredana Marcovecchio, Chantal Mathieu, Kellee M Miller, Holly K O'Donnell, Tal Oron, Shivajirao P Patil, Rodica Pop-Busui, Marian J Rewers, Stephen S Rich, Desmond A Schatz, Rifka Schulman-Rosenbaum, Kimber M Simmons, Emily K Sims, Jay S Skyler, Laura B Smith, Cate Speake, Andrea K Steck, Nicholas P B Thomas, Ksenia N Tonyushkina, Riitta Veijola, John M Wentworth, Diane K Wherrett, Jamie R Wood, Anette-Gabriele Ziegler, Linda A DiMeglio
No abstract text is available yet for this article.
September 4, 2024: Diabetologia
#26
JOURNAL ARTICLE
Rebecca L Thomson, James D Brown, Helena Oakey, Kirsten Palmer, Pat Ashwood, Megan A S Penno, Kelly J McGorm, Rachel Battersby, Peter G Colman, Maria E Craig, Elizabeth A Davis, Tony Huynh, Leonard C Harrison, Aveni Haynes, Richard O Sinnott, Peter J Vuillermin, John M Wentworth, Georgia Soldatos, Jennifer J Couper
AIMS/HYPOTHESIS: Dietary patterns characterised by high intakes of vegetables may lower the risk of pre-eclampsia and premature birth in the general population. The effect of dietary patterns in women with type 1 diabetes, who have an increased risk of complications in pregnancy, is not known. The aim of this study was to investigate the relationship between dietary patterns and physical activity during pregnancy and maternal complications and birth outcomes in women with type 1 diabetes...
September 2, 2024: Diabetologia
#27
JOURNAL ARTICLE
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, Paula O'Shea, Declan Devane, Paddy Gillespie, Aoife Egan, Martin O'Donnell, Andrew Smyth
AIMS/HYPOTHESIS: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes because of suboptimal glucose management and glucose control and excessive weight gain. Metformin can offset these factors but is associated with small for gestational age (SGA) infants. We sought to identify risk factors for SGA infants, including the effect of metformin exposure on SGA status. METHODS: In this prespecified secondary analysis of the EMERGE trial, which evaluated the effectiveness of metformin vs placebo in treating GDM and found reduced gestational weight gain and longer time to insulin initiation with metformin use, we included women with a live-born infant and known infant birthweight and gestational age at delivery...
August 31, 2024: Diabetologia
#28
EDITORIAL
Ritwika Mallik, Partha Kar, Hindrik Mulder, Anna Krook
No abstract text is available yet for this article.
August 30, 2024: Diabetologia
#29
LETTER
Renza Scibilia, Niki Breslin-Brooker, Chris Bright, Tinotenda Dzikiti, Salih Hendricks, Vilgot Shik, Jazz Sethi, Sara Vanhentenryk, Lakshminarayana Varimadugu, Jurgen Vercauteren
No abstract text is available yet for this article.
August 30, 2024: Diabetologia
#30
JOURNAL ARTICLE
Donna S-H Lin, Jen-Kuang Lee, Kuan-Chih Huang, Ting-Tse Lin, Hao-Yun Lo
AIMS/HYPOTHESIS: Although the benefits of sodium-glucose cotransporter 2 inhibitor (SGLT2i) use in chronic kidney disease (CKD) are well established, the effects of these therapeutic agents in patients with advanced CKD are less certain. We hypothesised that the continued use of these drugs, even when renal function deteriorates to stage 4 CKD or worse, is safe and associated with improved cardiorenal survival. METHODS: This is a retrospective cohort study utilising data from medical records from two institutions...
August 29, 2024: Diabetologia
#31
JOURNAL ARTICLE
William L Lowe, Alan Kuang, M Geoffrey Hayes, Marie-France Hivert, Denise M Scholtens
AIMS/HYPOTHESIS: Pregnancy is accompanied by maternal metabolic adaptations to ensure fetal growth and development, including insulin resistance, which occurs primarily during the second and third trimesters of pregnancy, and a decrease in fasting blood sugar levels over the course of pregnancy. Glucose-related traits are regulated by genetic and environmental factors and modulated by physiological variations throughout the life course. We addressed the hypothesis that there are both overlaps and differences between genetic variants associated with glycaemia-related traits during and outside of pregnancy...
August 24, 2024: Diabetologia
#32
REVIEW
Lianna W Wat, Katrin J Svensson
The tight regulation of glucose and lipid metabolism is crucial for maintaining metabolic health. Dysregulation of these processes can lead to the development of metabolic diseases. Secreted factors, or hormones, play an essential role in the regulation of glucose and lipid metabolism, thus also playing an important role in the development of metabolic diseases such as type 2 diabetes and obesity. Given the important roles of secreted factors, there has been significant interest in identifying new secreted factors and new functions for existing secreted factors that control glucose and lipid metabolism...
August 24, 2024: Diabetologia
#33
JOURNAL ARTICLE
Gian Paolo Fadini, Enrico Longato, Mario Luca Morieri, Enzo Bonora, Agostino Consoli, Bruno Fattor, Mauro Rigato, Federica Turchi, Stefano Del Prato, Angelo Avogaro, Anna Solini
AIMS/HYPOTHESIS: We compared the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on renal outcomes in individuals with type 2 diabetes, focusing on the changes in eGFR and albuminuria. METHODS: This was a multicentre retrospective observational study on new users of diabetes medications. Participant characteristics were assessed before and after propensity score matching. The primary endpoint, change in eGFR, was analysed using mixed-effects models...
August 23, 2024: Diabetologia
#34
JOURNAL ARTICLE
Hayato Tanabe, Masahiro Sato, Akimitsu Miyake, Yoshinori Shimajiri, Takafumi Ojima, Akira Narita, Haruka Saito, Kenichi Tanaka, Hiroaki Masuzaki, Junichiro J Kazama, Hideki Katagiri, Gen Tamiya, Eiryo Kawakami, Michio Shimabukuro
AIMS/HYPOTHESIS: Clustering-based subclassification of type 2 diabetes, which reflects pathophysiology and genetic predisposition, is a promising approach for providing personalised and effective therapeutic strategies. Ahlqvist's classification is currently the most vigorously validated method because of its superior ability to predict diabetes complications but it does not have strong consistency over time and requires HOMA2 indices, which are not routinely available in clinical practice and standard cohort studies...
August 21, 2024: Diabetologia
#35
JOURNAL ARTICLE
Kamlesh Khunti, Francesco Zaccardi, Aslam Amod, Vanita R Aroda, Pablo Aschner, Stephen Colagiuri, Viswanathan Mohan, Juliana C N Chan
A panel of primary care and diabetes specialists conducted focused literature searches on the current role of glycaemic control in the management of type 2 diabetes and revisited the evolution of evidence supporting the importance of early and intensive blood glucose control as a central strategy to reduce the risk of adverse long-term outcomes. The optimal approach to type 2 diabetes management has evolved over time as the evidence base has expanded from data from trials that established the role of optimising glycaemic control to recent data from cardiovascular outcomes trials (CVOTs) demonstrating organ-protective effects of newer glucose-lowering drugs (GLDs)...
August 19, 2024: Diabetologia
#36
LETTER
Carolin T Lehner, Gunther Schauberger, Stefanie J Klug
No abstract text is available yet for this article.
August 17, 2024: Diabetologia
#37
REVIEW
Bruce A Perkins, Lauren V Turner, Michael C Riddell
Challenges and fears related to managing glucose levels around planned and spontaneous exercise affect outcomes and quality of life in people living with type 1 diabetes. Advances in technology, including continuous glucose monitoring, open-loop insulin pump therapy and hybrid closed-loop (HCL) systems for exercise management in type 1 diabetes, address some of these challenges. In this review, three research or clinical experts, each living with type 1 diabetes, leverage published literature and clinical and personal experiences to translate research findings into simplified, patient-centred strategies...
August 15, 2024: Diabetologia
#38
LETTER
Peter M Nilsson, Allan Vaag
No abstract text is available yet for this article.
August 15, 2024: Diabetologia
#39
#40
JOURNAL ARTICLE
Jolade Adebekun, Ajay Nadig, Priscilla Saarah, Samira Asgari, Linda Kachuri, David A Alagpulinsa
AIMS/HYPOTHESIS: Type 1 diabetes is associated with excess coronary artery disease (CAD) risk even when known cardiovascular risk factors are accounted for. Genetic perturbation of haematopoiesis that alters leukocyte production is a novel independent modifier of CAD risk. We examined whether there are shared genetic determinants and causal relationships between type 1 diabetes, CAD and leukocyte counts. METHODS: Genome-wide association study summary statistics were used to perform pairwise linkage disequilibrium score regression and heritability estimation from summary statistics (ρ-HESS) to respectively estimate the genome-wide and local genetic correlations, and two-sample Mendelian randomisation to estimate the causal relationships between leukocyte counts (335,855 healthy individuals), type 1 diabetes (18,942 cases, 501,638 control individuals) and CAD (122,733 cases, 424,528 control individuals)...
August 14, 2024: Diabetologia
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